Jane Fearnside

BSc (Hons), DPhil

School of Health and Related Research

Research Fellow

NIHR Research Design Service Yorkshire and the Humber

j.fearnside@sheffield.ac.uk
+44 114 222 4384

+44 114 273 0547 (Fax)

2.08, Regent Court (ScHARR)

Full contact details

Jane Fearnside
School of Health and Related Research
2.08
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA

Profile

I joined the university in 2009 as part of the Late Effects Research Team in the Academic Unit of Clinical Oncology. As part of this team, I was project manager for a feasibility study investigating models of follow-up care in cancer survivors. I am a co-investigator on a study looking at return to work in cancer survivors and a pilot study, Fitness To Treat: effectiveness of a clinical assessment for older men with cancer (FiTT).

I joined ScHARR as a Research Fellow in May 2013 and my current position is Manager for the Sheffield spoke of the NIHR Research Design Service Yorkshire and Humber (RDS YH). As an RDS advisor, I offer generalist advice and support to researchers to develop and design high quality research proposals for submission to the NIHR and other national, peer-reviewed funding competitions for applied health or social care research.

My previous role was a post-doctoral researcher at The Wellcome Trust Centre for Human Genetics, University of Oxford investigating the genetics of diet-induced insulin resistance. Previous research has included working on the Biological Atlas of Insulin Resistance (BAIR), an International Consortium set up to characterise the molecular basis of insulin action and insulin resistance.

Current projects

• FiTT: Fitness to treat in older men with cancer
• ATWORK: Return to work in cancer survivors

Research interests: My research interests are investigating the long-term consequences of cancer treatment.

Publications

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Journal articles

Brial F, Le Lay A, Hedjazi L, Tsang T, Fearnside JF, Otto GW, Alzaid F, Wilder SP, Venteclef N, Cazier J-B , Nicholson JK et al (2019) Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment. Scientific Reports, 9. View this article in WRRO
Dumas M-E, Rothwell AR, Hoyles L, Aranias T, Chilloux J, Calderari S, Noll EM, Péan N, Boulangé CL, Blancher C , Barton RH et al (2017) Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance. Cell Reports, 20(1), 136-148. View this article in WRRO
Chilloux J, Fearnside J, Barton R, Fuchs J, Rothwell A, Hoyles L, Gerard C, Calderari S, Boulange C, Patel S , Scott J et al (2015) P145 La trimethylamine, métabolite du microbiote intestinal, inhibe la voie inflammatoire des Toll-Like Receptor (TLRs) via une inhibition directe d’une enzyme clé de la transduction du signal. Diabetes & Metabolism, 41, A69-A69.
Waller-Evans H, Hue C, Fearnside J, Rothwell AR, Lockstone HE, Caldérari S, Wilder SP, Cazier J-B, Scott J & Gauguier D (2013) Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome.. PLoS One, 8(12), e82825.
Diawara M, Dubois S, Fearnside J, Kaisaki P, Gauguier D & Calderari S (2011) Expression of microRNAs in response to high fat diet. DIABETES METAB, 37, A30-A31.
Pontoizeau C, Fearnside JF, Navratil V, Domange C, Cazier J-B, Fernández-Santamaría C, Kaisaki PJ, Emsley L, Toulhoat P, Bihoreau M-T , Nicholson JK et al (2011) Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains.. J Proteome Res, 10(4), 1675-1689.
Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, Bengtsson M, Fearnside J, Ramracheya R, Toye AA, Zhang Q , Clark A et al (2010) Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.. Diabetes, 59(5), 1192-1201.
Fearnside JF, Dumas ME, Rothwell AR, Wilder SP, Cloarec O, Toye A, Blancher C, Holmes E, Tatoud R, Barton RH , Scott J et al (2008) Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice. PLoS ONE, 3(2).
Dumas ME, Wilder SP, Bihoreau MT, Barton RH, Fearnside JF, Argoud K, D'Amato L, Wallis RH, Blancher C, Keun HC , Baunsgaard D et al (2007) Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nature Genetics, 39(5), 666-672.
Toye AA, Dumas ME, Blancher C, Rothwell AR, Fearnside JF, Wilder SP, Bihoreau MT, Cloarec O, Azzouzi I, Young S , Barton RH et al (2007) Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. Diabetologia, 50(9), 1867-1879.
Dumas M-E, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC , Mitchell SC et al (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.. Proc Natl Acad Sci U S A, 103(33), 12511-12516.

Conference proceedings papers

Calderari S, Diawara M, Dubois S, Fearnside JF, Kaisaki PJ, Lindgren CM & Gauguier D (2010) Altered microRNAs expression is associated with insulin resistance status in high fat diet fed mice. DIABETOLOGIA, Vol. 53 (pp S31-S32)
Collins SC, Hoppa MB, Fearnside J, Zhang Q, Amisten S, Walker JN, Gauguier D & Rorsman P (2009) Attenuation of Ca2+ microdomains and diet-induced diabetes in mice. DIABETOLOGIA, Vol. 52 (pp S163-S163)
Waller-Evans HE, Fearnside J, Argoud K, Burt A, Wilder SP, Gut I, Scott J & Gauguier D (2009) Identification and characterisation of candidate genes in diet-induced non-alcoholic fatty liver disease in inbred mice. DIABETOLOGIA, Vol. 52 (pp S259-S259)
Fearnside J, Waller-Evans H, Argoud K, Burt A, Wilder S, Gut I, Scott J & Gauguier D (2009) IDENTIFICATION OF CANDIDATE GENES IN DIET INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE IN INBRED MICE. JOURNAL OF HEPATOLOGY, Vol. 50 (pp S258-S258)

Teaching interests: I teach on the Research Methodology course for the Yorkshire and Humber Deanery and supervise masters and medical students.