Dr Lewis Quayle

Department of Oncology and Metabolism

Cancer Bioinformatician

l.quayle@sheffield.ac.uk
+44 114 215 9209

Full contact details

Dr Lewis Quayle
Department of Oncology and Metabolism
Room M120, M Floor
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
Profile

I obtained my PhD in the Bone Oncology groups of Prof. Ingunn Holen and Dr Penelope Ottewell in the Department of Oncology & Metabolism at The University of Sheffield. My PhD project focussed on developing novel models of mitotic quiescence and metastatic dormancy in breast cancer and my early postdoctoral work focussed on characterising the cellular sub-populations isolated from these model systems using a multitude of approaches, including next-generation sequencing.

During 2019, I undertook a three-month training placement in high-performance computing (HPC) and bioinformatic analysis of next-generation sequencing data at the Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research (Sydney, Australia) working under Dr Nenad Bartonicek in the Group of Prof. Alex Swarbrick.

Upon my return to The University of Sheffield, I transitioned to a two-year position as a postdoctoral cancer bioinformatician and in June 2022 moved to my current role as cancer bioinformatician embedded within the Sheffield Bioinformatics Core Facility and working in the groups of Prof. James Catto and Dr Dennis Wang.

My role within the Sheffield Bioinformatics Core Facility involves delivery of custom analyses, processed data, experimental results, and reports detailing quality control procedures and analytical workflows to core facility users. I am also involved in supporting the provision of best-practice training and workshops in next-generation sequencing and bioinformatics techniques to laboratory scientists, assisting investigators across the university in statistically sound experimental design, aiding interpretation of results, and grant or manuscript writing where these require extensive bioinformatics input.
 

Research interests

My current research activity is centred on a project aiming to create a mutational map of the non-coding regions of patient genomes for the bladder cancer arm of the 100,000 Genomes Project. I am also contributing bioinformatics capability to the Genotype of Urothelial Cancer - Stratified Treatment and Oncological outcomes (GUSTO) phase II clinical study. These roles involve contributing to the maintenance of well-curated, highly structured, transparent resources for integrating genomic and clinical data, and assessing, testing, and implementing best practice scalable HPC workflows and methods for genomic data analysis.

Publications

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Journal articles

Chapters

Conference proceedings papers

Professional activities

I am currently a member of the British Association for Cancer Research (BACR), the European Association for Cancer Research (EACR), the Institute of Biomedical Science (IBMS) and the Royal Society of Biology (RSB).