Honorary Professor Paul Evans

Clinical Medicine, School of Medicine and Population Health

Honorary Professor

paul.evans@sheffield.ac.uk

The Medical School

Full contact details

Honorary Professor Paul Evans
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

My research career commenced in Cambridge where I studied the immunology of transplant rejection as a PhD in Professor Graeme Alexander’s lab. Following Post-doctoral positions at the Fred Hutchinson Cancer Research Center (Seattle, USA) and the Babraham Institute, Cambridge, UK (with Dr Peter Kilshaw), I was awarded Training and Senior Fellowships by Kidney Research UK to study the intracellular signalling pathways that control activation and injury of endothelial cells.

This led to my discovery of a family of deubiquitinating enzymes that suppress inflammation by inhibiting the transcription factor NF-kB. Its significance was recognized by the British Transplantation Society who awarded me the Medawar Prize in 2000. I joined Imperial College London in 2004 as a Senior Lecturer (Reader in 2010) and established the Intracellular Signalling Laboratory within the BHF Cardiovascular Sciences Unit (headed by Prof. Dorian Haskard).

I was appointed Chair of Cardiovascular Science at the University of Sheffield in 2011. I moved to Queen Mary's in London in 2023.

Research interests

My research focusses on the bio-mechanical mechanisms that control atherosclerosis, a disease of arteries that can lead to angina, heart attack and stroke. Branches and bends of arteries are prone to atherosclerosis because complex patterns of blood flow at these sites generate frictional forces (shear stress) that trigger pathophysiological changes in endothelial cells.

My laboratory combines genomics approaches with unbiased functional screening and biochemical studies to identify the signalling pathways and transcriptional programs that regulate endothelial cell responses to flow. The goal is to identify molecules within these pathways that can be targeted to prevent or treat atherosclerosis. The cross-disciplinary nature of my work has led to interactions with physicist and engineers as well as molecular and cellular biologists and clinical scientists.

I have received >£5.8M research funding as Principal Investigator (PI) including a £1M BHF Program awarded in 2013. My research has been recognized by the British Atherosclerosis Society (John French Lecture) and the British Cardiovascular Society (Michael Davies Award). I have trained 20 PhD/MD students to completion (13 as 1st supervisor), 14 MSc/MRes students and mentored 12 Post-doctoral Research Associates, of whom three have subsequently obtained PI positions in other universities.

Members of my laboratory have won 17 prestigious national or international prizes including the European Society for Cardiology Young Investigator First Prize and UK Young Life Scientist First Prize.

Current Projects

Identification of novel mechanoresponsive signalling networks that control endothelial cell injury and activation. Professor Evans with Dr Tim Chico and Professor Henning Walczak (University College London). British Heart Foundation Program Funding.
The role of JAK-STAT signalling in vascular inflammation and atherosclerosis. Professor Evans and Dr Maria Fragiadaki. British Heart Foundation Funding.
HIF transcription factors in focal atherosclerosis. Professor Evans and Dr Maria Fragiadaki. A*STAR funding.
Role of c-Rel in vascular injury and atherogenesis. Professor Evans and Professor Fiona Oakley (University of Newcastle). DiMen funding.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
Luong L, Duckles H, Schenkel T, Mahmoud M, Lopez-Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M, van der Heiden K , Xing R et al (2017) Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thrombosis and Haemostasis, 116(1), 181-190. View this article in WRRO
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S , Thompson AAR et al (2017) Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2087-2101. View this article in WRRO
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY, Foin N, Bowden N , Hussain A et al (2016) Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase. Cardiovascular Research, 112(3), 689-701. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Enesa K, Moll HP, Luong L, Ferran C & Evans PC (2015) A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes. The FASEB Journal, 29(5), 1869-1878. View this article in WRRO
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS , Yuldasheva NY et al (2014) Piezo1 integration of vascular architecture with physiological force. Nature, 515(7526), 279-282. View this article in WRRO
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J , Davenport AP et al (2014) In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18 F-FEDAA1106. Molecular Imaging, 13(6), 7290.2014.00014-7290.2014.00014.
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO & Evans PC (2014) Requirement of JNK1 for endothelial cell injury in atherogenesis.. Atherosclerosis, 235(2), 613-618.
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK , Cheung W-M et al (2014) Disturbed flow promotes endothelial senescence via a p53-dependent pathway.. Arterioscler Thromb Vasc Biol, 34(5), 985-995.
Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M, Walmsley SR, Haskard DO , Maxwell PH et al (2013) Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.. Circ Res, 112(12), 1583-1591.
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I , Gsell W et al (2011) Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.. Circ Res, 108(8), 950-959.
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N , Athanasiou T et al (2011) Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?. Circulation, 123(5), 524-532.
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H , Haskard DO et al (2009) Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.. Arterioscler Thromb Vasc Biol, 29(11), 1851-1857.
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO & Evans PC (2008) Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.. Circ Res, 103(7), 726-732.

All publications

Journal articles

Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis.. Sci Adv, 8(35), eabo7958.
Nataraj R, Hiwarkar P, Bonney D, Campbell H, Jones S, Deambrosis D, Evans P, Poulton K, van Hasselt PM, Bierings MB , Boelens JJ et al (2022) B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome. Bone Marrow Transplantation, 57(1), 38-42.
Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2022) Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. View this article in WRRO
Chiva-Blanch G & Evans PC (2021) Scientists on the Spot: A matter of blood flow. Cardiovascular Research, 117(12), e162-e163.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T & Armitage P (2021) The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biology, 3(1), 1-16.
Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J & Weber C (2021) Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovascular Research, 117(10), 2161-2174.
Kraler S, Libby P, Evans PC, Akhmedov A, Schmiady MO, Reinehr M, Camici GG & Lüscher TF (2021) Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs. Arteriosclerosis, Thrombosis, & Vascular Biology, 41(8), 2237-2251.
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T & Badimon L (2021) Erratum to: The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. Cardiovascular Research, 117(9), 2107-2107.
An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C , Sun X et al (2021) Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.. Cardiovasc Res.
Wagner R, Maiti R, Carré MJ, Perrault CM, Evans PC & Lewis R (2021) Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research. Biotribology, 100169-100169.
Wang M, Murdoch CE, Brewer AC, Ivetic A, Evans P, Shah AM & Zhang M (2021) Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation. ESC Heart Failure. View this article in WRRO
Evans PC, Fragiadaki M, Morris PD & Serbanovic-Canic J (2020) Shear stress : the dark energy of atherosclerotic plaques. Cardiovascular Research. View this article in WRRO
Ward AO, Angelini GD, Caputo M, Evans PC, Johnson JL, Suleiman MS, Tulloh RM, George SJ & Zakkar M (2020) NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium. Scientific Reports, 10(1).
Pirri D, Fragiadaki M & Evans PC (2020) Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?. Bioscience Reports, 40(8).
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR, Lawford PV, Narracott A & Gunn JP (2020) A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
Naase H, Harling L, Kidher E, Sepehripour A, Nguyen B, Kapelouzou A, Cokkinos D, Stavridis G, Angelini G, Evans PC & Athanasiou T (2020) Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass. Journal of Cardiothoracic Surgery, 15.
Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F , De Carlo M et al (2020) Endothelial function in cardiovascular precision medicine: A position paper on behalf of the European Society of Cardiology. Cardiovascular Research. View this article in WRRO
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 10(1).
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology, 17(1), 52-63.
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P , van der Heiden K et al (2019) Expert recommendations on the assessment of wall shear stress in human coronary arteries : existing methodologies, technical considerations, and clinical applications. European Heart Journal, 40(41), 3421-3433. View this article in WRRO
Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O’Neill L , Weber C et al (2019) Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research, 115(9), 1385-1392.
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) β1 integrin is a sensor of blood flow direction. Journal of Cell Science. View this article in WRRO
Tardajos Ayllón B, Souilhol C, Oakley F & Evans P (2019) BS14 c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium. Basic Science.
Souilhol C, Canham L, Xueqi J & Evans P (2019) BS3 Notch ligand JAG1 promotes endothelial-to-mesenchymal transition and atherosclerosis at regions of disturbed flow. Basic Science.
Roddie H, Fragiadaki M & Evans P (2019) BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stress. Basic Science.
Serbanovic-Canic J, Souilhol C & Evans PC (2019) Shear stress makes its mark on the endothelial genome.. Cardiovascular Research. View this article in WRRO
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S , Evans P et al (2019) Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. Scientific Reports, 9(1). View this article in WRRO
Mahmoud M, Souilhol C, Serbanovic-Canic J & Evans P (2019) GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis. Cardiovascular Drugs and Therapy. View this article in WRRO
Tuñón J, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DFJ, Lutgens E , Matter CM et al (2019) Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovascular Research, 115(1), 10-19. View this article in WRRO
Fragiadaki M & Evans PC (2018) The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018. Cardiovascular Drugs and Therapy. View this article in WRRO
Xing R, Moerman AM, Ridwan RY, van Gaalen K, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH & Van der Heiden K (2018) The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice. Scientific Reports, 8(1). View this article in WRRO
Caporali A, Bäck M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat M-L, Siekmann AF, Sluimer JC , Steffens S et al (2018) Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology.. Cardiovascular Research, 114(11), 1411-1421. View this article in WRRO
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol MC, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism. Journal of the American Heart Association, 7(13). View this article in WRRO
Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DFJ , Lutgens E et al (2018) Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice. European Journal of Preventive Cardiology, 25(9), 948-955. View this article in WRRO
Evans PC, Gijsen FJH, Wentzel JJ & van der Heiden K (2018) Biomechanics in vascular biology and cardiovascular disease. Thrombosis and Haemostasis, 115(3), 465-466.
Green J, Souilhiol C, Xanthis I, Martinez-Campesino L, Bowden N, Evans P & Wilson H (2018) Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling. Cardiovascular Research, 114(2), 324-335. View this article in WRRO
Luong L, Duckles H, Schenkel T, Mahmoud M, Lopez-Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M, van der Heiden K , Xing R et al (2017) Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thrombosis and Haemostasis, 116(1), 181-190. View this article in WRRO
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S , Thompson AAR et al (2017) Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2087-2101. View this article in WRRO
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI, Caporali A, Dignat-George F , Evans PC et al (2017) Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology.. Thromb Haemost, 117(7), 1296-1316. View this article in WRRO
Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY, Foin N, Bowden N , Hussain A et al (2016) Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase. Cardiovascular Research, 112(3), 689-701. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I , Ridger VC et al (2016) Experimental Approaches to Study Endothelial Responses to Shear Stress. Antioxidants & Redox Signaling, 25(7), 389-400.
Halliday I, Lishchuk SV, Spencer TJ, Pontrelli G & Evans PC (2016) Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method. Physical Review E, 94(2).
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Holloway PM, Gillespie S, Becker F, Vital SA, Nguyen V, Alexander JS, Evans PC & Gavins FNE (2016) Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways. Vascular Pharmacology, 85, 29-38.
Nguyen BAV, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD & Evans PC (2016) Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial. The Annals of Thoracic Surgery, 101(4), 1454-1463.
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H & Bennett MR (2016) Role of biomechanical forces in the natural history of coronary atherosclerosis. Nature Reviews Cardiology, 13(4), 210-220.
Morris PD, Narracott A, Von Tengg-Kobligk H, Soto DAS, Hsiao S, Lungu A, Evans P, Bressloff NW, Lawford PV, Rodney Hose D & Gunn JP (2016) Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A & Frangi AF (2015) Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiology of Disease, 82, 593-606. View this article in WRRO
Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat M-L, Boulanger CM, Caligiuri G, Dimmeler S, Egido J , Evans PC et al (2015) Novel methodologies for biomarker discovery in atherosclerosis. European Heart Journal, 36(39), 2635-2642.
Mylroie H, Dumont O, Bauer A, Thornton CC, Mackey J, Calay D, Hamdulay SS, Choo JR, Boyle JJ, Samarel AM , Randi AM et al (2015) PKC -CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis. Cardiovascular Research, 106(3), 509-519. View this article in WRRO
Enesa K, Moll HP, Luong L, Ferran C & Evans PC (2015) A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes. The FASEB Journal, 29(5), 1869-1878. View this article in WRRO
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(suppl_1).
Kidher E, Jarral OA, Harling L, Anderson JR, Chukwuemeka A, Ashrafian H, Evans PC & Athanasiou T (2015) NR2 antibody is associated with quality of life in aortic valve replacement. Asian Cardiovascular and Thoracic Annals, 23(6), 690-700.
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS , Yuldasheva NY et al (2014) Piezo1 integration of vascular architecture with physiological force. Nature, 515(7526), 279-282. View this article in WRRO
Kidher E, Harling L, Sugden C, Ashrafian H, Casula R, Evans P, Nihoyannopoulos P & Athanasiou T (2014) Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis. Interactive CardioVascular and Thoracic Surgery, 19(4), 595-604.
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R , Lehoux S et al (2014) Biomechanical factors in atherosclerosis: mechanisms and clinical implications. European Heart Journal, 35(43), 3013-3020.
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J , Davenport AP et al (2014) In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18 F-FEDAA1106. Molecular Imaging, 13(6), 7290.2014.00014-7290.2014.00014.
Mahmoud M, Kim R, De Luca A, Gauci I, Hsiao S & Evans PC (2014) P470Disturbed flow promotes endothelial cell injury via the induction of developmental genes. Cardiovascular Research, 103(suppl 1), S86.1-S86.
Hsiao S, Tovar-Lopez FJ, Gunn J, Spencer T, Halliday I, Perrault C & Evans PC (2014) 292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition. Cardiovascular Research, 103(suppl 1), S53.3-S53.
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) Mechanoresponsive networks controlling vascular inflammation.. Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
Nguyen BAV, Suleiman M-S, Anderson JR, Evans PC, Fiorentino F, Reeves BC & Angelini GD (2014) Metabolic derangement and cardiac injury early after reperfusion following intermittent cross-clamp fibrillation in patients undergoing coronary artery bypass graft surgery using conventional or miniaturized cardiopulmonary bypass.. Mol Cell Biochem, 395(1-2), 167-175.
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO & Evans PC (2014) Requirement of JNK1 for endothelial cell injury in atherogenesis.. Atherosclerosis, 235(2), 613-618.
Hsiao S, Tovar F, Gunn J, Spencer T, Halliday I, Perrault C & Evans P (2014) 219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI. Heart, 100(Suppl 3), A120.1-A120.
Gauci I, Luong L, Mahmoud M, Duckles H, Hsiao S, DeLuca A & Evans P (2014) 192 The Induction of Homeobox Genes by Disturbed Flow Limits Inflammation at Atherosusceptible Sites. Heart, 100(Suppl 3), A106.2-A107.
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S & Evans P (2014) 189 Disturbed Flow Promotes Endothelial Cell Injury Via the Induction of Developmental Genes. Heart, 100(Suppl 3), A105.2-A105.
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK , Cheung W-M et al (2014) Disturbed flow promotes endothelial senescence via a p53-dependent pathway.. Arterioscler Thromb Vasc Biol, 34(5), 985-995.
Luong L, Duckles H, Schenkel T, Arnold N, Gsell W, Lungu A, Spencer T, Hose R, Halliday I & Evans P (2014) Abstract 258: A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(suppl_1).
Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C & Evans P (2014) Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(suppl_1).
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S & Evans PC (2014) Abstract 266: Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(suppl_1).
Enesa K & Evans P (2014) The Biology of A20-Like Molecules, 33-48.
Nguyen B, Naase H, Jakaj G, Finch J, Boyle J, de Luca A, Haskard DO, Luong L, Evans PC, Vives M , Mulholland JW et al (2014) Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery.
Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) Control of tissue morphology by Fasciclin III-mediated intercellular adhesion. Development, 140(18), 3858-3868.
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC & Krams R (2013) Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. European Heart Journal, 34(suppl 1), P582-P582.
Evans PC & Kwak BR (2013) Biomechanical factors in cardiovascular disease.. Cardiovasc Res, 99(2), 229-231.
Van der Heiden K, Gijsen FJH, Narracott A, Hsiao S, Halliday I, Gunn J, Wentzel JJ & Evans PC (2013) The effects of stenting on shear stress: relevance to endothelial injury and repair.. Cardiovasc Res, 99(2), 269-275.
Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M, Walmsley SR, Haskard DO , Maxwell PH et al (2013) Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.. Circ Res, 112(12), 1583-1591.
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
Haskard DO, Boyle JJ, Evans PC, Mason JC & Randi AM (2013) Cytoprotective signaling and gene expression in endothelial cells and macrophages-lessons for atherosclerosis.. Microcirculation, 20(3), 203-216.
Warboys CM, de Luca A, Amini N & Evans PC (2012) THE INFLUENCE OF FLOW ON VASCULAR ENDOTHELIAL CELL SENESCENCE. ATHEROSCLEROSIS, 225(2), E6-E6.
Golubnitschaja O & Costigliola V (2012) General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine. EPMA Journal, 3(1).
Dumont O, Mylroie H, Bauer A, Calay D, Sperone A, Thornton C, Hamdulay SS, Ali N, Boyle JJ, Choo JR , Samarel AM et al (2012) Protein kinase Cε activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection.. Biochem J, 447(2), 193-204.
Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VWY, Evans PC, Liu Y, Johns M, Kirkham P & Haskard DO (2012) Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway.. Am J Pathol, 181(1), 347-361.
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S & Schäfers M (2012) Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice.. Journal of visualized experiments : JoVE(59).
Van Der Heiden K, Groen HC, Evans PC, Speelman L, Gijsen F, De Jong M, Van Der Steen AFW & Wentzel JJ (2012) Non-invasive molecular imaging of shear stress-induced endothelial activation and atherosclerotic plaque vulnerability. ASME 2012 Summer Bioengineering Conference, SBC 2012, 91-92.
De Luca A, Warboys CM, Amini N, Ferreira P, Gatehouse P, Firmin D, Mason J, Sherwin S & Evans PC (2012) Image-based computational hemodynamics and microarray analysis of the porcine aortic arch reveals a correlation between shear stress and endothelial cell apoptosis. ASME 2012 Summer Bioengineering Conference, SBC 2012, 923-924.
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R & Kwak BR (2012) Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells. Journal of Molecular and Cellular Cardiology, 53(2), 299-309.
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S & Schäfers M (2012) Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice. Journal of Visualized Experiments(59), 1-6.
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R & Evans PC (2011) (18)FEDAA is a more specific probe than (18)FDG for imaging vascular inflammation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38, S210-S210.
Boyle JJ, Johns M, Lo J, Chiodini A, Ambrose N, Evans PC, Mason JC & Haskard DO (2011) Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage.. Arterioscler Thromb Vasc Biol, 31(11), 2685-2691.
Harling L, Warren OJ, Martin A, Kemp PR, Evans PC, Darzi A & Athanasiou T (2011) Do miniaturized extracorporeal circuits confer significant clinical benefit without compromising safety? A meta-analysis of randomized controlled trials.. ASAIO J, 57(3), 141-151.
Jevon M, Ansari TI, Finch J, Zakkar M, Evans PC, Shurey S, Sibbons PD, Hornick P, Haskard DO & Dorling A (2011) Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall.. Cardiovasc Pathol, 20(3), e91-e94.
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I , Gsell W et al (2011) Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.. Circ Res, 108(8), 950-959.
Warboys CM, Amini N, de Luca A & Evans PC (2011) The role of blood flow in determining the sites of atherosclerotic plaques.. F1000 Med Rep, 3. View this article in WRRO
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N , Athanasiou T et al (2011) Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?. Circulation, 123(5), 524-532.
Warboys CM, Amini N, Luca AD & Evans PC (2011) When stress is good. Scientist, 25(2), 52.
Luong LA & Evans PC (2011) Targeting inhibitor of apoptosis proteins to block vascular inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(10), 2165-2166.
Evans PC (2011) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease. EPMA Journal, 2(1), 9-14.
Sperone A, Dryden NH, Birdsey GM, Madden L, Johns M, Evans PC, Mason JC, Haskard DO, Boyle JJ, Paleolog EM & Randi AM (2011) The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.. Arterioscler Thromb Vasc Biol, 31(1), 142-150.
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R , Lawford PV et al (2011) Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33(7), 840-848.
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R , Lawford PV et al (2011) Multi-scale interaction of particulate flow and the artery wall.. Med Eng Phys, 33(7), 840-848.
Sperone A, Dryden N, Birdsey GM, Madden LE, Evans P, Mason JC, Boyle J, Paleolog E, Haskard DO & Randi AM (2010) The transcription factor Erg represses ICAM-1 expression and vascular inflammation. Atherosclerosis, 213(1), e17-e17.
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H, Krams R & Evans PC (2010) YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF- B transcription factors. Heart, 96(17), e10-e10.
Van der Heiden K, Cuhlmann S, Luong LA, Zakkar M & Evans PC (2010) Role of nuclear factor kappaB in cardiovascular health and disease.. Clin Sci (Lond), 118(10), 593-605.
Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP & Mason JC (2010) Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.. Free Radic Biol Med, 48(8), 1013-1023.
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R , Haskard DO et al (2010) c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis.. Arterioscler Thromb Vasc Biol, 30(3), 546-553.
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Le Luong A, Croft NM, Naik S , Frankel G et al (2010) Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. Journal of Immunology, 185(7), 4118-4127.
Amirak E, Zakkar M, Evans PC & Kemp PR (2010) Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.. Biochem Biophys Res Commun, 391(1), 818-823.
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H , Haskard DO et al (2009) Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.. Arterioscler Thromb Vasc Biol, 29(11), 1851-1857.
Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC & Mason JC (2009) Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow.. J Biol Chem, 284(28), 18882-18892.
Evans PC (2009) Nur77: Orphaned at birth but adopted by the nuclear factor κb signaling pathway. Circulation Research, 104(6), 707-709.
Evans PC (2008) Effects of shear stress on endothelial activation and vascular inflammation. Biomedicine & Pharmacotherapy, 62(8), 503-504.
Ridger V, Krams R, Carpi A & Evans PC (2008) Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update.. Biomed Pharmacother, 62(8), 536-540.
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO & Evans PC (2008) Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.. Circ Res, 103(7), 726-732.
Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO & Evans PC (2008) MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS. Atherosclerosis, 199(2), 465-465.
Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H, Terracciano CM, Barton PJR , Yacoub MH et al (2008) Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy.. Cardiovasc Res, 79(3), 472-480.
Enesa K, Ito K, Luong LA, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO, Boyle J, Adcock I & Evans PC (2008) Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.. J Biol Chem, 283(27), 18582-18590.
Kinderlerer AR, Ali F, Johns M, Lidington EA, Leung V, Boyle JJ, Hamdulay SS, Evans PC, Haskard DO & Mason JC (2008) KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature.. J Biol Chem, 283(21), 14636-14644.
Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, Mason JC, Haskard DO, Dean JLE & Evans PC (2008) NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.. J Biol Chem, 283(11), 7036-7045.
Mason JC, Kinderlerer A, Ali F, Johns M, Leung V, Boyle J, Evans P & Haskard DO (2008) KLF‐2‐dependent, shear stress‐induced expression of CD59: a novel cytoprotective mechanism against complement‐mediated injury in the vasculature. The FASEB Journal, 22, 471.2-471.2.
Evans P, Slingsby C & Wallace BA (2008) Association of partially folded lens βB2-crystallins with the α-crystallin molecular chaperone. Biochemical Journal, 409(3), 691-699.
Foin N, Evans P & Krams R (2008) Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque. Current Opinion in Lipidology, 19(1), 98-100.
Lutz J, Luong LA, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO , Baumann M et al (2008) The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Journal of Molecular Medicine, 86(12), 1329-1339.
Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M, Blomhoff R, Mason JC , Haskard DO et al (2007) Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells.. FASEB J, 21(13), 3553-3561.
Evans P, Bateman OA, Slingsby C & Wallace BA (2007) A reference dataset for circular dichroism spectroscopy tailored for the βγ-crystallin lens proteins. Experimental Eye Research, 84(5), 1001-1008.
Adcock I & Evans PC (2007) Resolution of Inflammatory Responses: a brief introduction.. Biochem Soc Trans, 35(Pt 2), 261-262.
Helderman F, Segers D, De Crom R, Hierck BP, Poelmann RE, Evans PC & Krams R (2007) Effect of shear stress on vascular inflammation and plaque development. Current Opinion in Lipidology, 18(5), 527-533.
Enesa K & Evans PC (2007) Ubiquitin in pro-inflammatory signalling: Chains of command. Biochemist, 29(4), 24-27.
Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC & Shang F (2006) The triage of damaged proteins: Degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB Journal, 20(6), 741-743.
Evans PC (2005) Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs.. Expert Rev Mol Med, 7(12), 1-19.
Macdonald JT, Purkiss AG, Smith MA, Evans P, Goodfellow JM & Slingsby C (2005) Unfolding crystallins: The destabilizing role of a β-hairpin cysteine in βB2-crystallin by simulation and experiment. Protein Science, 14(5), 1282-1292.
Goodman RS, Ewing J, Evans PC, Craig J, Poulton K, Dyer PA, Marcus RE & Taylor CJ (2005) Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation. Bone Marrow Transplantation, 36(2), 151-156.
Evans P, Wyatt K, Wistow GJ, Bateman OA, Wallace BA & Slingsby C (2004) The P23T Cataract Mutation Causes Loss of Solubility of Folded γD-Crystallin. Journal of Molecular Biology, 343(2), 435-444.
EVANS PC, OVAA H, HAMON M, KILSHAW PJ, HAMM S, BAUER S, PLOEGH HL & SMITH TS (2004) Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochemical Journal, 378(3), 727-734.
Evans PC, Smith TS, Lai M-J, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R, Blundell TL & Kilshaw PJ (2003) A Novel Type of Deubiquitinating Enzyme. Journal of Biological Chemistry, 278(25), 23180-23186.
Corps E, Carter C, Karecla P, Ahrens T, Evans P & Kilshaw P (2001) Recognition of E-cadherin by Integrin αEβ7. Journal of Biological Chemistry, 276(33), 30862-30870.
EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R & KILSHAW PJ (2001) Isolation and characterization of two novel A20-like proteins. Biochemical Journal, 357(3), 617-623.
EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R & KILSHAW PJ (2001) Isolation and characterization of two novel A20-like proteins. Biochemical Journal, 357(3), 617-617.
Evans PC, Smith S, Hirschfield G, Rigopoulou E, Wreghitt TG, Wight DGD, Taylor CJ & Alexander GJM (2001) Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts. Journal of Hepatology, 34(5), 711-715.
Buckley CD (2001) Signaling Through CD31 Protects Endothelial Cells from Apoptosis. Transplantation 2001; 71: 457.. Transplantation, 71(3), 343-344.
Evans PC, Taylor ER & Kilshaw PJ (2001) SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS. Transplantation, 71(3), 457-460.
Evans PC & Kilshaw PJ (2000) INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION. Transplantation, 70(6), 928-934.
Lambert NC, Evans PC, Hashizumi TL, Maloney S, Gooley T, Furst DE & Nelson JL (2000) Cutting Edge: Persistent Fetal Microchimerism in T Lymphocytes Is Associated with HLA-DQA1*0501: Implications in Autoimmunity. The Journal of Immunology, 164(11), 5545-5548.
Evans PC, Soin A, Wreghitt TG, Taylor CJ, Wight DGD & Alexander GJM (2000) AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION. Transplantation, 69(1), 30-30.
Evans PC, Coleman N, Wreghitt TG, Wight DGD & Alexander GJM (1999) Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts. Journal of Hepatology, 31(5), 913-920.
EVANS PC, GRAY JJ, WREGHITT TG, MARCUS RE & ALEXANDER GJM (1999) Comparison of three PCR techniques for detecting cytomegalovirus (CMV) DNA in serum, detection of early antigen fluorescent foci and culture for the diagnosis of CMV infection. Journal of Medical Microbiology, 48(11), 1029-1035.
Hobbins BL, Schofield PJ, Evans PC, Greer S & Alexander GJM (1999) Gene upregulation, including glyceraldehyde-3-phosphate dehydrogenase and glycoprotein PC-1, by hepatitis B virus (HBV) demonstrated by suppressive subtractive hybridisation.. HEPATOLOGY, 30(4), 447A-447A.
Nasu K, Whyte A, Green SJ, Evans PC & Kilshaw PJ (1999) ??-GALACTOSYL-MEDIATED ACTIVATION OF PORCINE ENDOTHELIAL CELLS. Transplantation, 68(6), 861-867.
Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC & Nelson JL (1999) Microchimerism of maternal origin persists into adult life. Journal of Clinical Investigation, 104(1), 41-47.
Evans PC, Lambert N, Maloney S, Furst DE, Moore JM & Nelson JL (1999) Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma. Blood, 93(6), 2033-2037.
Evans PC, Soin A, Wreghitt TG & Alexander GJ (1998) Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients. Journal of Clinical Pathology, 51(12), 914-921.
Evans PC, Gray J, Wreghitt TG & Alexander GJM (1998) Optimisation of the polymerase chain reaction and dot-blot hybridisation for detecting cytomegalovirus DNA in urine: comparison with detection of early antigen fluorescent foci and culture. Journal of Virological Methods, 73(1), 41-52.
Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C & Bianchi DW (1998) Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. The Lancet, 351(9102), 559-562.
Bianchi DW, Klinger KW, DeRiso M, Farina A, Furst DE, Maloney S, Evans PC & Nelson JL (1997) Detection of male fetal DNA in postpartum women with autoimmune disease.. AMERICAN JOURNAL OF HUMAN GENETICS, 61(4), A18-A18.
Nelson JL, Furst DE, Maloney S, Evans PC, Storek J, Bean MA, Ober C, Smith A, Gooley T & Bianchi DW (1997) Microchimerism and HLA-compatible relationships of pregnancy in women with scleroderma.. ARTHRITIS AND RHEUMATISM, 40(9), 1007-1007.
Evans PC, Wilson D, Myerson D, Furst DE, Maloney S, Moore JM & Nelson JL (1997) Evidence for fetal cells in skin, kidney and bronchoalveolar lavage of female scleroderma patients. ARTHRITIS AND RHEUMATISM, 40(9), 1012-1012.
Evans PC, Maloney S, Furst DE, Moore JM & Nelson JL (1997) Fetal specific DNA in peripheral blood mononuclear cells of female scleroderma patients. ARTHRITIS AND RHEUMATISM, 40(9), 1011-1011.
Evans PC, Taylor C, Wreghitt T & Alexander GJM (1996) Cytomegalovirus infection and the TNF-2 allele are synergistic risk factors for chronic rejection. HEPATOLOGY, 24(4), 1180-1180.
de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E , Dib L et al () Translational opportunities of single-cell biology in atherosclerosis. European Heart Journal.
Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M , Guzik TJ et al () From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022. Cardiovascular Research.
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G, Chiastra C, Halliday I , Morris PD et al () Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLOS ONE, 17(7), e0271469-e0271469.
Arbustini E, Behr ER, Carrier L, van Duijn C, Evans P, Favalli V, van der Harst P, Haugaa KH, Jondeau G, Kääb S , Kaski JP et al () Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. European Heart Journal.
Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B, Motterlini R, Francis S & Gunn J () Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model. Journal of Cardiovascular Pharmacology, 78(5), e656-e661.
Bowley G, Chico TJA, Serbanovic-Canic J & Evans PC () Quantifying endothelial cell proliferation in the zebrafish embryo. F1000Research, 10, 1032-1032.
Ward AO, Sala-Newby GB, Ladak S, Angelini GD, Caputo M, Suleiman M-S, Evans PC, George SJ & Zakkar M () Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells. Perfusion, 026765912110125-026765912110125.
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L & Weber C () THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS. Cardiovascular Research.
Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE , Newby DE et al () Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. European Heart Journal - Cardiovascular Imaging.
Evans PC, Ed Rainger G, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J , Weber C et al () Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovascular Research.
Patera F, Hautbergue GM, Wilson P, Evans PC, Ong ACM & Fragiadaki M () Ankhd1 enhances polycystic kidney disease development via promoting proliferation and fibrosis.
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli A, Fragiadaki M, Wong R, Shah D, Askari J, Canham L , Akhtar N et al () β1 integrin is a sensor of blood flow direction.
Nguyen BAV, McDonald G, Fiorentino F, Reeves BC, Kwak J, Pyo S, Angelini GD, Anderson JR, Frost G, Haskard DO & Evans PC () Consumption of Broccoli Sprouts Attenuates Intracellular P38 Map Kinase and Reactive Oxygen Species Pro-Inflammatory Activation in Human Leukocytes: A Randomised- Controlled Trial. Journal of Clinical Nutrition & Dietetics, 03(04).
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S & Schäfers M () Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. Journal of Visualized Experiments(59).
Zun PS, Narracott AJ, Evans PC, van Rooij BJM & Hoekstra AG () A particle-based model for endothelial cell migration under flow conditions. Biomechanics and Modeling in Mechanobiology. View this article in WRRO

Chapters

Chen Y, Evans PC & Wilkinson RN (2022) A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy, Methods in Molecular Biology (pp. 19-28). Springer US
Nayak A, König CS, Kishore U & Evans PC (2013) Regulation of Endothelial Activation and Vascular Inflammation by Shear Stress, Micro and Nano Flow Systems for Bioanalysis (pp. 77-85). Springer New York

Conference proceedings papers

Zhou Z, Wu J, Wentzel J, Schenkel T, Diagbouga M, Fragiadaki M, Simons M & Evans P (2022) BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaques. Basic science
Ayllón BT, Souilhol C, Oakley F & Evans PC (2021) A c-REL drives atherosclerosis at sites of disturbed blood flow. Young investigators award
Bowley G, Evans P, Serbanovic-Canic J & Chico T (2021) BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation. Basic science
Zhou Z, Van-Hateren N, Francis S, Fragiadaki M & Evans P (2021) BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques. Basic science
Ayllon BT, Oakley F & Evans PC (2019) The NF-kappaB Transcription Factor Subunit c-Rel Promotes Endothelial Proliferation and Inflammation in Response to Low Shear Stress. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 261-262)
Roddie H, Fragiadaki M & Evans P (2019) Endothelial STAT5A Is Enriched at Atheroprone Regions and Drives Inflammation in Response to Low Shear Stress. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 274-274)
Souilhol C, Feng S, Gauci I, Serbanovic-Canic J, Canham L & Evans PC (2019) Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272)
Serbanovic-Canic J, Feng S, Souilhol C & Evans PC (2019) The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273)
Green J, Evans P & Wilson H (2016) 191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium. Heart, Vol. 102(Suppl 6) (pp A130.1-A130)
Bowden N, Feng S, Francis S & Evans P (2016) 211 Non-Canonical NF-Îšb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress. Heart, Vol. 102(Suppl 6) (pp A140.1-A140), 6 June 2016 - 8 June 2016.
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna. Heart, Vol. 101(Suppl 4) (pp A122-A123), 8 June 2015 - 10 June 2015.
Alfaidi M, Schenkel T, Evans P, Chamberlain J & Francis S (2015) 192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions. Heart, Vol. 101(Suppl 4) (pp A107.2-A107)
Mahmoud M, Kim R, Hsiao S, Xing R, Heiden KVD, Mammoto A, Chen J, Gauci I, Feng S & Evans P (2015) 204 Disturbed Flow Promotes Atherogenesis through the Activation of Endothelial-Mesenchymal Transition. Heart, Vol. 101(Suppl 4) (pp A112.2-A113)
Bryan M, Xanthis I, Hsiao S & Evans P (2015) 206 Using Magnetic Tweezers to probe Mechanically-Induced Signalling in Endothelial Cells. Heart, Vol. 101(Suppl 4) (pp A113.2-A114)
Green J, Wilson H & Evans P (2015) 185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium. Heart, Vol. 101(Suppl 4) (pp A104.1-A104)
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 35(Supp 1) (pp A558-A558)
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS , Yuldasheva NY et al (2015) Piezo1 Integration of Vascular Architecture with Physiological Force. FASEB JOURNAL, Vol. 29
Evans P, Nederlof E & Richmond W (2015) Souring Development Associated with PWRI in a North Sea Field. SPE Produced Water Handling & Management Symposium
Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE & Evans PC (2014) Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne. Atherosclerosis, Vol. 237(2) (pp e2-e2)
Duckles H, Mahmoud M, Hsiao S, Gauci I, Bowden N, Luong L & Evans PC (2014) Identification of a molecular switch controlling the induction of senescence or quiescence by flow. Atherosclerosis, Vol. 237(2) (pp e7-e7)
Gauci I, Mahmoud M, Duckles H, Feng S, Hsiao S & Evans PC (2014) Disturbed flow influences endothelial activation by inducing homeobox transcription factors. Atherosclerosis, Vol. 237(2) (pp e8-e8)
Mahmoud M, Hsiao S, Gauci I, Kim HR & Evans PC (2014) GATA4 promotes endothelial cell turnover at regions of arteries exposed to disturbed flow. Atherosclerosis, Vol. 237(2) (pp e2-e3)
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S & Evans PC (2014) Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol. 34
Le L, Duckles H, Schenkel T, Arnold N, Gsell W, Lungu A, Spencer T, Hose R, Halliday I & Evans P (2014) A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol. 34
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC & Krams R (2013) Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. EUROPEAN HEART JOURNAL, Vol. 34 (pp 110-110)
De Luca A, Warboys C, Amini N, Ferreira P, Firmin D, Mason J, Sherwin S & Evans P (2013) 170 TRANSCRIPTOME PROFILING IN PORCINE ARTERIES TO IDENTIFY NOVEL SHEAR-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL FATE. Heart, Vol. 99(suppl 2) (pp A98.2-A99)
Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL. Heart, Vol. 99(suppl 2) (pp A6.1-A6)
Zuluaga E, Evans PJ, Nesom PR, Spratt PA & Daniels EJ (2010) Technical Evaluations to Support the Decision to Reinject Produced Water. SPE Annual Technical Conference and Exhibition
Evans P (2008) Reservoir Souring Modelling, Prediction and Mitigation. Volume 5: Materials Technology; CFD and VIV, 15 June 2008 - 20 June 2008.
Evans P & Dunsmore B (2006) Reservoir simulation of sulfate-reducing bacteria activity in the deep sub-surface. NACE - International Corrosion Conference Series (pp 066641-0666417)
Wallace BA, Wien F, Miles AJ, Lees JG, Vronning Hoffmann S, Evans P, Wistow GJ & Slingsby C (2004) Biomedical applications of synchrotron radiation circular dichroism spectroscopy: Identification of mutant proteins associated with disease and development of a reference database for fold motifs. Faraday Discussions, Vol. 126 (pp 237-237)

Preprints

Chen Y, Jiang Z, Fisher KH, Kim HR, Evans PC & Wilkinson RN () Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4, Cold Spring Harbor Laboratory.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T & Armitage P () The effect of absent blood flow on the zebrafish cerebral and trunk vasculature, Cold Spring Harbor Laboratory.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis, Cold Spring Harbor Laboratory.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al () Neutrophil microvesicles drive atherosclerosis by deliveringmiR-155to atheroprone endothelium, Cold Spring Harbor Laboratory.

Professional activities and memberships

Societies

Chair of the European Society for Cardiology Working Group on Atherosclerosis and Vascular Biology Chair (2016-2018)
European Society for Cardiology Council on Stroke (2016-2018)
European Vascular Biology Organisation Council Member (2014-2018)
British Society for Cardiovascular Research Board Member (2014-2018)
Committee Member for the International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease (2013-)
British Atherosclerosis Society Committee Member (2011-2014)

Grant and Fellowship Committees

MRC non-clinical Fellowships Panel (2017 – 2021)
NC3Rs Fellowships Committee Member (2015 – 2018)
External Examiner for the University of Cambridge MRes in Cardiovascular Research (2017-)
British Heart Foundation Project Grant Committee Member (2012-2015)
NC3Rs Project Grant Committee Member (2013 – 2015)
Rapporteur for the European Commission - Marie Curie Frameworks 7 (2010) and 6 (2005); Member of the MRC College of Experts (2004 - 2009); Member of the MRC Scientific Advisory Group (2003-2004)

Editorial Boards

Editorial Board Member for ATVB (2017-), Biochemical Journal (2009-) and Frontiers in Cardiovascular Medicine (2017-).
Guest Editor for Cardiovascular Research (2013; Spotlight Issue on Biomechanical Factors in Cardiovascular Disease).
Guest Editor for Thrombosis and Haemostasis (2015).
Senior Editor for the Journal of Inflammation (2009-2015).
Reviewer for international scientific journals including Circulation, Circ Res, ATVB, Cardiovasc Res, Scientific Rep, Nat Comm, J Biol Chem, Biochem J.
Reviewer of Project Grant/ Fellowship applications for BHF, MRC, BBSRC, NC3Rs, European Commission, international research councils and other UK medical charities.

Awards for the Evans Lab

Sept 2016 - British Atherosclerosis Society Best Poster Prize (Shuang Feng)
April 2015 - 10th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Marwa Mahmoud)
Sept 2014 - British Atherosclerosis Society Young Investigator Prize (Marwa Mahmoud)
July 2014 - ESC Frontiers in Cardiovascular Biology, Barcelona – poster prize (Ismael Gauci)
April 2014 - 9th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Dr Sarah Hsiao)
April 2012 - Society for Cardiovascular Surgery in Great Britain and Ireland – Ronald Edwards Medal (Bao Nguyen)
June 2011 - Scholarship to attend the MIT-Imperial Summer School, MIT, USA (Amalia de Luca)
June 2010 - British Atherosclerosis Society/ British Society for Cardiovascular Research Young Investigator Award (Simon Cuhlmann)
April 2010 - 5th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Dr Kim Van der Heiden)
March 2010 - Society for Cardiovascular Surgery in Great Britain and Ireland - Ronald Edwards Medal (Mustafa Zakkar)
May 2009 - Promega UK Young Life Scientist Award - 1st Prize (Dr Kim Van der Heiden)

School of Medicine and Population Health

Honorary Professor Paul Evans

Current Projects

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