Dr Patrick Herr

All publications

Journal articles

• Franco J, Piacente F, Walter M, Fratta S, Ghanem M, Benzi A, Caffa I, Kurkin AV, Altieri A, Herr P , Martínez-Bailén M et al (2022) Structure-based identification and biological characterization of new NAPRT inhibitors. Pharmaceuticals, 15(7).
• Walter M & Herr P (2022) Re-discovery of pyrimidine salvage as target in cancer therapy. Cells, 11(4). View this article in WRRO
• Visnes T, Benítez-Buelga C, Cázares-Körner A, Sanjiv K, Hanna BMF, Mortusewicz O, Rajagopal V, Albers JJ, Hagey DW, Bekkhus T , Eshtad S et al (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research. View this article in WRRO
• Herr P, Boström J, Rullman E, Rudd SG, Vesterlund M, Lehtiö J, Helleday T, Maddalo G & Altun M (2020) Cell cycle profiling reveals protein oscillation, phosphorylation, and localization dynamics. Molecular & Cellular Proteomics, 19(4), 608-623. View this article in WRRO
• Carter M, Jemth A-S, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T & Stenmark P (2018) Human NUDT22 is a UDP-glucose/galactose hydrolase exhibiting a unique structural fold. Structure, 26(2), 295-303.e6. View this article in WRRO
• Sokolova M, Turunen M, Mortusewicz O, Kivioja T, Herr P, Vähärautio A, Björklund M, Taipale M, Helleday T & Taipale J (2017) Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle, 16(2), 189-199.
• Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B , Chernobrovkin A et al (2016) Validation and development of MTH1 inhibitors for treatment of cancer. Annals of Oncology, 27(12), 2275-2283.
• Tanikawa M, Sanjiv K, Helleday T, Herr P & Mortusewicz O (2016) The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis, 5(12). View this article in WRRO
• Valerie NCK, Hagenkort A, Page BDG, Masuyer G, Rehling D, Carter M, Bevc L, Herr P, Homan E, Sheppard NG , Stenmark P et al (2016) NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine. Cancer Research, 76(18), 5501-5511.
• Valenta T, Degirmenci B, Moor AE, Herr P, Zimmerli D, Moor MB, Hausmann G, Cantù C, Aguet M & Basler K (2016) Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis. Cell Reports, 15(5), 911-918.
• Xie S, Mortusewicz O, Ma HT, Herr P, Poon RYC, Helleday T & Qian C (2016) Correction: Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell, 61(1), 181-181.
• Xie S, Mortusewicz O, Ma HT, Herr P, Poon RYC, Helleday T & Qian C (2015) Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell, 60(1), 163-176.
• Gay MH-P, Valenta T, Herr P, Paratore-Hari L, Basler K & Sommer L (2015) Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biology, 13(1).
• Herr P, Lundin C, Evers B, Ebner D, Bauerschmidt C, Kingham G, Palmai-Pallag T, Mortusewicz O, Frings O, Sonnhammer E & Helleday T (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery, 1(1). View this article in WRRO
• Herr P, Hausmann G & Basler K (2012) WNT secretion and signalling in human disease. Trends in Molecular Medicine, 18(8), 483-493.
• Herr P & Basler K (2012) Porcupine-mediated lipidation is required for Wnt recognition by Wls. Developmental Biology, 361(2), 392-402.
• Gasnereau I, Herr P, Chia PZC, Basler K & Gleeson PA (2011) Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling. Journal of Biological Chemistry, 286(50), 43324-43333.
• Herr P, Korniychuk G, Yamamoto Y, Grubisic K & Oelgeschläger M (2008) Regulation of TGF-β signalling by N-acetylgalactosaminyltransferase-like 1. Development, 135(10), 1813-1822.
• Port F, Kuster M, Herr P, Furger E, Bänziger C, Hausmann G & Basler K (2008) Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nature Cell Biology, 10(2), 178-185.
• Altun M, Walter TS, Kramer HB, Herr P, Iphöfer A, Boström J, David Y, Komsany A, Ternette N, Navon A , Stuart DI et al () The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages. PLOS ONE, 10(1), e0115344-e0115344.
• Mortusewicz O, Herr P & Helleday T () Early replication fragile sites: where replication–transcription collisions cause genetic instability. The EMBO Journal, 32(4), 493-495.

Conference proceedings papers

• Walter M, Homan E, Koolmeister T, Almlöf I, Helleday T & Herr P (2021) Development of small molecule NUDT22 inhibitors for uses in cancer. Medical Sciences Forum, Vol. 3(1). Online, 1 February 2021 - 14 February 2021. View this article in WRRO
• Sanjiv K, Gad H, Rudd S, Hurley R, Herr P, Montaño JMC, Mortusewicz O, Koolmeister T, Jaques S, Morón EB , Hoglund A et al (2016) Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell. Experimental and Molecular Therapeutics

Presentations

• Herr P NUDT22 promotes cancer growth through pyrimidine salvage and the TCA cycle.
• Herr P NUDT22 promotes cancer growth through pyrimidine salvage.
• Herr P NUDT22 COUNTERACTS REPLICATION STRESS THROUGH A NOVEL PYRIMIDINE SALVAGE PATHWAY.
• Herr P NUDT22 counteracts replication stress through pyrimidine salvage. online.

Preprints

• Walter M, Mayr F, Hanna BMF, Cookson V, Mortusewicz O, Helleday T & Herr P () NUDT22 promotes cancer growth through pyrimidine salvage and the TCA cycle, Research Square Platform LLC.