Dr Martin Zeidler BSc, DPhil
CRUK Senior Fellow and Reader, Department of Biomedical Science
Tel (office): +44 (0)114 222 6093 | Tel (lab): +44 (0)114 222 6094
The JAK/STAT Signalling Pathway
Following his PhD studies at the European Molecular Biology Laboratory Heidelberg (EMBL), Martin was a postdoctoral fellow at Harvard Medical School, Boston, USA. In 2000, he obtained a prestigious Emmy Noether Fellowship to set up his laboratory at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany before taking up a position in the Department of Biomedical Science (BMS) at the University of Sheffield. In 2007 he was awarded a Cancer Research UK Senior Cancer Research Fellowship and was promoted to Reader in Cellular Signalling.
The Zeidler lab is interested in the JAK/STAT signal transduction cascade, a cellular signalling pathway required for development, haematopoiesis and immunity. Recently, gain-of-function mutations in human JAK2 have been identified that are responsible for the vast majority of myeloproliferative neoplasias. In addition, inappropriate JAK/STAT signalling has also been associated with a wide range of leukaemias, lymphomas, head & neck cancers, melanomas and breast cancers. The principal focus of the lab is to identify and characterise the regulators of JAK/STAT signalling using a combination of Drosophila based forward and reverse genetics as well as human cell based assays. In particular, we use RNAi based approaches, in collaboration with the Wellcome Trust – supported Sheffield RNAi Screening Facility (SRSF), to identify genes that modulate these signalling pathways. Our experience in cell based screening is also being used to undertake small molecule drug screens. Ultimately, we hope that the insights we generate will have the potential to identify future drug targets to treat human cancers.
1. Müller, P, Pugachendhi, D, Zeidler, MP. (2012) Modulation of human JAK/STAT pathway signalling by functionally conserved regulators. JAK-STAT in press.
2. Vidal, O-M, Bausek, N, Smythe, E, Zeidler, MP. (2010) Negative Regulation of Drosophila JAK/STAT signalling by endocytic trafficking. J. Cell Sci 123: 3457–3466.
3. Bina, S., Wright, VM, Fisher, KH, Milo, M, Zeidler, MP. (2010) Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. EMBO Reports 11: 201–207.