Dr Francois Guesdon
Clinical Medicine, School of Medicine and Population Health
Honorary Lecturer
+44 114 215 9500
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
After obtaining my PhD in 1989 I joined the group of Jeremy Saklatvala in Cambridge. I was appointed in Sheffield in 1996 and am currently Course Tutor of the Msc in Molecular Medicine.
- Research interests
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My research interests are the signal transduction mechanisms of innate immunity cytokines such as IL-1, IL-17 or IL-25 and their roles in allergic (asthma) or chronic inflammatory diseases (arthritis).
Current Projects
- Induction of IL-25 expression by airborne allergens
- Regulation of the protein kinase TAK1
- Teaching activities
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- MSc module Leader: I have designed, set up and led six MSc modules since 2000, of which three are currently taught in the MSc of Molecular Medicine and / or the MSc in Reproductive and Developmental Medicine.
- Deputy Course Leader and Course Tutor of the MSc of Molecular Medicine: Responsible for progress monitoring, student support, disciplinary matters and chairing examination board meetings.
Programme development and support:
- 2000-present: I have designed, set up and led six MSc modules since 2000. I have also carried out yearly reviews of the contents, delivery formats and assessment of these modules and updated them when necessary.
- 2005: Key contributor to the process of reviewing two overlapping MSc courses and fusing them into a single modular course (MSc in Molecular Medicine), launched in 2006-2007.
- 2007-present: Designed and managed the personal tutoring scheme of the MSc in Molecular Medicine course and contributed to ensuring course compliance with QAA requirements
- 2010-2011: Led a task group that reviewed and improved the teaching and assessment of practical research professional skills in the MSc in Molecular Medicine.
- 2011-2012: Development and management of a new Faculty-wide training programme in Ethics and Integrity for post-graduate research students (in collaboration with Dr. P. Vivekananda-Schmidt).
- Professional activities and memberships
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2010 - University Senate Award for Excellence in Learning and Teaching (Collaboration category)
- Key Publications
See all publications on PubMed
Guesdon F, Kaabi Y, Riley AH, Wilkinson IR, Gray C, James DC, Artymiuk PJ, Sayers JR, Ross RJ. (2012) Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling. Biosci Rep, 32(6): 653-660.
Greetham D, Ellis CD, Mewar D, Fearon U, Ultaigh SNA, Veale DJ, Guesdon F & Wilson AG. (2007) Functional characterization of NF-kappa B inhibitor-like protein 1 (NF kappa BIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet, 16(24): 3027-36.
Ross K, Yang L, Dower S, Volpe F, Guesdon F. (2002) Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem,277(40): 37414-37421.
Dempsey CE, Sakurai H, Sugita T, Guesdon F. (2000) Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta, 1517(1): 46-52.
Guesdon F, Knight CG, Rawlinson LM, Saklatvala J. (1997) Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase. J Biol Chem, 272(48): 30017-30024.
Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78(6): 1039-1049.