Nicola BrownProfessor Nicola Brown BSc, PhD

Professor of Microcirculation Biology and Head of Microcirculation Research Group, Academic Unit of Surgical Oncology, Department of Oncology
Tel: +44 (0)114 271 2789 | Fax: +44 (0)114 271 3314 | Email: n.j.brown@sheffield.ac.uk

Link: www.shef.ac.uk/oncology/staffprofiles/brown

Cellular and Molecular Mechanisms Regulating Tumour Angiogenesis

Nicola completed her PhD in the Department of Physiology at the University of Sheffield in 1987, before becoming a Research Associate in the Medical School and establishing the Microcirculation Research Group. In 1994 she was appointed Lecturer in Microcirculation Studies, Senior Lecturer in 1999, Reader in 2000 and Professor in 2003. She is Head of the Academic Unit of Surgical Oncology, a member of the Breast Cancer Campaign Scientific Advisory Board, and an Expert Panel Member of the International Photodynamic Association advising the Director of NHS Cancer Services. She is an Associate Editor for Frontiers in Vascular Physiology and a member of the Editorial Board for the Journal of Vascular Research and Photochemistry and Photobiology. Research in the Microcirculation Research Group is currently focussing on determining the molecular and cellular mechanisms regulating angiogenesis in the development and progression of breast cancer and angiosarcoma, and the response of the tumour microenvironment to vascular-targeted therapy. Neural guidance molecules, recently identified as important in vascular development, may play a role in tumour angiogenesis, and we are currently investigating this new area. Collaborative research with colleagues in the UK, EU and USA, includes investigating mechanisms of tumour homing and localisation within bone, identification of tumour-endothelial interactions using atomic force microscopy, the delivery of vascular-targeted therapy using nanoparticles and the use of novel approaches to image the tumour microvasculature (CRUK/EPSRC/MRC/DoH programme). Research in her group is also funded by BCC, YCR and EPSRC.

Selected publications:

1. Michailidou M, Brown HK, Lefley D, Evans CA, Cross SS, Coleman RE, Holen I, Brown NJ (2010) Microvascular endothelial cell responses in vitro and in vivo : modulation by zoledronic acid and paclitaxel? J. Vasc. Res. 47: 481–493.
2. Bluff JE, Amarzguioui M, Slattery J, Reed MWR, Staton CA, Brown NJ (2010) Anti-Tissue Factor short hairpin RNA inhibits breast cancer growth in vivo. Breast Cancer Research and Treatment, 128: 691–701.
3. Staton CA, Shaw LA, Bluff JE, Cross SS, Reed MWR, Brown NJ (2011) Expression of class 3 semaphorins and their receptors in human breast neoplasia. Histopathology 59: 274–282.