@article{article, title = {{An enzyme with high catalytic proficiency utilizes distal site substrate binding energy to stabilize the closed state but at the expense of substrate inhibition}}, publisher = {{American Chemical Society}}, url = {{https://eprints.whiterose.ac.uk/id/eprint/183780 }}, year = {{2022}}, month = {{2}}, author = {{Robertson A and Cruz-Navarrete FA and Wood H and Vekaria N and Hounslow A and Bisson C and Cliff M and Baxter N and Waltho J}}, doi = {{10.1021/acscatal.1c05524}}, volume = {{12}}, journal = {{ACS Catalysis}}, issue = {{5}}, pages = {{3149-3164}}, note = {{Accessed on 2025/11/13}}}