Spencer Collis newDr Spencer Collis BSc, PhD

Reader in Genome Stability
CRUK Senior Cancer Research Fellow

Head of the Genome Stability Group
Department of Oncology & Metabolism
University of Sheffield

Tel: +44 (0)114 215 9043
Email: s.collis@sheffield.ac.uk

Link: Profile

The DNA Damage Response and cancer

Spencer was recruited to the Institute for Cancer Studies within the Department of Oncology in October 2009 to establish an independent research programme focussing on DNA repair pathways, which are often dysregulated in cancer. Before moving to Sheffield, Dr Collis completed his PhD studies at the CR-UK Paterson Institute for Cancer Research in Manchester and held postdoctoral research positions at Johns Hopkins University in Baltimore and CR-UK London Research Institute’s Clare Hall Laboratories.

The main goal of his work is to understand the complex mechanisms of DNA repair pathways in order to expand our knowledge of cancer development and progression. His lab focuses its efforts on the discovery and characterisation of new proteins that are involved in the detection, signalling and subsequent repair of DNA damage. His team also aims to determine if mutations in these proteins leads to the development of genetically unstable human diseases. It is hoped that this work will eventually lead to the development of new or improved anti-cancer treatments and/or clinically useful biomarkers.

In September 2010, Dr Collis was awarded a prestigious CR-UK Senior Cancer Research Fellowship worth
~£1.2 million over the next 6 years to enable his lab to carry out this work. Additional support for research in the lab, totalling over £200K, is provided by YCR, which includes collaborative projects with clinicians, biochemists and medicinal chemists based at Sheffield University, the Royal Hallamshire and Weston Park Hospitals. His lab currently comprises 2 post-docs, a Scientific Officer, 2 PhD students, a Research Technician and a Clinical Research Fellow.

Selected publications:

Barone G, Arora A, Ganesh A, Abdel-Fatah T, Moseley P, Ali R, Chan SYT, Savva C, Schiavone C, Carmell N, Myers KN, Rakha E, Madhusudan S & Collis SJ.  The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response.  Oncotarget: 9(50) 29508-29524, 2018.

Myers KN, Barone G, Staples CJ, Howard AE, Beveridge RD, Maslen S, Skehel JM & Collis SJ. The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. Scientific Reports: 6(35548), 2016.

Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel A, Skehel, JM & Collis SJ. MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.  Cell Reports: 16(10), 2565-2575, 2016.

Barone G, Staples CJ, Myers KN, Paterson KW, McKenzie EA, Eyers CE, Maslen S, Skehel, JM, Eyers PA* & Collis SJ*.
CDK18 promotes replication stress signalling and genome stability.  Nucleic Acids Research: 44(18), 8772-8785, 2016.  *Co-corresponding authors.

Johnson CA* & Collis SJ*.
Ciliogenesis and the DNA damage response; a stressful relationship..
Cilia; 5(19), 2016. *co-corresponding authors

Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ & Collis SJ.
The leukaemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signalling.
Cell Cycle 13(21), 3450-3459, 2014.

Patil AA, Sayal P, Depondt ML, Beveridge RD, Roylance A, Krinlani DH, Myers K, Cox A, Jelinek D, Fernando M, Carroll TA & Collis SJ.
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Amaemia pathway sensitises gliomas to chemotherapeutic agents
Oncotarget 5(15) 6414-6424, 2014.

Staples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee AJX, Swanton C, Howell M, Maslen S, Skehel JM, Boulton SJ & Collis SJ.
Ccdc13; a novel human centriolar satellite protein required for ciliogenesis and genome stability.
J Cell Sci. 127(13), 2910-2919, 2014.

Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ & Collis SJ.
The centriolar satellite protein Cep131 is important for genome stability.
J Cell Sci. 125(20), 4770-4779, 2012.