Dr Ning Wang

Department of Oncology and Metabolism

Principal Investigator

Principal Investigator

n.wang@sheffield.ac.uk
+44 114 215 9216

Full contact details

Dr Ning Wang
Department of Oncology and Metabolism
DU10, D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I undertook my undergraduate (BSc) and postgraduate (MRes) training in biology at Ocean University of China. After moving to the UK in 2004, I studied the trend of Biotech-industry development at Loughborough University and gained my MSc in Management the following year.

I then joined Professor Alison Gartland’s group in Sheffield and was awarded my PhD in 2010 after completing my PhD project in investigating the roles of purinergic signalling in osteoporosis. I was subsequently appointed as a Post-doctoral Research Associate in Dr Colby Eaton’s lab and developed the models used in the identification of dormant metastasis initiating tumour cells in a Cancer Research UK programme grant.

I was then employed as a Senior Post-doctoral Research Associate in Professor Tim Skerry’s group within the Department of Oncology & Metabolism and worked on the Wellcome Trust sponsored programme in development of novel agents for the treatment of pancreatic cancer. I am currently an independent Research Fellow in the Academic Group of Bone Biology.

Research interests

My research interests are focused on bone oncology and bone biology. My current autonomous research is to determine how exercise-induced cellular changes affect cancer bone metastasis.

I am also interested in characterizing metastasis initiating cells and investigating interactions between these cells and bone microenvironment, as continuous development of a Cancer Research UK sponsored research programme. In addition, investigating the role of purinergic signalling in other musculoskeletal diseases such as osteoporosis and osteoarthritis is also in my research interests.

Current projects

  • Determining the impact of mechanical loading induced bone remodelling on the initiation and progression of prostate cancer skeletal metastasis (Prostate Cancer UK Research Innovation Award)
  • Determining the impact of exercise on the initiation of breast cancer skeletal metastasis using pre-clinical models (Weston Park Cancer Charity Large Grant)
  • Defining the role of P2X7 receptor in the prostate cancer metastasizing into the skeleton (The Royal Society International Exchange Scheme)
Publications

Journal articles

Chapters

Conference proceedings papers

  • Arredondoo HM, Eaton CL & Wang N (2018) P2X7 receptor in prostate cancer bone metastasis initiating cells. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S13) RIS download Bibtex download
  • Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S67-S67) RIS download Bibtex download
  • Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S85-S86) RIS download Bibtex download
  • Wang N, Robaye B, Agrawal A, Reilly G, Boeynaems JM & Gartland A (2011) Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227) RIS download Bibtex download
  • Rumney RMH, Wang N & Gartland A (2010) The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129) RIS download Bibtex download
  • Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140) RIS download Bibtex download
  • Wang N, Rumney RMH, Agrawal A, Robaye B, Boeynaems JM & Gartland A (2010) Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144) RIS download Bibtex download
  • Martinez-Bautista S, Wang N, Richards Q & Skerry TM (2008) Mice Lacking NMDA Receptor Expression in Osteoblasts Have Pronounced Vertebral Bone Abnormalities. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S87-S87) RIS download Bibtex download
  • Rumney R, Wang N, Sittichokechaiwut A, Reilly G & Gartland A (2008) Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165) RIS download Bibtex download
  • Patel V, Rumney R, Wang N, Hipskind RH, Gallagher JA & Gartland A (2008) The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206) RIS download Bibtex download
Research group

PhD students

  • Hector M Arredondo
  • Jiepei He
Grants

Sponsors

Teaching interests

My teaching interests are mainly supervising research projects for both postgraduates (PhD and MSc) and undergraduate (BMedSci and SSC). I also teach cancer and bone biology related lectures on the MSc in Human Nutrition, MSc in Molecular Medicine, and the CIMA MRes Musculoskeletal Ageing.

Professional activities

I regularly review research articles for a number of international journals such as Scientific Reports, PlosOne, Anti-Cancer Drugs, and Journal of Bone Oncology, as well as grant applications for external funding bodies.