Sheffield Sarcoma Research Group - Clinical Trials

Clinical trials for Sarcoma patients at Weston Park Hospital, Sheffield (updated February 2016)

Summary Current Status
Trial set-up Open to recruitment Closed to new recruitment - follow-up continues

(EORTC 62092)

A phase III randomised study of pre-operative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcoma
Euro Ewing
International randomised controlled trial for the treatment of newly diagnosed Ewing’s sarcoma family of tumours
VORTEX A randomised trial of volume of post-operative radiotherapy given to adult patients with extremity soft tissue sarcoma
GOG-0277 A phase III randomised trial of gemcitabine plus docetaxel followed by doxorubicin versus observation for uterus-limited, high-grade uterine leiomyosarcoma
SSGXXII Three versus five years of adjuvant imatinib as treatment of patients with operable GIST with a high risk for recurrence
Advanced disease
ANNOUNCE A randomised, double-blind, placebo-controlled, phase 3 trial of doxorubicin plus olaratumab versus doxorubicin plus placebo in patients with advanced or metastatic soft tissue sarcoma
Axi-STS A clinicopathological phase II study of axitinib in patients with advanced angiosarcoma and other soft tissue sarcomas
rEECur An international randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma
SCART A phase I/II study of oral MEK inhibitor selumetinib in combination with highly active anti-retrovial therapy for HIV-associated Kaposi’s sarcoma