Introduction to Adaptive Designs with Application

2-Day Course: 2022 date and delivery method TBC

Register Interest

The use of innovative and efficient designs to study the effects of healthcare interventions is being encouraged by various stakeholders in clinical trials research (e.g. researchers, funders, and regulators). The aim is for patients to receive effective and safe treatments as soon as possible while offering value for money to research funders. Adaptive designs are a class of trial designs that can offer these benefits by allowing planned changes to be made to an ongoing trial based on data gathered on a fraction of participants while the trial is ongoing. However, first, not all research questions require to be addressed using an adaptive design and second, these designs require special practical and statistical considerations compared to traditional fixed trials. This is a primer course on adaptive designs across disciplines beyond statistical aspects is important.

Overview

This course will introduce attendees to what adaptive designs are and why one should consider using them (opportunities) in randomised trials as well as their limitations. We will cover real-life case studies of adaptive clinical trials and key considerations during planning, conduct, and reporting. At the end of the course, for a given research question and context, attendees should be able to understand when an adaptive design is applicable, what adaptations to consider, and whether it is feasible to implement as well as awareness of implementation resources. We will offer attendees an opportunity to discuss and translate their research ideas (if they have one) into action to help them design their first adaptive trial. We will also present tips when communicating adaptive designs to key stakeholders such as funders in grant applications.

Who will benefit from the course?

Ever wondered what adaptive designs are, why more people are now talking about them, opportunities and pitfalls? If so, this course is for you as it is suitable for researchers at different stages of their research careers who have little or no knowledge of adaptive designs, but are keen to understand more about them. The course will reflect on related statistical issues but will not cover statistical methods in depth. Typical multidisciplinary participants may include:

  • trial statisticians,
  • clinical researchers,
  • study or trial managers,
  • proposal developers.

Prerequisite

We expect attendees to have a basic understanding of randomised trials. Attendees do not necessarily need to have statistical skills or knowledge of statistical methods used in adaptive designs.

Learning Objectives

By the end of the course, participants should be:

  • able to understand what is an adaptive design, why one should consider using an adaptive design, and a broad range of available types of adaptive designs (in phase 2 and 3);
  • familiar with research questions that can be addressed using adaptive designs;
  • aware of a broad range of adaptive clinical trials that are ongoing or have been completed;
  • able to assess whether an adaptive design is appropriate, feasible to implement for a given research question(s)/goals and context, and worthwhile;
  • familiar with statistical and non-statistical issues that arise in adaptive clinical trials including potential sources of bias;
  • familiar with considerations during planning/design, conduct, and reporting of adaptive trials;
  • aware of available statistical and non-statistical resources available to help them design, run, and report an adaptive clinical trial;
  • familiar with aspects that are important when communicating adaptive designs (e.g. in grant proposals);
  • critically appraise an adaptive clinical trial in front of them.

Faculty

Munya Dimairo, is the course leader for this NEW ScHARR Short Course.

Mike Bradburn

Date and times

2-day course: 2022 date and delivery method TBC

This course is not currently open for bookings, but we are taking provisional bookings/expressions of interest.  Please complete the Google Form with your details by selecting the ‘Register interest’ green button or alternatively, forward your details to Karen Holden at scharr-scu@sheffield.ac.uk.  You will be contacted once further details have been confirmed.

Register Interest

Fees

The fee for this course will be updated once date and delivery method confirmed.

Booking and payment

This course is not currently open for bookings, but we are taking provisional bookings/expressions of interest.  Please complete the Google Form with your details by selecting the ‘Register interest’ green button or alternatively, forward your details to Karen Holden at scharr-scu@sheffield.ac.uk.  You will be contacted once further details have been confirmed.

Register Interest

Course delivery

Once the delivery method/platform has been confirmed, details will be updated accordingly.

Contact

For further information, please contact ScHARR Short Course Unit via email at scharr-scu@sheffield.ac.uk.

 Unfortunately, we are currently unable to take telephone enquiries due to the ongoing Covid-19 situation as staff are working remotely at this present time.  Please accept our sincere apologies for inconvenience this may cause.

The content of our courses is reviewed annually to make sure it is up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research, funding changes, professional accreditation requirements, student or employer feedback, outcomes of reviews, and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

Information last updated: 6 December 2021