Dr Lewis Quayle

I obtained my PhD in the Bone Oncology groups of Prof. Ingunn Holen and Dr Penelope Ottewell in the Department of Oncology & Metabolism at The University of Sheffield. My PhD project focussed on developing novel models of mitotic quiescence and metastatic dormancy in breast cancer and my early postdoctoral work focussed on characterising the cellular sub-populations isolated from these model systems using a multitude of approaches, including next-generation sequencing.

During 2019, I undertook a three-month training placement in high-performance computing (HPC) and bioinformatic analysis of next-generation sequencing data at the Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research (Sydney, Australia) working under Dr Nenad Bartonicek in the Group of Prof. Alex Swarbrick.

Upon my return to The University of Sheffield, I transitioned to a two-year position as a postdoctoral cancer bioinformatician and in June 2022 moved to my current role as cancer bioinformatician embedded within the Sheffield Bioinformatics Core Facility and working in the groups of Prof. James Catto and Dr Dennis Wang.

My role within the Sheffield Bioinformatics Core Facility involves delivery of custom analyses, processed data, experimental results, and reports detailing quality control procedures and analytical workflows to core facility users. I am also involved in supporting the provision of best-practice training and workshops in next-generation sequencing and bioinformatics techniques to laboratory scientists, assisting investigators across the university in statistically sound experimental design, aiding interpretation of results, and grant or manuscript writing where these require extensive bioinformatics input.