The University of Sheffield unveils revolutionary multi-million pound electron microscopy facility

The University of Sheffield's new multi-million pound electron microscopy facility was officially opened this week by 2017 Nobel Prize winner Dr Richard Henderson.

Dr Henderson was in Sheffield to deliver this year's Krebs Lecture, 'The increasing power of cryoEM for macromolecular structure determination'. He took a sold out audience through some of his recent research results before discussing the remaining barriers to progress in the field.

Cryo EM teamThe new electron microscopy facility will be used to exploit recent scientific developments that have revolutionised our ability to visualise the inner workings of living things. It has been funded through the University of Sheffield's Imagine: Imaging Life project, which is led by Professor Jamie Hobbs and Dr Ashley Cadby in the Department of Physics and Astronomy, and Professors Per Bullough and Simon Foster in the Department of Molecular Biology.

Imagine brings together biologists, physicists, and chemists in using revolutionary microscopy techniques to answer some of the biggest questions in biology and medicine. The significance of recent advances in microscopy was emphasised last autumn when the Nobel Prize in Chemistry was awarded to Dr Henderson, Jacques Dubochet and Joachim Frank for their work in pioneering the field of cryo-electron microscopy.

The centrepiece of Sheffield's new facility is an Arctica cryo-electron microscope (CryoEM) developed by FEI (Thermo Fischer). The Arctica incorporates state-of-the-art automation and detection technology to elucidate the three-dimensional structure of biological molecules and cells. It will allow the imaging of biological structures in the most exquisite detail, down to the the level of individual atoms.

The facility is housed in the University of Sheffield's Department of Molecular Biology and Biotechnology, where research groups and students will be able to use it to study the cellular structure of bacterial pathogens responsible for diseases such as C. difficile associated diarrhoea, MRSA and food poisoning. Researchers will also be looking into the internal workings of photosynthesis, with the potential for development of new energy technologies.

Professor Bullough, who trained with Dr Henderson early in his career, said: "The Arctica will lead us to exciting new discoveries that would never have been possible before. Biological imaging is a key research area in Sheffield and the new CryoEM facility will be equipped to allow us to integrate our work with other researchers working in ‘super-resolution’ light microscopy for cell biology applications. Thus Sheffield is becoming a world-class centre of excellence in biological imaging."

Imagine: Imaging Life

Lecture

Cryo EM Richard Henderson

Dr Richard Henderson

Richard Henderson