Professor Ian Sabroe

MBBS, BSc, AKC, PhD, FRCP

Clinical Medicine, School of Medicine and Population Health

Consultant in Respiratory Medicine

Honorary Professor of Medical Humanities

i.sabroe@sheffield.ac.uk

+44 114 271 1863 (Fax)

The Medical School

Full contact details

Professor Ian Sabroe
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile: I am a chest physician. My clinical work centres around two specialist conditions: severe asthma and pulmonary arterial hypertension. I co-lead a network supporting severe asthma care across Yorkshire, and I'm one of the Sheffield consultants working on a national pulmonary vascular disease centre. I trained at King's College London, undertook post-graduate training rotations at various London hospitals (including the Royal Brompton Hospital and the Hammersmith Hospital) and also in Leeds. I undertook a PhD at the National Heart and Lung Institute, a post-doctoral research fellowship at Imperial College London, and then came to Sheffield on an MRC Clinician Scientist Fellowship and then an MRC Senior Clinical Fellowship.

Research interests

Between 1994 and 2019, my research interests were dominantly in mechanisms of innate immunity as applied to lung disease. From about 2016 onwards I developed an interest in the medical humanities, where most of my current research interests lie. I am interested in the experience of doctors who have had personal illness, the experience of delivering clinical care, how doctors handle and experience errors, the ethics of healthcare, and issues of justice in healthcare.

Current areas of work include how RSV causes lung disease, the immune system in diabetes, clinical trials in asthma (including new studies of lung imaging), support for COVID research, studies of how doctors experience their practice, and work around how doctors are affected by medical errors they may be associated with. I have recently undertaken a period of research examining how medical humanities are used and taught in the USA, with a view to bringing this knowledge to the UK.

Publications

Journal articles

Lewis RA, Thompson AAR, Billings CG, Charalampopoulos A, Elliot CA, Hamilton N, Hill C, Hurdman J, Rajaram S, Sabroe I , Swift AJ et al (2020) Mild parenchymal lung disease and/or low diffusion capacity impacts survival and treatment response in patients diagnosed with idiopathic pulmonary arterial hypertension. European Respiratory Journal, 55(6). View this article in WRRO
Lewis RA, Johns CS, Cogliano M, Capener D, Tubman E, Elliot CA, Charalampopoulos A, Sabroe I, Thompson AAR, Billings CG , Hamilton N et al (2020) Identification of cardiac MRI thresholds for risk stratification in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468. View this article in WRRO
Rahman A, Henry KM, Herman KD, Thompson AAR, Isles HM, Tulotta C, Sammut D, Rougeot JJY, Khoshaein N, Reese AE , Higgins K et al (2019) Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. eLife, 8. View this article in WRRO
Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS & Parker LC (2019) Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC , Dockrell DH et al (2019) Pellino-1 regulates immune responses to Haemophilus influenzae in models of inflammatory lung disease. Frontiers in Immunology, 10. View this article in WRRO
Wilson A, Millard C & Sabroe I (2019) Physician narratives of illness. The Lancet, 394(10192), 20-21. View this article in WRRO
Billings CG, Lewis R, Hurdman JA, Condliffe R, Elliot C, Thompson AAR, Smith IA, Austin M, Armstrong IJ, Hamilton N , Charalampopoulos A et al (2019) Express: The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry.. Pulmonary Circulation. View this article in WRRO
Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA , Jacques RM et al (2019) Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
Germain L & Sabroe I (2019) The care of dying people in 16th- and 17th-century England. Death Studies. View this article in WRRO
Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H , Cole JE et al (2019) Toll-like receptor 3 is a therapeutic target for pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 199(2). View this article in WRRO
Manley GCA, Stokes CA, Marsh EK, Sabroe I & Parker LC (2019) DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
Sabroe I, Ho A & Dockrell DH (2019) Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold. American Journal of Respiratory and Critical Care Medicine, 199(12), 1451-1452.
Johns CS, Kiely DG, Rajaram S, Hill C, Thomas S, Karunasaagarar K, Garg P, Hamilton N, Solanki R, Capener DA , Elliot C et al (2018) Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models.. Radiology, 290(1). View this article in WRRO
Quadery SR, Swift AJ, Billings C, Thompson AAR, Elliot CA, Hurdman J, Charalampopoulos A, Sabroe I, Armstrong I, Hamilton N , Sephton P et al (2018) The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 52(3). View this article in WRRO
Peinhaupt M, Roula D, Theiler A, Sedej M, Schicho R, Marsche G, Sturm EM, Sabroe I, Rothenberg ME & Heinemann A (2018) DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator. Journal of Leukocyte Biology, 104(1), 159-171. View this article in WRRO
Charalampopoulos A, Lewis R, Hickey P, Durrington C, Elliot C, Condliffe R, Sabroe I & Kiely DG (2018) Pathophysiology and diagnosis of pulmonary hypertension due to left heart disease. Frontiers in Medicine, 5. View this article in WRRO
Hamilton N, Sabroe I & Renshaw SA (2018) A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research, 7, 594-594. View this article in WRRO
van Baalen S, Carusi A, Sabroe I & Kiely DG (2017) A social‐technological epistemology of clinical decision‐making as mediated by imaging. Journal of Evaluation in Clinical Practice, 23(5), 949-958. View this article in WRRO
Prince LR, Dannewitz Prosseda S, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P , Renshaw SA et al (2017) NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood, 130, 1014-1025. View this article in WRRO
Goddard J, Armstrong I, Kiely D, Elliot C, Charalampopoulos A, Condliffe R, Stone B & Sabroe I (2017) Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension. BMJ Open Respiratory Research, 4(1). View this article in WRRO
Billings CG, Hurdman JA, Condliffe RA, Elliot CA, Smith IA, Austin M, Armstrong IJ, Hamilton N, Charalampopoulos A, Sabroe I , Swift AJ et al (2017) Incremental Shuttle Walking Test Distance and Autonomic Dysfunction Predict Survival in Pulmonary Arterial Hypertension. The Journal of Heart and Lung Transplantation. View this article in WRRO
Stokes C, Kaur R, Edwards MR, Mohdhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2017) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10. View this article in WRRO
Ramjug S, Hussain N, Hurdman J, Billings C, Charampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ & Condliffe R (2017) Idiopathic and Systemic Sclerosis associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Haemodynamic and Magnetic Resonance Imaging Characteristics and Outcomes.. Chest.
Hickey PM, Thompson AA, Charalampopoulos A, Elliot CA, Hamilton N, Kiely DG, Lawrie A, Sabroe I & Condliffe R (2016) Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension. European Respiratory Journal, 48(5), 1514-1514.
Ramjug S, Hussain N, Hurdman J, Elliot CA, Sabroe I, Armstrong IJ, Billings C, Hamilton N, Kiely DG & Condliffe R (2016) Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension.. Respirology.
Carter SJ, Durrington HJ, Gibbs JE, Blaikley J, Loudon AS, Ray DW & Sabroe I (2016) A matter of time: study of circadian clocks and their role in inflammation. Journal of Leukocyte Biology, 99(4), 549-560.
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2016) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R , Arron JR et al (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71, 187-189. View this article in WRRO
Ramjug S, Hussain N, Hurdman J, Billings C, Charalampopoulos A, Elliot CA, Sabroe I, Kiely DG & Condliffe R (2016) Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic–pathophysiologic classification. The Journal of Heart and Lung Transplantation, 35(5), 610-618. View this article in WRRO
Thomas MR, Outteridge SN, Ajjan RA, Phoenix F, Sangha GK, Faulkner RE, Ecob R, Judge HM, Khan H, West LE , Dockrell DH et al (2015) Platelet P2Y 12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(12), 2562-2570. View this article in WRRO
Quadery R, Elliot CA, Hurdman J, Kiely DG, Maclean RM, Sabroe I, van Veen JJ & Condliffe R (2015) Management of acute pulmonary embolism. British Journal of Hospital Medicine, 76(10), C150-C155.
Alsharif KF, Thomas MR, Judge HM, Khan H, Prince LR, Sabroe I, Ridger VC & Storey RF (2015) Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascular Pharmacology, 71, 201-207. View this article in WRRO
Rajaram S, Swift AJ, Condliffe R, Johns C, Elliot CA, Hill C, Davies C, Hurdman J, Sabroe I, Wild JM & Kiely DG (2015) CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry. Thorax, 70(4), 382-387. View this article in WRRO
Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
Sabroe I, Dockrell DH & Culley FJ (2014) Editorial: RSV: a new box of delights for an old enemy. Journal of Leukocyte Biology, 96(6), 945-947.
Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE , Marsden R et al (2014) The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 190(2), 145-154.
Thomas M, Judge H, Dockrell D, Sabroe I & Storey R (2014) 215 Ticagrelor Inhibits Release of Pro-inflammatory Cytokines TNF and IL-6 during Human Endotoxaemia.. Heart, 100 Suppl 3, A117-A118.
Condliffe R, Elliot CA, Hurdman J, Sabroe I, Billings C, Kiely DG & Hamilton N (2014) Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre.. Ther Adv Respir Dis, 8(3), 71-77.
Condliffe R, Elliot CA, Hughes RJ, Hurdman J, Maclean RM, Sabroe I, van Veen JJ & Kiely DG (2014) Management dilemmas in acute pulmonary embolism.. Thorax, 69(2), 174-180. View this article in WRRO
Parker LC, Stokes CA & Sabroe I (2014) Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
Thomas A, Green RH, Niven RM, Saha S, Hall I, Heaney LG & Sabroe I (2014) Practical phenotyping of difficult asthma.. Thorax, 69(3), 299-301.
Ramjug S, Hurdman J, Hussain N, Sabroe I, Elliot C, Kiely D & Condliffe R (2013) Pulmonary hypertension associated with congenital heart disease (PH-CHD): Results from the ASPIRE registry. EUROPEAN RESPIRATORY JOURNAL, 42.
Sabroe I, Postma D, Heijink I & Dockrell DH (2013) The yin and the yang of immunosuppression with inhaled corticosteroids.. Thorax, 68(12), 1085-1087.
Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C , Pollard L et al (2013) Pulmonary hypertension in COPD: results from the ASPIRE registry.. Eur Respir J, 41(6), 1292-1301.
Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
Sammut D, Elliot CA, Kiely DG, Armstrong IJ, Martin L, Wilkinson J, Sephton P, Jones J, Hamilton N, Hurdman J , McLellan E et al (2013) Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension.. Eur J Clin Microbiol Infect Dis, 32(7), 883-889.
Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice and zebrafish. Blood, 123(3), 366-376.
Sabroe RA, Stokes CA, Parker LC, Higgins K, Prince LR & Sabroe I (2013) Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
Kiely DG, Elliot CA, Sabroe I & Condliffe R (2013) Pulmonary hypertension: diagnosis and management.. BMJ, 346, f2028.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC & Sabroe I (2012) Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107. View this article in WRRO
Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
Hurdman J, Condliffe R, Elliot CA, Davies C, Hill C, Wild JM, Capener D, Sephton P, Hamilton N, Armstrong IJ , Billings C et al (2012) ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.. Eur Respir J, 39(4), 945-955.
Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ & Whyte MKB (2012) Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.. PLoS One, 7(2), e31506. View this article in WRRO
McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.. Infect Immun, 80(3), 1140-1149. View this article in WRRO
Prince LR, Whyte MK, Sabroe I & Parker LC (2011) The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in WRRO
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
Bennett J, Prince L, Sabroe I & Whyte M (2011) Investigating The Role Of Pellino1, An E3 Ubiquitin Ligase, In Modulating Signalling Pathways Controlling The Inflammatory Response. B31. COMPLICATING INFECTIONS: INFLUENZA AND RHINOVIRUS.
Walmsley SR, Chilvers ER, Thompson A, Vaughan K, Marriott H, Parker L, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell D et al (2011) Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
Basran AK, Bingle L, Jabeen M, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2011) Neutrophil Recruitment In Response To Intradermal Endotoxin Challenge In The Human. C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE.
Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
Wardle DJ, Burgon J, Sabroe I, Bingle CD, Whyte MKB & Renshaw SA (2011) Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation.. PLoS One, 6(1), e15768. View this article in WRRO
Collini P, Noursadeghi M, Sabroe I, Miller RF & Dockrell DH (2010) Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.. Curr Mol Med, 10(8), 727-740. View this article in WRRO
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
Parker L, Alfieri A, Brookes Z & Sabroe I (2010) Phosphatidylserine Species Are Novel Inhibitors Of A Range Of TLR-induced Inflammatory Responses Through Disruption Of Membrane Microdomains. D37. IMMUNE MECHANISMS IN THE LUNG.
Druce CLARE, Bennett J, Kay L, Parker L & Sabroe I (2010) Investigation Of Cell Networks Involved In Airway Responses To Acute Infections. D33. AIRWAY INFECTION: MICROBIOME AND MECHANISMS.
Chaudhuri N, Piddock K, Donaldson K, Parker L & Sabroe I (2010) Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
Ward JR, Francis SE, Marsden L, Suddason T, Lord GM, Dower SK, Crossman DC & Sabroe I (2009) A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.. Immunology, 128(1), 58-68.
Anwar S, Prince LR, Foster SJ, Whyte MKB & Sabroe I (2009) The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes.. Clin Exp Immunol, 157(2), 216-224.
Dick EP, Prince LR, Prestwich EC, Renshaw SA, Whyte MKB & Sabroe I (2009) Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.. Immunology, 127(2), 249-255.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.. Clin Exp Immunol, 156(3), 386-394.
Sabroe I (2009) Innate Immunity in Allergic Disease, 1, 187-202.
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2009) The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
Parker LC, Prince LR, Buttle DJ & Sabroe I (2009) The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
Chaudhuri N & Sabroe I (2008) Basic science of the innate immune system and the lung.. Paediatr Respir Rev, 9(4), 236-242.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
Dick EP, Prince LR & Sabroe I (2008) Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.. Stem Cells, 26(10), 2552-2563.
West PW, Parker LC, Ward JR & Sabroe I (2008) Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
Francis JN, Sabroe I, Lloyd CM, Durham SR & Till SJ (2008) Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response.. Clin Exp Immunol, 152(3), 440-447.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2008) Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH & Whyte MKB (2008) Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.. J Immunol, 180(5), 3502-3511. View this article in WRRO
Sabroe I, Parker LC, Dower SK & Whyte MKB (2008) The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW & Whyte MKB (2008) Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.. Am J Respir Crit Care Med, 177(1), 35-43. View this article in WRRO
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A & Whyte MKB (2007) Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.. J Immunol, 179(12), 8544-8553.
Sabroe I & Whyte MKB (2007) Incapacitating the immune system in cystic fibrosis.. Nat Med, 13(12), 1417-1418.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2007) Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
Sabroe I & Whyte MKB (2007) Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease.. Biochem Soc Trans, 35(Pt 6), 1492-1495.
Kosta K, Sabroe I, Goke J, Nibbs RJ, Tsanakas J, Whyte MK & Teare MD (2007) A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees.. Am J Hum Genet, 81(4), 808-812.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2007) Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
Chaudhuri N, Whyte MKB & Sabroe I (2007) Reducing the toll of inflammatory lung disease.. Chest, 131(5), 1550-1556.
Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK & Whyte MKB (2007) Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311. View this article in WRRO
Parker LC, Prince LR & Sabroe (2007) Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol, 147, 199-207.
Parker LC, Prince LR & Sabroe I (2007) Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
Sandig H, Pease JE & Sabroe I (2007) Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.. J Leukoc Biol, 81(2), 372-382.
Francis JN, Lloyd CM, Sabroe I, Durham SR & Till SJ (2007) T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy.. Allergy, 62(1), 59-65.
Sabroe I, Dockrell DH, Vogel SN, Renshaw SA, Whyte MKB & Dower SK (2007) Identifying and hurdling obstacles to translational research.. Nat Rev Immunol, 7(1), 77-82. View this article in WRRO
Morris GE, Parker LC, Ward JR, Jones EC, Whyte MKB, Brightling CE, Bradding P, Dower SK & Sabroe I (2006) Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
Wakelin SJ, Sabroe I, Gregory CD, Poxton IR, Forsythe JLR, Garden OJ & Howie SEM (2006) "Dirty little secrets"--endotoxin contamination of recombinant proteins.. Immunol Lett, 106(1), 1-7.
Medvedev AE, Sabroe I, Hasday JD & Vogel SN (2006) Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. Journal of Endotoxin Research, 12(3), 133-150.
Ward JR, Dower SK, Whyte MKB, Buttle DJ & Sabroe I (2006) Potentiation of TLR4 signalling by plasmin activity.. Biochem Biophys Res Commun, 341(2), 299-303.
Bianchi SM, Dockrell DH, Renshaw SA, Sabroe I & Whyte MKB (2006) Granulocyte apoptosis in the pathogenesis and resolution of lung disease.. Clin Sci (Lond), 110(3), 293-304. View this article in WRRO
Sandig H, Andrew D, Barnes AA, Sabroe I & Pease J (2006) 9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2.. FEBS Lett, 580(2), 373-379.
Medvedev AE, Sabroe I, Hasday JD & Vogel SN (2006) Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.. J Endotoxin Res, 12(3), 133-150.
Parker LC, Jones EC, Prince LR, Dower SK, Whyte MKB & Sabroe I (2005) Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
Sabroe I, Dower SK & Whyte MKB (2005) The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.. Clin Infect Dis, 41 Suppl 7, S421-S426.
Ward JR, Bingle L, Judge HM, Brown SB, Storey RF, Whyte MKB, Dower SK, Buttle DJ & Sabroe I (2005) Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor.. Thromb Haemost, 94(4), 831-838.
Chaudhuri N, Dower SK, Whyte MKB & Sabroe I (2005) Toll-like receptors and chronic lung disease.. Clin Sci (Lond), 109(2), 125-133.
Parker LC, Whyte MKB, Dower SK & Sabroe I (2005) The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
Sabroe I, Jones EC, Whyte MKB & Dower SK (2005) Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.. Immunology, 115(1), 90-98.
Morris GE, Whyte MKB, Martin GF, Jose PJ, Dower SK & Sabroe I (2005) Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.. Am J Respir Crit Care Med, 171(8), 814-822.
Sabroe I, Jorritsma A, Stubbs VEL, Xanthou G, Jopling LA, Ponath PD, Williams TJ, Murphy PM & Pease JE (2005) The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner.. Eur J Immunol, 35(4), 1301-1310.
Francis JN, Till SJ, Banfield GK, Sabroe I & Durham SR (2005) CCR6 as a peripheral tissue trafficking marker. Journal of Allergy and Clinical Immunology, 115(2), S14-S14.
Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MKB & Sabroe I (2004) The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.. Am J Pathol, 165(5), 1819-1826.
Walmsley SR, Cowburn AS, Sobolewski A, Murray J, Farahi N, Sabroe I & Chilvers ER (2004) Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.. Biochem Soc Trans, 32(Pt3), 456-460.
Sabroe I, Prince LR, Dower SK, Walmsley SR, Chilvers ER & Whyte MKB (2004) What can we learn from highly purified neutrophils?. Biochem Soc Trans, 32(Pt3), 468-469.
Parker LC, Whyte MKB, Vogel SN, Dower SK & Sabroe I (2004) Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
FRANCIS J (2004) T cell expression of CXCR1 is a marker of atopic allergy and is downregulated following grass pollen immunotherapy*1. Journal of Allergy and Clinical Immunology, 113(2), S106-S106.
Sabroe I, Whyte MKB, Wilson AG, Dower SK, Hubbard R & Hall I (2004) Toll-like receptor (TLR) 4 polymorphisms and COPD.. Thorax, 59(1), 81.
Francis JN, Jacobson MR, Lloyd CM, Sabroe I, Durham SR & Till SJ (2004) CXCR1+CD4+ T cells in human allergic disease.. J Immunol, 172(1), 268-273.
Conroy DM, Jopling LA, Lloyd CM, Hodge MR, Andrew DP, Williams TJ, Pease JE & Sabroe I (2003) CCR4 blockade does not inhibit allergic airways inflammation.. J Leukoc Biol, 74(4), 558-563.
Sabroe I, Read RC, Whyte MKB, Dockrell DH, Vogel SN & Dower SK (2003) Toll-like receptors in health and disease: complex questions remain.. J Immunol, 171(4), 1630-1635. View this article in WRRO
Phillips RM, Stubbs VEL, Henson MR, Williams TJ, Pease JE & Sabroe I (2003) Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.. J Immunol, 170(12), 6190-6201.
Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK & Whyte MKB (2003) Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.. J Immunol, 170(10), 5268-5275.
Heinemann A, Schuligoi R, Sabroe I, Hartnell A & Peskar BA (2003) Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis.. J Immunol, 170(9), 4752-4758.
Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ & Kay AB (2002) Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.. J Immunol, 169(5), 2712-2718.
Stubbs VEL, Schratl P, Hartnell A, Williams TJ, Peskar BA, Heinemann A & Sabroe I (2002) Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.. J Biol Chem, 277(29), 26012-26020.
Benarafa C, Collins ME, Hamblin AS, Sabroe I & Cunningham FM (2002) Characterisation of the biological activity of recombinant equine eotaxin in vitro.. Cytokine, 19(1), 27-30.
Sabroe IAN, Jones EC, Usher LR, Alapati S, Parker LC, Whyte MKB & Dower SK (2002) The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
Sabroe I, Parker LC, Wilson AG, Whyte MKB & Dower SK (2002) Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
Nouri-Aria KT, Wilson D, Francis JN, Jopling LA, Jacobson MR, Hodge MR, Andrew DP, Till SJ, Varga E-M, Williams TJ , Pease JE et al (2002) CCR4 in human allergen-induced late responses in the skin and lung.. Eur J Immunol, 32(7), 1933-1938.
Bryan SA, Jose PJ, Topping JR, Wilhelm R, Soderberg C, Kertesz D, Barnes PJ, Williams TJ, Hansel TT & Sabroe I (2002) Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.. Am J Respir Crit Care Med, 165(12), 1602-1609.
Sabroe I, Jones EC, Usher LR, Whyte MKB & Dower SK (2002) Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.. J Immunol, 168(9), 4701-4710.
Sabroe RA, Glendinning A-K, Sabroe I, Lawlor F & Kobza Black A (2002) An audit of the use of self-administered adrenaline syringes in patients with angio-oedema.. Br J Dermatol, 146(4), 615-620.
Heinemann A, Stubbs VEL, Schartl P, Peskar BA & Sabroe I (2002) Indomethacin induces chemotaxis of human peripheral blood eosinophils in vitro. N-S ARCH PHARMACOL, 365, R77-R77.
Jopling LA, Sabroe I, Andrew DP, Mitchell TJ, Li Y, Hodge MR, Williams TJ & Pease JE (2002) The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.. J Biol Chem, 277(9), 6864-6873.
Sabroe I, Lloyd CM, Whyte MKB, Dower SK, Williams TJ & Pease JE (2002) Chemokines, innate and adaptive immunity, and respiratory disease.. Eur Respir J, 19(2), 350-355.
Menzies-Gow A, Stubbs V, Sabroe I & Kay AB (2002) Is eotaxin-induced neutrophil infiltration in human skin CCR3-dependent?. J ALLERGY CLIN IMMUN, 109(1), S364-S364.
Durham S, Nouri-Aria KT, Wilson DR, Jacobson MR, Varga EM, Williams T, Pease J, Lloyd C & Sabroe I (2002) Regulation of CCR4 expression after segmental bronchial allergen challenge in atopic asthmatics. J ALLERGY CLIN IMMUN, 109(1), S41-S41.
Francis J, Till S, Qin SX, Williams T, Durham S, Lloyd C & Sabroe I (2002) Characterisation and regulation of lymphocyte chemokine receptor expression in normal and atopic donors. J ALLERGY CLIN IMMUN, 109(1), S62-S63.
Pease JE & Sabroe I (2002) The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy.. Am J Respir Med, 1(1), 19-25.
Sabroe I, Jones EC, Usher LR, Dower SK & Whyte MKB (2001) Expression and function of Toll-like receptors TLR2 and TLR4 in human neutrophils, eosinophils and basophils. THORAX, 56, 9-9.
Chadwick SL, Walker S, Muramaki K, Heinemann A, Hartnell A, Williams TJ, Durham SR & Sabroe I (2001) Basophil gated fluorescence/forward scatter (bGFS) assay for the investigation of IgE mediated allergic responses and its comparison to skin prick testing. THORAX, 56, 34-34.
Martinelli R, Sabroe I, LaRosa G, Williams TJ & Pease JE (2001) The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b.. J Biol Chem, 276(46), 42957-42964.
Francis J, Till S, Lloyd C, Sabroe I, Williams T & Durham S (2001) Chemokine receptor-4 expression in peripheral blood T lymphocytes derived from atopic and normal donors. CLIN EXP ALLERGY, 31(7), 1161-1161.
Nouri-Aria KT, Walker S, Jopling LA, Jacobson MR, Pease J, Sabroe I, Williams T & Durham SR (2001) Up-regulation of CCR4 mRNA expression after intradermal allergen challenge in atopic rhinitics. CLIN EXP ALLERGY, 31(7), 1149-1149.
SABROE I, WILLIAMS TJ & PEASE JE (2001) GLAXO/MRS PAPERRoles of chemokines in the regulation of leucocyte recruitment*. Clinical Science, 100(4), 359-362.
Sabroe I, Williams TJ & Pease JE (2001) Roles of chemokines in the regulation of leucocyte recruitment.. Clin Sci (Lond), 100(4), 359-362.
Till S, Jopling L, Wachholz P, Robson R, Qin S, Andrew D, Wu L, van Neerven J, Williams T, Durham S & Sabroe I (2001) T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4.. J Immunol, 166(4), 2303-2310.
Menzies-Gow A, Sabroe I, Meng Q, Soler D, Clarke-Lewis I, Williams TJ, Ying S & Kay AB (2001) Intracutaneous eotaxin and eotaxin-2 induces the local accumulation of eosinophils, basophils, macrophages and neutrophils in human atopic and non-atopic subjects. J ALLERGY CLIN IMMUN, 107(2), S324-S324.
Bryan SA, Leckie MJ, Jenkins G, Barnes PJ, Williams TJ, Sabroe I & Hansel TT (2001) Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry.. Methods Mol Med, 56, 345-355.
Heinemann A, Hartnell A, Stubbs VE, Murakami K, Soler D, LaRosa G, Askenase PW, Williams TJ & Sabroe I (2000) Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.. J Immunol, 165(12), 7224-7233.
Sabroe I, Hartnell A, Williams TJ & Heinemann A (2000) Regulation of basophil chemokine responses by sequential and co-operative receptor signalling. THORAX, 55, A21-A21.
Culley FJ, Brown A, Conroy DM, Sabroe I, Pritchard DI & Williams TJ (2000) Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo.. J Immunol, 165(11), 6447-6453.
Sabroe I, Pease JE & Williams TJ (2000) Asthma and MIF: innately Th1 and Th2.. Clin Exp Allergy, 30(9), 1194-1196.
Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ & Pease JE (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.. J Biol Chem, 275(34), 25985-25992.
Sabroe I, Heinemann A, Stubbs VEL, Jorritsma A, Jopling LA, Pease JE & Williams TJ (2000) Targeting Eosinophil and Basophil Recruitment: Antagonism of Chemokine Receptor Signalling. Clinical Science, 99(s43), 4P-4P.
Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD & Williams TJ (1999) Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.. J Immunol, 162(5), 2946-2955.
Till SJ, Sabroe I, Birch D, Williams TJ, van Neerven J, Qin S & Durham SR (1999) Differential cytokine production and chemokine receptor expression by T-cell lines derived from nasal mucosal biopsies and peripheral blood of normal controls.. J ALLERGY CLIN IMMUN, 103(1), S175-S175.
Sabroe I, Conroy DM, Gerard NP, Li Y, Collins PD, Post TW, Jose PJ, Williams TJ, Gerard CJ & Ponath PD (1998) Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo.. J Immunol, 161(11), 6139-6147.
Sabroe I, Hartnell A, Conroy D, Collins PD, Gerard NP, Gerard C, Ponath P & Williams TJ (1998) The Role of Eosinophil Chemokine Receptors in Allergic Inflammation in Vivo. Clinical Science, 95(s39), 13P-13P.
Sabroe I, Williams TJ, Hébert CA & Collins PD (1997) Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation.. J Immunol, 158(3), 1361-1369.
Sabroe I, Hébert CA, Williams TJ & Collins PD (1996) Cross-desensitisation of neutrophil IL-8 receptors involves differential receptor subtype regulation. Thorax, 51(SUPPL. 3).
Jarman PR, Whyte MK, Sabroe I & Hughes JM (1995) Sarcoidosis presenting with chylothorax.. Thorax, 50(12), 1324-1325.
Sabroe I, McHale J, Tait DR, Lynn WA, Ward KN & Shaunak S (1995) Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin.. Thorax, 50(11), 1219-1220.
Sabroe I (1995) Thromboembolic occlusion of a pulmonary arteriovenous malformation. A very unusual pulmonary embolism.. BMJ, 311(7004), 553-555.
Sabroe I, Bloom S, Hughes JMB, Shaunak S & Robertson I (1995) Thromboembolic occlusion of a pulmonary arteriovenous malformation. British Medical Journal, 311(7004), 553-555.
Browne TF, Sivananthan UM, Sabroe I & Rees MR (1992) Use of thermal imaging to monitor crural thrombolysis. Blood Coagulation & Fibrinolysis, 3(4), 489-491.
Browne TF, Sivananthan UM, Sabroe I & Rees MR (1992) Use of thermal imaging to monitor crural thrombolysis.. Blood Coagul Fibrinolysis, 3(4), 489-491.
Billings CG, Lewis R, Armstrong IJ, Hurdman JA, Smith IA, Austin M, Elliot CA, Charalampopoulos A, Sabroe I, Lawrie A , Thompson AAR et al () Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I. Frontiers in Medicine, 5. View this article in WRRO
Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S & Whyte MK () Macrophage Phenotype Is Associated with Disease Severity in Preterm Infants with Chronic Lung Disease. PLoS ONE, 9(8), e103059-e103059. View this article in WRRO

Chapters

Sabroe I & Withington P (2016) Language matters: 'Counsel' in early modern and modern medicine, The Edinburgh Companion to the Critical Medical Humanities (pp. 508-526).
Sabroe I (2010) Toll-like receptor 4, New Drugs and Targets for Asthma and COPD (pp. 81-86). KARGER
Dockrell DH, McGrath EE, Whyte MKB & Sabroe I (2007) The Neutrophil, Immunology of Fungal Infections (pp. 51-73). Springer Netherlands
Sabroe I, Dower SK & Whyte MKB (2006) TOLL-LIKE RECEPTORS, Encyclopedia of Respiratory Medicine (pp. 235-239). Elsevier
Sabroe I, Williams TJ & Pease JE (2006) EOTAXINS, Encyclopedia of Respiratory Medicine (pp. 125-129). Elsevier
Sabroe I, Chilvers ER & Whyte MKB (2006) LEUKOCYTES | Neutrophils, Encyclopedia of Respiratory Medicine (pp. 547-551). Elsevier
Sabroe I & Williams TJ (2001) Chemokines: An Overview, New Drugs for Asthma, Allergy and COPD (pp. 280-283). KARGER

Conference proceedings papers

Mussell G, Marshall H, Smith L, Biancardi A, Hughes P, Swift A, Collier G, Wild J & Sabroe I (2019) Correlations of ventilation heterogeneity and spirometry in asthma; initial experience with hyperpolarised gas MRI in a clinical setting. Imaging
Ramjug S, Billings C, Bowater S, Charalampopoulos A, Clift P, Elliot C, Hurdman J, Jenkins P, Kiely D, Lewis R , Oliver J et al (2019) Risk stratification of pulmonary arterial hypertension (PAH) associated with adult congenital heart disease (ACHD). Pulmonary hypertension
Swift A, Johns C, Chin M, Currie B, Elliot C, Charalampopolous T, Sabroe I, Dwivedi K, Rajaram S, Hill C , Wild J et al (2019) Diagnostic and prognostic value of a diagnostic CT regression model in suspected pulmonary hypertension. Pulmonary hypertension
Lewis R, Billings C, Hurdman J, Smith I, Austin M, Armstrong I, Swift A, Rothman A, Charalampopoulos A, Sabroe I , Elliot C et al (2019) The Incremental Shuttle Walking Test Can Be Used to Risk Stratify Patients with Pulmonary Hypertension as Per the European Respiratory/Cardiac Society Guidelines. A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH
Lewis R, Cogliano M, Johns CS, Billings CG, Hamilton N, Elliot CA, Charalampopoulos A, Sabroe I, Thompson R, Condliffe R , Wild JM et al (2019) Cardiac MRI: Identifying Thresholds to Predict Mortality in Pulmonary Arterial Hypertension. B27. HEARTBREAKER: HEART FAILURE AND PULMONARY HYPERTENSION
Lewis R, Billings C, Johns C, Hurdman J, Hamilton N, Elliot C, Charalampopoulos A, Sabroe I, Wild J, Swift A , Kiely D et al (2018) P16 Identifying partial anomalous pulmonary venous drainage (PAPVD) in patients presenting with suspected pulmonary hypertension (PH). Under pressure: an update in pulmonary vascular disease
Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
Pippard B, Neal M, Maunder A, Forrest I, Sabroe I, Lawson R, Simpson AJ, Wild J & Thelwall P (2018) S90 Assessing regional lung ventilation in patients and healthy volunteers using 19F-MRI of inhaled perfluoropropane. It’s all about your image: new approaches to thoracic imaging
Mills J, Sabroe I, Midwood K & Parker L (2018) Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
Iqbal A, Prince L, Novodvorsky P, Bernjak A, Thomas M, Birch L, Lambert D, Kay L, Wright F, Jacques R , Storey R et al (2018) Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
Ming M, Nair A, Saunders S, Condliffe R, Elliot C, Charalampopoulos A, Sabroe I, Lewis R, Armstrong I, Sephton P , Hamilton N et al (2018) Good outcomes following elective lower limb orthopaedic surgery in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Pulmonary hypertension
Pippard B, Neal M, Maunder A, Forrest I, Sabroe I, Lawson R, Simpson AJ, Wild J & Thelwall P (2018) Assessing regional lung ventilation with 19F-MRI of inhaled perfluoropropane. Imaging
Billings C, Lewis R, Armstrong I, Hurdman J, Smith I, Austin M, Elliot C, Charalampopoulos A, Sabroe I, Lawrie A , Thompson R et al (2018) Incremental shuttle walking test distance is reduced in patients with pulmonary hypertension in WHO Functional Class I. Pulmonary hypertension
Billings C, Lewis R, Hurdman J, Armstrong I, Smith I, Austin M, Elliot C, Charalampopoulos A, Sabroe I, Lawrie A , Thompson R et al (2018) Incremental Shuttle Walk Test predicts survival in non-Group 1 Pulmonary Hypertension without a ceiling effect. Pulmonary hypertension
Lewis R, Billings C, Johns C, Hurdman J, Hamilton N, Elliot C, Charalampopoulos A, Sabroe I, Wild J, Swift A , Kiely D et al (2018) Anomalous pulmonary venous drainage (APVD) in patients with suspected pulmonary hypertension (PH). Pulmonary hypertension
Quadery SR, Swift AJ, Billings C, Thompson AAR, Elliot CA, Hurdman J, Garrod S, Charalampopolous A, Sabroe I, Armstrong I , Hamilton N et al (2017) P183 Impact of patient choice on survival in patients with chronic thromboembolic pulmonary hypertension offered pulmonary endarterectomy. Pulmonary vascular disease: monitoring and managing
Klooster LT, Wilson V, Selby K, Newton R, Gandhi S, Bonnet T, Fletcher J, Armstrong I, Martin L, Hamilton N , Mills G et al (2017) P180 Managing pregnancy in pulmonary hypertension using a multi-professional approach: a 16-year experience in a specialist referral centre. Pulmonary vascular disease: monitoring and managing
ten Klooster L, Theodorou C, Wilson V, Selby K, Newton R, Gandhi S, Bonnett T, Fletcher J, Armstrong I, Martin L , Hamilton N et al (2017) Managing pregnancy in pulmonary hypertension using a multi-professional approach: a 16-year experience in a specialist referral centre. Pulmonary Circulation and Pulmonary Vascular Disease
Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Effect of Hypoglycemia on Platelet Reactivity and Platelet-Leukocyte Kinetics. DIABETES, Vol. 66 (pp A41-A41)
Quadery SR, Condliffe RA, Billings C, Thompson R, Elliot CA, Charalampopolous A, Hurdman J, Hamilton N, Armstrong I, Sephton P , Sabroe I et al (2016) P28 Chronic thromboembolic pulmonary hypertension: long term outcomes in surgical and non-surgical patients. Thorax, Vol. 71(Suppl 3) (pp A98.1-A98)
Ramjug S, Hussain N, Hurdman J, Billings C, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ & Condliffe R (2016) S111 Differences in characteristics and outcomes in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. Thorax, Vol. 71(Suppl 3) (pp A66-A67)
Thompson AAR, Arnold ND, Braithwaite AT, Casbolt HL, Iremonger J, Pickworth JA, Monaco C, Cole JE, Sabroe I & Lawrie A (2016) S87 Deficiency of toll-like receptor 3 (TLR3) exacerbates pulmonary hypertension in mice. Thorax, Vol. 71(Suppl 3) (pp A50.1-A50)
Quadery S, Billings C, Wild J, Swift A, Rajaram S, Davies C, Hill C, Thomas S, Braidley P, Hunter S , Armstrong I et al (2016) Chronic thrombo-embolic pulmonary hypertension: Long-term outcomes in operated and non-operated patients. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
Thomas MR, Iqbal A, Outteridge SN, Judge HM, Dockrell DH, Sabroe I & Storey RF (2016) Platelet P2Y12 inhibitors enhance expansion of the intermediate monocyte population following systemic inflammation in humans. EUROPEAN HEART JOURNAL, Vol. 37 (pp 904-904)
Iqbal A, Novodvorksy P, Bernjak A, Chow E, Birch L, Lambert D, Kay L, Wright FJ, Prince L, Francis S , Sabroe I et al (2016) Hypoglycemia Increases Circulating Proatherogenic Intermediate Monocytes in Healthy Volunteers. DIABETES, Vol. 65 (pp A104-A104)
Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Goddard J, Armstrong I, Stone B & Sabroe I (2016) New Approaches In Narrative Analysis Highlight Marked Issues Of Adaptation And Change For Patients With Pulmonary Hypertension And Explore How Identity Is Modified In The Context Of Clinical Care. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Thompson AAR, Arnold ND, Braithwaite AT, Casbolt HL, Pickworth JA, Cole JE, Monaco C, Kiely D, Sabroe I & Lawrie A (2016) Deficiency Of Toll-Like Receptor 3 (tlr3) Exacerbates Pulmonary Hypertension In Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Wild JM, Collier G, Marshall H, Smith L, Norquay G, Swift AJ, Horn FC, Chan F, Stewart NJ, Hutchison LC , Rao M et al (2015) P283 Hyperpolarised Gas MRI – a pathway to Clinical Diagnostic Imaging. Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
Thomas M, Ajjan R, Phoenix F, Outteridge S, Dockrell D, Sabroe I & Storey R (2015) 203 Ticagrelor and Clopidogrel Attenuate the Prothrombotic State induced by Bacterial Endotoxaemia. Heart, Vol. 101(Suppl 4) (pp A112.1-A112)
Thomas MR, Ajjan RA, Phoenix F, Outteridge SN, Dockrell DH, Sabroe I & Storey RF (2015) TICAGRELOR INHIBITS CHANGES IN FIBRIN CLOT STRUCTURE INDUCED BY BACTERIAL ENDOTOXEMIA. Journal of the American College of Cardiology, Vol. 65(10) (pp A12-A12)
Thomas MR, Alsharif KF, Prince LR, Ridger VC, Judge HM, Dockrell DH, Sabroe I & Storey RF (2015) TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES. Journal of the American College of Cardiology, Vol. 65(10) (pp A259-A259)
Sithamparanathan S, Thirugnanasothy L, Nair A, Goghlan G, Elliot C, Fisher A, Gaine S, Gibbs S, Gatzoulis M, Handler C , Howard L et al (2014) Portopulmonary hypertension in United Kingdom; A contemporary, national, observational study. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
Thomas MR, Outteridge SN, Ecob R, Sangha GK, Faulkner RE, West LE, Judge HM, Dockrell DH, Sabroe I & Storey RF (2014) Ticagrelor inhibits release of pro-inflammatory cytokines TNF and IL-6 during human endotoxaemia. European Heart Journal, Vol. 35(Supp1) (pp 1170-1170), 30 August 2014 - 3 September 2014.
Ismail S, Roberts RL, Stokes CA, Juss JK, Sabroe I & Parker LC (2013) Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
Condliffe R, Elliot CA, Sabroe I, Zamanian RT, Morton A, Swift AJ, Kiely DG & Lawrie A (2013) HEPATOCYTE GROWTH FACTOR CONCENTRATION CORRELATES WITH HAEMODYNAMIC SEVERITY IN CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 68 (pp A146-A147)
Prestwich E, Paiva C, Parker L & Sabroe I (2013) The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
Stokes CA, Glanville N, Kaur R, Hume RD, Robinson D, Perrie Y, Edwards MR, O'Donnell V, Harwood J, Parker LC & Sabroe I (2013) Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
Basran A, Bingle L, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2013) Neutrophil recruitment in response to intradermal endotoxin challenge in man. LANCET, Vol. 381 (pp 22-22)
Walmsley SR, Thompson AAR, Marriott H, Williams L, Lewis A, Sabroe I, Dockrell D, Taylor CT, Chilvers E, Pugh C , Ratcliffe P et al (2013) Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 187
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Parmar S, Shaw G, Eamsamarng S, McGrath EE, Formenti F, Van Eeden FJ , Kinnula VL et al (2012) HYPOXIA-INDUCIBLE FACTOR 2 alpha REGULATES NEUTROPHILIC INFLAMMATION IN HUMANS, MICE AND ZEBRAFISH. THORAX, Vol. 67 (pp A1-A1)
Hurdman J, Condliffe R, Elliot CA, Rajaram S, Swift AJ, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C , Pollard L et al (2012) Characteristics And Outcomes In Pulmonary Hypertension Associated With COPD/ Emphysema: Results From The ASPIRE Registry. B107. BIOMARKERS AND PREDICTORS OF OUTCOMES IN PULMONARY HYPERTENSION
Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Shaw G, Parmar S, Formenti F, Van Eden FJ, Pugh CW, Sabroe I , Dockrell DH et al (2012) HIF-2± Regulates Neutrophilic Inflammation In Humans, Mice And Zebrafish. C31. REGULATION OF LUNG INFLAMMATION
Chaudhuri N, Jary H, Lea S, Khan N, Parker LC, Singh D & Sabroe I (2011) CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
Hurdman J, Condliffe RA, Elliot CA, Sabroe I & Kiely DG (2010) PULMONARY HYPERTENSION (PH) ASSOCIATED WITH LUNG DISEASE/HYPOXIA. THORAX, Vol. 65 (pp A93-A93)
Stokes CA, Dick EP, Bennett JA, Ismail S, Edwards MR, Sabroe I & Parker L (2010) S80 The role of MyD88 in rhinovirus 1B infection. Thorax, Vol. 65(Suppl 4) (pp A37-A38)
Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
Chaudhuri N, Parker LC, Sabroe I & Donaldson K (2009) DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
Anwar S, Sabroe I, Foster SJ & Whyte MK (2009) SUBVERSION OF NEUTROPHIL APOPTOSIS BY STAPHYLOCOCCUS AUREUS: CONSEQUENCES FOR BACTERIAL PATHOGENESIS AND HOST DEFENCE. THORAX, Vol. 64 (pp A36-A36)
Anwar S, Prince LR, Sabroe I, Foster SJ & Whyte MK (2007) Subversion of neutrophil apoptosis by Staphylococcus aureus. THORAX, Vol. 62 (pp A114-A115)
Teare MD, Sabroe I, Goeke J & Whyte M (2007) Family based association analysis of a copy number polymorphism in asthma families. GENETIC EPIDEMIOLOGY, Vol. 31(5) (pp 500-500)
West PW, Parker LC, Ward JR & Sabroe I (2007) Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
Parker LC, Jones EC, Ward JR & Sabroe I (2007) Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
Ward JR, Francis SE, Marsden LL, Dower SK, Crossman DC & Sabroe I (2007) Bidirectional signalling between monocytes and endothelial cells regulate responses to TLR4 agonists in coculture models of vascular inflammation. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2007) The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
Dick EP, Prince LR, Jones EC, Renshaw SA, Whyte MK & Sabroe I (2007) Lentivirus: A tool for the study of neutrophil biology. JOURNAL OF LEUKOCYTE BIOLOGY (pp 36-36)
Parker LC, Jones EC, Morris GE, Dower SK, Whyte MK & Sabroe I (2006) The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
Morris GE, Whyte MKB, Brightling CE, Bradding P, Dower SK & Sabroe I (2005) Cooperative roles of toll-like receptors in the induction of antiviral responses in cocultures of airway smooth muscle cells and leukocytes. THORAX, Vol. 60 (pp II118-II118)
Ward JR, Whyte M, Dower S, Buttle D & Sabroe I (2005) Plasmin pretreatment enhances LPS signalling in RAW 264.7 cells. FASEB JOURNAL, Vol. 19(4) (pp A354-A355)
Parker LC, Jones EC, Whyte MKB, Dower SK & Sabroe I (2005) Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
Jones EC, Whyte MKB, Dower SK & Sabroe I (2004) Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors (TLR)2 and TLR4. JOURNAL OF LEUKOCYTE BIOLOGY (pp 29-29)
Bianchi SM, Prince LR, Sabroe I, Dockrell DH, Taylor GW, Buttle DJ & Whyte MKB (2004) The Pseudomonas aeruginosa exotoxin pyocyanin induces cathepsin D-mediated neutrophil apoptosis. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-43)
Parker LC, Jones EC, Whyte MK, Dower SK & Sabroe I (2004) Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
Sabroe I, Prince LR, Jones EC, Dower SK & Whyte MKB (2003) The role of toll-like receptors in the regulation of neutrophilic lung inflammation. EUROPEAN RESPIRATORY JOURNAL, Vol. 22 (pp 48S-49S)

Teaching interests: I teach clinical respiratory medicine, undergraduate medical sciences, the medical humanities, and post-graduate medical education.

Professional activities and memberships: I have worked for a number of national grant reviewing bodies. I am a Churchill Fellow, a Fellow of the Royal Society of Arts, and a Fellow of other respiratory specialist bodies