Dr Ning Wang

All publications

Journal articles

• Scott E, Archer Goode E, Garnham R, Hodgson K, Orozco-Moreno M, Turner H, Livermore K, Putri Nangkana K, Frame FM, Bermudez A , Jose Garcia Marques F et al (2023) ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.. J Pathol.
• Scott E, Hodgson K, Calle B, Turner H, Cheung K, Bermudez A, Marques FJG, Pye H, Yo EC, Islam K , Oo HZ et al (2023) Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Oncogene, 42, 926-937.
• Agrawal A, Ellegaard M, Haanes KA, Wang N, Gartland A, Ding M, Praetorius H & Jørgensen NR (2022) Absence of P2Y2 receptor does not prevent bone destruction in a murine model of muscle paralysis-induced bone loss. Frontiers in Endocrinology, 13. View this article in WRRO
• He J, Zhou Y, Carrera HA, Wang N & Gartland A (2022) Defining the role of P2X4 receptor in the prostate cancer bone metastasis. Bone Reports, 16, 101209-101209.
• Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W , Zhang H et al (2022) PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. Bone Research, 10(1). View this article in WRRO
• Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery, 8(1). View this article in WRRO
• Li R, Guan Z, Bi S, Wang F, He L, Niu X, You Y, Liu Y, Ding Y, Siwko S , Wang N et al (2022) The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling. Cell Death & Disease, 13(2).
• Wang F, Liu M, Wang N & Luo J (2022) G protein-coupled receptors in osteoarthritis. Frontiers in Endocrinology, 12. View this article in WRRO
• Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z , Li Z et al (2022) RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis. Journal of Clinical Investigation, 132(2). View this article in WRRO
• Pacharne S, Livesey M, Kadmiel M, Wang N, Caron KM, Richards GO & Skerry TM (2022) Accelerated development with increased bone mass and skeletal response to loading suggest receptor activity modifying protein-3 as a bone anabolic target. Frontiers in Endocrinology, 12. View this article in WRRO
• Zhou Y, Arredondo HM & Wang N (2022) P2Y receptors in bone - anabolic, catabolic, or both?. Frontiers in Endocrinology, 12.
• Zirimwabagabo J-O, Jailani ABA, Avgoustou P, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Wang N , Skerry TM et al (2021) Discovery of a first-in-class small molecule antagonist against the adrenomedullin-2 receptor: structure–activity relationships and optimization. Journal of Medicinal Chemistry. View this article in WRRO
• He J, Zhou Y, Arredondo Carrera HM, Sprules A, Neagu R, Zarkesh SA, Eaton C, Luo J, Gartland A & Wang N (2020) Inhibiting the P2X4 receptor suppresses prostate cancer growth in vitro and in vivo, suggesting a potential clinical target. Cells, 9(11). View this article in WRRO
• Arredondo H, Sprules A, Eaton C & Wang N (2020) Different prostate cancer bone metastasis models respond differently to treadmill exercise. Bone Reports, 13, 100309-100309.
• Bishop RT, Marino S, Carrasco G, Li B, Allen RJ, Sparatore A, Ottewell PD, Mollat P, Sims AH, Capulli M , Wang N et al (2020) Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis. Cancer Letters, 488, 27-39.
• Wang N, Niger C, Li N, Richards GO & Skerry TM (2020) Cross-species RNA-seq study comparing transcriptomes of enriched osteocyte populations in the tibia and skull. Frontiers in Endocrinology, 11. View this article in WRRO
• Avgoustou P, Jailani ABA, Zirimwabagabo J-O, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay P , WANG N et al (2020) Discovery of a first-in-class potent small molecule antagonist against the adrenomedullin-2 receptor. ACS Pharmacology & Translational Science. View this article in WRRO
• Roberts BC, Arredondo Carrera HM, Zanjani-pour S, Boudiffa M, Wang N, Gartland A & Dall’Ara E (2020) PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. Scientific Reports, 10(1). View this article in WRRO
• Roberts BC, Giorgi M, Oliviero S, Wang N, Boudiffa M & Dall'Ara E (2019) The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia : a comparison between two mouse strains. Bone, 127, 260-270. View this article in WRRO
• Allocca G, Hughes R, Wang N, Brown HK, Ottewell PD, Brown NJ & Holen I (2019) The bone metastasis niche in breast cancer–potential overlap with the haematopoietic stem cell niche in vivo. Journal of Bone Oncology, 17. View this article in WRRO
• Bishop RT, Marino S, de Ridder D, Allen RJ, Lefley DV, Sims AH, Wang N, Ottewell PD & Idris AI (2019) Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer. Cancer Letters, 450, 76-87. View this article in WRRO
• Brown HK, Allocca G, Ottewell PD, Wang N, Brown NJ, Croucher PI, Eaton CL & Holen I (2018) Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer.. International Journal of Molecular Sciences, 19(10). View this article in WRRO
• Wang N, Agrawal A, Jørgensen NR & Gartland A (2018) P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis. Scientific Reports, 8(1). View this article in WRRO
• Warrington JI, Richards GO & Wang N (2017) The Role of the Calcitonin Peptide Family in Prostate Cancer and Bone Metastasis. Current Molecular Biology Reports, 3(3), 197-203. View this article in WRRO
• Ellegaard M, Agca C, Petersen S, Agrawal A, Kruse LS, Wang N, Gartland A, Jensen J-EB, Jørgensen NR & Agca Y (2017) Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor. Purinergic Signalling.
• Allocca G, Kusumbe AP, Ramasamy SK & Wang N (2016) Confocal/two-photon microscopy in studying colonisation of cancer cells in bone using xenograft mouse models. BoneKEy Reports, 5, 851-851. View this article in WRRO
• Dai J, Hensel J, Wang N, Kruithof-de Julio M & Shiozawa Y (2016) Mouse models for studying prostate cancer bone metastasis. BoneKEy Reports, 5. View this article in WRRO
• Wang N, Reeves KJ, Brown HK, Fowles ACM, Docherty FE, Ottewell PD, Croucher PI, Holen I & Eaton CL (2015) The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. Journal of Experimental and Clinical Cancer Research, 34(1), 124-124. View this article in WRRO
• Ottewell PD, Wang N, Brown HK, Fowles CA, Croucher PI, Eaton CL & Holen I (2015) OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone. International Journal of Cancer, 137(4), 968-977. View this article in WRRO
• Wang N, Docherty F, Brown HK, Reeves K, Fowles A, Lawson M, Ottewell PD, Holen I, Croucher PI & Eaton CL (2015) Mitotic quiescence, but not unique “stemness,” marks the phenotype of bone metastasis-initiating cells in prostate cancer. The FASEB Journal, 29(8), 3141-3150. View this article in WRRO
• Wang N, Docherty FE, Brown HK, Reeves KJ, Fowles ACM, Ottewell PD, Dear TN, Holen I, Croucher PI & Eaton CL (2014) Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models.. J Bone Miner Res, 29(12), 2688-2696. View this article in WRRO
• Ottewell PD, Wang N, Meek J, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone. Endocrine Related Cancer, 21(5), 769-781.
• Wang N & Gartland A (2014) Targeting P2 receptors--current progress in treating musculoskeletal diseases.. Curr Opin Pharmacol, 16, 122-126. View this article in WRRO
• Ottewell PD, Wang N, Brown HK, Reeves KJ, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo.. Clin Cancer Res, 20(11), 2922-2932. View this article in WRRO
• Wang N, Robaye B, Gossiel F, Boeynaems J-M & Gartland A (2014) The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development.. FASEB J, 28(5), 2249-2259. View this article in WRRO
• Biver G, Wang N, Gartland A, Orriss I, Arnett TR, Boeynaems JM & Robaye B (2013) Role of the P2Y13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes. Stem Cells, 31(12), 2747-2758. View this article in WRRO
• Wang N & Gartland A (2013) Role of the P2X7 receptor in the osteogenic differentiation of mesenchymal cells and in osteoclast fusion: Presented by: Maria P. Abbracchio. Purinergic Signalling, 9(3), 281-284. View this article in WRRO
• Wang N, Rumney RMH, Yang L, Robaye B, Boeynaems J-M, Skerry TM & Gartland A (2013) The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.. J Bone Miner Res, 28(6), 1446-1456. View this article in WRRO
• Holen I, Wang N, Reeves KJ, Fowles AM, Croucher PI, Eaton CL & Ottewell PD (2012) Abstract PD07-08: Zoledronic acid specifically inhibits development of bone metastases in the post-menopausal setting – evidence from an in vivo breast cancer model. Poster Discussion Abstracts.
• Rumney RMH, Wang N, Agrawal A & Gartland A (2012) Purinergic signalling in bone.. Front Endocrinol (Lausanne), 3, 116. View this article in WRRO
• Wang N, Robaye B, Agrawal A, Skerry TM, Boeynaems J-M & Gartland A (2012) Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.. Mol Endocrinol, 26(1), 142-152. View this article in WRRO
• Orriss IR, Wang N, Burnstock G, Arnett TR, Gartland A, Robaye B & Boeynaems J-M (2011) The P2Y(6) receptor stimulates bone resorption by osteoclasts.. Endocrinology, 152(10), 3706-3716. View this article in WRRO
• Orriss I, Syberg S, Wang N, Robaye B, Gartland A, Jorgensen NR, Arnett T & Boeynaems JM (2011) Bone phenotypes of P2 receptor knockout mice. Frontiers in Bioscience(S3), 1038-1046.
• Huang YZ, Shen JL, Gong LZ, Zheng PH, Liu Y, Yin WJ, Cen J, Wang N & Zhao DF (2010) [In vitro activity of human bone marrow cells after cryopreservation in liquid nitrogen for 21 - 25 years].. Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, 18(1), 224-229.
• Wu Z, Jiang G, Xiang P, Yang D & Wang N (2008) Purification and characterization of trypsin-like enzymes from North Pacific krill (Euphausia pacifica).. Biotechnol Lett, 30(1), 67-72. View this article in WRRO
• Wu Z, Jiang G, Wang N, Wang J, Chen S & Xu Z (2008) Relating trypsin enzymatic properties with amino acid composition. International Journal of Peptide Research and Therapeutics, 14(2), 81-87.
• Huang YZ, Shen JL, Yang PD, Wu NH, Tang XF, Gong LZ, Cen J, Wang LX, Wang N & Zheng PH (2008) [Comparison of different cryopreservation systems for peripheral blood stem cells].. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 24(1), 125-128.
• Goode EA, Wang N & Munkley J () Prostate cancer bone metastases biology and clinical management (Review). Oncology Letters, 25(4).
• Song H, Arredondo Carrera HM, Sprules A, Ji Y, Zhang T, He J, Lawrence E, Gartland A, Luo J & Wang N () C‐terminal variants of the P2X7 receptor are associated with prostate cancer progression and bone metastasis – evidence from clinical and pre‐clinical data. Cancer Communications.
• Amin ZS, Docherty F, Eaton C & Wang N () Gene expression of P2 receptors in mitotically quiescent, prostate cancer bone metastasis initiating cells. Bone Abstracts.
• Pacharne S, Richards G, Wang N, Skerry T & Caron K () Role of receptor activity modifying proteins in skeletal regulation. Bone Abstracts.
• Livesey M, Pacharne S, Wang N, Grabowski P, Yang L, Richards G & Skerry T () Role of receptor activity modifying protein 3 in the response of bone to mechanical loading. Bone Abstracts.

Chapters

• Arredondo Carrera HM & Wang N (2022) Dormancy in cancer bone metastasis, Bone Cancer (pp. 393-410). Elsevier
• Allocca G & Wang N (2019) Tracking Cancer Cells Colonization in Rodent Bone Using Two-Photon Microscopy, Methods in Molecular Biology (pp. 631-639). Springer New York

Conference proceedings papers

• Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Abstract 2904: Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone. Tumor Biology
• Al-janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) Abstract 2797: Changes in the phenotype of macrophages and CD8+ T Cells in the perivascular niche of prostate tumours following androgen deprivation. Cancer Research, Vol. 81(13_Supplement) (pp 2797-2797)
• Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
• Wang N, Arredondo HM, Sprules AR & Eaton CL (2020) Abstract 3481: Continuous load bearing exercise inhibits the development of prostate cancer bone metastasis. Molecular and Cellular Biology / Genetics
• Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology
• Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology
• Roberts B, Carrera HA, Pour SZ, Boudiffa M, Gartland A, Wang N & Dall'Ara E (2019) Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259)
• Arredondo H, Sprules A, Eaton C & Wang N (2019) Determining the impact of mechanical loading on the arrival of prostate cancer in bone. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 201-201)
• Arredondoo HM, Eaton CL & Wang N (2018) P2X7 receptor in prostate cancer bone metastasis initiating cells. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S13)
• Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S85-S86)
• Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S67-S67)
• Wang N, Robaye B, Agrawal A, Reilly G, Boeynaems JM & Gartland A (2011) Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227)
• Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140)
• Wang N, Rumney RMH, Agrawal A, Robaye B, Boeynaems JM & Gartland A (2010) Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144)
• Rumney RMH, Wang N & Gartland A (2010) The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129)
• Martinez-Bautista S, Wang N, Richards Q & Skerry TM (2008) Mice Lacking NMDA Receptor Expression in Osteoblasts Have Pronounced Vertebral Bone Abnormalities. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S87-S87)
• Rumney R, Wang N, Sittichokechaiwut A, Reilly G & Gartland A (2008) Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165)
• Patel V, Rumney R, Wang N, Hipskind RH, Gallagher JA & Gartland A (2008) The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206)

Preprints

• Munkley J, Scott E, Hodgson K, Calle B, Turner H, Cheung K, Bermudez A, Marques F, Pye H, Yo EC , Islam K et al (2022) Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth, Research Square Platform LLC.
• Roberts BC, Cheong VS, Oliviero S, Carrera HMA, Wang N, Gartland A & Dall’Ara E () Combining PTH(1-34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice, Research Square Platform LLC.