Manmohi Dake

First year PhD student


Research Interests

My research focuses on how a variety of cardiovascular risk factors influence brain structure and function, particularly in Alzheimer’s Disease (AD). The brain undergoes age-related ischemic changes with time. These changes may be influenced by factors such as smoking, obesity etc., which could influence brain structure and function via the modulation of the cerebrovascular system. I am keen on exploring the underlying mechanisms that could result in changes in blood supply leading to subsequent changes in neural tissue and its corresponding function. I am also interested in the interplay between cognitive factors, Alzheimer’s Disease pathology, cardiovascular risk factors and brain structure and function. My main focus is to attempt to identify preclinical biomarkers that could aid in disease diagnosis, the development of new interventions and the improvement of existing treatments.

Current Projects

The correlation between different indices of obesity and brain structure in Alzheimer’s Disease

To assess blood flow in the cerebrovascular system using Arterial Spin Labelling among diabetic patients with or without Alzheimer’s Disease

Research Team

Translational Neuropsychology Group

Publications

Patterns of Body Fat Distribution and Brain Structure in Alzheimer’s Disease: A multi-centric study. Dake M, De Marco M, Bell SM, Blackburn DJ, Wilkinson ID, Remes A, Liu Y, Pikkarainen M, Soininen H, Venneri A (manuscript preparation)

Biography

My interest in Neuroscience began during my BA in Psychology at Fergusson College, Pune India. This led me to pursue two masters degrees in Neuropsychology and Cognitive Neuroscience at the universities of Bristol and Sheffield respectively. After my masters at Sheffield, I decided to continue working with the Translational Neuropsychology Team, which led to my ongoing PhD in Neuroscience.

Teaching Interests

Functional neuroanatomy, dementia, cognitive neuroscience