Dr Peter Grabowski PhD, RNutr (Nutrition Science), SFHEA

Senior University Teacher

On secondment to the School of Health and Related Research, September 2018-20

School of Health and Related ResearchGrabowski
Regent Court
30 Regent Street
Sheffield
S1 4DA UK

Tel: +44 (0)114 215 9047

email: p.grabowski@sheffield.ac.uk

Biography

I studied Pharmacology at the University of Liverpool and was awarded my PhD in 1987. I undertook postdoctoral research on drug metabolism in patients with liver disease in Kiel, Germany and on thyroid autoantibody repertoires and on the cellular and molecular biology of bones and joints at the University of Aberdeen. Following a spell at the University of York as a Smith & Nephew Postdoctoral Fellow in bone and joint biology, I joined the University of Sheffield in 1999 as Lecturer in Bone Biology in the Academic Unit of Child Health. I moved to the Academic Unit of Human Nutrition in 2012 to focus on teaching on the MMedSci in Human Nutrition and I am now a Senior University Teacher and a Faculty Officer for Learning and Teaching (Teaching Excellence).  I am currently on secondment to ScHARR.

Teaching interests

Nutrition and bone biology: I am the Programme Director for the MSc in Human Nutrition (accredited by the Association for Nutrition) and I lead the Nutritional Biochemistry and Molecular Nutrition modules. I also teach Human Nutrition on the MRC-AR UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) MRes in Musculoskeletal Ageing, a teaching collaboration across the Universities of Liverpool, Newcastle and Sheffield. I developed and deliver the Nutrition teaching on CIMA’s "The Musculoskeletal System: The Science of Staying Active Into Old Age" free online course, which has been rated one of the top 50 MOOCs of all time. I also teach on the MSc(Res) in Translational Oncology and on the MSc in Molecular Medicine, for which I was the Experimental Medicine Pathway lead prior to 2012. I am a founding faculty member for the Advanced Course in Paediatric Bone and Mineral Disorders, on which I have taught bone biology to Doctors in Training.

Research skills: I teach evidence based research and critical appraisal for Postgraduate Taught students, drawing upon over twenty years of experience supporting Postgraduate Research Student development in the Medical School, as a Lead Year Tutor (over 10 years) and through the Doctoral Development Programme.

Student engagement and representation: Through my role as a PGR Lead Year Tutor and as a Faculty Officer for Learning and Teaching, I have been an academic lead on a variety of student engagement projects, including redevelopment of the Medical School’s Literature Review assessment and Poster Presentation modules for the Doctoral Development Programme; directing projects for Student Associates in Learning and Teaching on spaces for learning and teaching (2017-18) and student engagement (2016-17). Both projects were accepted for oral presentation at RAISE conferences, and our team won a best poster prize in 2018. Following on from the student engagement project, I worked on the Students Union/University of Sheffield task and finish group redeveloping student representation for 2018.

Mentoring and coaching: I am a mentor for Early Career Researchers through the 'Think Ahead' mentoring scheme.

Research Interests

h-index of 29 (Web of Science) with 47 peer reviewed publications and over 75 peer reviewed conference abstracts. My current research interests are in the roles of nutritional and non-nutritional factors in health and disease, including bones and joints and cancer, with a focus on cellular and molecular mechanisms and the potential for bioinformatics to inform nutrition science and research.

Professional Activities

Registered Nutritionist (Nutrition Science) on the UK Voluntary Register of Nutritionists
• Senior Fellow of the Higher Education Academy
• Member of the Course Accreditation and Standards Committee of the Association for Nutrition
• Member of the Nutrition Society, Bone Research Society, British Society for Matrix Biology
• Affiliate member of the Royal College of Paediatrics and Child Health, contributing to the activities of the British Paediatric and Adolescent Bone Group.

Current research topics

  • Methyl donor nutrients and cervical cancer risk
  • Acid sensing proteins in bone and joint health and disease
  • Gut related peptides, feeding and bone health
  • Microindentation to measure bone fracture risk in children

Key Publications

  1. Sprake EF, Russell JM, Cecil JE, Cooper RJ, Grabowski P, Pourshahidi LK, Barker ME. Dietary patterns of university students in the UK: a cross-sectional study. Nutr J. 2018 Oct 5;17(1):90. doi: 10.1186/s12937-018-0398-y.
  2. Robinson N, Grabowski P, Rehman I. Alzheimer's disease pathogenesis: Is there a role for folate? Mech Ageing Dev. 2018 Sep;174:86-94. doi: 10.1016/j.mad.2017.10.001. Epub 2017 Oct 13. Review.
  3. Poomipark N, Flatley JE, Hill MH, Mangnall B, Azar E, Grabowski P, Powers HJ. Methyl Donor Status Influences DNMT Expression and Global DNA Methylation in Cervical Cancer Cells. Asian Pac J Cancer Prev. 2016;17(7):3213-22.
  4. Dall'Ara E, Grabowski P, Zioupos P, Viceconti M. Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation. J Biomech. 2015 Nov 26;48(15):4073-80. doi: 10.1016/j.jbiomech.2015.10.001. Epub 2015 Oct 9.
  5. Grabowski P. Physiology of Bone. Endocr Dev. 2015;28:33-55. doi: 10.1159/000380991. Epub 2015 Jun 12. Review.
  6. Besio R, Maruelli S, Gioia R, Villa I, Grabowski P, Gallagher O, Bishop NJ, Foster S, De Lorenzi E, Colombo R, Diaz JL, Moore-Barton H, Deshpande C, Aydin HI, Tokatli A, Kwiek B, Kasapkara CS, Adisen EO, Gurer MA, Di Rocco M, Phang JM, Gunn TM, Tenni R, Rossi A, Forlino A. Lack of prolidase causes a bone phenotype both in human and in mouse. Bone. 2015 Mar;72:53-64. doi: 10.1016/j.bone.2014.11.009. Epub 2014 Nov 20.
  7. Little R, Muimo R, Robson L, Harris K, Grabowski PS. The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake. PLoS One. 2011;6(11):e28166. doi: 10.1371/journal.pone.0028166. Epub 2011 Nov 29.
  8. Grabowski P. Physiology of bone. Endocr Dev. 2009;16:32-48. doi: 10.1159/000223687. Epub 2009 Jun 3. Book chapter.
  9. Still K, Grabowski P, Mackie I, Perry M, Bishop N. The peroxisome proliferator activator receptor alpha/delta agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo. Calcif Tissue Int. 2008 Oct;83(4):285-92. doi: 10.1007/s00223-008-9175-9. Epub 2008 Oct 4.
  10. Afifi A, Olpin S, Dalton A, Bishop N, Grabowski PS. Failure to repair the c.338C>T mutation in carnitine palmitoyl transferase 2 deficient skin fibroblasts using chimeraplasty. Mol Genet Metab. 2008 Mar;93(3):347-9. Epub 2007 Nov 19.
  11. Holmes S, Smith S, Borthwick L, Dunford J, Rogers M, Bishop N, Grabowski PS. CMT3 alters mitochondrial function in murine osteoclast lineage cells. Biochem Biophys Res Commun. 2008 Jan 25;365(4):840-5. Epub 2007 Nov 26.
  12. Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet. 2007 Aug;39(8):960-2. Epub 2007 Jul 15.
  13. Del Fattore A, Peruzzi B, Rucci N, Recchia I, Cappariello A, Longo M, Fortunati D, Ballanti P, Iacobini M, Luciani M, Devito R, Pinto R, Caniglia M, Lanino E, Messina C, Cesaro S, Letizia C, Bianchini G, Fryssira H, Grabowski P, Shaw N, Bishop N, Hughes D, Kapur RP, Datta HK, Taranta A, Fornari R, Migliaccio S, Teti A. Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment. J Med Genet. 2006 Apr;43(4):315-25. Epub 2005 Aug 23.

Other Organisations

Current PhD Students

  • Munirah Ismail