Professor Allan Pacey
BSc, PhD, FRCOG
Clinical Medicine, School of Medicine and Population Health
Honorary Professor of Andrology
a.pacey@sheffield.ac.uk
FU19, F Floor, The Medical School
Full contact details
Professor Allan Pacey
Clinical Medicine, School of Medicine and Population Health
FU19, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
FU19, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
I was awarded my PhD in 1991 from the University of St. Andrews after which I undertook a one-year Research Fellowship funded by the Royal Society at the Station Zoologique, Villefrance-sur-Mer, France.
I joined the University of Sheffield in 1992, first as a Postdoctoral Research Assistant and then was appointed as lecturer in 1997. In 2001 was appointed as Senior Lecturer in Andrology and in 2015 Professor of Andrology.
I became Head of Department of Oncology and Metabolism in October 2017 and then Head of the Department of Infection, Immunity & Cardiovascular Disease in January 2022. In August 2023, I moved to the Universty of Manchester to take up the position of Deputy Vice President and Deputy Dean of the faculty of Biology, Medicine and Health.
- Research interests
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I am interested in the biology of human spermatozoa and aspects of semen quality and fertility in males. It is estimated that 1 in 6 couples have a problem in conceiving a child and in about half of these cases, a problem is identified with the male partner. This may be a result of too few sperm being produced, or the fact that sperm have poor motility (swimming ability) or morphology (size and shape).
In recent years, my research has focussed on how micro-organisms such as Chlamydia trachomatis interact with sperm and affect sperm function.
This is in collaboration with Adrian Eley and has shown that the bacteria can trigger signalling pathways in sperm that lead to premature sperm death. We have investigated the molecular nature of this process and have recently shown that sperm washing methods currently in use in clinics are not effective in removing C. trachomatis from sperm.
In the search for better diagnostic methods in the clinic, I have recently collaborated with engineers from the University of Glasgow (Green/Gilles) and applied modelling techniques used in fluid mechanics to better understand how sperm swim.
This paper was published in the Journal of Fluid Mechanics in 2008 and shows that swimming speed is closely related to the side and shape of the sperm head.
Work with Urologists in Sheffield has developed a new diagnostic test for men who have small numbers of non-motile sperm in their ejaculates following vasectomy.
In some men, these sperm are present for many months or years meaning the men cannot be discharged from care or cease using contraception because it is not be certain if the surgery has been successful.
We have employed a fluorescent test that allows us to determine if these sperm are dead or alive in order to discriminate between failed vasectomy and inadequate clearance of dead sperm.
Finally, I am interested in occupational and environmental influences on semen quality. In collaboration with colleagues from the University of Manchester, I conducted a large multi-centre study of semen quality at 14 clinics within the UK, relating measures of semen quality to.
In 2008 we published the first paper describing how occupational exposure to glycol ethers (found in paints) was associated with a low motile sperm count. Further papers from this data are being prepared and will be published shortly.
Current Projects
- Immediate and longer-term consequences for men who bank sperm prior to cancer treatment.
- Trans-national reproduction: an exploratory study of UK residents who travel abroad for fertility treatment.
- A pilot study to investigate the interaction between cytomegalovirus (CMV) infection and human spermatozoa.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Defining critical factors in multi-country studies of assisted reproductive technologies (ART): data from the US and UK health systems. Journal of Assisted Reproduction and Genetics, 37(11), 2767-2775.
- Phytoestrogen intake and other dietary risk factors for low motile sperm count and poor sperm morphology. Andrology. View this article in WRRO
- The current status and future of andrology: A consensus report from the Cairo workshop group. Andrology, 8(1), 27-52.
- A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. European Journal of Nutrition, 59(2), 825-833. View this article in WRRO
- Male Infertility and Future Cardiometabolic Health: Does the Association Vary by Sociodemographic Factors?. Urology, 133, 121-128.
- The Development of an International Oncofertility Competency Framework: A Model to Increase Oncofertility Implementation. The Oncologist, 24(12).
- Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial. The Lancet, 393(10170), 416-422. View this article in WRRO
- Probing human sperm metabolism using 13C-magnetic resonance spectroscopy.. Molecular Human Reproduction, 25(1), 30-41. View this article in WRRO
- How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care. Human Reproduction Update, 25(2), 159-179.
- Preserving fertility in women with cancer (PreFer): Decision‐making and patient‐reported outcomes in women offered egg and embryo freezing prior to cancer treatment. Psycho-Oncology.
- Is sperm DNA fragmentation a useful test that identifies a treatable cause of male infertility?. Best Practice & Research Clinical Obstetrics & Gynaecology, 53, 11-19.
- 1H Magnetic Resonance Spectroscopy of live human sperm. Molecular Human Reproduction, 23(7), 441-451. View this article in WRRO
- Evidence for Rapid Oxidative Phosphorylation and Lactate Fermentation in Motile Human Sperm by Hyperpolarized 13C Magnetic Resonance Spectroscopy. Scientific Reports, 7. View this article in WRRO
- An analysis of the outcome of 11 712 men applying to be sperm donors in Denmark and the USA. Human Reproduction.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database of Systematic Reviews.
- The fertility fitness paradox of anabolic‐androgenic steroid abuse in men. Journal of Internal Medicine.
Chapters
- The Effect of Age on Male Fertility and the Health of Offspring, Male and Sperm Factors that Maximize IVF Success (pp. 73-82). Cambridge University Press
Conference proceedings papers
- Human reproduction keynote lecture - Modifiable and non-modifiable risk factors for poor sperm morphology. HUMAN REPRODUCTION, Vol. 31 (pp 1-1)
All publications
Books
- Sperm Banking: Theory and Practice. Cambridge University Press.
Journal articles
- Patient and professional perspectives about using in vitro fertilisation add-ons in the UK and Australia: a qualitative study. BMJ Open, 13(7), e069146-e069146.
- Experiences and attitudes of Danish men who were sperm donors more than 10 years ago; a qualitative interview study. PLoS ONE, 18(2).
- Thank you and goodbye!. Human Fertility, 25(5), 805-805.
- Thank you and goodbye!. Hum Fertil (Camb), 25(5), 805.
- Celebrating the peer reviewers of Human Fertility (2005–2022). Human Fertility, 25(4), 607-607.
- Effects of virtual reality erotica on ejaculate quality of sperm donors: a balanced and randomized controlled cross-over within-subjects trial. Reproductive Biology and Endocrinology, 20(1).
- Editorial board members of Human Fertility 1998 to 2022. Human Fertility, 25(3), 407-409.
- Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology. Human Reproduction.
- MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization. Science Advances, 8(36).
- O-227 Has time-lapse technology finally proven its clinical benefit?. Human Reproduction, 37(Supplement_1).
- O-187 An analysis of the outcome of 11,712 men applying to be sperm donors at Cryos International in Denmark and the USA. Human Reproduction, 37(Supplement_1).
- O-078 The VALUE study: a qualitative semi-structured interview study of add-on use by patients, clinicians, and embryologists in the UK and Australia. Human Reproduction, 37(Supplement_1).
- 24 years of policy statements, guidelines, and policy and practice articles in Human Fertility. Human Fertility, 25(2), 203-208.
- Protocol for developing a core outcome set for male infertility research: an international consensus development study. Human Reproduction Open, 2022(2).
- Outcome reporting across randomized controlled trials evaluating potential treatments for male infertility: a systematic review. Human Reproduction Open, 2022(2).
- NMR Spectroscopy of live human asthenozoospermic and normozoospermic sperm metabolism. Reproduction and Fertility.
- The first 25 years of Human Fertility. Human Fertility, 25(1), 1-3.
- Are UK policies and practices for regulated donor insemination forcing women to find unregulated sperm donors online? A perspective on the available evidence. Frontiers in Global Women's Health, 3.
- Counting the hidden costs of male reproductive health. World Journal of Men's Health, 40.
- The 44th and 45th meeting of the Human Fertility Editorial Board. Human Fertility, 24(5), 315-315.
- Screening for Chlamydia trachomatis and other sexually transmitted infections in the fertility clinic. Human Fertility, 24(4), 229-229.
- P–537 What is the attitude of gamete donors towards expanded genetic testing. Human Reproduction, 36(Supplement_1).
- O-037 The impact of COVID-19 on male fertility: what do we know?”. Human Reproduction, 36(Supplement_1).
- 2020 impact factor. Human Fertility, 24(3), 151-151. View this article in WRRO
- Attitudes of sperm donors towards offspring, identity release and extended genetic screening. Reproductive BioMedicine Online, 43(4), 700-707.
- VALUE study: a protocol for a qualitative semi-structured interview study of IVF add-ons use by patients, clinicians and embryologists in the UK and Australia. BMJ Open, 11(5), e047307-e047307.
- Varicoceles and other controversies. Human Fertility, 24(2), 77-77.
- Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women.. Mol Med Rep, 23(4), 1.
- Human Fertility gets bigger!. Human Fertility, 24(1), 1-2.
- Developing a core outcome set for future infertility research: an international consensus development study. Fertility and Sterility, 115(1), 191-200.
- A global approach to addressing the policy, research and social challenges of male reproductive health. Human Reproduction Open, 2021(1).
- Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study. Human Reproduction, 35(12), 2735-2745.
- Developing a core outcome set for future infertility research: an international consensus development study. Human Reproduction, 35(12), 2725-2734.
- Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study. Fertility and Sterility, 115(1), 201-212.
- A thank you to Jane Denton!. Human Fertility, 23(4), 225-225.
- In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters. Obstetrical & Gynecological Survey, 75(10), 608-609.
- Defining critical factors in multi-country studies of assisted reproductive technologies (ART): data from the US and UK health systems. Journal of Assisted Reproduction and Genetics, 37(11), 2767-2775.
- 2019 Impact factor. Human Fertility, 23(3), 149-149.
- Fertility preservation for women undergoing breast cancer treatment: a postcode lottery?. The Breast Journal, 26(10), 2117-2118.
- Phytoestrogen intake and other dietary risk factors for low motile sperm count and poor sperm morphology. Andrology. View this article in WRRO
- GM-CSF (granulocyte macrophage colony-stimulating factor) supplementation in culture media for women undergoing assisted reproduction. Cochrane Database of Systematic Reviews, 7.
- Coronovirus and reproductive medicine, getting back to (the new) normal?. Human Fertility, 23(2), 75-75.
- Lockdown. Human Fertility, 23(1), 1-1.
- Reply to the letter: Lycopene improves sperm motility and morphology: a promising agent for treating male infertility. European Journal of Nutrition, 59(2), 837-837.
- The current status and future of andrology: A consensus report from the Cairo workshop group. Andrology, 8(1), 27-52.
- In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters. American Journal of Obstetrics and Gynecology, 222(4), 350.e1-350.e13.
- A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. European Journal of Nutrition, 59(2), 825-833. View this article in WRRO
- Add-ons in the laboratory: hopeful, but not always helpful. Fertility and Sterility, 112(6), 994-999.
- The ABC of IVF and COI. Human Fertility, 22(4), 229-229.
- In vitro fertilization and gestational hypertension/preeclampsia risk: effect of diagnosis versus treatment parameters. Fertility and Sterility, 112(3), e299-e299.
- Male Infertility and Future Cardiometabolic Health: Does the Association Vary by Sociodemographic Factors?. Urology, 133, 121-128.
- 2018 Impact factor. Human Fertility, 22(3), 153-153.
- Male fertility and the need for more research. Human Fertility, 22(2), 77-77.
- The Development of an International Oncofertility Competency Framework: A Model to Increase Oncofertility Implementation. The Oncologist, 24(12).
- 17. Fertility preservation provision for breast cancer patients in England – a postcode lottery. European Journal of Surgical Oncology, 45(5), 881-881.
- Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial. The Lancet, 393(10170), 416-422. View this article in WRRO
- Volume 22 is here!. Human Fertility, 22(1), 1-1.
- Probing human sperm metabolism using 13C-magnetic resonance spectroscopy.. Molecular Human Reproduction, 25(1), 30-41. View this article in WRRO
- How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care. Human Reproduction Update, 25(2), 159-179.
- No more donor secrets in the genomic age. Human Fertility, 21(4), 223-224.
- Studying the nuts and bolts of spermatozoa.. Molecular Human Reproduction. View this article in WRRO
- Preserving fertility in women with cancer (PreFer): Decision‐making and patient‐reported outcomes in women offered egg and embryo freezing prior to cancer treatment. Psycho-Oncology.
- 2017 Impact factor. Human Fertility, 21(3), 155-155.
- IVF’s 40th birthday. Human Fertility, 21(2), 85-85.
- Focus on fertility preservation. Human Fertility, 21(1), 1-2.
- Time-lapse systems for ART. Reproductive BioMedicine Online, 36(3), 288-289.
- Is sperm DNA fragmentation a useful test that identifies a treatable cause of male infertility?. Best Practice & Research Clinical Obstetrics & Gynaecology, 53, 11-19.
- Effects of Chlamydia trachomatis infection on sperm chromatin condensation and DNA integrity. Andrologia. View this article in WRRO
- Sitting on the editorial fence. Human Fertility, 20(4), 223-223.
- 2016 Impact factor. Human Fertility, 20(3), 147-147.
- 1H Magnetic Resonance Spectroscopy of live human sperm. Molecular Human Reproduction, 23(7), 441-451. View this article in WRRO
- Evidence for Rapid Oxidative Phosphorylation and Lactate Fermentation in Motile Human Sperm by Hyperpolarized 13C Magnetic Resonance Spectroscopy. Scientific Reports, 7. View this article in WRRO
- Classification systems in Gestational trophoblastic neoplasia - Sentiment or evidenced based?. Cancer Treatment Reviews, 56, 47-57.
- The 40th Meeting of the Editorial Board. Human Fertility, 20(2), 73-73.
- Volume 20: a major landmark.. Hum Fertil (Camb), 20(1), 1-1.
- Relationship between Chlamydia trachomatis and Mycoplasma genitalium infection and pregnancy rate and outcome in Iranian infertile couples. Andrologia. View this article in WRRO
- Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial. BMJ Open, 6(10). View this article in WRRO
- On the shoulders of giants. Human Fertility, 19(3), 150-150.
- Semen inflammatory markers and Chlamydia trachomatis infection in male partners of infertile couples. Andrologia, 48(7), 729-736.
- Cross-border-assisted reproduction: a qualitative account of UK travellers’ experiences. Human Fertility, 19(2), 102-110.
- New editorial board members. Human Fertility, 19(2), 79-79.
- From one to two: the effect of women and the economy on China’s One Child Policy. Human Fertility, 19(1), 1-2.
- Our history. Human Fertility, 18(4), 231-231.
- Evaluation of immunological interaction between spermatozoa and fallopian tube epithelial cells. Andrologia, 47(10), 1120-1130.
- Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage. Asian Journal of Andrology, 17(4), 681-685. View this article in WRRO
- With many thanks to Henry Leese. Human Fertility, 18(2), 79-80.
- eSET, Impact Factors and a return to Taylor & Francis. Human Fertility, 18(3), i-i.
- How do men in the United Kingdom decide to dispose of banked sperm following cancer treatment?. Human Fertility, 17(4), 285-288.
- Occupation exposures and sperm morphology: a case-referent analysis of a multi-centre study.. Occup Environ Med, 71(9), 598-604.
- Modifiable and non-modifiable risk factors for poor sperm morphology.. Hum Reprod, 29(8), 1629-1636.
- Why don't some men with banked sperm respond to letters about their stored samples?. Hum Fertil (Camb), 17(4), 278-284.
- The importance of fertility preservation in cancer patients.. Expert Rev Anticancer Ther, 14(5), 487-489.
- Reduced curvilinear velocity of boar sperm on substrates with increased hydrophobicity.. Theriogenology, 81(5), 764-769. View this article in WRRO
- Sperm protection in the male reproductive tract by Toll-like receptors.. Andrologia, 46(7), 784-790.
- Will it be possible to restore sperm production after childhood cancer treatment?. Regen Med, 8(5), 523-525.
- Discussing fertility preservation at the time of cancer diagnosis: dissatisfaction of young females.. Pediatr Blood Cancer, 60(12), 1996-2000.
- Chlorination by-products in tap water and semen quality in England and Wales.. Occup Environ Med, 70(11), 754-760.
- Implications of sperm banking for health-related quality of life up to 1 year after cancer diagnosis.. Br J Cancer, 108(5), 1004-1011. View this article in WRRO
- Infertility and assisted reproduction: counselling and psychosocial aspects.. Hum Fertil (Camb), 16(1), 1.
- Reproductive fitness. NEW SCIENTIST, 217(2905), 31-31.
- Are sperm counts declining? Or did we just change our spectacles?. Asian J Androl, 15(2), 187-190.
- 'What are you going to do, confiscate their passports?' Professional perspectives on cross-border reproductive travel. Journal of Reproductive and Infant Psychology, 31(1), 46-57.
- Fins improve the swimming performance of fish sperm: a hydrodynamic analysis of the Siberian sturgeon Acipenser baerii.. Cytoskeleton (Hoboken), 70(2), 85-100.
- Sperm speed is associated with sex bias of siblings in a human population.. Asian J Androl, 15(1), 152-154.
- Variation in mean human sperm length is linked with semen characteristics.. Hum Reprod, 28(1), 22-32.
- Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment.. Hum Reprod, 27(11), 3132-3139.
- Finding out about sperm banking: what information is available online for men diagnosed with cancer?. Hum Fertil (Camb), 15(3), 121-128.
- Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study.. Hum Reprod, 27(9), 2799-2806.
- Assessment of male factor.. Best Pract Res Clin Obstet Gynaecol, 26(6), 739-746.
- Mitochondrial haplotype does not influence sperm motility in a UK population of men.. Hum Reprod, 27(3), 641-651.
- ANDROLOGY. Human Reproduction, 27(suppl 2), ii121-ii150.
- Male fertility and infertility in 2011 and beyond. Obstetrics, Gynaecology and Reproductive Medicine, 22(1), 16-20.
- Banking sperm is only the first of many decisions for men: what healthcare professionals and men need to know.. Hum Fertil (Camb), 14(4), 208-217.
- The legacy of sperm banking: how fertility monitoring and disposal of sperm are linked with views of cancer treatment.. Hum Reprod, 26(10), 2791-2798.
- Crossing borders for fertility treatment: motivations, destinations and outcomes of UK fertility travellers.. Hum Reprod, 26(9), 2373-2381.
- Cross-border reproductive care: a review of the literature.. Reprod Biomed Online, 22(7), 673-685.
- Using erotica in government-funded health service clinics.. J Sex Med, 8(5), 1261-1265.
- Sexual functioning in male survivors of lymphoma: a systematic review (CME).. J Sex Med, 8(7), 1833-1841. View this article in WRRO
- POSTER VIEWING SESSION - ANDROLOGY. Human Reproduction, 26(Supplement 1), i123-i148.
- Male fertility and infertility in 2011 and beyond. Obstetrics, Gynaecology and Reproductive Medicine.
- A novel cost-effective approach to post-vasectomy semen analysis.. BJU Int, 107(9), 1447-1452.
- The value of testing semen for Chlamydia trachomatis in men of infertile couples.. Int J Androl, 34(5 Pt 1), 391-401.
- Environmental and lifestyle factors associated with sperm DNA damage.. Hum Fertil (Camb), 13(4), 189-193.
- Andrology in 2010.. Hum Fertil (Camb), 13(4), 180-181.
- Impact of Chlamydia trachomatis in the reproductive setting: British Fertility Society Guidelines for practice.. Human Fertility, 13(3), 115-125. View this article in WRRO
- Analysis of modulated gene expression in a model of Interferon-gamma-induced persistence of Chlamydia trachomatis in HEp-2 cells.. Microb Pathog, 49(5), 217-225.
- Session 51: Cross Border Reproductive Care. Human Reproduction, 25(Supplement 1), i77-i79.
- Health-related quality of life in survivors of lymphoma: a systematic review and methodological critique.. Leuk Lymphoma, 51(4), 628-640. View this article in WRRO
- Raised inflammatory markers in semen from men with asymptomatic chlamydial infection.. J Androl, 31(2), 114-120.
- Sperm donor recruitment in the UK. The Obstetrician & Gynaecologist, 12(1), 43-48.
- Quality assurance and quality control in the laboratory andrology.. Asian J Androl, 12(1), 21-25.
- Real-time polymerase chain reaction shows that density centrifugation does not always remove Chlamydia trachomatis from human semen.. Fertil Steril, 92(5), 1606-1615.
- Mannose-binding lectin is present in human semen and modulates cellular adhesion of Neisseria gonorrhoeae in vitro.. Clin Exp Immunol, 157(3), 408-414.
- Hydrodynamic propulsion of human sperm. J FLUID MECH, 625, 445-474.
- Sperm, human fertility and society, 565-597.
- Long term attitudes to banked sperm following cancer treatment: Clinic attendance and attitudes to disposal. PSYCHOLOGY & HEALTH, 24, 84-84.
- IDENTIFICATION OF HUMAN SPERM-BINDING PEPTIDE MOTIFS USING A COMBINATORIAL BEAD LIBRARY. JOURNAL OF ANDROLOGY, 30, 88-88.
- Male fertility and infertility. Poloznictwo Ginekologia i Medycyna Rozrodu, 3(4), 306-312.
- Male fertility and infertility. Obstetrics, Gynaecology and Reproductive Medicine, 19(2), 42-47.
- Occupation and male infertility: glycol ethers and other exposures.. Occup Environ Med, 65(10), 708-714.
- Working Party on Sperm Donation Services in the UK: report and recommendations.. Hum Fertil (Camb), 11(3), 147-158.
- The evolutionary ecology of pre- and post-meiotic sperm senescence.. Trends Ecol Evol, 23(3), 131-140.
- UK guidelines for the medical and laboratory screening of sperm, egg and embryo donors (2008). Human Fertility, 11(4), 201-210.
- Sperm donation in the UK.. BMJ, 337, a2318.
- Fertility issues in survivors from adolescent cancers.. Cancer Treat Rev, 33(7), 646-655.
- The use of pornographic materials by adolescent male cancer patients when banking sperm in the UK: legal and ethical dilemmas.. Hum Fertil (Camb), 10(3), 159-163.
- Spermicidal activity of bacterial lipopolysaccharide is only partly due to lipid A.. J Androl, 27(6), 774-779.
- Relationship between the fertile period and sperm transport in the bitch.. Theriogenology, 66(6-7), 1410-1418.
- Is quality assurance in semen analysis still really necessary? A view from the andrology laboratory.. Hum Reprod, 21(5), 1105-1109.
- Sperm transport in the female reproductive tract.. Hum Reprod Update, 12(1), 23-37.
- Lack of compliance by UK andrology laboratories with World Health Organization recommendations for sperm morphology assessment.. Hum Reprod, 20(12), 3441-3445.
- Sperm donation: coping with change.. Hum Fertil (Camb), 8(3), 173-174.
- Apoptosis of ejaculated human sperm is induced by co-incubation with Chlamydia trachomatis lipopolysaccharide.. Hum Reprod, 20(9), 2601-2607.
- Endometriosis affects sperm-endosalpingeal interactions.. Hum Reprod, 20(2), 448-451.
- Can Chlamydia trachomatis directly damage your sperm?. Lancet Infect Dis, 5(1), 53-57.
- Chlamydia trachomatis and male fertility.. Hum Fertil (Camb), 7(4), 271-276.
- Semen quality of men with asymptomatic chlamydial infection.. J Androl, 25(1), 104-109.
- Sperm you can bank on. BRITISH MEDICAL JOURNAL, 327(7427), 1354-1354.
- Practical aspects of sperm banking for cancer patients.. Hum Fertil (Camb), 6(3), 100-105.
- Does the Arg-Gly-Asp (RGD) adhesion sequence play a role in mediating sperm interaction with the human endosalpinx?. Hum Reprod, 18(7), 1461-1468.
- Chlamydia trachomatis-induced death of human spermatozoa is caused primarily by lipopolysaccharide.. J Med Microbiol, 52(Pt 3), 193-200.
- Production of activins by the human endosalpinx.. J Clin Endocrinol Metab, 87(11), 5283-5289.
- Infectivity of Chlamydia trachomatis serovar LGV but not E is dependent on host cell heparan sulfate.. Infect Immun, 69(2), 968-976.
- Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death.. Hum Reprod, 16(2), 293-299.
- Coincubation of human spermatozoa with Chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins.. Infect Immun, 68(9), 4872-4876.
- Contact of dog spermatozoa with homologous uterine tube epithelium prolongs flagellar activity in relation to the stage of the estrous cycle.. Theriogenology, 54(1), 109-118.
- Changes in human uterine (Fallopian) tube mucosa around the time of ovulation. HUM REPROD, 14, 222-223.
- Greater numbers of human spermatozoa associate with endosalpingeal cells derived from the isthmus compared with those from the ampulla.. Hum Reprod, 12(9), 1985-1992.
- Proteins secreted by the epithelium of the human uterine (Fallopian) tube interact with human spermatozoa. HUM REPROD, 12(5), S18-S18.
- The potential shortcomings of measuring hyperactivated motility by computer-aided sperm analysis when sperm motion is multiphasic.. Hum Reprod Update, 3(3), 185-193.
- Interactions between spermatozoa and epithelial cells of the human uterine (fallopian) tube in vitro.. BIOL REPROD, 54, 189-189.
- Secretion of glycoproteins by human uterine (fallopian) tube epithelium in vitro and their association with spermatozoa.. BIOL REPROD, 54, 257-257.
- Hyperactivation may assist human spermatozoa to detach from intimate association with the endosalpinx.. Hum Reprod, 10(10), 2603-2609.
- The interaction in vitro of human spermatozoa with epithelial cells from the human uterine (fallopian) tube.. Hum Reprod, 10(2), 360-366.
- PURINERGIC RECEPTOR-MEDIATED INCREASES IN INTRACELLULAR CA2+ IN SINGLE ISOLATED EPITHELIAL-CELLS OF THE HUMAN UTERINE TUBE. J PHYSIOL-LONDON, 482P, P45-P45.
- Workshop report: clinical CASA--the quest for consensus.. Reprod Fertil Dev, 7(4), 951-959.
- THE ACQUISITION OF FORWARD MOTILITY IN THE SPERMATOZOA OF THE POLYCHAETE ARENICOLA-MARINA. J EXP BIOL, 195, 259-280.
- The sequential effects of human cervical mucus, oviductal fluid, and follicular fluid on sperm function.. Fertil Steril, 61(6), 1129-1135.
- Computer-assisted measurement of hyperactivation in human spermatozoa: differences between European and American versions of the Hamilton-Thorn motility analyser.. Hum Reprod, 9(3), 456-462.
- Human oviductal fluid prolongs sperm survival.. Fertil Steril, 61(2), 360-366.
- Intermittent swimming in the spermatozoa of the lugworm Arenicola marina (L.) (Annelida: Polychaeta).. Cell Motil Cytoskeleton, 29(2), 186-194.
- AGONISTS OF SPERM MATURATION IN ARENICOLA-MARINA (ANNELIDA, POLYCHAETA) INCREASE THE OXYGEN-CONSUMPTION OF SPERM SUSPENSIONS IN-VITRO. INVERTEBR REPROD DEV, 24(1), 27-38.
- THE FATTY-ACID 8,11,14-EICOSATRIENOIC ACID INDUCES SPAWNING IN THE MALE LUGWORM ARENICOLA-MARINA. J EXP BIOL, 173, 165-179.
- PHYSIOLOGICAL AND ENVIRONMENTAL-CONTROL OF REPRODUCTION IN POLYCHAETES. OCEANOGR MAR BIOL, 30, 443-481.
- AN ULTRASTRUCTURAL-STUDY OF SPERMATOGENESIS AND SPERM MORULA BREAKDOWN IN ARENICOLA-MARINA (L) (ANNELIDA, POLYCHAETA). HELGOLANDER MEERESUN, 46(2), 185-199.
- INTERMITTENT SWIMMING IN THE SPERMATOZOA OF THE POLYCHAETE ARENICOLA-MARINA (L). CELL MOTIL CYTOSKEL, 23(4), 305-305.
- THE ROLE OF ARACHIDONIC-ACID AND EICOSATRIENOIC ACIDS IN THE ACTIVATION OF SPERMATOZOA IN ARENICOLA-MARINA L (ANNELIDA, POLYCHAETA). BIOL BULL, 178(1), 1-9.
- A SCANNING ELECTRON MICROSCOPICAL STUDY OF SPERM DEVELOPMENT AND ACTIVATION IN ARENICOLA-MARINA-L (ANNELIDA, POLYCHAETA). INVERTEBR REPROD DEV, 15(3), 211-219.
- Accessing publicly funded donor insemination treatment in the UK: is funding information available on fertility clinic websites?. Human Fertility, 1-7.
- Fertility preservation and realignment in transgender women. Human Fertility, 1-20.
- An analysis of the outcome of 11 712 men applying to be sperm donors in Denmark and the USA. Human Reproduction.
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PREDICT‐GTN 1: Can we improve theFIGO scoring system in Gestational Trophoblastic Neoplasia?. International Journal of Cancer.
- Availability of services for the diagnosis and treatment of infertility in The Gambia`s public and private health facilities: a cross-sectional survey. BMC Health Services Research, 22(1).
- GM-CSF (granulocyte macrophage colony stimulating factor) supplementation in culture media for women undergoing assisted reproductive technology (ART). Cochrane Database of Systematic Reviews.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database of Systematic Reviews.
- The fertility fitness paradox of anabolic‐androgenic steroid abuse in men. Journal of Internal Medicine.
- Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCT. Efficacy and Mechanism Evaluation, 6(1), 1-80.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database of Systematic Reviews.
- Imaging seminiferous tubules – a 9.4T MRI mouse model.
- Men and infertility in The Gambia: Limited biomedical knowledge and awareness discourage male involvement and exacerbate gender-based impacts of infertility. PLOS ONE, 16(11), e0260084-e0260084.
- Barriers and facilitators for the inclusion of fertility care in reproductive health policies in Africa: a qualitative evidence synthesis. Human Reproduction Update.
Chapters
- Sperm Counts Are Falling Worldwide, 50 Big Debates in Reproductive Medicine (pp. 181-182). Cambridge University Press
- Andrology and Infertility, Reproductive Medicine for the MRCOG (pp. 43-53). Cambridge University Press
- The Effect of Age on Male Fertility and the Health of Offspring, Male and Sperm Factors that Maximize IVF Success (pp. 73-82). Cambridge University Press
- Male Fertility Preservation, Subfertility, Reproductive Endocrinology and Assisted Reproduction (pp. 222-226). Cambridge University Press
- Referring Patients for Sperm Banking In Pacey AA & Tomlinson MJ (Ed.), Sperm Banking: Theory and Practice (pp. 30-40). Cambridge University Press
- List of Contributors, Sperm Biology (pp. vii-viii). Elsevier
- Sperm, human fertility and society, Sperm Biology (pp. 565-597). Elsevier
- The psychological and psychosocial issues surrounding sperm banking, SPERM BANKING: THEORY AND PRACTICE (pp. 41-57).
- Sperm Banking: Theory and Practice Preface, SPERM BANKING: THEORY AND PRACTICE (pp. VII-VII).
- Sperm processing and storage, SPERM BANKING: THEORY AND PRACTICE (pp. 86-104).
- The history of sperm cryopreservation, SPERM BANKING: THEORY AND PRACTICE (pp. 1-17).
- Effects of antineoplastic and other medical treatments on sperm production, SPERM BANKING: THEORY AND PRACTICE (pp. 18-29).
- Legal and ethical aspects of sperm banking, SPERM BANKING: THEORY AND PRACTICE (pp. 58-72).
- Methods of sperm retrieval and banking in cancer patients, SPERM BANKING: THEORY AND PRACTICE (pp. 73-85).
- Assisted reproduction using banked sperm, SPERM BANKING: THEORY AND PRACTICE (pp. 105-114).
- Cryopreservation and storage of spermatozoa, Textbook of Assisted Reproductive Technologies (pp. 311-321). CRC Press
- Fertility Preservation Methods and Treatments for Males In Balen R & Crawshaw M (Ed.), Sexuality and Fertility Issues in Ill Health and Disability: From Early Adolescence to Adulthood (pp. 99-112). Jessica Kingsley Publishers
- Implantation and early development In Group RCOOAGGBS, Critchley HOD, Cameron IT, Smith SK & Britain RCOOAGG (Ed.), Implantation and early development
- Environmental chemicals and the threat to male fertility in mammals: evidence and perspective, Reproductive Science and Integrated Conservation (pp. 57-66). Cambridge University Press
- The Consultation with Older Men Seeking ART Treatment, Practical Problems in Assisted Conception (pp. 32-35). Cambridge University Press
- The Human Spermatozoa, Clinical Reproductive Science (pp. 65-73). John Wiley & Sons, Ltd
- Future developments for fertility preservation in men, Sperm Banking (pp. 115-121). Cambridge University Press
Conference proceedings papers
- The VALUE study: a qualitative semi-structured interview study of add-on use by patients, clinicians, and embryologists in the UK and Australia. HUMAN REPRODUCTION, Vol. 37
- Has time-lapse technology finally proven its clinical benefit?. HUMAN REPRODUCTION, Vol. 37 (pp I135-I135)
- An analysis of the outcome of 11,712 men applying to be sperm donors at Cryos International in Denmark and the USA. HUMAN REPRODUCTION, Vol. 37 (pp I109-I110)
- What is the attitude of gamete donors towards expanded genetic testing. HUMAN REPRODUCTION, Vol. 36 (pp 382-382)
- COVID-19, vertical transmission and ART pregnancy outcomes. HUMAN REPRODUCTION, Vol. 36 (pp 49-49)
- Examining the effect of nicotine on a mouse model of the ovarian reserve. HUMAN REPRODUCTION, Vol. 34 (pp 457-457)
- Time-lapse Systems for ART - a systematic review. HUMAN REPRODUCTION, Vol. 32 (pp 225-226)
- Human reproduction keynote lecture - Modifiable and non-modifiable risk factors for poor sperm morphology. HUMAN REPRODUCTION, Vol. 31 (pp 1-1)
- An algorithm for Morphological classification of motile human sperm. 2015 Sensor Data Fusion: Trends, Solutions, Applications (SDF), 6 October 2015 - 8 October 2015. View this article in WRRO
- Sperm DNA damage should be considered in infertile couples due to production of high inflammatory cytokines via toll-like receptors. HUMAN REPRODUCTION, Vol. 30 (pp 149-149)
- Sperm protection by TLRs in the male reproductive tract. HUMAN REPRODUCTION, Vol. 27
- Male Infertility and Cancer. EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S37-S37)
- Changes in sperm donor demographics in response to regulatory change. HUMAN REPRODUCTION, Vol. 26 (pp I145-I145)
- Travelling abroad for fertility treatment: an exploratory study of UK residents seeking cross-border care. HUMAN REPRODUCTION, Vol. 25 (pp I78-I78)
- Trihalomethanes and Semen Quality in England and Wales. EPIDEMIOLOGY, Vol. 20(6) (pp S196-S196)
- Advances in male fertility preservation. EJC SUPPLEMENTS, Vol. 7(2) (pp 15-15)
- Audit of an approach to post-vasectomy semen analysis (PVSA) - reliability, cost-effectiveness and feasibility of application to a nurse-led service.. BJU INTERNATIONAL, Vol. 99 (pp 38-38)
- Fluorescent viability testing of human sperm - a novel technique to establish vasectomy success in early postvasectomy recanalisation. BJU INTERNATIONAL, Vol. 99 (pp 38-38)
- Sex drugs and y-front - Modern threats to male reproductive health?. CLINICA CHIMICA ACTA, Vol. 355 (pp S455-S455)
- Increased sperm DNA damage in partners of women with unexplained recurrent miscarriages: preliminary report.. FERTILITY AND STERILITY, Vol. 78(3) (pp S166-S166)
- ASPECTS OF SPERM MOTILITY ACQUISITION IN ARENICOLA-MARINA L(ANNELIDA, POLYCHAETA). COMPARATIVE SPERMATOLOGY 20 YEARS AFTER, Vol. 75 (pp 527-531)
Patents
- Analysis Of Cell Morphology And Motility. Appl. 01 Sep 2005.
- Defining critical factors in multi-country studies of assisted reproductive technologies (ART): data from the US and UK health systems. Journal of Assisted Reproduction and Genetics, 37(11), 2767-2775.
- Research group
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Current Collaborators
- Lorraine Culley
- Christine Eiser
- Gary England
- Adrian Eley
- Eric Gillies
- Richard Green
- Teaching interests
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I lecture in Phase 1b (GU and Endocrine) and Phase 3 (Women´s Health) of the Bachelor of Medicine and Bachelor of Surgery (MBChB) course. I also contribute to the Student Selected Components of Phase 1a (Critical Analysis) and Phase 1b (Research Methods) and offer B. Med. Sci., projects.
Outside the Medical School, I lecture on Module MBB 331 (Gametes and Embryos) in the Department of Molecular Biology and Biotechnology and also the APS 120 (Reproduction and Development) module in the Department of Animal and Plant Sciences.
I am also the Course Director and Admissions Tutor for the MSc in Science Communication which is starting in the Autumn of 2011.
- Teaching activities
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- Medical Degree –MBChB
- MSc in Science Communication (new)
- Media involvement
TV Programmes
- Britain's Biggest Code Breaker
- Donor Unknown
- The Great Sperm Race (Channel 4)
- The Truth About Food (BBC Two)
- Lab Rats (Open University)
Selected Radio Interviews
- Consent to Sperm Donation
- Donor Egg Raffle
- Laboratory created sperm
- Donor sperm crisis affects couples
- Why do men find it harder to confront infertility?
- Intra-cytoplasmic morphologically selected sperm injection
- Is it a boy or a girl?
- Male Infertility
Recent Press Comments