Ms Lynda WyldMs Lynda Wyld BMedSci, MBChB, PhD, FRCS (Gen Surg)

Senior Lecturer in Surgical Oncology, Department of Oncology
Tel: +44 (0)114 271 3243 | Fax: +44 (0)114 271 3314 | Email: l.wyld@sheffield.ac.uk

Link: www.shef.ac.uk/oncology/staffprofiles/wyld

Breast cancer

Lynda holds Medical and PhD degrees from the University of Sheffield, and undertook her surgical training in Leeds, Sheffield, Nottingham and Manchester. She was appointed consultant and Senior Lecturer in 2002, and is based in the Department of Oncology. Lynda’s primary research interests are breast cancer in older women and familial breast cancer and stress proteins in cancer. The breast cancer in older women project area is clinically based, NIHR funded and involves collaborations with a team of experts around the UK. It focuses on the use and appropriateness of primary endocrine therapy and how to ensure that both clinicians and patients are supported in deciding on optimal treatment modality. The familial breast cancer project is local to the Sheffield region, and enjoys close collaboration with Sheffield Hallam University. It seeks to understand the physical and psychological outcomes for women at increased familial breast cancer risk and the genetic factors that may underlie this risk. Lynda’s ‘stress protein’ research stream investigates the unfolded protein response, a stress response signalling pathway that is implicated in the resistance mechanisms to anticancer drugs found in many cancer cells.

Selected publications:

1. Collins K, Winslow M, Reed MW, Walters SJ, Robinson T, Madan JJ, Green T, Cocker H and Wyld L. (2010). The views of older women towards mammographic screening: a qualitative and quantitative study. British Journal of Cancer, 102: 1461–1467.
2. Al-Rawashdeh F, Scriven P, Cameron IC, Vergani P and Wyld L, (2010). Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma. European Journal Gastroenterology and Hepatology. 9: 1099–1005.
3. Cooper K, Meng Y, Harnan S, Ward S, Fitzgerald P, Papaionnou D, Wyld L, Ingram CE, Wilkinson I and Lorenze E (2011). Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the evaluation of axillary lymph node metastases in breast cancer: systematic review and economic analysis. HTA Journal. 15: 1–134.