Professor Alireza Fazeli, PhD

Alireza Fazeli

Academic Unit of Reproductive and Developmental Medicine
Department of Oncology & Metabolism

Level 4, Jessop Wing
Sheffield
S10 2SF
United Kingdom

Office: JW408

Tel:    +44 114 226 8345
Email: a.fazeli@sheffield.ac.uk

Biography

I started my career as a Research Scientist at the Institute of Zoology, Zoological Society of London between 1996 and 2002. In 2002 I joined the Academic Unit of Reproductive and Developmental Medicine where I am a Professor of Reproductive and Developmental Medicine.

Research Interests

I am interested in the cross-talk between gametes and embryos, and the maternal tract. Since the innate immune system plays a major role in this communication I am keen to understand how the innate immunity is involved in this maternal communication.

Teaching Interests

  • Train postgraduate research students through MSc and PhD programs in different aspects of maternal communication with gametes and embryo and innate immunity.
  • Contribute to the education of postgraduate students on the MSc in Reproductive and Developmental Medicine course.
  • Coordinate the Reproduction module of Phase 1B in the MBChB Medicine undergraduate course and contribute to the Student Selected Components.
  • Mentor undergraduate and postgraduate students.

Professional Activities

  • Trustee of the Infertility Research Trust.
  • Vice-chairman and grant holder of the `Epigenetics and Periconception Environment´ collaborational research project funded by the European Cooperation in Science and Technology (COST Action FA1201) (2012-2016).
  • Member of the Postgraduate Research Committee for the Department of Human Metabolism.
  • Graduate selector for the Academic Unit of Reproductive and Developmental Medicine.
  • Panel member in the Research Grant Review Committee of Royal Society, the Biotechnology and Biological Sciences Research Council (BBSRC) and Irish Research and Technology Council.
  • Member of the Editorial Board for the journal `Reproduction´.
  • Invited presenter on 50 international meetings.
  • Organiser of 17 scientific conferences.
  • Regular external examiner in PhD student thesis and promotion panels.

Current Projects

  • Clinical significance of Toll-like receptors expression in the diagnosis of female infertility in Saudi-Arabia, 2013-2014,  Kingdom of Saudi Arabia National Guard Health Affairs, 84,706 EUR
  • Broodfish epigenetic models, 2013-2014, European Union Seventh Framework Programme (FP7): Infrastructures: Aquaculture infrastructures for excellence in European fish research, (AQUAEXCEL), 40,000 EUR
  • Epigenetics and periconception environment, 2012-2016, European Cooperation in Science and Technology (COST), 1,000,000 EUR

Key Publications

Alminana C, Fazeli A. Exploring the application of high-throughput genomics technologies in the field of maternal-embryo communication. Theriogenology, 2012, 77: 717-737.
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Aboussahoud W, Bruce C, Elliott S, Fazeli A. Activation of Toll-like receptor 5 decreases the attachment of human trophoblast cells to endometrial cells in vitro. Human Reproduction, 2010, 25: 2217-2228.
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Van Soom A, Vandaele L, Peelman LJ, Goossens K, Fazeli A. Modeling the interaction of gametes and embryos with the maternal genital tract: From in vivo to in silico. Theriogenology, 2010, 73: 828-837.
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Pewsey E, Bruce C, Georgiou AS, Jones M, Baker D, Ow SY, Wright PC, Freberg CK, Collas P, Fazeli A. Proteomics Analysis of Epithelial Cells Reprogrammed in Cell-free Extract. Molecular & Cellular Proteomics, 2009, 8: 1401-1412.
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Fazeli A. Maternal communication with gametes and embryos. Theriogenology, 2008, 70: 1182-1187.
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