Dr Tom Jenkins MBChB MRCP PhDTom Jenkins

Senior Clinical Lecturer
Consultant Neurologist
Co-Director MND Care Centre
Course Lead, MSc Clinical Neurology

Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
UK

Tel: +44 (0) 114 215 9101
Email: t.m.jenkins@sheffield.ac.uk

Academic Secretary: Rebecca Brown
Tel: +44 (0) 114 22 22261
Email: rebecca.brown@sheffield.ac.uk

Profile

Biography Dr Jenkins studied Medicine at the University of Manchester and obtained his PhD in Clinical Neuroscience from the UCL Institute of Neurology, Queen Square in 2010.  His specialist clinical interest is neuromuscular disease and area of research expertise is neuroimaging.   He has experience in running longitudinal clinical, imaging and neurophysiological studies with the aim of developing tools to decipher disease mechanisms and facilitate future clinical trials in motor neuron disease (MND) and other neurodegenerative disorders. Current areas of novel investigation include whole-body muscle imaging of denervation in MND and 31-phosphorus spectroscopy to assess energy metabolism in several neurodegenerative conditions.   Dr Jenkins is Principal Investigator on current and forthcoming studies and clinical trials in MND.
Research Interests

Magnetic resonance imaging (MRI) is a safe way of investigating people- there is no radiation involved in the scans- and offers a window with which to study disease mechanisms in living patients. This is crucial in neurodegenerative diseases, which remain incompletely understood. MRI also has potential as a biomarker, with which to investigate the effect of new treatments, so important in these currently incurable conditions. I have two main studies active at present. We are investigating the potential of whole-body muscle MRI (example picture attached) as a biomarker in patients with motor nerve disorders. I am also very interested in deficiencies in the way that patients with motor neuron disease use energy and was recently awarded a grant by Neurocare and the Ryder-Briggs Trust to develop MR spectroscopy to assess this further. Lastly, we are collecting scans from patients with motor neuron disorders to contribute to a large multi-centre database to further research at international collaborative level.

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Teaching Interests

I find teaching one of the most enjoyable parts of my job and I give regular lectures and clinical demonstrations to medical students, nurses, newly qualified doctors, psychiatrists and dentists. The lectures cover a wide range of aspects of clinical neurology, from the features of diseases such as MND, multiple sclerosis and other neurological disorders, through to the neuroanatomical basis of emotions.

Professional Activities

I am module lead for Cerebrovascular disease and disorders of consciousness on the MSc course in Clinical Neurology at the University of Sheffield.
I represent the University of Sheffield as a member of the Neuroimaging Society on Amyotrophic Lateral Sclerosis (NiSALS), an international collaboration to forward neuroimaging research in MND.

Current Projects I am in the process of establishing a new research project which aims to assess deficits of energy metabolism in patients with MND using MR spectroscopy.
Publications

Key publications

Jenkins TM, Burness C, Connolly DJ, et al. A prospective pilot study measuring muscle volumetric change in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2013: In press.


Jenkins TM, Ciccarelli O, Atzori M, et al. Early pericalcarine atrophy in acute optic neuritis is associated with conversion to MS. J Neurol Neurosurg Psychiatry 2011; 82(9): 1017-1021.


Jenkins TM, Toosy AT, Ciccarelli O, et al. Neuroplasticity predicts visual recovery in acute optic neuritis independent of tissue damage. Ann Neurol 2010; 67(1): 99-113.


Jenkins TM, Ciccarelli O, Toosy AT, et al. Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticity. Hum Brain Mapp 2010; 31(2): 276-286.


Kolappan M, Henderson AP, Jenkins TM, et al. Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis. J Neurol 2009; 256: 309-319.