Dr. Jon Wood PhDWood

Department of Neuroscience
Sheffield Institute for Translational Neuroscience
University of Sheffield
Room B28
385a Glossop Road
Sheffield
S10 2HQ

Telephone: +44 (0)114 22 22243
Fax: +44 (0)114 22 22290
E-mail: J.D.Wood1@sheffield.ac.uk

Biography:

I joined the department in 2001 after postdoctoral work on Huntington disease and other polyglutamine disorders at the University of Wales College of Medicine in Cardiff (1994-96) and the Laboratory of Molecular Neurobiology at the Johns Hopkins Medical Institutions in Baltimore (1996-2001).

Research Interests:

My research is focussed on molecular mechanisms underlying neurodegenerative disorders such as ALS and neurodevelopmental pathways that confer susceptibility to psychiatric disease, with a particular interest in the role of myelinating cells in these disorders. Much of this work is carried out in collaboration with colleagues in the Bateson Centre

Teaching Activities:

I am course lead for the MSc in Translational Neuroscience and deliver teaching for the MSc in Translational Neuroscience, MSc in Clinical Neurology, MSc in Genomic Medicine and the MSc in Molecular Medicine. I also demonstrate neuroanatomy to first year MBChB students.

Key Publications

Seytanoglu, A., Alsomali, N.I, Valori, C.F., McGown, A., Kim, H.R., Ning, K., Ramesh, T., Sharrack, B., Wood, J.D., Azzouz, M. (2015). Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience 322, 287-97 Abstract


Boyd, P.J., Cunliffe, V.T., Roy, S. & Wood, J.D. (2015). Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): Implications for mental illness. Biology Open 4, 1336-43 Abstract


Highley, J.R., Lorente Pons, A., Cooper-Knock, J., Wharton, S.B., Ince, P.G., Shaw, P.J., Wood, J. & Kirby, J. (2015). Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate repeat length CAG repeat expansions in Ataxin-2 does not have polyglutamine inclusions. Neuropathology and Applied Neurobiology 42, 377-89 Abstract


Fullstone, G., Wood, J., Holcombe, M. & Battaglia, G. (2015). Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based Approach. Scientific Reports 5, 10649 Abstract


Butler, R., Wood, J.D., Landers, J.A. & Cunliffe, V.T. (2010). Genetic and chemical modulation of Spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in Hereditary Spastic Paraplegia. Disease Models and Mechanisms Abstract


Wood, J.D., Bonath, F., Kumar, S., Ross, C.A. & Cunliffe, V.T. (2009). Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Human Molecular Genetics 18, 391-404. Abstract


Sato, T., Miura, M., Yamada, M., Yoshida, T., Wood, J.D., Yazawa, I., Masuda, M., Suzuki, T., Shin, R.-M., Yau, H.-J., Liu, F.-C., Shimohata, T., Igarashi, S., Onodera, O., Ross, C.A., Katsuki, M., Takahashi, H., Kano, M., Aosaki, T. & Tsuji, S. (2009). Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Human Molecular Genetics 18, 723-736. Abstract


Kasher, P.R., De Vos, K.J., Wharton, S.B., Manser, C., Bennett, E.J., Bingley, M., Wood, J.D., Milner, R., McDermott, C.J., Miller, C.C.J., Shaw, P.J. & Grierson, A.J. (2009). Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. Journal of Neurochemistry 110, 34-44 Abstract


Wood, J.D., Landers, J.A., Bingley, M., McDermott, C.J., Thomas-McArthur, V.T., Gleadall, L.J., Shaw, P.J. & Cunliffe, V.T. (2006). The microtubule-severing protein spastin is required for motor axon outgrowth in the zebrafish embryo. Human Molecular Genetics 15, 2763-2771. Abstract.