I obtained a bachelor’s degree in Bioengineering from Ege University (Turkey) in 2016 with the thesis is titled ‘Design of serum-free media for human adipose-derived mesenchymal stem cells’ followed by MSc from Izmir Katip Celebi University (Turkey), Biomedical Technologies in 2018. In my master’s degree, I gained experience in a range of techniques, including peptide production and 3-dimensional cell culture. In my thesis I studied how to prevent growth of micro tumour tissues using bioactive peptides. It is titled ‘Antitumour effect of RGD peptide on cancer microtissues’. In the meantime, I gained the right to study abroad by passing the written and oral exams needed for the Turkish government scholarship. In March 2019, I began my PhD under the supervision of Professor Ingunn Holen and Professor Nicola Brown in the Department of Oncology and Metabolism. Thanks to this opportunity, I will be able to work in the field of bone oncology and pursue my interest in cancer research.
My PhD project is titled ‘The bone microenvironment as a therapeutic target in breast cancer bone metastasis – role of progenitor and immune cell populations’. This project aims to determine the effects of different cell types in the bone marrow that contributes to the development of breast cancer bone metastasis, as well as their modifications by therapeutic agents. I will use in vivo models to characterise the bone marrow and determine the effects of presence tumour cells on the bone marrow cell populations. These will be assessed in both immunocompetent and immunocompromised models to further investigate the role of the immune system in this process. The final aim of my project is to investigate the effects of the hematopoietic bone marrow niche modulation on tumour growth in bone. The data I generate during my PhD may help identify potential therapeutic and diagnostic targets in bone metastatic breast cancer.
V.K. Aydin, M. Sen (2017), "A facile method for fabricating carbon fiber-based gold ultramicroelectrodes with different shapes using flame etching and electrochemical deposition", Journal of Electroanalytical Chemistry, Vol.799, 525-530.