Laura MandefieldLaura Mandefield size 300

Medical Statistician

Clinical Trials Research Unit (CTRU), ScHARR
The University of Sheffield
Regent Court, 30 Regent Street

Office:  3.10 - Innovation Centre

Tel: +44 (0) 114 22 20750




I joined the University of Sheffield as a Medical Statistician in January 2015 and work within the Clinical Trials Research Unit of ScHARR. Before that, I graduated with a BSc (Hons) in Biological Sciences from The University of Edinburgh and an MSc in Statistics from The University of Leeds. I also gained a teaching qualification from The University of York.

I am currently providing statistical support on a number of trials within Sheffield CTU and am part of a methodological research group looking at methods for analysing trials with clustering in one arm.

Research Interests

  • Methods for handling missing data
  •  Analysis of cluster RCTs and trials with clustering by health professional
  • Design and analysis of pilot trials

Current Projects

  • BEADS: Behavioural Activiation therapy for Depression After Stroke
  • E-SEE: Enhancing Social-Emotional Health and Wellbeing in the Early Years: A Community-based Randomised Controlled Trial (and Economic) Evaluation of the Incredible Years Infant and Toddler (0-2) Parenting Programmes
  • MERIDIAN: Magnetic Resonance Imaging to Enhance the Diagnosis of Fetal Development Brain Abnormalities In Utero
  • CFHealthHub: Development and evaluation of an intervention to support adherence to treatment in adults with Cystic Fibrosis


  • Tutor for HAR 6035 `An Introduction to Statistics and Critical Appraisal´ module on the Master of Public Health programme

Laura is part of Design, Trials and Statistics

Journal articles

Conference proceedings papers

  • Thomas SA, Drummond A, Lincoln NB, Palmer R, dasnair R, Latimer N, Hackney G, Hatton R, Walters S, Mandefield L, Cooper C, Chater T, Callaghan P, England TJ, Coates L, Sutherland K & Eshtan S (2017) Behavioural activation therapy for depression after stroke (BEADS): a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. INTERNATIONAL JOURNAL OF STROKE, Vol. 12 (pp 15-15) RIS download Bibtex download
  • Mandefield L, Walters S & Team BEADST (2017) Estimating the underlying overall and centre recruitment rates in external pilot trials-how many centre-months of recruitment data do we need? A case study of the BEADS pilot trial. TRIALS, Vol. 18 RIS download Bibtex download


  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download
  • Walters S, Lee E, Flight L, Mandefield L, Dimario M & Allison A (2015) Analysis and reporting of individually randomised controlled trials with clustering in one arm only: how should we do it?. RIS download Bibtex download