Mike Holmes BSc (Sheffield Hallam)

Mike Holmes

Operational Research Analyst

The University of Sheffield
Regent Court, 30 Regent Street
Sheffield S1 4DA

Tel: (+44) (0)114 222 0745
Fax: (+44) (0)114 222 0749
E-mail: m.w.holmes@sheffield.ac.uk
Room: 1012/13

ORCiD: 0000-0002-8054-4379


I joined ScHARR in July 2001. I am an operational researcher in the Health Economics and Decision Science (HEDS) department of the School of Health and Related Research (ScHARR). I have led a number of projects including NICE and HTA assessments as well as consultancy based projects. I have done cost-effectiveness analysis in a range of disease areas such as: mental health, diabetes, venous thromboembolism and chronic obstructive pulmonary disease. I have been most heavily involved in modelling the cost-effectiveness of treatments in the fields of cardiovascular and renal disease. This has included modelling the cost-effectiveness of drugs for the prevention of stroke, myocardial infarction and assessing the cost-effectiveness of strategies for preventing heart disease. I have worked on several projects in the area of renal disease including the evaluation of immunosuppressive drugs for renal transplantation, the evaluation of techniques to store kidneys prior to transplantation, the cost-effectiveness of renal risk reducing strategies and the cost-effectiveness of screening programmes.

I have given 8 invited presentations at conferences and academic institutions, and have a number of published articles in the form of HTA monographs as well as conventional peer-reviewed journals.

Research interests

  • Modelling in healthcare
  • Economic modelling of renal transplantation therapies
  • Economic modelling of coronary heart disease
  • Economic modelling of type 2 diabetes mellitus
  • Economic modelling of dermatitis


I am currently the lead modeller for a HTA funded project investigating the cost-effectiveness of investigation and hospital admission for minor (GCS 13-15) head injury. The research objective is to identify the optimal strategy for managing adults and children with minor head injury. The specific objectives are to:

  1. Estimate the diagnostic accuracy of clinical assessment, clinical decision rules, skull X-ray, cranial CT and inpatient observation for identifying intracranial bleeding requiring neurosurgery in adults and children with minor (GCS 13-15) head injury
  2. Estimate the cost-effectiveness of diagnostic strategies for minor head injury, in terms of the cost per Quality Adjusted Life Year (QALY) gained by each strategy
  3. Identify the optimal strategy for managing minor head injury in the NHS, defined as the most cost-effective strategy at the NICE threshold for willingness to pay per QALY gained
  4. Identify the critical areas of uncertainty in the management of minor head injury, where future primary research would produce the most benefit

Extended List of Publications

Journal articles

Conference proceedings papers

  • Holmes M, Brazier J, Tumur I, Ferriter M, Parry G, Dent-Brown K & Paisley S (2007) A probabilistic cost-effectiveness analysis of psychological therapies including dialectical behaviour therapy for borderline personality disorder.. J MENT HEALTH POLICY, Vol. 10 (pp S18-S19) RIS download Bibtex download