Dr Patrick Herr

Department of Oncology and Metabolism

Research Fellow

p.herr@sheffield.ac.uk

Full contact details

Dr Patrick Herr
Department of Oncology and Metabolism
FU03, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Research interests

The overall aim of my research is to understand fundamental processes in cancer biology and to translate those findings into clinically relevant applications. A central part to this work is to understand the mechanisms that control DNA damage, repair, nucleotide metabolism and the maintenance of nucleotide pool balance in cancer. This involves the identification and molecular and functional characterization of novel proteins in these processes as well as the development and validation of small molecules to target these enzymes. This work is done in close collaboration with a multidisciplinary team of researchers from various disciplines from medicinal chemistry to proteomics, metabolomics and computational science.

I initiated this work during my time as a Postdoctoral Research Fellow and Project Lead at the Karolinska Institute in Stockholm in Sweden where I initially worked on the link between transcription and homologous recombination-mediated DNA repair. 

My interest in cancer biology originated from my earlier work on signalling pathways that control early embryogenesis and tissue differentiation. I received my PhD from the University of Zürich, Switzerland for unraveling new mechanisms that control WNT signaling molecule secretion and signal transduction in Drosophila and mouse. I received my Diploma in Biology from the Albert-Ludwigs University and Max Planck Institute in Freiburg, Germany for the characterisation of a novel regulator of TGF-β signalling.

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Conference proceedings papers