Professor Ian Sabroe
MBBS, BSc, AKC, PhD, FRCP
Clinical Medicine, School of Medicine and Population Health
Consultant in Respiratory Medicine
Honorary Professor of Medical Humanities
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I am a chest physician. My clinical work centres around two specialist conditions: severe asthma and pulmonary arterial hypertension. I co-lead a network supporting severe asthma care across Yorkshire, and I'm one of the Sheffield consultants working on a national pulmonary vascular disease centre. I trained at King's College London, undertook post-graduate training rotations at various London hospitals (including the Royal Brompton Hospital and the Hammersmith Hospital) and also in Leeds. I undertook a PhD at the National Heart and Lung Institute, a post-doctoral research fellowship at Imperial College London, and then came to Sheffield on an MRC Clinician Scientist Fellowship and then an MRC Senior Clinical Fellowship.
- Research interests
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Between 1994 and 2019, my research interests were dominantly in mechanisms of innate immunity as applied to lung disease. From about 2016 onwards I developed an interest in the medical humanities, where most of my current research interests lie. I am interested in the experience of doctors who have had personal illness, the experience of delivering clinical care, how doctors handle and experience errors, the ethics of healthcare, and issues of justice in healthcare.
Current areas of work include how RSV causes lung disease, the immune system in diabetes, clinical trials in asthma (including new studies of lung imaging), support for COVID research, studies of how doctors experience their practice, and work around how doctors are affected by medical errors they may be associated with. I have recently undertaken a period of research examining how medical humanities are used and taught in the USA, with a view to bringing this knowledge to the UK.
- Publications
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Journal articles
- Mild parenchymal lung disease and/or low diffusion capacity impacts survival and treatment response in patients diagnosed with idiopathic pulmonary arterial hypertension. European Respiratory Journal, 55(6). View this article in WRRO
- Identification of cardiac MRI thresholds for risk stratification in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468. View this article in WRRO
- Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. eLife, 8. View this article in WRRO
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- Pellino-1 regulates immune responses to Haemophilus influenzae in models of inflammatory lung disease. Frontiers in Immunology, 10. View this article in WRRO
- Physician narratives of illness. The Lancet, 394(10192), 20-21. View this article in WRRO
- Express: The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry.. Pulmonary Circulation. View this article in WRRO
- Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- The care of dying people in 16th- and 17th-century England. Death Studies. View this article in WRRO
- Toll-like receptor 3 is a therapeutic target for pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 199(2). View this article in WRRO
- DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
- Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold. American Journal of Respiratory and Critical Care Medicine, 199(12), 1451-1452.
- Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models.. Radiology, 290(1). View this article in WRRO
- The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 52(3). View this article in WRRO
- DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator. Journal of Leukocyte Biology, 104(1), 159-171. View this article in WRRO
- Pathophysiology and diagnosis of pulmonary hypertension due to left heart disease. Frontiers in Medicine, 5. View this article in WRRO
- A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research, 7, 594-594. View this article in WRRO
- A social‐technological epistemology of clinical decision‐making as mediated by imaging. Journal of Evaluation in Clinical Practice, 23(5), 949-958. View this article in WRRO
- NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood, 130, 1014-1025. View this article in WRRO
- Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension. BMJ Open Respiratory Research, 4(1). View this article in WRRO
- Incremental Shuttle Walking Test Distance and Autonomic Dysfunction Predict Survival in Pulmonary Arterial Hypertension. The Journal of Heart and Lung Transplantation. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10. View this article in WRRO
- Idiopathic and Systemic Sclerosis associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Haemodynamic and Magnetic Resonance Imaging Characteristics and Outcomes.. Chest.
- Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension. European Respiratory Journal, 48(5), 1514-1514.
- Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension.. Respirology.
- A matter of time: study of circadian clocks and their role in inflammation. Journal of Leukocyte Biology, 99(4), 549-560.
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
- Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71, 187-189. View this article in WRRO
- Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic–pathophysiologic classification. The Journal of Heart and Lung Transplantation, 35(5), 610-618. View this article in WRRO
- Platelet P2Y 12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(12), 2562-2570. View this article in WRRO
- Management of acute pulmonary embolism. British Journal of Hospital Medicine, 76(10), C150-C155.
- Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascular Pharmacology, 71, 201-207. View this article in WRRO
- CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry. Thorax, 70(4), 382-387. View this article in WRRO
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Editorial: RSV: a new box of delights for an old enemy. Journal of Leukocyte Biology, 96(6), 945-947.
- The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 190(2), 145-154.
- 215 Ticagrelor Inhibits Release of Pro-inflammatory Cytokines TNF and IL-6 during Human Endotoxaemia.. Heart, 100 Suppl 3, A117-A118.
- Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre.. Ther Adv Respir Dis, 8(3), 71-77.
- Management dilemmas in acute pulmonary embolism.. Thorax, 69(2), 174-180. View this article in WRRO
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Practical phenotyping of difficult asthma.. Thorax, 69(3), 299-301.
- The yin and the yang of immunosuppression with inhaled corticosteroids.. Thorax, 68(12), 1085-1087.
- Pulmonary hypertension in COPD: results from the ASPIRE registry.. Eur Respir J, 41(6), 1292-1301.
- The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
- Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension.. Eur J Clin Microbiol Infect Dis, 32(7), 883-889.
- Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice and zebrafish. Blood, 123(3), 366-376.
- Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
- Pulmonary hypertension: diagnosis and management.. BMJ, 346, f2028.
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
- Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107. View this article in WRRO
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.. Eur Respir J, 39(4), 945-955.
- Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.. PLoS One, 7(2), e31506. View this article in WRRO
- Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
- Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.. Infect Immun, 80(3), 1140-1149. View this article in WRRO
- The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in WRRO
- TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
- Investigating The Role Of Pellino1, An E3 Ubiquitin Ligase, In Modulating Signalling Pathways Controlling The Inflammatory Response. B31. COMPLICATING INFECTIONS: INFLUENZA AND RHINOVIRUS.
- Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
- Neutrophil Recruitment In Response To Intradermal Endotoxin Challenge In The Human. C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation.. PLoS One, 6(1), e15768. View this article in WRRO
- Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.. Curr Mol Med, 10(8), 727-740. View this article in WRRO
- Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
- Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- Phosphatidylserine Species Are Novel Inhibitors Of A Range Of TLR-induced Inflammatory Responses Through Disruption Of Membrane Microdomains. D37. IMMUNE MECHANISMS IN THE LUNG.
- Investigation Of Cell Networks Involved In Airway Responses To Acute Infections. D33. AIRWAY INFECTION: MICROBIOME AND MECHANISMS.
- A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.. Immunology, 128(1), 58-68.
- The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes.. Clin Exp Immunol, 157(2), 216-224.
- Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.. Immunology, 127(2), 249-255.
- Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.. Clin Exp Immunol, 156(3), 386-394.
- Innate Immunity in Allergic Disease, 1, 187-202.
- The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
- Basic science of the innate immune system and the lung.. Paediatr Respir Rev, 9(4), 236-242.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.. Stem Cells, 26(10), 2552-2563.
- Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
- Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response.. Clin Exp Immunol, 152(3), 440-447.
- Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.. J Immunol, 180(5), 3502-3511. View this article in WRRO
- The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.. Am J Respir Crit Care Med, 177(1), 35-43. View this article in WRRO
- Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.. J Immunol, 179(12), 8544-8553.
- Incapacitating the immune system in cystic fibrosis.. Nat Med, 13(12), 1417-1418.
- Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
- Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease.. Biochem Soc Trans, 35(Pt 6), 1492-1495.
- A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees.. Am J Hum Genet, 81(4), 808-812.
- Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Reducing the toll of inflammatory lung disease.. Chest, 131(5), 1550-1556.
- Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311. View this article in WRRO
- Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
- Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.. J Leukoc Biol, 81(2), 372-382.
- T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy.. Allergy, 62(1), 59-65.
- Identifying and hurdling obstacles to translational research.. Nat Rev Immunol, 7(1), 77-82. View this article in WRRO
- Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
- "Dirty little secrets"--endotoxin contamination of recombinant proteins.. Immunol Lett, 106(1), 1-7.
- Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. Journal of Endotoxin Research, 12(3), 133-150.
- Potentiation of TLR4 signalling by plasmin activity.. Biochem Biophys Res Commun, 341(2), 299-303.
- Granulocyte apoptosis in the pathogenesis and resolution of lung disease.. Clin Sci (Lond), 110(3), 293-304. View this article in WRRO
- 9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2.. FEBS Lett, 580(2), 373-379.
- Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.. J Endotoxin Res, 12(3), 133-150.
- Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.. Clin Infect Dis, 41 Suppl 7, S421-S426.
- Toll-like receptors and chronic lung disease.. Clin Sci (Lond), 109(2), 125-133.
- The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.. Immunology, 115(1), 90-98.
- Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.. Am J Respir Crit Care Med, 171(8), 814-822.
- The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner.. Eur J Immunol, 35(4), 1301-1310.
- CCR6 as a peripheral tissue trafficking marker. Journal of Allergy and Clinical Immunology, 115(2), S14-S14.
- The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.. Am J Pathol, 165(5), 1819-1826.
- Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.. Biochem Soc Trans, 32(Pt3), 456-460.
- What can we learn from highly purified neutrophils?. Biochem Soc Trans, 32(Pt3), 468-469.
- Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
- T cell expression of CXCR1 is a marker of atopic allergy and is downregulated following grass pollen immunotherapy*1. Journal of Allergy and Clinical Immunology, 113(2), S106-S106.
- CXCR1+CD4+ T cells in human allergic disease.. J Immunol, 172(1), 268-273.
- CCR4 blockade does not inhibit allergic airways inflammation.. J Leukoc Biol, 74(4), 558-563.
- Toll-like receptors in health and disease: complex questions remain.. J Immunol, 171(4), 1630-1635. View this article in WRRO
- Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.. J Immunol, 170(12), 6190-6201.
- Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.. J Immunol, 170(10), 5268-5275.
- Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis.. J Immunol, 170(9), 4752-4758.
- Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.. J Immunol, 169(5), 2712-2718.
- Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.. J Biol Chem, 277(29), 26012-26020.
- Characterisation of the biological activity of recombinant equine eotaxin in vitro.. Cytokine, 19(1), 27-30.
- The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
- Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
- CCR4 in human allergen-induced late responses in the skin and lung.. Eur J Immunol, 32(7), 1933-1938.
- Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.. Am J Respir Crit Care Med, 165(12), 1602-1609.
- Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.. J Immunol, 168(9), 4701-4710.
- An audit of the use of self-administered adrenaline syringes in patients with angio-oedema.. Br J Dermatol, 146(4), 615-620.
- The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.. J Biol Chem, 277(9), 6864-6873.
- Chemokines, innate and adaptive immunity, and respiratory disease.. Eur Respir J, 19(2), 350-355.
- The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy.. Am J Respir Med, 1(1), 19-25.
- The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b.. J Biol Chem, 276(46), 42957-42964.
- GLAXO/MRS PAPERRoles of chemokines in the regulation of leucocyte recruitment*. Clinical Science, 100(4), 359-362.
- T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4.. J Immunol, 166(4), 2303-2310.
- Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry.. Methods Mol Med, 56, 345-355.
- Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.. J Immunol, 165(12), 7224-7233.
- Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo.. J Immunol, 165(11), 6447-6453.
- Asthma and MIF: innately Th1 and Th2.. Clin Exp Allergy, 30(9), 1194-1196.
- A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.. J Biol Chem, 275(34), 25985-25992.
- Targeting Eosinophil and Basophil Recruitment: Antagonism of Chemokine Receptor Signalling. Clinical Science, 99(s43), 4P-4P.
- The Role of Eosinophil Chemokine Receptors in Allergic Inflammation in Vivo. Clinical Science, 95(s39), 13P-13P.
- Sarcoidosis presenting with chylothorax.. Thorax, 50(12), 1324-1325.
- Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin.. Thorax, 50(11), 1219-1220.
- Thromboembolic occlusion of a pulmonary arteriovenous malformation. A very unusual pulmonary embolism.. BMJ, 311(7004), 553-555.
- Use of thermal imaging to monitor crural thrombolysis. Blood Coagulation & Fibrinolysis, 3(4), 489-491.
- Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I. Frontiers in Medicine, 5. View this article in WRRO
- Macrophage Phenotype Is Associated with Disease Severity in Preterm Infants with Chronic Lung Disease. PLoS ONE, 9(8), e103059-e103059. View this article in WRRO
Chapters
- Toll-like receptor 4, New Drugs and Targets for Asthma and COPD (pp. 81-86). KARGER
- The Neutrophil, Immunology of Fungal Infections (pp. 51-73). Springer Netherlands
- TOLL-LIKE RECEPTORS, Encyclopedia of Respiratory Medicine (pp. 235-239). Elsevier
- EOTAXINS, Encyclopedia of Respiratory Medicine (pp. 125-129). Elsevier
- LEUKOCYTES | Neutrophils, Encyclopedia of Respiratory Medicine (pp. 547-551). Elsevier
- Chemokines: An Overview, New Drugs for Asthma, Allergy and COPD (pp. 280-283). KARGER
Conference proceedings papers
- Correlations of ventilation heterogeneity and spirometry in asthma; initial experience with hyperpolarised gas MRI in a clinical setting. Imaging
- Risk stratification of pulmonary arterial hypertension (PAH) associated with adult congenital heart disease (ACHD). Pulmonary hypertension
- Diagnostic and prognostic value of a diagnostic CT regression model in suspected pulmonary hypertension. Pulmonary hypertension
- The Incremental Shuttle Walking Test Can Be Used to Risk Stratify Patients with Pulmonary Hypertension as Per the European Respiratory/Cardiac Society Guidelines. A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH
- Cardiac MRI: Identifying Thresholds to Predict Mortality in Pulmonary Arterial Hypertension. B27. HEARTBREAKER: HEART FAILURE AND PULMONARY HYPERTENSION
- P16 Identifying partial anomalous pulmonary venous drainage (PAPVD) in patients presenting with suspected pulmonary hypertension (PH). Under pressure: an update in pulmonary vascular disease
- S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
- S90 Assessing regional lung ventilation in patients and healthy volunteers using 19F-MRI of inhaled perfluoropropane. It’s all about your image: new approaches to thoracic imaging
- Good outcomes following elective lower limb orthopaedic surgery in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Pulmonary hypertension
- Assessing regional lung ventilation with 19F-MRI of inhaled perfluoropropane. Imaging
- Incremental shuttle walking test distance is reduced in patients with pulmonary hypertension in WHO Functional Class I. Pulmonary hypertension
- Incremental Shuttle Walk Test predicts survival in non-Group 1 Pulmonary Hypertension without a ceiling effect. Pulmonary hypertension
- Anomalous pulmonary venous drainage (APVD) in patients with suspected pulmonary hypertension (PH). Pulmonary hypertension
- P183 Impact of patient choice on survival in patients with chronic thromboembolic pulmonary hypertension offered pulmonary endarterectomy. Pulmonary vascular disease: monitoring and managing
- P180 Managing pregnancy in pulmonary hypertension using a multi-professional approach: a 16-year experience in a specialist referral centre. Pulmonary vascular disease: monitoring and managing
- Managing pregnancy in pulmonary hypertension using a multi-professional approach: a 16-year experience in a specialist referral centre. Pulmonary Circulation and Pulmonary Vascular Disease
- P28 Chronic thromboembolic pulmonary hypertension: long term outcomes in surgical and non-surgical patients. Thorax, Vol. 71(Suppl 3) (pp A98.1-A98)
- S111 Differences in characteristics and outcomes in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. Thorax, Vol. 71(Suppl 3) (pp A66-A67)
- S87 Deficiency of toll-like receptor 3 (TLR3) exacerbates pulmonary hypertension in mice. Thorax, Vol. 71(Suppl 3) (pp A50.1-A50)
- Chronic thrombo-embolic pulmonary hypertension: Long-term outcomes in operated and non-operated patients. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
- P283 Hyperpolarised Gas MRI – a pathway to Clinical Diagnostic Imaging. Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- 203 Ticagrelor and Clopidogrel Attenuate the Prothrombotic State induced by Bacterial Endotoxaemia. Heart, Vol. 101(Suppl 4) (pp A112.1-A112)
- TICAGRELOR INHIBITS CHANGES IN FIBRIN CLOT STRUCTURE INDUCED BY BACTERIAL ENDOTOXEMIA. Journal of the American College of Cardiology, Vol. 65(10) (pp A12-A12)
- TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES. Journal of the American College of Cardiology, Vol. 65(10) (pp A259-A259)
- HEPATOCYTE GROWTH FACTOR CONCENTRATION CORRELATES WITH HAEMODYNAMIC SEVERITY IN CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 68 (pp A146-A147)
- HYPOXIA-INDUCIBLE FACTOR 2 alpha REGULATES NEUTROPHILIC INFLAMMATION IN HUMANS, MICE AND ZEBRAFISH. THORAX, Vol. 67 (pp A1-A1)
- Characteristics And Outcomes In Pulmonary Hypertension Associated With COPD/ Emphysema: Results From The ASPIRE Registry. B107. BIOMARKERS AND PREDICTORS OF OUTCOMES IN PULMONARY HYPERTENSION
- Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
- HIF-2± Regulates Neutrophilic Inflammation In Humans, Mice And Zebrafish. C31. REGULATION OF LUNG INFLAMMATION
- CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
- INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
- PULMONARY HYPERTENSION (PH) ASSOCIATED WITH LUNG DISEASE/HYPOXIA. THORAX, Vol. 65 (pp A93-A93)
- S80 The role of MyD88 in rhinovirus 1B infection. Thorax, Vol. 65(Suppl 4) (pp A37-A38)
- DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
- DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
- SUBVERSION OF NEUTROPHIL APOPTOSIS BY STAPHYLOCOCCUS AUREUS: CONSEQUENCES FOR BACTERIAL PATHOGENESIS AND HOST DEFENCE. THORAX, Vol. 64 (pp A36-A36)
- Mild parenchymal lung disease and/or low diffusion capacity impacts survival and treatment response in patients diagnosed with idiopathic pulmonary arterial hypertension. European Respiratory Journal, 55(6). View this article in WRRO
- Teaching interests
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I teach clinical respiratory medicine, undergraduate medical sciences, the medical humanities, and post-graduate medical education.
- Professional activities and memberships
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I have worked for a number of national grant reviewing bodies. I am a Churchill Fellow, a Fellow of the Royal Society of Arts, and a Fellow of other respiratory specialist bodies