Dr. Gaynor Miller B.Sc.(Hons), Ph.D, P.G.Cert.H.E., F.H.E.A.

LecturerGaynor Miller


Department Address

Academic Unit of Bone Biology
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Office: DU39

Tel: +44 (0)114 215 9056
Email: g.miller@sheffield.ac.uk

Biography

I studied Genetics at the University of Sheffield and spent a brief period of time working in the research labs at the Forensic Science service before studying for a PhD at the University of London. After my PhD I took up a Postdoctoral Research Fellow position in the Department of Biomedical Science at the University of Leeds. I then spent the next five years at the University of California Los Angeles where I first worked as a Postdoctoral Research Fellow before becoming an Assistant Researcher. In 2006 I was appointed to my current post of non-clinical lecturer at the University of Sheffield.

Research Interests

My research interests are the molecular basis of muscle wasting and the role of macrophages in disease.

Teaching Interests

I lecture on: ‘Genome to Gene Function’ (MSc module MED6002); ‘Human Genetics of Single Gene Disorders’ (L3 undergraduate module MBB320); ‘Cell Signalling’ (L2 undergraduate module BMS 215) and run a Doctoral Developmental Programme module ‘Effective presentation and seminar participation skills’ (MED605).

Current Projects

  • The Effect of the Selective and Inducible Depletion of CD68-Positive Macrophages on Tumour Progression- in collaboration with Prof Gill Tozer
  • Determining the Role of CD68+ve Cells and NF-kB in Muscular Dystrophy – in collaboration with Dr Neil Chapman
  • Tryosine phosphorylation as a target for muscular dystrophy treatment- in collaboration with Prof Steve Winder
  • Regulation of sarcospan expression in muscle.
  • Combating macrophage induced muscle damage in muscular dystrophy- in collaboration with Dr Neil Chapman, Dr Allie Gartland and Prof Steve Winder
  • The role of macrophages in bone metabolism- in collaboration with Dr Allie Gartland

Key Publications

  1. Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN and Miller G. (2012). Generation of a Novel Mouse Model for the Inducible Depletion of Macrophages In Vivo. genesis: The Journal of Genetics and Development. PMID: 22927121
  2. Miller G, Moore CJ, Terry R, Riviere TL, Mitchell A, Piggott R, Dear TN, Wells DJ, Winder SJ. (2012). Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse. Hum Mol Genet. PMID: 22810924
  3. Miller G, Neilan M, Chia R, Gheryani N, Holt N, Charbit A, Wells S, Tucci V, Lalanne Z, Denny P, Fisher EMC, Cheeseman M, Askew GN and Dear TN. (2010). ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2. PLoS ONE. 5, e9137
  4. Peter AK*, Miller G*, and Crosbie RH. (2007) "Disrupted mechanical stability of the dystrophin-glycoprotein complex causes severe muscular dystrophy in sarcospan transgenic mice". J. Cell Sci. 120, 996-1008. *These authors contributed equally to this work.
  5. Miller G, Wang EL, Nassar KL, Peter AK and Crosbie RH. (2007). "Structural and Functional Analysis of the Sarcoglycan-Sarcospan Subcomplex" Exp. Cell. Res. 313: 639-51.
  6. Miller G, Peter AK, Heighway J, Espinoza E and Crosbie RH. (2006). "Over-expression of Microspan, a Novel Component of the Sarcoplasmic reticulum, causes a severe muscle pathology with triad abnormalities." J Muscle Res Cell Motil.; 27, 545-558.
  7. Invited Review
    Barbaric I, Miller G and Dear TN. (2007). Appearances can be deceiving: phenotypes of knockout mice. Brief Funct Genomic Proteomic. 6, 91-103

    BBC Radio Sheffield Interview with Dr Miller about her Muscular Dystrophy research





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