Alcohol is associated with 2.8 million deaths each year worldwide
- Globally, one in three people drink alcohol (equivalent to 2.4 billion people), and 2.2 per cent of women and 6.8 per cent of men die from alcohol-related health problems each year
- Alcohol use was ranked as the seventh leading risk factor for premature death and disability worldwide in 2016, and was the leading cause for people aged 15-49 years old
- For people aged 50 years and older, cancers were a leading cause of alcohol-related death, constituting 27.1 per cent of deaths in women and 18.9 per cent of deaths in men
- The authors suggest there is no safe level of alcohol as beneficial effects against ischemic heart disease are outweighed by the adverse effects on other areas of health, particularly cancers
Alcohol is a leading risk factor for death and disease worldwide, and is associated with nearly one in 10 deaths in people aged 15-49 years old, according to a new study involving researchers from the University of Sheffield.
The Global Burden of Disease study, published in The Lancet, estimates levels of alcohol use and health effects in 195 countries between 1990 and 2016.
Based on the analysis, authors of the international study suggest that there is no safe level of alcohol consumption as any health benefits of alcohol are outweighed by its adverse effects on other aspects of health, particularly cancers.
They estimate that, for one year, in people aged 15-95 years, drinking one alcoholic drink per day  increases the risk of developing one of the 23 alcohol-related health problems  by 0.5 per cent, compared with not drinking at all (from 914 people in 100,000 for one year for non-drinkers aged 15-95 years, to 918 in 100,000 people a year for 15-95 year olds who consume one alcoholic drink a day) .
Alcohol has a complex association with health, affecting it in multiple ways. Regular consumption has adverse effects on organs and tissues, acute intoxication can lead to injuries or poisoning, and alcohol dependence may lead to frequent intoxication, self-harm or violence. Some previous research has suggested that low levels of consumption can have a protective effect against heart disease and diabetes.
Colin Angus, from the University of Sheffield’s Alcohol Research Group and one of the study authors, said: “This study represents the most comprehensive effort to date to estimate the impact that alcohol has on drinkers' health around the world.
“Alcohol was responsible for 32,000 deaths in the UK in 2016 and the findings highlight the substantial burden that alcohol places on society – particularly people aged 15-49 for whom alcohol is the leading cause of avoidable death globally.”
He added: “The research also found that any level of alcohol consumption is associated with an increased risk of ill health, even after accounting for the fact that moderate drinking may protect against heart disease.
“However, it is important to note that many everyday activities, such as driving, carry risks which we deem to be acceptable – studies like this one can help people make more informed choices about which risks they wish to take.”
The study used data from 694 studies to estimate how common drinking alcohol is worldwide and used 592 studies including 28 million people worldwide to study the health risks associated with alcohol  between 1990 to 2016 in 195 countries. In the study, a standard alcoholic drink is defined as 10g alcohol .
Lead author, Dr Max Griswold from the Institute of Health Metrics and Evaluation at the University of Washing USA, said: “Previous studies have found a protective effect of alcohol on some conditions, but we found that the combined health risks associated with alcohol increase with any amount of alcohol.
“In particular, the strong association between alcohol consumption and the risk of cancer, injuries, and infectious diseases offset the protective effects for ischaemic heart disease in women in our study. Although the health risks associated with alcohol starts off being small with one drink a day, they then rise rapidly as people drink more.
“Policies focussing on reducing alcohol consumption to the lowest levels will be important to improve health. The widely held view of the health benefits of alcohol needs revising, particularly as improved methods and analyses continue to shed light on how much alcohol contributes to global death and disability.” 
Globally, one in three people (32.5 per cent) drink alcohol – equivalent to 2.4 billion people – including 25 per cent of women (0.9 billion women) and 39 per cent of men (1.5 billion men). On average, each day women consumed 0.73 alcoholic drinks, and men drank 1.7 drinks.
Drinking patterns varied globally , the highest number of current alcohol drinkers was in Denmark (95.3 per cent of women, and 97.1 per cent of men) while the lowest were in Pakistan for men (0.8 per cent) and Bangladesh for women (0.3 per cent). Men in Romania and women in Ukraine drank the most (8.2 and 4.2 drinks a day respectively), whereas men in Pakistan and women in Iran drank the least (0.0007 and 0.0003 drinks a day respectively).
Drinking alcohol was the seventh leading risk factor for premature death and disease in 2016 world-wide, accounting for 2.2 per cent of deaths in women and 6.8 per cent of deaths in men. However, in people aged 15-49 years old, alcohol was the leading risk factor in 2016, with 3.8 per cent of deaths in women and 12.2 per cent of deaths in men attributable to alcohol.
The main causes of alcohol-related deaths in this age group were tuberculosis (1.4 per cent of deaths), road injuries (1.2 per cent), and self-harm (1.1 per cent). For people aged 50 years and older, cancers were a leading cause of alcohol-related death, constituting 27.1 per cent of deaths in women and 18.9 per cent of deaths in men.
The health problems associated with alcohol at age 50 or older varied depending on region. In high-income countries, cancers were the most common alcohol-related premature death and disease, while in low-income countries tuberculosis was the leading cause, followed by cirrhosis and chronic liver diseases. In middle- and high-to-middle income countries stroke was the main alcohol-related burden.
The authors found that there was only a protective effect between alcohol and ischemic heart disease, and there were possible protective effects for diabetes and ischemic stroke but these were not statistically significant. The risk of developing all other health problems increased with the number of alcoholic drinks consumed each day.
Combining these findings, the protective effect of alcohol was offset by the risks and overall the health risks associated with alcohol rose in line with the amount consumed each day. Therefore, the authors conclude that there is no safe level of alcohol.
Specifically, comparing no drinks with one drink a day the risk of developing one of the 23 alcohol-related health problems was 0.5 per cent higher – meaning 914 in 100,000 15-95 year olds would develop a condition in one year if they did not drink, but 918 people in 100,000 who drank one alcoholic drink a day would develop an alcohol-related health problem in a year.
Professor Emmanuela Gakidou, Institute for Health Metrics and Evaluation, University of Washington, USA, says: “Alcohol poses dire ramifications for future population health in the absence of policy action today. Our results indicate that alcohol use and its harmful effects on health could become a growing challenge as countries become more developed, and enacting or maintaining strong alcohol control policies will be vital.”
“Worldwide we need to revisit alcohol control policies and health programmes, and to consider recommendations for abstaining from alcohol. These include excise taxes on alcohol, controlling the physical availability of alcohol and the hours of sale, and controlling alcohol advertising. Any of these policy actions would contribute to reductions in population-level consumption, a vital step toward decreasing the health loss associated with alcohol use.” 
This study was funded by the Bill & Melinda Gates Foundation. It was conducted by researchers from the GBD 2016 Alcohol Collaborators.
 One standard drink is defined as 10 grams of pure alcohol. Examples include:
• A small glass of red wine (100ml or 3.4 fluid ounces) at 13 per cent alcohol by volume;
• A can or bottle of beer (375 ml or 12 fluid ounces) at 3.5 per cent alcohol by volume; or
• A shot of whiskey or other spirits (30 ml or 1.0 fluid ounces) at 40 per cent alcohol by volume.
 These health issues include:
• Cardiovascular diseases: atrial fibrillation and flutter, hemorrhagic stroke, ischemic stroke, hypertensive heart disease, ischemic heart disease, and alcohol cardiomyopathy;
• Cancers: breast, colorectal, esophageal, larynx, lip and oral cavity, liver, and nasal and mouth cavities;
• Other non-communicable diseases: cirrhosis of the liver due to alcohol use, diabetes, epilepsy, pancreatitis, and alcohol use disorders;
• Communicable diseases: lower respiratory infections, and tuberculosis;
• Intentional injuries: interpersonal violence, and self-harm;
• Unintentional injuries: exposure to mechanical forces, poisonings, fire, heat, and hot substances, drowning, and other unintentional injuries; and
• Transportation-related injuries.
 The relative risk associated with 0-15 alcoholic drinks is available in Figure 5 of the paper. The absolute risks used to calculate this are provided by the authors.
 Quote direct from author and cannot be found in the text of the Article.
The University of Sheffield
With almost 29,000 of the brightest students from over 140 countries, learning alongside over 1,200 of the best academics from across the globe, the University of Sheffield is one of the world’s leading universities.
A member of the UK’s prestigious Russell Group of leading research-led institutions, Sheffield offers world-class teaching and research excellence across a wide range of disciplines.
Unified by the power of discovery and understanding, staff and students at the university are committed to finding new ways to transform the world we live in.
Sheffield is the only university to feature in The Sunday Times 100 Best Not-For-Profit Organisations to Work For 2018 and for the last eight years has been ranked in the top five UK universities for Student Satisfaction by Times Higher Education.
Sheffield has six Nobel Prize winners among former staff and students and its alumni go on to hold positions of great responsibility and influence all over the world, making significant contributions in their chosen fields.
Global research partners and clients include Boeing, Rolls-Royce, Unilever, AstraZeneca, Glaxo SmithKline, Siemens and Airbus, as well as many UK and overseas government agencies and charitable foundations.
For further information please contact:
Media Relations Officer
University of Sheffield
0114 222 9859