Laura MandefieldLaura Mandefield size 300

Medical Statistician

Clinical Trials Research Unit (CTRU), ScHARR
The University of Sheffield
Regent Court, 30 Regent Street

Office:  3.10 - Innovation Centre

Tel: +44 (0) 114 22 20750




I joined the University of Sheffield as a Medical Statistician in January 2015 and work within the Clinical Trials Research Unit of ScHARR. Before that, I graduated with a BSc (Hons) in Biological Sciences from The University of Edinburgh and an MSc in Statistics from The University of Leeds. I also gained a teaching qualification from The University of York.

I am currently providing statistical support on a number of trials within Sheffield CTU and am part of a methodological research group looking at methods for analysing trials with clustering in one arm.

Research Interests

  • Methods for handling missing data
  •  Analysis of cluster RCTs and trials with clustering by health professional
  • Design and analysis of pilot trials

Current Projects

  • BEADS: Behavioural Activiation therapy for Depression After Stroke
  • E-SEE: Enhancing Social-Emotional Health and Wellbeing in the Early Years: A Community-based Randomised Controlled Trial (and Economic) Evaluation of the Incredible Years Infant and Toddler (0-2) Parenting Programmes
  • MERIDIAN: Magnetic Resonance Imaging to Enhance the Diagnosis of Fetal Development Brain Abnormalities In Utero
  • CFHealthHub: Development and evaluation of an intervention to support adherence to treatment in adults with Cystic Fibrosis


  • Tutor for HAR 6035 `An Introduction to Statistics and Critical Appraisal´ module on the Master of Public Health programme

Laura is part of Design, Trials and Statistics

Journal articles

Conference proceedings papers

  • Thomas SA, Drummond A, Lincoln NB, Palmer R, dasnair R, Latimer N, Hackney G, Hatton R, Walters S, Mandefield L , Cooper C et al (2017) Behavioural activation therapy for depression after stroke (BEADS): a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. INTERNATIONAL JOURNAL OF STROKE, Vol. 12 (pp 15-15) RIS download Bibtex download
  • Mandefield L, Walters S & Team BEADST (2017) Estimating the underlying overall and centre recruitment rates in external pilot trials-how many centre-months of recruitment data do we need? A case study of the BEADS pilot trial. TRIALS, Vol. 18 RIS download Bibtex download


  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download
  • Walters S, Lee E, Flight L, Mandefield L, Dimario M & Allison A (2015) Analysis and reporting of individually randomised controlled trials with clustering in one arm only: how should we do it?. RIS download Bibtex download