Mike Holmes BSc (Sheffield Hallam)
Operational Research Analyst
The University of Sheffield
Regent Court, 30 Regent Street
Sheffield S1 4DA
Tel: (+44) (0)114 222 0745
Fax: (+44) (0)114 222 0749
I joined ScHARR in July 2001. I am an operational researcher in the Health Economics and Decision Science (HEDS) department of the School of Health and Related Research (ScHARR). I have led a number of projects including NICE and HTA assessments as well as consultancy based projects. I have done cost-effectiveness analysis in a range of disease areas such as: mental health, diabetes, venous thromboembolism and chronic obstructive pulmonary disease. I have been most heavily involved in modelling the cost-effectiveness of treatments in the fields of cardiovascular and renal disease. This has included modelling the cost-effectiveness of drugs for the prevention of stroke, myocardial infarction and assessing the cost-effectiveness of strategies for preventing heart disease. I have worked on several projects in the area of renal disease including the evaluation of immunosuppressive drugs for renal transplantation, the evaluation of techniques to store kidneys prior to transplantation, the cost-effectiveness of renal risk reducing strategies and the cost-effectiveness of screening programmes.
I have given 8 invited presentations at conferences and academic institutions, and have a number of published articles in the form of HTA monographs as well as conventional peer-reviewed journals.
- Modelling in healthcare
- Economic modelling of renal transplantation therapies
- Economic modelling of coronary heart disease
- Economic modelling of type 2 diabetes mellitus
- Economic modelling of dermatitis
I am currently the lead modeller for a HTA funded project investigating the cost-effectiveness of investigation and hospital admission for minor (GCS 13-15) head injury. The research objective is to identify the optimal strategy for managing adults and children with minor head injury. The specific objectives are to:
- Estimate the diagnostic accuracy of clinical assessment, clinical decision rules, skull X-ray, cranial CT and inpatient observation for identifying intracranial bleeding requiring neurosurgery in adults and children with minor (GCS 13-15) head injury
- Estimate the cost-effectiveness of diagnostic strategies for minor head injury, in terms of the cost per Quality Adjusted Life Year (QALY) gained by each strategy
- Identify the optimal strategy for managing minor head injury in the NHS, defined as the most cost-effective strategy at the NICE threshold for willingness to pay per QALY gained
- Identify the critical areas of uncertainty in the management of minor head injury, where future primary research would produce the most benefit
- Holmes M, Davis S & Simpson E (2015) Alteplase for the Treatment of Acute Ischaemic Stroke: A NICE Single Technology Appraisal; an Evidence Review Group Perspective. PharmacoEconomics, 33(3), 225-233. View this article in WRRO
- Holmes M, Rathbone J, Littlewood C, Rawdin A, Stevenson M, Stevens J, Archer R, Evans P & Wang J (2014) Routine echocardiography in the management of stroke and transient ischaemic attack: a systematic review and economic evaluation.. Health Technol Assess, 18(16), 1-176.
- Holmes M, Carroll C & Papaioannou D (2013) Dabigatran etexilate for the prevention of venous thromboembolism in patients undergoing elective hip or knee surgery-a NICE single technology appraisal. PharmacoEconomics - Italian Research Articles, 15(2), 83-90.
- Holmes MW, Goodacre S, Stevenson MD, Pandor A & Pickering A (2013) The cost-effectiveness of diagnostic management strategies for children with minor head injury.. Arch Dis Child, 98(12), 939-944.
- Holmes MW, Goodacre S, Stevenson MD, Pandor A & Pickering A (2012) The cost-effectiveness of diagnostic management strategies for adults with minor head injury.. Injury, 43(9), 1423-1431.
- Pandor A, Goodacre S, Harnan S, Holmes M, Pickering A, Fitzgerald P, Rees A & Stevenson M (2011) Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation.. Health Technol Assess, 15(27), 1-202.
- Ward S, Lloyd Jones M, Pandor A, Holmes M, Ara R, Ryan A, Yeo W & Payne N (2007) A systematic review and economic evaluation of statins for the prevention of coronary events.. Health Technol Assess, 11(14), 1-iv.
- Brazier J, Tumur I, Holmes M, Ferriter M, Parry G, Dent-Brown K & Paisley S (2006) Psychological therapies including dialectical behaviour therapy for borderline personality disorder: a systematic review and preliminary economic evaluation.. Health Technol Assess, 10(35), iii-117.
- Holmes M, Chilcott J, Walters S, Whitby S & Akehurst R (2004) Economic evaluation of everolimus versus mycophenolate mofetil in combination with cyclosporine and prednisolone in de novo renal transplant recipients.. Transpl Int, 17(4), 182-187.
- Wight JP, Chilcott JB, Holmes MW & Brewer N (2003) Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review.. Clin Transplant, 17(4), 293-307.
- Chilcott JB, Holmes MW, Walters S, Akehurst RL & Nashan B (2002) The economics of basiliximab (Simulect) in preventing acute rejection in renal transplantation.. Transpl Int, 15(9-10), 486-493.
- Beard SM, Holmes M, Price C & Majeed AW (2000) Hepatic resection for colorectal liver metastases: A cost-effectiveness analysis.. Ann Surg, 232(6), 763-776.