Karen SisleyDr Karen Sisley BSc, PhD

Senior Lecturer, Department of Oncology
Tel: +44 (0)114 271 3199 | Fax: +44 (0)114 271 3314 | Email: k.sisley@sheffield.ac.uk

Link: www.shef.ac.uk/oncology/staffprofiles/sisley

Genetics of Rare Cancers

Karen has an interest in rare tumours and specialises in ocular tumours and sarcomas, working with Ian Rennie and Malcolm Reed. Her research focuses on the genetic changes related to subtypes of rare tumours and the impact these have on the tumour behaviour, and uses a broad based scientific approach. Karen was the first to establish that a combination of genetic abnormalities in Uveal melanomas could be used to reliably predict their prognosis, and now uses molecular cytogenetics to underpin her research.

Selected publications:

1. Sisley K, Doherty R, Cross NA (2011) What hope for the future? GNAQ and uveal melanoma. Br J Ophthalmol. 95(5): 620–3.
2. Ul-Hassan A, Sisley K, Hughes D, Hammond DW, Robinson MH, Reed MW (2009). Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement. Int J Exp Pathol. 90(5): 549–57.