Professor Richard J Ross

MD, FRCP

Department of Oncology and Metabolism

Professor of Endocrinology

Richard Ross
r.j.ross@sheffield.ac.uk
+44 114 215 9089
+44 114 215 9004 (Secretary: Lindsey Crowson)

Full contact details

Professor Richard J Ross
Department of Oncology and Metabolism
Office: EU14
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact - om-operational@sheffield.ac.uk

I trained in medicine at The Royal London Hospital (1974-1979) and in Endocrinology at St Bartholomew´s Hospital, London (1983-1988). I was appointed to Sheffield University in 1995 and am Head of the Unit of Diabetes and Endocrinology.

I previously served on the Medical School Council as Head of Section for Endocrinology and Reproduction (2005-2008) and as Director of Sheffield Health Innovation Centre subsequently Sheffield Healthcare Gateway (2008-2018).

My research and clinical interests are in pituitary and adrenal disease, transition endocrinology and the late effects of cancer therapy.

I am a founding Director of two university spin-out companies; Asterion Ltd and Diurnal Plc.

I served on the editorial boards of: Clinical Endocrinology (1996-2000), Growth & Growth Factors (1986-2006), Hormones (2004-), and J Clin Endocrinol Metab (2010-2014).

I am a council member for the Society of Endocrinology (1999-2002), Editor Endocrinologist (2001-2004), Chair of CaHASE (2002-2015), member of the Bioscientifica Board (2006-2010), Society for Endocrinology Public Engagement Committee (2008-2011) and Nominations Committee (2010-2012).

Executive Committee of the European Society of Endocrinology (2011-2015), Treasurer of the European Society of Endocrinology (2013-2015), and The Growth Hormone Research Society Council (2011-2016).

I am currently the Chief Scientific Officer and Director on the Board of Diurnal Group Plc.

Research interests

The focus of both my clinical and basic research is on optimising endocrine hormone replacement. My group have identified and characterised uncommon mutations in the growth hormone receptor which have led to fundamental observations on the mechanism by which the growth hormone receptor signals through a pre-formed dimer.

This work led to a greater understanding of the regulation of growth hormone secretion and the group have developed a long acting form of growth hormone and this work was published in Nature Medicine in 2007. The group are now actively developing a long acting growth hormone antagonist.

The Clinical Research Programme has been investigating different regimens for replacing cortisol, testosterone and oestrogen in hypopituitary, hypogonadal and adrenal insufficient patients.

The group have designed modified release forms of hydrocortisone, including Infacort for the treatment of neonates and children with adrenal insufficiency and Chronocort, to replicate the normal circadian rhythm of cortisol.

Infacort received a Market Authorisation from EMA in 2018 and is being marketed under the trade name Alkindi and Chronocort is currently completing phase 3 clinical trials in patients with congenital adrenal hyperplasia. Other work has examined the incidence of hypogonadism in cancer survivors and replacing testosterone in young male cancer survivors.

The Endocrine Unit consists of 6 Consultant Endocrinologists and runs a number of unique and innovative specialist clinics in the Health Care Trust including: Pituitary Clinic, Transition Clinic for Paediatric Endocrinology, Late Effects Clinic for Cancer survivors, Joint Surgical Endocrine Clinics, Obesity Clinic, Genetic Endocrine Clinic and a Pituitary Multidisciplinary Team.

Publications and Patents: 286 publications during career, Scopus h-index of 46. 35 patents granted from 7 independent patent families.


Current projects

  • Improving the care of patients with congenital adrenal hyperplasia and adrenal insufficiency
  • Development of long-acting biologicals including growth hormone antagonists for the treatment of acromegaly
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

  • Blair JC, Debono M & Ross R (2019) Steroid Replacement in Adrenal Insufficiency, Encyclopedia of Endocrine Diseases (pp. 172-184). Elsevier RIS download Bibtex download
  • Adams EF, Arvat E, Barkan AL, Bengtsson B-Å, Bercu BB, Berti F, Bowers CY, Briard N, Broglio F, Camanni F , Casanueva FF et al (1999) Contributing Authors, Growth Hormone Secretagogues (pp. ix-xiv). Elsevier RIS download Bibtex download
  • Ross RJ, Thorpe A, Freeman H, Pradhananga S & Wilkinson I () Long-Acting Growth Hormone Analogues In Ho E (Ed.), Growth Hormone Related Diseases and Therapy (pp. 361-373). RIS download Bibtex download

Conference proceedings papers

  • Riley A, Ross R & James D (2010) Engineering transient production of recombinant proteins by mammalian cells using siRNA. JOURNAL OF BIOTECHNOLOGY, Vol. 150 (pp S86-S87) RIS download Bibtex download
  • Ross RJM (2000) GH, IGF-I and binding proteins in altered nutritional states. INTERNATIONAL JOURNAL OF OBESITY, Vol. 24 (pp S92-S95) RIS download Bibtex download
  • Ross RJM (1999) Truncated growth hormone receptor isoforms. ACTA PAEDIATRICA, Vol. 88 (pp 164-166) RIS download Bibtex download
  • Ayling RM, Ross RJM, Towner P, Von Laue S, Finidori J, Moutoussamy S, Buchanan CR, Clayton PE & Norman MR (1999) New growth hormone receptor exon 9 mutation causes genetic short stature. ACTA PAEDIATRICA, Vol. 88 (pp 168-172) RIS download Bibtex download
  • Jenkins RC & Ross RJM (1997) The use of growth hormone and insulin-like growth factor-I in catabolic states. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol. 10 (pp 131-136) RIS download Bibtex download
  • ROSS RJM, RODRIGUEZARNAO J, BENTHAM J & MIELL JP (1993) CLINICAL-APPLICATIONS OF IGF-I. TWO DECADES OF EXPERIENCE IN GROWTH, Vol. 100 (pp 39-50) RIS download Bibtex download
  • GOODWIN FJ & ROSS RJM (1983) ALTERATION OF PITUITARY-THYROID FUNCTION IN PATIENTS TREATED WITH HEMODIALYSIS (HD) AND CHRONIC AMBULATORY PERITONEAL-DIALYSIS (CAPD). CLINICAL SCIENCE, Vol. 65(3) (pp P14-P14) RIS download Bibtex download

Patents

  • Ross RJ, Riley A & James D (2010) Recombinant Protein Production. WO/2010/100437 Appl. 10 Sep 2010. RIS download Bibtex download
  • Ross RJ, Sayers J & Artymuik P (2010) Cytokine Variant Polypeptides. WO01/096565 Appl. 05 May 2010. RIS download Bibtex download
  • Ross RJ & Huatan H (2010) Treatment of Adrenal Insufficiency. WO/2010/032006 Appl. 25 Mar 2010. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2010) GLP-1 FUSION POLYPEPTIDES. WO/2010/020767 Appl. 25 Feb 2010. RIS download Bibtex download
  • Ross RJ & Artymuik P (2010) INTERLEUKIN FUSION POLYPEPTIDES. WO/2010/020766 Appl. 25 Feb 2010. RIS download Bibtex download
  • Ross RJ & Artymiuk P (2010) INSULIN FUSION POLYPEPTIDES. WO/2010/001134 Appl. 07 Jan 2010. RIS download Bibtex download
  • Ross RJ & Artymiuk P (2009) THYROID STIMULATING HORMONE FUSION PROTEINS. WO/2009/115809 Appl. 24 Sep 2009. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2009) MODIFIED LINKERS. WO/2009/103965 Appl. 27 Aug 2009. RIS download Bibtex download
  • Ross RJ & Artymiuk P (2009) PROLACTIN FUSION PROTEINS. WO/2009/077731 Appl. 25 Jun 2009. RIS download Bibtex download
  • Ross RJ, Sayers J & Artymiuk P (2009) MODIFIED GROWTH HORMONE POLYPEPTIDES. WO/2009/047474 Appl. 16 Apr 2009. RIS download Bibtex download
  • Ross RJ, Artymuik P & Sayers J (2009) ERYTHROPOIETIN FUSION PROTEINS. WO/2009/019458 Appl. 12 Feb 2009. RIS download Bibtex download
  • Ross RJ, Artymuik P & Sayers J (2009) INSULIN-LIKE GROWTH FACTOR FUSION PROTEINS. WO/2009/019465 Appl. 12 Feb 2009. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2009) GRANULOCYTE COLONY STIMULATING FACTOR. WO/2009/019441 Appl. 12 Feb 2009. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2009) Leptin Fusion Protein. WO/2009/019427 Appl. 12 Feb 2009. RIS download Bibtex download
  • Ross RJ & Huatan H (2009) Lipid Compositions Comprising Androgens. WO/2009/133352 Appl. 05 Nov 2009. RIS download Bibtex download
  • Ross RJ, Sayers J & Artymiuk P (2009) GROWTH HORMONE FUSION PROTEINS. WO/2009/013461 Appl. 29 Jan 2009. RIS download Bibtex download
  • Ross RJ (2008) Treatment of Inflammation. WO/2008/065386 Appl. 05 Jun 2008. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2008) GROWTH FACTOR. WO/2008/032059 Appl. 20 Mar 2008. RIS download Bibtex download
  • Ross RJ & Huatan H (2008) T3/T4 Sustained Release. WO/2008/129303 Appl. 30 Oct 2008. RIS download Bibtex download
  • Ross RJ, Sayers J, Artymiuk P, Pradhananga S & Asterion Ltd (2007) Circular Permutations. WO/2007/128979 Appl. 15 Nov 2007. RIS download Bibtex download
  • Ross RJ, Artymiuk P, Sayers J, Pradhananga S & Asterion Ltd (2006) Rigid Linkers. WO/2006/010891 Appl. 02 Feb 2006. RIS download Bibtex download
  • Ross RJ (2005) Depression Treatment. WO/2005/065692 Appl. 21 Jul 2005. RIS download Bibtex download
  • Ross RJ, STRASBURGER C, BIDLINGMAIER M, WU Z & MATARESE G (2005) Leptin antagonis 9F8. WO/2005/049655 Appl. 02 Jun 2005. RIS download Bibtex download
  • Ross RJ, Sayers J, Artymiuk P & Asterion Ltd (2004) CYTOKINE POLYPEPTIDES AND ANTIBODIES CONTAINING A SIGNAL SEQUENCE FOR THE ATTACHEMENT OF GLYCOSYLPHOSPHATIDYLINOSITOL. WO/2004/090135 Appl. 21 Oct 2004. RIS download Bibtex download
  • Ross RJ, Artymiuk P & Sayers J (2003) GROWTH HORMONE FUSION PROTEIN. WO/2003/070765 Appl. 28 Aug 2003. RIS download Bibtex download
  • Ross RJ (2003) Tandem Polypeptides. WO/2003/062276 Appl. 31 Jul 2003. RIS download Bibtex download
  • Ross RJ (2003) CHIMERIC GLYCOSYLPHOSPHATIDYLINOSITOL CONTAINING PEPTIDES CHIMERIC GLYCOSYLPHOSPHATIDYLINOSITOL CONTAINING PEPTIDES CHIMERIC GLYCOSYLPHOSPHATIDYLINOSITOL CONTAINING PEPTIDES. WO/2003/034275 Appl. 24 Apr 2003. RIS download Bibtex download
  • Ross R, Artymiuk P & Sayers J () Growth hormone fusion proteins. 8,470,559 (USA). Appl. 01 Jan 1970. RIS download Bibtex download
Teaching activities

I lecture medical students in Endocrinology and supervise PhD and BMedSci students.

Professional activities

Editorship

  • Editorial Board Clinical Endocrinology 1996-2000
  • Editor: Growth and Growth Factors 1986-2006
  • Editorial Board: Journal of Endocrinological Investigation 2004-07
  • Editorial Board: Journal of Clinical Endocrinology & Metabolism 2010-

Advisory Boards

  • NICE appraisal of adult growth hormone replacement 2003-04
  • Member of Lilly HYPOCCS International Advisory Board 1999-2007

Society for Endocrinology

  • Society for Endocrinology Media Committee 2009=-2012
  • SFE Nomination Committee 2010
  • A Director of Bioscientifica (2006-2010), the company that supports the Society for Endocrinology and promotes endocrinology internationally.
  • I chair the Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE 2002-2015) which is a national group undertaking major research in the management of patients with congenital adrenal hyperplasia. We completed a study of over 200 patients published in J Clin Endocrinol Metab 2010.

University Spin Out Companies

  • Founding Director Asterion Ltd, MD 2001-06, CSO 2006-
  • Founding Director and now CSO of Diurnal Ltd and Director of Diurnal Plc

National Committee Membership

  • Council Member, Society for Endocrinology 1999-01
  • Society for Endocrinology Clinical Subcommittee, Audit 1997-99, Program Organiser 2000-02
  • Treasurer of the European Society of Endocrinology (2013-2015),
  • The Growth Hormone Research Society Council (2011-2016).