Welcome to the Design, Trials & Statistics Section of ScHARR
Design, Trials & Statistics (DTS)
Design, Trials & Statistics (DTS) is a section within ScHARR and consists of three subgroups:
The group aims to design, conduct, analyse and report high quality randomised controlled trials (RCTs) and other studies to evaluate the clinical and cost-effectiveness of new services, therapies and health technologies.
The group also aims to develop and deliver excellent quality, research-informed teaching relevant to today's students, at undergraduate, postgraduate and professional development levels.
We can assist your research from the earliest stages from identifying funding sources and protocol development through to implementation and publication. If you have a study in mind, please contact us to discuss your requirements.
DTS is proud to support the Clinical Research Academy (CRA).
Director: Professor Steven Julious
Deputy Director: Professor Cindy Cooper
Chatters R, Roberts J, Mountain G, Cook S, Windle G, Craig C & Sprange K (2017) The long-term (24 month) effect on health and well-being of the Lifestyle Matters community-based intervention in people aged 65 years and over: a qualitative study. BMJ OPEN 2017; 7.
Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A, Campbell M, Cooper C, Dimairo M, Dixon S, Elliott J, Evans M, Green F, Hackney G, Hammond P, Hallowell N, Jaap A, Kennon B, Kirkham J, Lindsay R, Mansell P, Papaioannou D, Rankin D, Royle P, Smithson WH & Taylor C (2017) A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
Hind D, Parkin J, Whitworth V, Rex S, Young T, Hampson L, Sheehan J, Maguire C, Cantrill H, Scott E, Epps H, Main M, Geary M, McMurchie H, Pallant L, Woods D, Freeman J, Lee E, Eagle M, Willis T, Muntoni F & Baxter P (2017) Aquatic therapy for children with Duchenne muscular dystrophy: a pilot feasinility randomised controlled trial and mixed-methods process evaluation. HEALTH TECHNOLOGY ASSESSMENT, 21(27), 1-+.
Loban A, Mandefield L, Hind D & Bradburn M (2017) A randomized trial found online questionnaires supplemented by postal reminders generated a cost-effective and generalizable sample but don’t forget the reminders. Journal of Clinical Epidemiology. View this article in WRRO
Walters SJ, Henriques-Cadby I, Bortolami O, Flight L, Hind D, Jacques RM, Knox C, Nadin B, Rothwell J, Surtees M, Julious SA. (2017) Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme. BMJ OPEN 2017;7.
The STEPWISE trial randomised 414 (104%) participants between 12 March 2015 and 31 March 2016. Across the ten NHS Trusts that took part, 33 STEPWISE (intervention) courses were delivered during the trial.
We aimed to successfully follow-up at least 80% of participants at 12 months post-randomisation. A total of 338 (81.6%) participants contributed their weight (primary outcome) at 12 months, exceeding this target.
Researchers at the University of Sheffield completed over 50 interviews with a sample of participants receiving the intervention, with course facilitators and intervention developers. Researchers at University Hospitals of Leicester observed a sample of sessions to see whether courses were delivered as planned. This work helped us to understand how the intervention was delivered and whether it was acceptable to service users and healthcare professionals.
The results were presented at the World Psychiatric Association XVII World Congress of Psychiatry in Berlin on 11 October 2017. The project team submitted a draft final report to the funder which will be published in full in the NIHR Journal. Further information is available at https://www.journalslibrary.nihr.ac.uk/programmes/hta/122805/#/.
Latest Research Studies
ASPECT: Alleviating Specific Phobias Experienced by Children Trial.
ASTICLite: Autologous Stem cell Transportation In refractory Crohn's disease - Low Intensity Therapy Evaluation.
COMMEND: A feasibility study and randmoised controlled trial of acceptance and COMmitment therapy for people with Motor nEuroN Disease.
DAFNEplus: Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.
OPTION-DM: Optimal Pathway for Treating neuropathic paiN in Diabetes Mellitus trial.