Professor Alison Condliffe
Clinical Medicine, School of Medicine and Population Health
Professor of Respiratory Medicine
a.m.condliffe@sheffield.ac.uk
+44 114 215 9519
+44 114 215 9519
The Medical School
Full contact details
Professor Alison Condliffe
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
I am a clinician scientist with an interest in respiratory infection, immune deficiency and inflammation. I studied medicine in Cambridge and London, and undertook clinical training in London and Edinburgh. My PhD was supervised by Professor Chris Haslett and Professor Edwin Chilvers in Edinburgh, and identified a key role for the phosphoinositde 3-kinase (PI3K) signalling pathway in neutrophil priming and activation. I was awarded a Wellcome Trust Intermediate Fellowship to pursue this finding at the Inositide Laboratory at the Babraham Institute in Cambridge, with Dr Phill Hawkins and Dr Len Stephens. My subsequent appointment as a University Lecturer in Cambridge in 2007 enabled a more translational research focus, in particular studying the impact of hypoxia on neutrophil function and establishing novel imaging techniques using radiolabelled neutrophils and eosinophils in man; during this time I forged clinical and research links with the Department of Immunology in Cambridge. This collaboration facilitated the identification the ‘Activated PI3-kinase Delta Syndrome’ or APDS, a novel immune deficiency syndrome characterised by severe recurrent respiratory infection, viral infections, autoimmunity and lymphoproliferation, and caused by excessive PI3K delta signalling in immune cells. I was appointed as Professor of Respiratory Medicine at the University of Sheffield in 2015.
- Research interests
-
Defects in innate and adaptive immunity lead to infection with a predilection for the respiratory tract, yet immune cell infiltration underpins a range of inflammatory and allergic respiratory diseases such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS) and asthma. To clarify the role of dysregulated immunity in these diseases, I wish to address the following questions:
- How does immune cell function become deranged to promote disease pathogenesis rather than host defence?
- Can we identify cellular defects that predispose to recurrent respiratory infections?
- How can we use this knowledge to further diagnostic, prognostic and therapeutic interventions in diseases driven by aberrant immunity?
My current research funding encompasses the role of inappropriate neutrophil activation in COPD and ARDS, the impact of hypoxia on neutrophil function, and the role of PI3K delta in immune cell and airway biology.
Current projects:
- How does hypoxia impact on host-pathogen interactions?
- Contribution of hypoxic upregulation of neutrophil degranulation to airway disease and endothelial dysfunction in COPD
- Characterisation of a mouse model of the APDS (MRC program grant; with Dr Klaus Okkenhaug, Babraham Institute, Cambridge).
- Development of zebrafish models to characterise PI3K signalling in host-pathogen interactions (with Professor Steve Renshaw).
- Use of novel PI3Kδ inhibitors in APDS (MRC-Industrial Collaboration Award, GSK).).
- Identification of mutations in patients with bronchiectasis and/or recurrent infection (CTTV award with Dr David Michalovitch (GSK), Dr Paul Kelham (Wellcome Trust Sanger Centre) and Professor Andres Floto (Papworth Hospital NHS Foundation Trust)).
- Role of PI3K signalling in airway epithelial-mediated host defence.
- Role of hypoxia in driving antimicrobial evolution (with Professor Michael Brockhurst).
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. The Journal of Allergy and Clinical Immunology: In Practice, 5(4), 938-945. View this article in WRRO
- Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.. J Allergy Clin Immunol, 139(2), 597-606.e4. View this article in WRRO
- Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition. American Journal of Respiratory and Critical Care Medicine, 194(8), 961-973. View this article in WRRO
- Hypoxia upregulates neutrophil degranulation and potential for tissue injury. Thorax, 71(11), 1030-1038. View this article in WRRO
- PI3Kδ and primary immunodeficiencies. Nature Reviews Immunology. View this article in WRRO
- Phosphoinositide 3-Kinase Gene Mutation Predisposes to Respiratory Infection and Airway Damage. Science, 342(6160), 866-871.
- Use of Technetium-99m–labeled Eosinophils to Detect Active Eosinophilic Inflammation in Humans. American Journal of Respiratory and Critical Care Medicine, 188(7), 880-882.
- The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?. American Journal of Respiratory Cell and Molecular Biology, 48(5), 531-539.
- Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing ofStaphylococcus aureusin Human Neutrophils. The Journal of Immunology, 186(1), 453-463.
- Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils. Nature Cell Biology, 8(11), 1303-1309.
- RhoG Regulates the Neutrophil NADPH Oxidase. The Journal of Immunology, 176(9), 5314-5320.
- Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood, 106(4), 1432-1440.
- Moving in mysterious ways. Nature, 404(6774), 135-137.
- Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival. PLoS ONE, 7(9), e45933-e45933. View this article in WRRO
All publications
Journal articles
- Antibiotics limit adaptation of drug-resistant Staphylococcus aureus to hypoxia. Antimicrobial Agents and Chemotherapy.
- Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial. The Lancet Respiratory Medicine. View this article in WRRO
- A fun-guide to innate immune responses to fungal infections. Journal of Fungi, 8(8). View this article in WRRO
- Hypoxia increases the potential for neutrophil-mediated endothelial damage in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 205(8), 903-916. View this article in WRRO
- Granulomatous–lymphocytic interstitial lung disease : an international research prioritisation. ERJ Open Research, 7(4). View this article in WRRO
- Xenon ventilation MRI in difficult asthma; initial experience in a clinical setting. European Respiratory Journal, 7(3). View this article in WRRO
- Circulating BMP9 Protects the Pulmonary Endothelium During Inflammation-induced Lung Injury in Mice. American Journal of Respiratory and Critical Care Medicine, 203(11), 1419-1430. View this article in WRRO
- Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS Pathogens, 17(3). View this article in WRRO
- Parental experience of prophylactic antibiotics. Archives of Disease in Childhood, 106(6), 577-582. View this article in WRRO
- Role of unfolded proteins in lung disease. Thorax, 76(1), 92-99. View this article in WRRO
- Interstitial lung disease in primary immunodeficiency: towards a brighter future. European Respiratory Journal, 55(4), 2000089-2000089.
- Prekallikrein – an emerging therapeutic target for
Klebsiella pneumoniae infection? †. The Journal of Pathology, 250(4), 359-361.
- Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review. Clinical Reviews in Allergy & Immunology, 59(3), 323-333.
- The impact of hypoxia on the host-pathogen interaction between neutrophils and staphylococcus aureus. International Journal of Molecular Sciences, 20(22). View this article in WRRO
- Pellino-1 regulates immune responses to Haemophilus influenzae in models of inflammatory lung disease. Frontiers in Immunology, 10. View this article in WRRO
- Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. Journal of Experimental Medicine, 216(9), 1986-1998.
- Neutrophil GM-CSF receptor dynamics in acute lung injury.. Journal of Leukocyte Biology, 105(6), 1183-1194. View this article in WRRO
- Correction to: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group. Journal of Clinical Immunology, 39(2), 225-227.
- The clinical consequences of neutrophil priming. Current Opinion in Hematology, 26(1), 22-27.
- Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group. Journal of Clinical Immunology, 39(1), 45-54. View this article in WRRO
- Reply. Journal of Allergy and Clinical Immunology, 143(3), 1265-1266.
- PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nature Communications, 9(-), ---. View this article in WRRO
- In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatics.. Journal of Allergy and Clinical Immunology. View this article in WRRO
- Priming and de‐priming of neutrophil responses in vitro and in vivo. European Journal of Clinical Investigation. View this article in WRRO
- Disease evolution and response to rapamycin in activated phosphoinositide 3-kinase δ syndrome: The European society for immunodeficiencies-activated phosphoinositide 3-kinase δ syndrome registry. Frontiers in Immunology, 9, 543-543. View this article in WRRO
- Phosphoinositide 3-kinase δ (PI3Kδ) in respiratory disease. Biochemical Society Transactions. View this article in WRRO
- Respiratory Manifestations of the Activated Phosphoinositide 3-Kinase Delta Syndrome. Frontiers in Immunology, 9. View this article in WRRO
- NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation, 127(9), 3521-3526. View this article in WRRO
- Hypoxia causes IL‐8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid‐induced apoptosis in human eosinophils. Clinical and Experimental Allergy, 47(6), 770-784. View this article in WRRO
- Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. The Journal of Experimental Medicine, 214(4), 1111-1128. View this article in WRRO
- British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. The Journal of Allergy and Clinical Immunology: In Practice, 5(4), 938-945. View this article in WRRO
- Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.. J Allergy Clin Immunol, 139(2), 597-606.e4. View this article in WRRO
- PI3K delta and primary immunodeficiencies (vol 16, pg 702, 2016). NATURE REVIEWS IMMUNOLOGY, 16(11), 715-715. View this article in WRRO
- Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection. Microbes and Infection. View this article in WRRO
- Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition. American Journal of Respiratory and Critical Care Medicine, 194(8), 961-973. View this article in WRRO
- Hypoxia upregulates neutrophil degranulation and potential for tissue injury. Thorax, 71(11), 1030-1038. View this article in WRRO
- PI3Kδ and primary immunodeficiencies. Nature Reviews Immunology. View this article in WRRO
- Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit. Thorax, thoraxjnl-2016-208402-thoraxjnl-2016-208402. View this article in WRRO
- Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung: Figure 1. Thorax, 70(11), 1085-1086. View this article in WRRO
- Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome. The Lancet, 385, S55-S55.
- Familial Hepatopulmonary Syndrome in Common Variable Immunodeficiency. Journal of Clinical Immunology, 35(3), 302-304.
- The effects of hypoxia on neutrophil degranulation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 23-24.
- Effects of hypoxia on granulocyte function: apoptosis, efferocytosis and sensitivity to glucocorticosteroids. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 32-32.
- Biomarkers of eosinophilic inflammation in asthma. Expert Review of Respiratory Medicine, 8(2), 143-150.
- Respiratory infection and primary immune deficiency – what does the general physician need to know?. The Journal of the Royal College of Physicians of Edinburgh, 44(2), 149-155.
- Measurement of Eosinophil Kinetics in Healthy Volunteers, 165-176.
- The United Kingdom Primary Immune Deficiency (UKPID) Registry: report of the first 4 years' activity 2008-2012. Clinical & Experimental Immunology, 175(1), 68-78.
- Phosphoinositide 3-Kinase Gene Mutation Predisposes to Respiratory Infection and Airway Damage. Science, 342(6160), 866-871.
- Use of Technetium-99m–labeled Eosinophils to Detect Active Eosinophilic Inflammation in Humans. American Journal of Respiratory and Critical Care Medicine, 188(7), 880-882.
- The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?. American Journal of Respiratory Cell and Molecular Biology, 48(5), 531-539.
- Effects of hypoxia on neutrophil apoptosis, efferocytosis and sensitivity to glucocorticosteroids. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 43, 6-7.
- The effects of hypoxia on neutrophil degranulation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 43, 31-32.
- Coexistence of Bronchiectasis and Rheumatoid Arthritis: Revisited. Respiratory Care, 58(4), 694-701.
- Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects. Blood, 120(19), 4068-4071.
- Respiratory disease in common variable immunodeficiency and other primary immunodeficiency disorders. Clinical Radiology, 67(6), 587-595.
- Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Clinical & Experimental Allergy, 41(5), 673-687.
- Measuring Eosinophil Kinetics In Humans. C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE.
- Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing ofStaphylococcus aureusin Human Neutrophils. The Journal of Immunology, 186(1), 453-463.
- Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils. Thorax, 65(12), 1116-1117.
- Neutrophil kinetics in health and disease. Trends in Immunology, 31(8), 318-324.
- Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. European Respiratory Journal, 35(6), 1264-1272.
- Azithromycin therapy for neutrophilic airways disease: myth or magic?. Thorax, 64(3), 186-189.
- The Effects of Hypoxia on Neutrophil Phagocytosis, Respiratory Burst Activity and Bactericidal Capacity.. B101. GRANULOCYTE ACTIVATION AND EXECUTION OF EFFECTOR FUNCTIONS IN THE LUNG.
- Advances in Neutrophil Biology. Chest, 134(3), 606-612.
- Prolonged survival of neutrophils from patients with F508 CFTR mutations. Thorax, 63(7), 660-661.
- Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. Journal of Experimental Medicine, 205(7), 1573-1582. View this article in WRRO
- Expression of cystic fibrosis transmembrane regulator (CFTR) in human bone cells. Journal of Cystic Fibrosis, 7, S20-S20.
- Expression of cystic fibrosis transmembrane regulator (CFTR) in human bone cells. CALCIFIED TISSUE INTERNATIONAL, 82, S125-S126.
- Nontuberculous mycobacteria in bronchiectasis: Prevalence and patient characteristics (vol 28, pg 1204, 2006). EUROPEAN RESPIRATORY JOURNAL, 29(3), 614-615.
- Nontuberculous mycobacteria in bronchiectasis: prevalence and patient characteristics. European Respiratory Journal, 28(6), 1204-1210.
- Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils. Nature Cell Biology, 8(11), 1303-1309.
- RhoG Regulates the Neutrophil NADPH Oxidase. The Journal of Immunology, 176(9), 5314-5320.
- P-Rex1 Regulates Neutrophil Function. Current Biology, 15(20), 1867-1873.
- Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood, 106(4), 1432-1440.
- Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity. Journal of Experimental Medicine, 201(1), 105-115. View this article in WRRO
- Regulation of Phosphatidylinositol 3-Kinase Activity and Phosphatidylinositol 3,4,5-Trisphosphate Accumulation by Neutrophil Priming Agents. The Journal of Immunology, 169(6), 3336-3344.
- Phosphoinositide 3-kinase: A critical signalling event in pulmonary cells. Respiratory Research, 1(1), 24-29. View this article in WRRO
- Moving in mysterious ways. Nature, 404(6774), 135-137.
- The function and fate of neutrophils at the inflamed site: Prospects for therapeutic intervention. Journal of the Royal College of Physicians of London, 34(1), 68-74.
- Priming of human neutrophil superoxide generation by tumour necrosis factor-α is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Letters, 439(1-2), 147-151.
- Neutrophil Priming: Pathophysiological Consequences and Underlying Mechanisms. Clinical Science, 94(5), 461-471.
- Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro. Blood, 90(7), 2772-2783.
- Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro. Blood, 90(7), 2772-2783.
- Demonstration of reversible priming of human neutrophils using platelet- activating factor. Blood, 88(11), 4330-4337.
- Demonstration of reversible priming of human neutrophils using platelet- activating factor. Blood, 88(11), 4330-4337.
- Priming differentially regulates neutrophil adhesion molecule expression/function. Immunology, 89(1), 105-111.
- Characterization of inositol hexakisphosphate (InsP6)3-mediated priming in human neutrophils: lack of extracellular [3H]-InsP6 receptors. British Journal of Pharmacology, 117(5), 979-985.
- Wortmannin enhances tumour necrosis factorα-stimulated neutrophil apoptosis. Biochemical Society Transactions, 24(1), 80S-80S.
- Lack of effect of recombinant platelet-derived growth factor on human neutrophil function. Journal of Immunology, 154(8), 4133-4141.
- Lack of effect of recombinant platelet-derived growth factor on human neutrophil function. Journal of Immunology, 154(8), 4133-4141.
- Induction of Neutrophil Apoptosis by Tnfα: Differential Effect Compared to other Priming Agents. Clinical Science, 88(s32), 28P-28P.
- Priming Effect of Inositol Hexakisphosphate and Identification of [3H]Inositol Hexakisphosphate Binding Sites in Human Neutrophils. Clinical Science, 87(s31), 31P-31P.
- L-Selectin Loss is a Sensitive Indicator of Lipopolysaccharide-Induced Neutrophil Priming. Clinical Science, 87(s31), 3P-3P.
- The Biological Role of Pleural Fluid PAI-1 and Sonographic Septations in Pleural Infection: Analysis of a Prospectively Collected Clinical Outcome Study. American Journal of Respiratory and Critical Care Medicine.
- Managing Granulomatous–Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders: e-GLILDnet International Clinicians Survey. Frontiers in Immunology, 11.
- The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host. International Journal of Molecular Sciences, 21(4), 1183-1183.
- Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival. PLoS ONE, 7(9), e45933-e45933. View this article in WRRO
- Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone. Thorax, 62(7), 650-651.
- Effect of priming on activation and localization of phospholipase D-1 in human neutrophils. European Journal of Biochemistry, 271(13), 2755-2764.
Chapters
- Neutrophils: Biological Properties and Role in Health and Allergic Diseases, Allergy and Allergic Diseases (pp. 295-319). Wiley-Blackwell
Conference proceedings papers
- Profiling systemic inflammation and neutrophil function in hospitalized patients with COVID19: results from PREDICT-COVID19. Respiratory infections and bronchiectasis
- A Randomized Double-Blind Placebo-Controlled Trial of Dipeptidyl Peptidase-1 Inhibition in Hospitalized Patients with COVID-19: The STOP-COVID19 Trial. D17. TOP KNOWLEDGE IN COVID
- Endogenous Circulating BMP9 Maintains Endothelial Cell Barrier Function. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 269-270)
- Neutrophils activated with Hif-1 alpha are protective in zebrafish tuberculosis in vivo models. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol. 49 (pp 67-68)
- S39 Endogenous circulating BMP9 maintains endothelial barrier function. Fundamental mechanisms of pulmonary arterial hypertension
- Activated PI3-kinase Delta Syndrome (APDS): Genetics, Immunodeficiency, Diagnosis and Related Pathology. JOURNAL OF PATHOLOGY, Vol. 238 (pp S3-S3)
- Role of Eros, a novel transmembrane protein, in regulation of host defence. The Lancet, Vol. 387 (pp S12-S12)
- Bone Morphogenetic Protein 9 (bmp9), A Vascular Quiescence Factor, Is Regulated By Inflammation And Neutrophil Activation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
- S2 Vascular Quiescence Factor BMP9 is Regulated by Inflammation and Neutrophil Activation. Thorax, Vol. 70(Suppl 3) (pp A5.2-A5)
- Activated PI3-Kinase Delta Syndrome: Clinical, Radiological And Laboratory Features Of A Large Cohort.. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol. 182 (pp 22-23)
- SPECT/CT to quantify eosinophil migration into the lungs. JOURNAL OF NUCLEAR MEDICINE, Vol. 56(3)
- The Clinical Manifestations, Management and Outcomes of Activated PI3K-Delta Syndrome (APDS) in UK and Ireland Cohort. JOURNAL OF CLINICAL IMMUNOLOGY, Vol. 34 (pp S163-S163)
- A Multicentre Approach to Document Bronchial Pathology in Computed Tomography of the Chest: Data from the Chest CT in Antibody-Deficiency Group. JOURNAL OF CLINICAL IMMUNOLOGY, Vol. 34 (pp S323-S324)
- Functional And Phenotypic Heterogeneity Of Alveolar And Circulating Neutrophil Subsets In Acute Respiratory Distress Syndrome (ards). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- S115 The effects of hypoxia on neutrophil-mediated tissue damage in the lung. Thorax, Vol. 68(Suppl 3) (pp A60.1-A60)
- P156 Neutrophil and redox dependent proteolysis of bone morphogenetic protein 9: potential role in the pathogenesis of pulmonary arterial hypertension. Thorax, Vol. 68(Suppl 3) (pp A146.1-A146)
- Use Of 111-Indium-Labelled Autologous Eosinophils To Establish The In Vivo Kinetics Of Human Eosinophils In Healthy Subjects. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 187
- S117 Effects of Hypoxia on Eosinophil Apoptosis, Efferocytosis and Sensitivity to Glucocorticosteroids. Thorax, Vol. 67(Suppl 2) (pp A57.2-A57)
- P255 The Effects of Hypoxia on Neutrophil Degranulation. Thorax, Vol. 67(Suppl 2) (pp A176.2-A176)
- T3 Measuring eosinophil kinetics in humanS. Thorax, Vol. 66(Suppl 4) (pp A2-A2)
- S148 Regulation of neutrophil apoptosis by phosphoinositide 3-kinases. Thorax, Vol. 65(Suppl 4) (pp A67-A67)
- S34 Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Thorax, Vol. 65(Suppl 4) (pp A18-A18)
- INTERLEUKIN-5 INDUCES GLUCOCORTICOID RESISTANCE IN HUMAN EOSINOPHILS. THORAX, Vol. 64 (pp A42-A42)
- Lung function does not decline in an eight-year surveillance study of bronchiectasis patients attending a regional specialist centre. THORAX, Vol. 62 (pp A51-A51)
- The function and fate of neutrophils in cystic fibrosis. THORAX, Vol. 60 (pp II93-II94)
- Hypoxia inhibits neutrophil apoptosis via hypoxia inducible factor (HIF)-1 alpha-dependent regulation of NF kappa B. THORAX, Vol. 59(1) (pp 2-2)
- Diminished neutrophil responses in mice lacking the regulatory subunit of phosphoinositide 3-hydroxykinase gamma (PI3K gamma). THORAX, Vol. 57
- Neutrophil phagocytosis and oxidative burst. European Respiratory Review, Vol. 12(86-87) (pp 332-333)
Preprints
- Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice, Cold Spring Harbor Laboratory.
- PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner, Cold Spring Harbor Laboratory.
- British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. The Journal of Allergy and Clinical Immunology: In Practice, 5(4), 938-945. View this article in WRRO
- Teaching interests
-
I am committed to medical education and prior to my recent move to Sheffield was the Departmental lead for Educational Supervision. My teaching focuses on respiratory infection and host-pathogen interactions.
- Professional activities and memberships
-
- Scientific Advisory Board member for the Institute of Ageing and Inflammation, University of Birmingham.
- MRC Clinical Research Training Fellowship panel member.
- External Examiner for Year 3 Medical Examinations, University of Edinburgh (2015-2019).
- British Thoracic Society Scientific Committee member (2015–2018).
- British Thoracic Society Lung Infection Specialist Advisory Group member (2015-2018).
- British Lung Foundation Scientific Committee Member (2011-2017).
- Lead for Educational Supervision, Respiratory Medicine, Addenbrookes Hospital (2010-2015).
- Program Committee Member, American Thoracic Society, Respiratory Cell and Molecular Biology Assembly (2007-2011).
- Planning Committee Member, American Thoracic Society, Respiratory Cell and Molecular Biology Assembly (2009-2012).