Professor Allan Lawrie

All publications

Journal articles

• Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B , Sitbon O et al (2022) Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 205(12), 1449-1460.
• Alandejani F, Alabed S, Garg P, Goh ZM, Karunasaagarar K, Sharkey M, Salehi M, Aldabbagh Z, Dwivedi K, Mamalakis M , Metherall P et al (2022) Training and clinical testing of artificial intelligence derived right atrial cardiovascular magnetic resonance measurements. Journal of Cardiovascular Magnetic Resonance, 24(1).
• Alandejani F, Hameed A, Tubman E, Alabed S, Shahin Y, Lewis RA, Dwivedi K, Mahmood A, Middleton J, Watson L , Alkhanfar D et al (2022) Imaging and risk stratification in pulmonary arterial hypertension : time to include right ventricular assessment. Frontiers in Cardiovascular Medicine, 9. View this article in WRRO
• Jones RJ, De Bie EMDD, Groves E, Zalewska KI, Swietlik EM, Treacy CM, Martin JM, Polwarth G, Li W, Guo J , Baxendale HE et al (2022) Autoimmunity is a significant feature of idiopathic pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 206(1), 81-93.
• Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. The Lancet Microbe, 3(1), e21-e31. View this article in WRRO
• Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T , Lutz KA et al (2021) Correction to: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Medicine, 13(1).
• Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D , Mascarenhas TS et al (2021) Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood. Nature Communications, 12.
• Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB, Lone NI, Leavy OC , Daines L et al (2021) Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.. The Lancet Respiratory Medicine. View this article in WRRO
• Errington N, Iremonger J, Pickworth JA, Kariotis S, Rhodes CJ, Rothman AMK, Condliffe R, Elliot CA, Kiely DG, Howard LS , Wharton J et al (2021) A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach. EBioMedicine, 69. View this article in WRRO
• Lawrie A & Francis SE (2021) Frataxin and endothelial cell senescence in pulmonary hypertension. Journal of Clinical Investigation, 131(11).
• Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2021) Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology. View this article in WRRO
• Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T , Lutz KA et al (2021) Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Medicine, 13(1), 80-80.
• Goh ZM, Alabed S, Shahin Y, Rothman AMK, Garg P, Lawrie A, Capener D, Thompson AAR, Alandejani FAA, Johns CS , Lewis RA et al (2020) Right Ventricular Adaptation Assessed Using Cardiac Magnetic Resonance Predicts Survival in Pulmonary Arterial Hypertension. JACC: Cardiovascular Imaging.
• Sofianopoulou E, Church C, Coghlan G, Howard L, Johnson M, Kiely DG, Lawrie A, Lordan J, Wilkins MR, Wort SJ , Morrell NW et al (2020) Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease?. European Respiratory Journal, 56(2). View this article in WRRO
• Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E , Maimaris J et al (2020) Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 584(7819), E2-E2.
• Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E , Maimaris J et al (2020) Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. View this article in WRRO
• Rhodes CJ, Otero-Núñez P, Wharton J, Swietlik EM, Kariotis S, Harbaum L, Dunning MJ, Elinoff JM, Errington N, Thomson AAR , Iremonger J et al (2020) Whole blood RNA profiles associated with pulmonary arterial hypertension and clinical outcome. American Journal of Respiratory and Critical Care Medicine. View this article in WRRO
• Lewis RA, Johns CS, Cogliano M, Capener D, Tubman E, Elliot CA, Charalampopoulos A, Sabroe I, Thompson AAR, Billings CG , Hamilton N et al (2020) Identification of cardiac MRI thresholds for risk stratification in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468. View this article in WRRO
• Swift AJ, Lu H, Uthoff J, Garg P, Cogliano M, Taylor J, Metherall P, Zhou S, Johns CS, Alabed S , Condliffe RA et al (2020) A machine learning cardiac magnetic resonance approach to extract disease features and automate pulmonary arterial hypertension diagnosis. European Heart Journal - Cardiovascular Imaging. View this article in WRRO
• Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y , Lawrie A et al (2020) Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling. Circulation Research, 126(2), 243-257. View this article in WRRO
• Bellantuono I, de Cabo R, Ehninger D, Di Germanio C, Lawrie A, Miller J, Mitchell SJ, Navas-Enamorado I, Potter PK, Tchkonia T , Trejo JL et al (2020) A toolbox for the longitudinal assessment of healthspan in aging mice. Nature Protocols, 15(2), 540-574.
• Turro E, Astle WJ, Megy K, Gräf S, Greene D, Shamardina O, Allen HL, Sanchis-Juan A, Frontini M, Thys C , Stephens J et al (2020) Whole-genome sequencing of patients with rare diseases in a national health system. Nature, 583(7814), 96-102.
• Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M , Southgate L et al (2020) Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 201(5), 575-585.
• Kiely DG, Lawrie A & Humbert M (2019) Screening strategies for pulmonary arterial hypertension. European Heart Journal Supplements, 21(Supplement_K), K9-K20. View this article in WRRO
• Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V , McCourt M et al (2019) A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nature Communications, 10(1). View this article in WRRO
• Kiely DG, Doyle O, Drage E, Jenner H, Salvatelli V, Daniels FA, Rigg J, Schmitt C, Samyshkin Y, Lawrie A & Bergemann R (2019) Utilising artificial intelligence to determine patients at risk of a rare disease : idiopathic pulmonary arterial hypertension. Pulmonary Circulation, 9(4). View this article in WRRO
• Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC , Brennan P et al (2019) Germline selection shapes human mitochondrial DNA diversity. Science, 364(6442), eaau6520-eaau6520.
• Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL , Pressler RM et al (2019) Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. The American Journal of Human Genetics, 104(5), 948-956.
• Billings CG, Lewis R, Hurdman JA, Condliffe R, Elliot C, Thompson AAR, Smith IA, Austin M, Armstrong IJ, Hamilton N , Charalampopoulos A et al (2019) Express: The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry.. Pulmonary Circulation. View this article in WRRO
• Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard L , Johnson M et al (2019) Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: A United Kingdom cohort study analysis.. European Respiratory Journal. View this article in WRRO
• Sweatt AJ, Hedlin HK, Balasubramanian V, Hsi A, Blum LK, Robinson WH, Haddad F, Hickey PM, Condliffe RA, Lawrie A , Nicolls MR et al (2019) Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.. Circulation Research, 124(6), 904-919. View this article in WRRO
• Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B , Arora A et al (2019) Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. The Lancet Respiratory Medicine, 7(3), 227-238. View this article in WRRO
• Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H , Cole JE et al (2019) Toll-like receptor 3 is a therapeutic target for pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 199(2). View this article in WRRO
• Ihugba JC, Kurusamy S, Naomi R, Khan K, Arnold N, Polla P, Gomez-del Arco P, Miguel Redondo J, Cotton J, Upton PD , Morrell NW et al (2019) Plasma Membrane Calcium ATPase 4 Gene Expression is Downregulated in Pulmonary Artery Endothelial Cells Treated with Inducers of Pulmonary Arterial Hypertension. JOURNAL OF VASCULAR RESEARCH, 56, 6-6.
• Farmery JHR, Smith ML & Lynch AG (2018) Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Scientific Reports, 8(1). View this article in WRRO
• Bohnen MS, Ma L, Zhu N, Qi H, McClenaghan C, Gonzaga-Jauregui C, Dewey FE, Overton JD, Reid JG, Shuldiner AR , Baras A et al (2018) Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension. Circulation. Genomic and precision medicine, 11(10). View this article in WRRO
• Quadery SR, Swift AJ, Billings C, Thompson AAR, Elliot CA, Hurdman J, Charalampopoulos A, Sabroe I, Armstrong I, Hamilton N , Sephton P et al (2018) The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 52(3). View this article in WRRO
• Bergemann R, Allsopp J, Jenner H, Daniels FA, Drage E, Samyshkin Y, Schmitt C, Wood S, Kiely DG, Lawrie A & SPHInX Project team (2018) High levels of healthcare utilization prior to diagnosis in idiopathic pulmonary arterial hypertension support the feasibility of an early diagnosis algorithm: the SPHInX project.. Pulmonary Circulation, 8(4), 1-9. View this article in WRRO
• Ramakrishnan L, Pedersen SL, Toe QK, West LE, Mumby S, Casbolt H, Issitt T, Garfield B, Lawrie A, Wort SJ & Quinlan GJ (2018) The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells. Scientific Reports, 8(1). View this article in WRRO
• Braithwaite AT, Marriott H & Lawrie A (2018) Divergent Roles for TRAIL in Lung Diseases. Frontiers in Medicine, 5. View this article in WRRO
• Chen K-H, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K , Theilmann AL et al (2018) Epigenetic Dysregulation of the Drp1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.. Circulation, 138(3), 287-304. View this article in WRRO
• Ito Y, Carss KJ, Duarte ST, Hartley T, Keren B, Kurian MA, Marey I, Charles P, Mendonça C, Nava C , Pfundt R et al (2018) De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures. The American Journal of Human Genetics, 103(1), 144-153. View this article in WRRO
• Whitworth J, Smith PS, Martin J-E, West H, Luchetti A, Rodger F, Clark G, Carss K, Stephens J, Stirrups K , Penkett C et al (2018) Comprehensive cancer-predisposition gene testing in an adult multiple primary tumor series shows a broad range of deleterious variants and atypical tumor phenotypes. The American Journal of Human Genetics, 103(1), 3-18. View this article in WRRO
• Hickey PM, Lawrie A & Condliffe R (2018) Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data.. Frontiers in Medicine, 5. View this article in WRRO
• Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M , Machado RD et al (2018) Identification of rare sequence variation underlying heritable pulmonary arterial hypertension. Nature Communications, 9(1). View this article in WRRO
• Boehm M, Arnold N, Braithwaite A, Pickworth J, Lu C, Novoyatleva T, Kiely DG, Grimminger F, Ghofrani HA, Weissmann N , Seeger W et al (2018) Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension. BMC Pulmonary Medicine, 18(1). View this article in WRRO
• Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2018) Selective improvement of pulmonary arterial hypertension with a dual ET A /ET B receptors antagonist in the apolipoprotein E −/− model of PAH and atherosclerosis. Pulmonary Circulation, 8(1), 1-11. View this article in WRRO
• Zhang H-D, Lv Z-C, Wang L-T, Rothman A, Lian T-Y, He Y-Y, Wu Y, Lawrie A, Beghetti M & Jing Z-C (2017) Prognostic Significance of Reduced Blood Pressure Response to Exercise in Pediatric Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 196(11). View this article in WRRO
• Luong L, Duckles H, Schenkel T, Mahmoud M, Lopez-Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M, van der Heiden K , Xing R et al (2017) Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thrombosis and Haemostasis, 116(1), 181-190. View this article in WRRO
• Hadinnapola C, Bleda M, Haimel M, Screaton N, Swift AJ, Dorfmüller P, Preston SD, Southwood M, Hernandez-Sanchez J, Martin J , Treacy C et al (2017) Phenotypic Characterisation of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically with Pulmonary Arterial Hypertension.. Circulation, 136(21), 2022-2033. View this article in WRRO
• Pickworth JA, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey P, Gladson S, Shay S, Morrell N, Francis S , West JD et al (2017) Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. Pulmonary Circulation. View this article in WRRO
• Rhodes CJ, Wharton J, Ghataorhe P, Watson G, Girerd B, Howard LS, Gibbs JSR, Condliffe R, Elliot CA, Kiely DG , Simonneau G et al (2017) Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. The Lancet Respiratory Medicine, 5(9), 717-726. View this article in WRRO
• Swift AJ, Capener D, Johns C, Hamilton N, Rothman A, Elliot C, Condliffe R, Charalampopoulos A, Rajaram S, Lawrie A , Campbell MJ et al (2017) Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 196(2). View this article in WRRO
• Khan KN, El-Asrag ME, Ku CA, Holder GE, McKibbin M, Arno G, Poulter JA, Carss K, Bommireddy T, Bagheri S , Bakall B et al (2017) Specific Alleles of CLN7/MFSD8, a Protein That Localizes to Photoreceptor Synaptic Terminals, Cause a Spectrum of Nonsyndromic Retinal Dystrophy. Investigative Opthalmology & Visual Science, 58(7), 2906-2906.
• Billings CG, Hurdman JA, Condliffe RA, Elliot CA, Smith IA, Austin M, Armstrong IJ, Hamilton N, Charalampopoulos A, Sabroe I , Swift AJ et al (2017) Incremental Shuttle Walking Test Distance and Autonomic Dysfunction Predict Survival in Pulmonary Arterial Hypertension. The Journal of Heart and Lung Transplantation. View this article in WRRO
• Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A , Coelho PDS et al (2017) Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism. Science Immunology, 2(8). View this article in WRRO
• Arno G, Carss KJ, Hull S, Zihni C, Robson AG, Fiorentino A, Hardcastle AJ, Holder GE, Cheetham ME, Plagnol V , Moore AT et al (2017) Biallelic Mutation of ARHGEF18 , Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. The American Journal of Human Genetics, 100(2), 334-342.
• Rhodes CJ, Ghataorhe P, Wharton J, Rue-Albrecht KC, Hadinnapola C, Watson G, Bleda M, Haimel M, Coghlan G, Corris PA , Howard LS et al (2017) Plasma Metabolomics Implicate Modified Transfer RNAs and Altered Bioenergetics in the Outcome of Pulmonary Arterial Hypertension.. Circulation, 135, 460-475. View this article in WRRO
• Carss KJ, Arno G, Erwood M, Stephens J, Sanchis-Juan A, Hull S, Megy K, Grozeva D, Dewhurst E, Malka S , Plagnol V et al (2017) Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. The American Journal of Human Genetics, 100(1), 75-90.
• Thompson AAR & Lawrie A (2017) Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension. Trends in Molecular Medicine, 23(1), 31-45. View this article in WRRO
• Boehm M, Lawrie A, Wilhelm J, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT & Kojonazarov B (2016) Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice.. Experimental Physiology. View this article in WRRO
• Hickey PM, Thompson AA, Charalampopoulos A, Elliot CA, Hamilton N, Kiely DG, Lawrie A, Sabroe I & Condliffe R (2016) Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension. European Respiratory Journal, 48(5), 1514-1514.
• Rothman AM, Rowlands DJ & Lawrie A (2016) miRNA-140-5p: new avenue for pulmonary arterial hypertension drug development?. Epigenomics. View this article in WRRO
• Rothman AM, Arnold N, Pickworth J, Iremonger J, Ciuclan L, Allan R, Guth-Gundel S, Southwood M, Morrell N, Thomas M , Francis S et al (2016) MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. Journal of Clinical Investigation, 126(7), 2495-2508. View this article in WRRO
• Zhou L, Zhang J, Jiang X-M, Xie D-J, Wang J-S, Li L, Li B, Wang Z-M, Rothman AMK, Lawrie A & Chen S-L (2015) Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline. JACC: Cardiovascular Interventions, 8(15), 2013-2023.
• Rothman AMK, Arnold ND, Chang W, Watson O, Swift AJ, Condliffe R, Elliot CA, Kiely DG, Suvarna SK, Gunn J & Lawrie A (2015) Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension. Circulation: Cardiovascular Interventions, 8(11), e002569-e002569. View this article in WRRO
• Spiekerkoetter E, Sung YK, Sudheendra D, Bill M, Aldred MA, van de Veerdonk MC, Noordegraaf AV, Long-Boyle J, Dash R, Yang PC , Lawrie A et al (2015) Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 192(2), 254-257. View this article in WRRO
• Pérez de Ciriza C, Lawrie A & Varo N (2015) Osteoprotegerin in Cardiometabolic Disorders. International Journal of Endocrinology, 2015, 1-15. View this article in WRRO
• Lawrie A (2014) The role of the osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the pathogenesis of pulmonary arterial hypertension. Vascular Pharmacology, 63(3), 114-117.
• Pérez de Ciriza C, Lawrie A & Varo N (2014) Influence of pre-analytical and analytical factors on osteoprotegerin measurements.. Clin Biochem, 47(13-14), 1279-1285.
• Lawrie A (2014) A report on the use of animal models and phenotyping methods in pulmonary hypertension research.. Pulm Circ, 4(1), 2-9.
• Rothman AMK, Chico TJA & Lawrie A (2014) MicroRNA in pulmonary vascular disease.. Prog Mol Biol Transl Sci, 124, 43-63.
• Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.. Cardiovasc Res, 100(2), 252-261. View this article in WRRO
• Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C , Pollard L et al (2013) Pulmonary hypertension in COPD: results from the ASPIRE registry.. Eur Respir J, 41(6), 1292-1301.
• Rhodes CJ, Wharton J, Boon RA, Roexe T, Tsang H, Wojciak-Stothard B, Chakrabarti A, Howard LS, Gibbs JSR, Lawrie A , Condliffe R et al (2013) Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.. Am J Respir Crit Care Med, 187(3), 294-302.
• Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) No evidence for cardiac dysfunction in Kif6 mutant mice.. PLoS One, 8(1), e54636. View this article in WRRO
• Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.. J Exp Med, 209(11), 1919-1935. View this article in WRRO
• Hurdman J, Condliffe R, Elliot CA, Davies C, Hill C, Wild JM, Capener D, Sephton P, Hamilton N, Armstrong IJ , Billings C et al (2012) ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.. Eur Respir J, 39(4), 945-955.
• Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE , Crossman DC et al (2012) Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.. Pulm Circ, 2(1), 21-27. View this article in WRRO
• McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
• McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
• Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC & Francis SE (2011) Paigen diet-fed apolipoprotein e knockout mice develop severe pulmonary hypertension in an interleukin-1-Dependent Manner. American Journal of Pathology, 179(4), 1693-1705. View this article in WRRO
• Spiekerkoetter E, Guignabert C, Perez VD, Alastalo TP, Powers JM, Wang LL, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M , Ashley RH et al (2009) S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho-Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4. CIRC RES, 105(7), 639-U37.
• Lawrie A, Waterman E, Southwood M, Evans D, Suntharalingam J, Francis S, Crossman D, Croucher P, Morrell N & Newman C (2008) Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension.. Am J Pathol, 172(1), 256-264.
• Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CM (2007) Abstract 376: A Potential Role for TRAIL in the Pathogenesis of Pulmonary Arterial Hypertension. Circulation, 116(suppl_16).
• Spiekerkoetter E, Lawrie A, Merklinger S, Ambartsumian N, Lukanidin E, Schmidt A-M & Rabinovitch M (2005) Mts1/S100A4 Stimulates Human Pulmonary Artery Smooth Muscle Cell Migration Through Multiple Signaling Pathways. Chest, 128(6), 577S-577S.
• Akowuah EF, Gray C, Lawrie A, Sheridan PJ, Su C-H, Bettinger T, Brisken AF, Gunn J, Crossman DC, Francis SE , Baker AH et al (2005) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.. Gene Ther, 12(14), 1154-1157.
• Sheridan PJ, Lawrie A, Crossman DC, Holt CM & Newman CM (2005) VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection.. J Gene Med, 7(3), 375-385.
• Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E & Rabinovitch M (2005) Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circulation Research, 97(3), 227-235.
• Leung WCY, Lawrie A, Demaries S, Massaeli H, Burry A, Yablonsky S, Sarjeant JM, Fera E, Rassart E, Pickering JG & Rabinovitch M (2004) Apolipoprotein D and platelet-derived growth factor-BB synergism mediates vascular smooth muscle cell migration. CIRC RES, 95(2), 179-186.
• Sarjeant JM, Lawrie A, Kinnear C, Yablonsky S, Leung W, Massaeli H, Prichett W, Veinot JP, Rassart E & Rabinovitch M (2003) Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus. ARTERIOSCL THROM VAS, 23(12), 2172-2177.
• Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
• Newman CM, Lawrie A, Brisken AF & Cumberland DC (2001) Ultrasound gene therapy: on the road from concept to reality.. Echocardiography, 18(4), 339-347.
• Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC & Newman CM (2000) Microbubble-enhanced ultrasound for vascular gene delivery.. Gene Ther, 7(23), 2023-2027.
• Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC & Newman CM (1999) Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro.. Circulation, 99(20), 2617-2620.
• Alkhanfar D, Shahin Y, Alandejani F, Dwivedi K, Alabed S, Johns C, Lawrie A, Thompson AAR, Rothman AMK, Tschirren J , Uthoff JM et al () Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative CT. ERJ Open Research, 00503-2021.
• Turton HA, Pickworth J, Paterson GG, Lawrie A, Baillie JK & Thompson AAR () Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude. Frontiers in Physiology, 13.
• Dowey R, Cole J, Roger Thompson AA, Hull RC, Huang C, Whatmore J, Iqbal A, Bradley KL, McKenzie J, Lawrie A , Condliffe AM et al () Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin. ERJ Open Research, 00596-2021.
• Rhodes CJ, Wharton J, Swietlik EM, Harbaum L, Girerd B, Coghlan JG, Lordan J, Church C, Pepke-Zaba J, Toshner M , Wort SJ et al () Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine.
• Swift AJ, Wilson F, Cogliano M, Kendall L, Alandejani F, Alabed S, Hughes P, Shahin Y, Saunders L, Oram C , Capener D et al () Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study. Thorax.
• Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M , Roux S et al () Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort. European Respiratory Journal, 2002591-2002591.
• Swietlik EM, Greene D, Zhu N, Megy K, Cogliano M, Rajaram S, Pandya D, Tilly T, Lutz KA, Welch CCL , Pauciulo MW et al () Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension. Circulation: Genomic and Precision Medicine.
• Zawia A, Arnold ND, West L, Pickworth JA, Turton H, Iremonger J, Braithwaite AT, Cañedo J, Johnston SA, Thompson AAR , Miller G et al () Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology.
• Ulrich A, Otero-Núñez P, Wharton J, Swietlik EM, Gräf S, Morrell NW, Wang D, Lawrie A, Wilkins MR, Prokopenko I , Rhodes CJ et al () Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension. Genes, 11(11), 1247-1247.
• Lewis RA, Billings CG, Hurdman JA, Smith IA, Austin M, Armstrong IJ, Middleton J, Rothman AMK, Harrington J, Hamilton N , Hameed AG et al () Maximal Exercise Testing Using the Incremental Shuttle Walking Test Can Be Used to Risk Stratify Patients with Pulmonary Arterial Hypertension. Annals of the American Thoracic Society.
• Omura J, Habbout K, Shimauchi T, Wu W-H, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F , Perron J et al () Identification of The Long Non-Coding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension. Circulation.
• Mamazhakypov A, Viswanathan G, Lawrie A, Schermuly RT & Rajagopal S () The role of chemokines and chemokine receptors in pulmonary arterial hypertension. British Journal of Pharmacology.
• Billings CG, Lewis R, Armstrong IJ, Hurdman JA, Smith IA, Austin M, Elliot CA, Charalampopoulos A, Sabroe I, Lawrie A , Thompson AAR et al () Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I. Frontiers in Medicine, 5. View this article in WRRO
• McCullagh BN, Costello CM, Li L, O’Connell C, Codd M, Lawrie A, Morton A, Kiely DG, Condliffe R, Elliot C , McLoughlin P et al () Elevated Plasma CXCL12α Is Associated with a Poorer Prognosis in Pulmonary Arterial Hypertension. PLOS ONE, 10(4), e0123709-e0123709. View this article in WRRO
• Thompson AAR, Wilkins MR, Wild JM, Kiely DG & Lawrie A () Editorial : pulmonary hypertension : mechanisms and management, history and future. Frontiers in Medicine, 7. View this article in WRRO
• Dawson S & Lawrie A () From bones to blood pressure, developing novel biologic approaches targeting the osteoprotegein pathway for pulmonary vascular disease. Pharmacology & Therapeutics. View this article in WRRO

Chapters

• Hickey PM, Condliffe R, Lawrie A & Kiely DG (2018) Pulmonary Hypertension, Foundations of Respiratory Medicine (pp. 315-330). Springer International Publishing

Conference proceedings papers

• Alandejani F, Tubman E, Shahin Y, Lewis R, Dwivedi K, Alkhanfar D, Alabed S, Johns C, Garg P, Condliffe R , Lawrie A et al (2020) Cardiac MRI right atrial area measurement thresholds for risk stratification in patients with PAH. Pulmonary hypertension
• Lewis RA, Kelly T, Drew E, Billings CG, Hurdman J, Smith I, Austin M, Armstrong IJ, Middleton J, Rothman AMK , Harrington J et al (2020) Percent-predicted incremental shuttle walking test distance stratifies risk in pulmonary arterial hypertension. Pulmonary hypertension
• Uthoff J, Alabed S, Garg P, Lawrie A, Wild JM, Kiely DG, Lu H & Swift AJ (2020) Sex bias exists in diagnosing pulmonary arterial hypertension via machine learning. Pulmonary hypertension
• Otero-Núñez P, Rhodes C, Wharton J, Swietlik E, Kariotis S, Harbaum L, Dunning M, Elinoff J, Errington N, Thomson R , Iremonger J et al (2020) Multi-omic profiling in pulmonary arterial hypertension. Pulmonary hypertension
• Lawrie A, Toshner M, Fong Y-L, Jatkoe T, Cheng H, Zhou L, Bridges C, Howard LS & Wilkins MR (2020) Feasibility of MicroRNA-Based Signatures for Early Detection of Pulmonary Hypertension Using Machine Learning Methods. D25. O BRAVE NEW WORLD! OMICS, SYSTEM BIOLOGY, AND NEW MOLECULAR MECHANISMS OF PULMONARY HYPERTENSION
• Lawrie A, Arnold ND, Pickworth JA, West LE, Papworth J, Germaschewski V, Thompson AAR & Francis SE (2020) The Anti-Osteoprotegerin (OPG) Antibody Ky3 Attenuates OPG-Fas Mediated Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Pro-Inflammatory Signalling In Vitro and In Vivo. A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
• Omura J, Habbout K, Shimauchi T, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Potus F, Archer SL, Lin J , Zafar H et al (2020) Long Non-Coding RNA H19 Promotes Right Ventricular Failure in PAH. A93. TRANSLATIONAL RESEARCH; EARLY CLINICAL FINDINGS AND OMICS ADVENTURE IN PULMONARY HYPERTENSION: FROM BIOMARKERS TO NEW THERAPEUTIC TARGETS
• Omura J, Habbout K, Shimauchi T, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Potus F, Archer SL, Lin J , Zafar H et al (2020) Identification of Circulating Long Non-Coding RNA H19 as a Novel Biomarker for Right Ventricular Failure Associated with Pulmonary Arterial Hypertension. C105. WITH ALL MY HEART: SEX, ESTROGEN, AND RIGHT VENTRICLE IN PULMONARY VASCULAR DISEASE AND BEYOND
• Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L & Arthur HM (2020) LOSS OF ENDOTHELIAL ENDOGLIN IN ADULT LIFE LEADS TO PERIPHERAL ARTERIOVENOUS SHUNTING AND HIGH OUTPUT HEART FAILURE.. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 34(2) (pp 277-277)
• Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L & Arthur H (2019) Amplified responses to VEGF signaling following loss of endothelial Endoglin leads to peripheral arteriovenous shunting and high-output heart failure. ANGIOGENESIS, Vol. 22(4) (pp 600-600)
• Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L & Arthur HM (2019) Increased vascular endothelial growth factor signalling following loss of endothelial endoglin leads to peripheral arteriovenous shunting and high output heart failure. EUROPEAN HEART JOURNAL, Vol. 40 (pp 3716-3716)
• Cogliano M, Lawrie A, Kiely DG, Condliffe RA, Rajaram S, Screaton N, Hadinnapola C, Swietlik EM, Gräf S, Howard LS , Coghlan G et al (2019) Thoracic CT features of patients with BMPR2 mutation: preliminary analysis from the UK National Cohort Study of Idiopathic and Heritable PAH. Pulmonary hypertension
• Kiely D, Swift A, Cogliano M, Kendall L, Oram C, Capener D, Rothman A, Garg P, Johns C, Austin M , Pickworth J et al (2019) A prospective study comparing the repeatability and sensitivity to change of non-invasive endpoints in pulmonary arterial hypertension: the RESPIRE study. Pulmonary hypertension
• Swift A, Cogliano M, Oram C, Kendall L, Capener D, Garg P, Johns C, Macdonald A, Wilson F, Cahn T , Lawrie A et al (2019) Repeatability and Sensitivity to change of right ventricular analysis methods using cardiac magnetic resonance imaging in PAH: results from the RESPIRE Study. Imaging
• Lewis R, Billings C, Hurdman J, Smith I, Austin M, Armstrong I, Swift A, Rothman A, Charalampopoulos A, Sabroe I , Elliot C et al (2019) The Incremental Shuttle Walking Test Can Be Used to Risk Stratify Patients with Pulmonary Hypertension as Per the European Respiratory/Cardiac Society Guidelines. A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH
• Carr PL, Jiang Z, Savage AM, Noël ES, Wilkinson RN & Lawrie A (2019) Validating the Zebrafish Aortic Arch Development as a Model to Study the Molecular Mechanisms Underlying Idiopathic Pulmonary Arterial Hypertension. C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH
• Swietlik EM, Hodgson J, Hadinnapola C, Bleda M, Haimel M, Church C, Coghlan G, Condliffe R, Corris PA, Gibbs JSR , Holden S et al (2018) S40 Phenotypic characterisation of GDF2 mutation carriers in a large cohort of patients with pulmonary arterial hypertension. Fundamental mechanisms of pulmonary arterial hypertension
• Lin J, Iremonger J, Pickworth J, Rothman A, Casbolt H, Arnold N, Elliot C, Condliffe R, Kiely D, Jing ZC & Lawrie A (2018) S43 Circulatory levels of microrna-34a expression identify patients with poor clinical outcome, and regulate pulmonary vascular cell phenotype. Fundamental mechanisms of pulmonary arterial hypertension
• Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) T6 Vascular smooth muscle derived TRAIL underlies pulmonary vascular remodelling in sugen 5416/hypoxia mice. BTS/BALR/BLF Early Career Investigators awards symposium
• Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) Vascular Smooth Muscle Derived TRAIL is Required for Development of Pulmonary Arterial Hypertension in Sugen 5416 / Hypoxia Mice. CIRCULATION, Vol. 138
• Kiely D, Lawrie A, Doyle O, Salvatelli V, Daniels F, Drage E, Jenner H, Rigg J, Schmitt C, Samyshkin Y & Bergemann R (2018) Real world data from hospital episode statistics can be used to determine patients at risk of idiopathic pulmonary arterial hypertension. Pulmonary hypertension
• Billings C, Lewis R, Armstrong I, Hurdman J, Smith I, Austin M, Elliot C, Charalampopoulos A, Sabroe I, Lawrie A , Thompson R et al (2018) Incremental shuttle walking test distance is reduced in patients with pulmonary hypertension in WHO Functional Class I. Pulmonary hypertension
• Billings C, Lewis R, Hurdman J, Armstrong I, Smith I, Austin M, Elliot C, Charalampopoulos A, Sabroe I, Lawrie A , Thompson R et al (2018) Incremental Shuttle Walk Test predicts survival in non-Group 1 Pulmonary Hypertension without a ceiling effect. Pulmonary hypertension
• Arthur H, Tual-Chalot S, Davison B, Redgrave R, Singh E & Lawrie A (2018) 126 Endothelial endoglin is required to protect against high output heart failure. Basic Science
• Ihugba JC, Kurusamy S, Arnold N, Polla P, Arco PG-D, Strehler EE, Redondo JM, Cotton J, Lawrie A & Armesilla AL (2018) P11 Plasma membrane calcium atpase 1 gene expression increases in vascular smooth muscle cells treated with inducers of pulmonary arterial hypertension. Abstracts
• Bergemann R, Allsopp J, Jenner H, Daniels FA, Drage E, Samyshkin Y, Schmitt C, Kiely D & Lawrie A (2018) Development of a Predictive Algorithm Based on Healthcare Behaviour to Support Earlier Diagnosis of Idiopathic Pulmonary Arterial Hypertension: Results of a Feasibility Study in the UK. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
• Lawrie A, West L, Arnold N, Casbolt H, Pickworth JA, Carvalho J, Iremonger J, Renshall L, Braithwaite A, McCourt M & Germaschewski V (2018) Enhanced Therapeutic Efficacy of Vasodilator Therapy in Combination with a Novel Human Anti-OPG Antibody in Experimental Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
• Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Girerd B, Arora A , Knight J et al (2018) Genetic Determinants of Risk and Survival in Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
• Das Gupta A, Chen K, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K , Theilmann AL et al (2018) Critical Role of Drp1 Binding Partners (MiD49 and MiD51) Mediated Mitotic Fission in Pulmonary Arterial Hypertension: Mechanistic Implications. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
• Zhang H, He Y, Wang L, Lv Z, Jiang A, Xu X, Iremonger J, Thompson R, Rothman A, Lawrie A & Jing Z (2018) Prognostic Implications of Cardiopulmonary Exercise Testing in Congenital Heart Disease Associated with Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
• Dirir O, Lodge KM, Creaser-Myers A, Walker S, Kiely DG, Condliffe AM, Lawrie A & Thompson AAR (2017) S111 Altered neutrophil phenotypes in pulmonary arterial hypertension. Advances in understanding chronic thrombo-embolic disease and pulmonary hypertension
• Quadery SR, Swift AJ, Billings C, Thompson AAR, Elliot CA, Hurdman J, Garrod S, Charalampopolous A, Sabroe I, Armstrong I , Hamilton N et al (2017) P183 Impact of patient choice on survival in patients with chronic thromboembolic pulmonary hypertension offered pulmonary endarterectomy. Pulmonary vascular disease: monitoring and managing
• Arnold ND, Pickworth JA, Carvalho JA, Braithwaite AT, Iremonger J, West L, Casbolt HL, Renshall LJ, Germaschewski V, McCourt M , Evans HR et al (2017) Development of a Novel Human Anti-OPG Antibody That Attenuates Experimental Pulmonary Arterial Hypertension. CIRCULATION, Vol. 136
• Rothman A, Arnold N, Abou Hanna J, Rowland H, Poff B, Macdonald K, Nagy M, Panian T, Sundaram B, Pham P , Forouzan O et al (2017) P612Feasibility and safety of a wireless pulmonary artery pressure monitoring system in chronic porcine models of pulmonary hypertension. European Heart Journal, Vol. 38(suppl_1) View this article in WRRO
• Ihugba JC, Kurusamy S, Arnold N, Polla PPC, Cotton J, Arco PG-D, Redondo JM, Lawrie A & Armesilla AL (2017) 156 Inducers of pulmonary arterial hypertension upregulate the expression of plasma membrane calcium atpase 1 in pulmonary artery smooth muscle cells. Heart, Vol. 103(Suppl 5) (pp A113.1-A113)
• Hadinnapola C, Haimel M, Bleda M, Bogaard H, Coghlan G, Corris P, Gibbs S, Kiely D, Lawrie A, Peacock A , Pepke-Zaba J et al (2016) S107 Genotype-phenotype associations in pulmonary arterial hypertension caused by BMPR2 and EIF2AK4 variants. Thorax, Vol. 71(Suppl 3) (pp A63-A64)
• Zawia A, Arnold N, Braithwaite A, Pickworth J, Hopkinson K, Iremonger J, Miller G & Lawrie A (2016) S85 Reduction of CD68 macrophages causes gender specific spontaneous pulmonary arterial hypertension in mice. Thorax, Vol. 71(Suppl 3) (pp A49.1-A49)
• Dickinson RS, Thompson AAR, Thomson JP, Murphy F, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Forbes S , Stimson RH et al (2016) S104 Hypoxia preconditions the innate immune response to acute bacterial pulmonary infections. Thorax, Vol. 71(Suppl 3) (pp A61.2-A62)
• Thompson AAR, Arnold ND, Braithwaite AT, Casbolt HL, Iremonger J, Pickworth JA, Monaco C, Cole JE, Sabroe I & Lawrie A (2016) S87 Deficiency of toll-like receptor 3 (TLR3) exacerbates pulmonary hypertension in mice. Thorax, Vol. 71(Suppl 3) (pp A50.1-A50)
• Lin J, Iremonger J, Pickworth J, Rothman A, Casbolt H, Arnold N, Elliot C, Condliffe R, Kiely D & Lawrie A (2016) P245 Whole blood levels of microrna-34a predict survival and regulate genes associated with pulmonary arterial hypertension. Thorax, Vol. 71(Suppl 3) (pp A220.2-A221)
• Ramjug S, Hussein N, Billings C, Charalampopoulos A, Elliot C, Kiely D, Lawrie A, Rajaram S, Swift A, Wild J & Condliffe R (2016) Idiopathic and systemic sclerosis-associated PAH: A comprehensive haemodynamic and radiological comparison. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
• Swift A, Lungu A, Capener D, Hammerton C, Rothman A, Lawrie A, Elliot C, Condliffe R, Kiely D & Wild J (2016) Age is independently associated with pulmonary arterial compliance in health and in patients with pulmonary vascular disease. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
• Swift A, Lungu A, Capener D, Hammerton C, Rothman A, Lawrie A, Elliot C, Condliffe R, Kiely D & Wild J (2016) Age is independently associated with pulmonary arterial compliance in health and in patients with pulmonary vascular disease. EUROPEAN RESPIRATORY JOURNAL, Vol. 48
• Ramjug S, Hussein N, Billings C, Charalampopoulos A, Elliot C, Kiely D, Lawrie A, Rajaram S, Swift A, Wild J & Condliffe R (2016) Idiopathic and systemic sclerosis-associated PAH: A comprehensive haemodynamic and radiological comparison. EUROPEAN RESPIRATORY JOURNAL, Vol. 48
• Quadery S, Billings C, Wild J, Swift A, Rajaram S, Davies C, Hill C, Thomas S, Braidley P, Hunter S , Armstrong I et al (2016) Chronic thrombo-embolic pulmonary hypertension: Long-term outcomes in operated and non-operated patients. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
• Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Thomas M , Francis SE et al (2016) E microRNA-140-5p and SMURF1 Regulate Pulmonary Arterial Hypertension. Heart, Vol. 102(Suppl 6) (pp A147-A147)
• Rhodes C, Wharton J, Ghataorhe P, Watson G, Girerd B, Howard LS, Gibbs S, Condliffe R, Elliot CA, Kiely D , Simonneau G et al (2016) Plasma Proteome Analysis In Idiopathic Pulmonary Arterial Hypertension Identifies A Panel Of Prognostic Proteins. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Hadinnapola C, Bleda M, Haimel M, Bogaard HJ, Coghlan G, Corris PA, Gibbs JS, Kiely DG, Lawrie A, Peacock AJ , Machado RD et al (2016) Utility Of Deep Phenotyping In The Identification And Validation Of Novel Causal Whole Genome Sequencing Variation In Patients With Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Graf S, Bleda M, Hadinnapola C, Haimel M, Bogaard HJ, Coghlan G, Corris PA, Gibbs JS, Kiely DG, Lawrie A , Machado RD et al (2016) Whole Genome Sequencing In Idiopathic And Heritable Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Iremonger J, Rothman AM, Rhodes C, Condliffe R, Elliot CA, Kiely D, Howard LS, Gibbs S, Wharton J, Wilkins MR & Lawrie A (2016) Investigating The Diagnostic Potential Of Circulating Mirna Signatures In Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Boehm M, Lu C, Novoyatleva T, Arnold ND, Braithwaite AT, Grimminger F, Ghofrani H, Weissmann N, Seeger W, Lawrie A , Schermuly RT et al (2016) Effects Of Pharmacological Aldosterone Antagonism By Eplerenone On Pressure Overload-Induced Right Ventricular Dysfunction. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Treacy C, Blenda M, Hadinnapola C, Haimel M, Coghlan G, Corris PA, Gibbs JS, Kiely DG, Lawrie A, Peacock AJ , Pepke-Zaba J et al (2016) The Uk National Cohort Study Of Idiopathic And Heritable Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Thompson AAR, Arnold ND, Braithwaite AT, Casbolt HL, Pickworth JA, Cole JE, Monaco C, Kiely D, Sabroe I & Lawrie A (2016) Deficiency Of Toll-Like Receptor 3 (tlr3) Exacerbates Pulmonary Hypertension In Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
• Pickworth J, Shay S, Gladson S, Iremonger J, Rothman AMK, Francis S, West J & Lawrie A (2015) S3 Reduced BMPR2 expression potentiates a pulmonary artery smooth muscle cell specific IL-1ß response. Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
• Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Francis SE , Rowlands DJ et al (2015) T5 MicroRNA-140–5p Regulates Disease Phenotype in Experimental Pulmonary Arterial Hypertension via SMURF1. Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
• Dawson S, Pickworth J, Rothman A, Iremonger J, Arnold N, Francis S & Lawrie A (2014) T5 Opg Regulates Pulmonary Arterial Smooth Muscle Cell Proliferation And The Expression Of Pah-associated Genes Via Fas. Thorax, Vol. 69(Suppl 2) (pp A2-A3)
• Dawson S, Pickworth J, Rothman A, Iremonger J, Arnold N & Lawrie A (2014) 183 Novel OPG Protein Interactions Regulate Survival, Proliferation And Pah-associated Gene Expression in Pulmonary Arterial Smooth Muscle Cells.. Heart, Vol. 100 Suppl 3 (pp A102-A103). England
• Selej M, Tian L, Scalfone L, Lawrie A, Nicolls MR, Robinson W, Rabinovitch M & Zamanian RT (2014) Novel Risk Score Prediction Using Inflammatory Cytokines In Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
• Arnold N, Dawson S, Pickworth J, Rothman AMK, Iremonger J, Francis S & Lawrie A (2014) Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
• Rothman AMK, Arnold N, Dawson S, Chang W, Suvarna K, Kiely D, Gunn J & Lawrie A (2014) Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
• Dawson S, Pickworth J, Rothman AMK, Iremonger J, Arnold N & Lawrie A (2014) Novel Osteoprotegerin Protein Interactions Regulate Pulmonary Arterial Smooth Muscle Cell Survival And Proliferation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
• Condliffe R, Elliot CA, Sabroe I, Zamanian RT, Morton A, Swift AJ, Kiely DG & Lawrie A (2013) P157 Hepatocyte growth factor concentration correlates with haemodynamic severity in connective tissue disease-associated pulmonary arterial hypertension. Thorax, Vol. 68(Suppl 3) (pp A146.2-A147)
• Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2013) Tumour necrosis factor-related apoptosis-inducing ligand is a novel therapeutic target in pulmonary arterial hypertension. The Lancet, Vol. 381 (pp S47-S47)
• Hameed AG, Arnold ND, Chamberlain J, Pickworth J, Newman CMH, Crossman DC, Francis SE & Lawrie A (2012) 03 Tissue Trail Drives Pulmonary Vascular Remodeling and its Inhibition Reverses Experimental Pulmonary Arterial Hypertension. Heart, Vol. 98(Suppl 3) (pp A1.3-A1)
• Pickworth J, Hopkinson K, Francis SE, Kiss-Toth E & Lawrie A (2012) Interplay Between Interleukin-1 And Dysfunctional BMP Signalling May Play A Role In The Pathogenesis Of Pulmonary Arterial Hypertension. B26. PULMONARY VASCULAR SIGNALING IN PULMONARY HYPERTENSION
• Shepherd AJ, Hopkinson K, Walker SJ, Elliot CA, Condliffe RA, Kiely DG, Pockley G & Lawrie A (2012) Characterising Peripheral Blood Lymphocyte Subpopulations In Clinical And Experimental Pulmonary Hypertension. C28. DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION
• Hurdman J, Condliffe R, Elliot CA, Rajaram S, Swift AJ, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C , Pollard L et al (2012) Characteristics And Outcomes In Pulmonary Hypertension Associated With COPD/ Emphysema: Results From The ASPIRE Registry. B107. BIOMARKERS AND PREDICTORS OF OUTCOMES IN PULMONARY HYPERTENSION
• Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
• Lawrie A, Hameed AG, Arnold N, Chamberlain J, Pickworth J, Dawson S, Newman CMH & Francis SE (2012) Osteoprotegerin Blockade Prevents And Reverses Experimental Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, Vol. 185(1 MeetingAbstracts) (pp A6515)
• Condliffe R, Pickworth J, Hopkinson K, Hameed A, Walker S, Elliot C, Francis S, Newman C, Crossman D, Morton A , Kiely D et al (2011) SERUM OSTEOPROTEGERIN PREDICTS MORTALITY IN A PROSPECTIVE STUDY ON INCIDENT CASES OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 66 (pp A34-A34)
• Zawia A, Arnold N, Pickworth J, Hameed A, Hopkinson K, Miller G & Lawrie A (2011) PULMONARY HYPERTENSION IN A MOUSE MODEL WITH REDUCED MACROPHAGE NUMBER (MACLOW). THORAX, Vol. 66 (pp A68-A69)
• McGrath EE, Lawrie A, Marriott H, Mercer PF, Cross SS, Chambers RC, Dockrell DH & Whyte MKB (2011) THE ROLE OF TNF-RELATED APOPTOSIS INDUCING LIGAND (TRAIL) IN PULMONARY FIBROSIS. THORAX, Vol. 66 (pp A51-A52)
• Hameed AG, Arnold ND, Pickworth J, Chamberlain JC, Newman CMH, Crossman DC, Francis SE & Lawrie A (2011) TRAIL IS A POTENTIAL NOVEL THERAPEUTIC TARGET IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 66 (pp A3-A3)
• Lawrie A, Hameed AG, Chamberlain J, Arnold N, Crossman DC & Francis SE (2011) PAIGEN DIET-FED APOLIPOPROTEIN E KNOCK-OUT MICE DEVELOP SEVERE PULMONARY HYPERTENSION IN AN INTERLEUKIN-1 DEPENDENT MANNER. HEART, Vol. 97(20) (pp 10-10)
• McGrath EE, Marriott H, Lawrie A, Cross S, Mercer P, Hellewell P, Chambers RC, Dockrell D & Whyte MK (2011) The Role Of TNF-Related Apoptosis Inducing Ligand (TRAIL) In Idiopathic Pulmonary Fibrosis (IPF). D14. INSIGHTS INTO PATHOGENESIS OF LUNG FIBROSIS AND GRANULOMAS
• Hameed AG, Chamberlain J, Arnold N, Newman C, Francis S, Crossman D & Lawrie A (2011) Beneficial Effects Of Inhibiting Trail In Monocrotaline-Induced Experimental Pulmonary Hypertension. B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
• Shepherd AJ, Hopkinson K, Kiely DG, Elliot CE, Condliffe R, Crossman DC, Pockley AG & Lawrie A (2010) CHARACTERISING T CELL SUB-POPULATIONS IN PULMONARY HYPERTENSION. THORAX, Vol. 65 (pp A91-A91)
• Hameed AG, Chamberlain J, Arnold ND, Francis SE, Newman CMH, Crossman DC & Lawrie A (2010) TRAIL DEFICIENCY IS PROTECTIVE IN EXPERIMENTAL PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 65 (pp A68-A68)
• Hameed AG, Francis SE, Crossman DC & Lawrie A (2010) TRAIL Deficiency Protects Fat-fed ApoE-/- Mice From Pulmonary Arterial Hypertension. A96. INFLAMMATION AND BONE MARROW DERIVED CELLS IN PULMONARY ARTERIAL HYPERTENSION
• Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) FAT-FED APOE/IL-1R1 DOUBLE-DEFICIENT MICE ARE PROTECTED FROM ATHEROSCLEROSIS BUT DEVELOP SEVERE PULMONARY HYPERTENSION. THORAX, Vol. 64 (pp A9-A10)
• Condliffe R, Hameed AG, Paiva C, Suntharalingam J, Francis SE, Newman CMH, Crossman DC, Morrell NW & Lawrie A (2009) OSTEOPROTEGERIN/TUMOUR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND PATHWAY: A POTENTIAL BIOMARKER FOR PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A58-A59)
• Hameed AG, Vinogradova T, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) TRAIL EXPRESSION IS INCREASED IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A8-A8)
• Vinogradova T, Hameed AG, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) OSTEOPROTEGERIN EXPRESSION IS INCREASED PRIOR TO HAEMODYNAMIC ALTERATIONS IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A9-A9)
• Paiva C, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) REGULATION OF EXPRESSION AND FUNCTION OF OSTEOPROTEGERIN IN PULMONARY ARTERY SMOOTH MUSCLE CELLS IN VITRO. THORAX, Vol. 64 (pp A9-A9)
• Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) Fat Fed ApoE/IL-1R1 Double Deficient Mice Are Protected From Atherosclerosis but Develop Severe Pulmonary Hypertension. CIRCULATION, Vol. 120(18) (pp S751-S751)
• Watt V, Soon E, Suntharalingam J, Paiva C, Hameed AG, Francis SE, Newman CM, Crossman DC, Morrell NW & Lawrie A (2009) OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
• Lawrie A, Paiva C, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CMH (2008) THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
• Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW, Morrell NW & Newman CM (2007) A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
• Lawrie A, Suntharalingham J, Southwood M, Francis S, Crossman D, Morrell N & Newman C (2007) A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
• Lawrie A, Waterman EA & Evans DJ (2006) Genes associated with pulmonary hypertension regulate osteoprotegerin in human pulmonary artery smooth muscle cells in vitro.. CIRCULATION, Vol. 114(18) (pp 130-131)
• Lawrie A, Evans DJW, Waterman EA, Francis SE, Crossman DC & Newman CMH (2006) Osteoprotegerin is up-regulated by BMP-R2 RNA-interference and induces proliferation and migration of human pulmonary artery smooth cells in vitro. Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
• Spiekerkoetter E, Lawrie A, Merklinger S, Ambartsumian N, Lukanidin E, Schmidt A-M & Rabinovitch M (2005) Mts1/S100A4 stimulates human pulmonary artery smooth muscle cell migration through multiple signaling pathways.. Chest, Vol. 128(6 Suppl) (pp 577S). United States
• Spiekerkoetter E, Merklinger SL, Lawrie A, Ambartsumian N, Lukanidin E & Rabinovitch M (2004) Combined environmental stimuli, d-fenfluramine and hypoxia, induce severe pulmonary hypertension in S100A4/Mts1-overexpressing mice that are prone to develop pulmonary vascular obliterative disease (PVOD). CIRCULATION, Vol. 110(17) (pp 19-19)
• Lawrie A, Ambartsumian N, MacLean MR & Lukanidin E (2004) Serotonin induction of S100A4/Mts1 expression in human pulmonary artery smooth muscle cells is dependent on both the serotonin transporter and receptor. CIRCULATION, Vol. 110(17) (pp 19-19)
• Spiekerkoetter EF, Lawrie A, Merklinger SL & Rabinovitch M (2003) Mts1, a novel gene in the pathogenesis of pulmonary hypertension, induces migration of human pulmonary artery smooth muscle cells via the receptor for advanced glycation end products (RAGE). CIRCULATION, Vol. 108(17) (pp 122-123)
• Lawrie A, Brisken AF, Francis SE, Crossman DC, Cumberland D & Newman CM (1999) Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
• Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) High frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
• Dawson S, Arnold N, Pickworth J, Francis S & Lawrie A () TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension. Diseases, Vol. 2(3) (pp 260-273) View this article in WRRO

Patents

• Wharton SP & Higenbottam TW (2001) Pulmonary hypertension. Appl. 01 Jan 2001.

Other

• Farmery JHR, Smith ML & Lynch AG (2018) Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Scientific Reports, 8(1).

Preprints

• Dowey R, Cole J, Thompson AAR, Huang C, Whatmore J, Iqbal A, Bradley KL, McKenzie J, Hull RC, Lawrie A , Condliffe AM et al (2021) Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin, medRxiv.
• Jones R, De Bie E, Groves E, Zalewska KI, Swietlik EM, Treacy C, Martin J, Polwarth G, Guo J, Baxendale H , Coleman S et al () Autoimmunity is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension.
• Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T , Lutz KA et al () Rare variant analysis of 4,241 pulmonary arterial hypertension cases from an international consortium implicate FBLN2, PDGFD and rare de novo variants in PAH, Cold Spring Harbor Laboratory.
• Swietlik EM, Greene D, Zhu N, Megy K, Cogliano M, Rajaram S, Pandya D, Tilly T, Lutz KA, Welch CCL , Pauciulo MW et al () Bayesian inference associates rare KDR variants with specific phenotypes in pulmonary arterial hypertension, Cold Spring Harbor Laboratory.
• Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B , Arora A et al () Genetic determinants of risk and survival in pulmonary arterial hypertension, Cold Spring Harbor Laboratory.
• Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M , Machado RD et al () Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension, Cold Spring Harbor Laboratory.
• Saunders LC, Collier GJ, Chan H-F, Hughes PJC, Smith LJ, Watson J, Meiring J, Gabriel Z, Newman T, Plowright M , Eaden JA et al () Longitudinal lung function assessment of patients hospitalised with COVID-19 using ¹H and ¹²⁹Xe lung MRI, Cold Spring Harbor Laboratory.