Dr Laura West

All publications

Journal articles

• Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
• Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V , McCourt M et al (2019) A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nature Communications, 10(1). View this article in WRRO
• Ramakrishnan L, Pedersen SL, Toe QK, West LE, Mumby S, Casbolt H, Issitt T, Garfield B, Lawrie A, Wort SJ & Quinlan GJ (2018) The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells. Scientific Reports, 8(1). View this article in WRRO
• Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2018) Selective improvement of pulmonary arterial hypertension with a dual ET A /ET B receptors antagonist in the apolipoprotein E −/− model of PAH and atherosclerosis. Pulmonary Circulation, 8(1), 1-11. View this article in WRRO
• Thomas MR, Outteridge SN, Ajjan RA, Phoenix F, Sangha GK, Faulkner RE, Ecob R, Judge HM, Khan H, West LE , Dockrell DH et al (2015) Platelet P2Y 12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(12), 2562-2570. View this article in WRRO
• West LE, Steiner T, Judge HM, Francis SE & Storey RF (2014) Vessel wall, not platelet, P2Y12 potentiates early atherogenesis.. Cardiovasc Res, 102(3), 429-435.
• West LE, Steiner T, Francis SE & Storey RF (2013) The role of vessel wall P2Y12 in early atherogenesis is not blocked by ticagrelor or clopidogrel. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 156-156.
• Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) Sustained P2Y12 Receptor Inhibition is Required to Effectively Inhibit Neointima Formation in a Murine Vascular Injury Model. CIRCULATION, 122(21).
• Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima.. Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
• Evans DJW, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K, Norman KE, Francis SE & Storey RF (2009) Platelet P2Y(12) receptor influences the vessel wall response to arterial injury and thrombosis.. Circulation, 119(1), 116-122.
• Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH () Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice. Frontiers in Cellular and Infection Microbiology, 13.
• Zawia A, Arnold ND, West L, Pickworth JA, Turton H, Iremonger J, Braithwaite AT, Cañedo J, Johnston SA, Thompson AAR , Miller G et al () Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology.

Chapters

• Jackman LE & Storey RF (2009) MRS 2395 In Editors-in-Chief:  S.J. Enna & David B. Bylund (Ed.), xPharm: The Comprehensive Pharmacology Reference (pp. 1-2). New York: Elsevier.
• Jackman LE & Storey RF (2009) Prasugrel In Editors-in-Chief:  S.J. Enna & David B. Bylund (Ed.), xPharm: The Comprehensive Pharmacology Reference (pp. 1-4). New York: Elsevier.

Conference proceedings papers

• Turton H, West L, Arnold N, Wright C, Francis S, Marriott H, Lawrie A & Thompson R (2023) Prior lung inflammation induced by intranasal double-stranded RNA does not exacerbate pulmonary hypertension in a mouse model. 13.01 - Pulmonary hypertension
• Lawrie A, Zawia A, West L, Arnold N, Pickworth J, Turton H, Thompson AAR & Francis SE (2023) Osteoprotegerin Has Distinct Roles in Pulmonary Vascular and Cardiac Remodelling in a Mouse Model of Pulmonary Arterial Hypertension. A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION
• Lawrie A, Arnold ND, Pickworth JA, West LE, Papworth J, Germaschewski V, Thompson AAR & Francis SE (2020) The Anti-Osteoprotegerin (OPG) Antibody Ky3 Attenuates OPG-Fas Mediated Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Pro-Inflammatory Signalling In Vitro and In Vivo. A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
• Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) T6 Vascular smooth muscle derived TRAIL underlies pulmonary vascular remodelling in sugen 5416/hypoxia mice. BTS/BALR/BLF Early Career Investigators awards symposium
• Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) Vascular Smooth Muscle Derived TRAIL is Required for Development of Pulmonary Arterial Hypertension in Sugen 5416 / Hypoxia Mice. CIRCULATION, Vol. 138
• Thomas MR, Outteridge SN, Ecob R, Sangha GK, Faulkner RE, West LE, Judge HM, Dockrell DH, Sabroe I & Storey RF (2014) Ticagrelor inhibits release of pro-inflammatory cytokines TNF and IL-6 during human endotoxaemia. European Heart Journal, Vol. 35(Supp1) (pp 1170-1170), 30 August 2014 - 3 September 2014.
• West L, Francis S & Storey R (2013) YIA6: VESSEL WALL, BUT NOT PLATELET, P2Y12 CONTRIBUTES TO EARLY ATHEROGENESIS. Heart, Vol. 99(suppl 2) (pp A7-A7)

Preprints

• Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D () Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice, Research Square Platform LLC.
• Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al () Neutrophil microvesicles drive atherosclerosis by deliveringmiR-155to atheroprone endothelium, Cold Spring Harbor Laboratory.