ACtiFlogo

Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis (ACtiF)

Objectives

  1. To embed adherence measurement in routine Cystic Fibrosis care by (i) building the IT infrastructure to capture adherence data from nebulisers and dry powders (ii) developing a web-portal ‘CF Healthhub’ to display adherence data to people with Cystic Fibrosis (PWCF) and clinicians, and (iii) co-producing the web-portal interface with patients and clinicians to facilitate maximum utility.
  2. To develop a Behaviour Change Intervention (BCI) that uses feedback of measured adherence data, linked to a range of evidence based interventions including Problem Solving and Implementation Plans to increase adherence.
  3. To test the cost effectiveness of the BCI by (i) exploring its feasibility and acceptability in a mixed methods study, (ii) testing its efficacy in an RCT of 550 patients in 12 CF Units, (iii) understanding its implementation in practice using a process evaluation, and (iv) modelling its cost effectiveness.

The Team

Applicants Position Held Institution
Lead Applicant
Dr Martin Wildman

Consultant in Respiratory
Medicine and Adult Cystic Fibrosis

Honorary Senior Clinical Lecturer Health Services Research

Sheffield Teaching Hospitals NHS Foundation Trust

ScHARR, The University of Sheffield

Joint Lead Applicant
Professor Alicia O'Cathain Professor of Health Services Research ScHARR, The University of Sheffield
Co-Applicants
Mr John Ainsworth Senior Research Fellow The Farr Institute of Health Informatics Research, University of Manchester

Professor Madelynne Arden

Professor of Health Psychology Sheffield Hallam University
Mr Daniel Beever Person with CF, PPI Lead ScHARR, The University of Sheffield
Professor Judy Bradley Professor in Physiotherapy/Northern Ireland Clinical Research Network (NICRN)
Co-lead
Queens University Belfast
Professor Iain Buchan Clinical Professor in Public
Health Informatics
The Farr Institute of Health Informatics Research, University of Manchester
Professor Stuart Elborn Consultant Physician, Respiratory Medicine Belfast Health and Social Care Trust
Professor Rachel Elliot Lord Trent Professor of Medicines and Health Faculty of Science , The University of Nottingham
Dr Daniel Hind Assistant Director, Clinical Trials
Research Unit
ScHARR, The University of Sheffield
Ms Marlene Hutchings Band 7 Physiotherapist, Intervention Delivery Sheffield Teaching Hospitals NHS Foundation Trust
Professor Susan Michie Professor of Health Psychology University College London
Professor Mohammed A Mohammed Professor of Quality and Effectiveness University of Bradford
Professor Jon Nicholl Dean of School (ScHARR) ScHARR, The University of Sheffield
Dr Paul Tappenden Reader in Health Economic
Modelling
ScHARR, The University of Sheffield
Professor Stephen Walters Professor of Medical Statistics and Clinical Trials ScHARR, The University of Sheffield
Mr Robert Rathbone General Manager Emergency Care Sheffield Teaching Hospitals NHS Foundation Trust
Susan Kirkpatrick Senior Qualitative Researcher University of Oxford

Funding

NIHR Applied Research Programme Grant £2M.

Timing

Start date March 2015, for 5 years.

Contact

For more information, please contact Dr Martin Wildman