Professor Thomas Helleday
Clinical Medicine, School of Medicine and Population Health
Honorary Professor of Translational Oncology
t.helleday@sheffield.ac.uk
+46 (0) 8 524 815 30
+46 (0) 8 524 815 30
+46 (0) 70 024 84 53
(Fax)
The Medical School
Full contact details
Professor Thomas Helleday
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
I obtained a lectureship at the Institute for Cancer Studies, University of Sheffield in 2000 where I researched basic mechanisms of DNA damage response and repair and made the discovery of the PARP inhibitor treatment in BRCA mutated cancers. I became professor at both University of Sheffield and Stockholm University in 2006, prior to being recruited as MRC Professor of Cancer Therapeutics at the MRC/CRUK Gray Institute for Radiation Oncology and Biology at the University of Oxford. In 2012, I was called to the Söderberg Professor of Translational Medicine and Chemical Biology at the Karolinska Institutet in Stockholm, Sweden. In 2018, I returned to the University of Sheffield to establish the Sheffield Cancer Centre. Following the corona pandemic, I returned to Karolinska Institutet in 2020 to focus on translational research in my group. The focus of the research in my lab has been basic DNA repair research translated into novel treatments. I have received numerous international awards and prizes such as the Eppendorf-Nature Young European Investigator Award 2005, the European Association for Cancer Research Young Cancer Researchers Award 2007, the Swiss Bridge Award 2008, the Svedberg Award 2008, Carcinogenesis Young Investigator Award 2010 and ERC Advanced Grant Awards (2010 and 2016).
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Development of a chemical probe against NUDT15. Nature Chemical Biology. View this article in WRRO
- Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362(6416), 834-839. View this article in WRRO
- Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 9(1). View this article in WRRO
- Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair. Science Translational Medicine, 7(312), ---.
- Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell, 60(1), 163-176.
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature, 508(7495), 215-221.
- miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors. Molecular Cell, 41(2), 210-220.
- Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair. Molecular Cell, 37(4), 492-502.
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature, 434(7035), 913-917.
- The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biology, 7(2), 195-201.
All publications
Journal articles
- Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy. International Journal of Immunopathology and Pharmacology, 37, 039463202311580-039463202311580.
- Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature Communications, 14.
- Pharmacological OGG1 inhibition decreases murine allergic airway inflammation. Frontiers in Pharmacology, 13.
- Spatially resolved clonal copy number alterations in benign and malignant tissue. Nature, 608(7922), 360-367.
- The first structure of human MTHFD2L and its implications for the development of isoform‐selective inhibitors. ChemMedChem. View this article in WRRO
- Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376(6600), 1471-1476.
- NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. Journal of Hepatology, 77(5), 1311-1324.
- Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. Journal of Biological Chemistry, 298(8). View this article in WRRO
- Targeting the DNA damage response and repair in cancer through nucleotide metabolism.. Mol Oncol.
- OGG1 inhibition triggers synthetic lethality and enhances the effect of PARP inhibitor olaparib in BRCA1-deficient TNBC cells. Frontiers in Oncology, 12. View this article in WRRO
- Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer, 3(2), 156-172.
- Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML. Molecular Cancer Therapeutics, 21(5), 703-714.
- MutT homolog 1 inhibitor karonudib attenuates autoimmune hepatitis by inhibiting DNA repair in activated T cells. Hepatology Communications.
- MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia. Cancer Research, 81(22), 5733-5744. View this article in WRRO
- Editor's Note: Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer. Clinical Cancer Research, 27(21), 6066-6066.
- Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proceedings of the National Academy of Sciences, 118(36).
- Coexpression of MTH1 and PMS2 Is Associated with Advanced Disease and Disease Progression after Therapy in Melanoma. Journal of Investigative Dermatology.
- NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chemical Biology.
- NEIL3 prevents senescence in hepatocellular carcinoma by repairing oxidative lesions at telomeres during mitosis.. Cancer Res.
- NEIL1 and NEIL2 are recruited as potential backup for OGG1 upon OGG1 depletion or inhibition by TH5487. International Journal of Molecular Sciences, 22(9). View this article in WRRO
- Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. Journal of Biological Chemistry, 296.
- Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. Scientific Reports, 11(1).
- MTH1 inhibitors for the treatment of psoriasis. Journal of Investigative Dermatology.
- Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Scientific Reports, 11(1).
- MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells. Cell Death and Differentiation.
- Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research. View this article in WRRO
- Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma. Neoplasia, 22(9), 390-398. View this article in WRRO
- Development of a chemical probe against NUDT15. Nature Chemical Biology. View this article in WRRO
- AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma. Cell Death & Differentiation, 27, 2081-2098. View this article in WRRO
- High content drug screening for Fanconi anemia therapeutics. Orphanet Journal of Rare Diseases, 15(1).
- Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. Journal of Biological Chemistry, 295(33), 11656-11668.
- MetaCNV - a consensus approach to infer accurate copy numbers from low coverage data. BMC Medical Genomics, 13(1).
- In silico druggability assessment of the NUDIX hydrolase protein family as a workflow for target prioritization. Frontiers in Chemistry, 8. View this article in WRRO
- MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG. Cancer Research. View this article in WRRO
- Cell cycle profiling reveals protein oscillation, phosphorylation, and localization dynamics. Molecular & Cellular Proteomics, 19(4), 608-623. View this article in WRRO
- Managing COVID-19 in the oncology clinic and avoiding the distraction effect. Annals of Oncology. View this article in WRRO
- MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. Journal of Biological Chemistry. View this article in WRRO
- Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy. EMBO Molecular Medicine, 12(3). View this article in WRRO
- TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model. EBioMedicine, 53. View this article in WRRO
- Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget, 11(8).
- Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds. Cancer Research, 80(7), 1538-1550.
- The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Cell Death & Differentiation, 27(2), 773-789. View this article in WRRO
- Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Cell Death & Disease, 11(2).
- Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles. Annals of Oncology, 31(2), 167-168.
- Gefitinib and afatinib show potential efficacy for Fanconi anemia-related head and neck cancer. Clinical Cancer Research. View this article in WRRO
- The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products. Journal of Molecular Biology, 432(4), 1126-1142.
- Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 10(1).
- Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma. Annals of Oncology, 30, vii8-vii8.
- Karonudib is a promising anticancer therapy in hepatocellular carcinoma. Therapeutic Advances in Medical Oncology, 11. View this article in WRRO
- Restriction of AID activity and somatic hypermutation by PARP-1. Nucleic Acids Research, 47(14), 7418-7429. View this article in WRRO
- Computational and experimental druggability assessment of human DNA glycosylases. ACS Omega, 4(7), 11642-11656. View this article in WRRO
- Structural basis of inhibition of the human serine hydroxymethyltransferase
SHMT
2 by antifolate drugs. FEBS Letters, 593(14), 1863-1873.
- The DNA damaging revolution : PARP inhibitors and beyond. American Society of Clinical Oncology Educational Book(39), 185-195. View this article in WRRO
- Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.. Biochemistry, 58(7), 887-899. View this article in WRRO
- Ex Vivo Culture of Cells Derived From Circulating Tumour Cell Xenograft to support Small Cell Lung Cancer Research and Experimental Therapeutics. British Journal of Pharmacology. View this article in WRRO
- Making immunotherapy ‘cold’ tumours ‘hot’ by chemotherapy-induced mutations—a misconception. Annals of Oncology, 30(3), 360-361.
- MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. Nucleic Acids Research, 46(20), 10888-10904. View this article in WRRO
- Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362(6416), 834-839. View this article in WRRO
- Targeting BER enzymes in cancer therapy. DNA Repair, 71, 118-126. View this article in WRRO
- STAT3 Differential Scanning Fluorimetry and Differential Scanning Light Scattering Assays: addressing a missing link in the characterization of STAT3 Inhibitor interactions. Journal of Pharmaceutical and Biomedical Analysis, 160, 80-88. View this article in WRRO
- The Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions. Oncotarget, 9(80), 35069-35084. View this article in WRRO
- Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nature Communications, 9(1), 3872-3872. View this article in WRRO
- Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments. EMBO reports, 19(9).
- A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Cell Death and Disease, 9(8). View this article in WRRO
- Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity. Nature Communications, 9(1). View this article in WRRO
- Germline variation in the oxidative DNA repair genes NUDT1
and OGG1
is not associated with hereditary colorectal cancer or polyposis. Human Mutation, 39(9), 1214-1225.
- An orthotopic glioblastoma animal model suitable for high-throughput screenings. Neuro-Oncology, 20(11), 1475-1484.
- Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation. Cell Cycle, 17(5), 568-579.
- Human NUDT22 is a UDP-glucose/galactose hydrolase exhibiting a unique structural fold. Structure, 26(2), 295-303.e6. View this article in WRRO
- Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry, 57(5), 593-603.
- U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta Oncologica, 57(2), 187-194.
- Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 9(1). View this article in WRRO
- Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer. PLoS ONE, 13(1). View this article in WRRO
- A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. Nature Communications, 8(1). View this article in WRRO
- Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget, 8(49), 94671-84684. View this article in WRRO
- Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space. Journal of Medicinal Chemistry, 60(19), 8160-8169.
- Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm. Bioorganic & Medicinal Chemistry Letters, 27(18), 4462-4466.
- Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. Journal of Medicinal Chemistry, 60(17), 7614-7614.
- Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination. DNA Repair, 57, 116-124.
- Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nature Communications, 8(1). View this article in WRRO
- Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines. Bioorganic & Medicinal Chemistry Letters, 27(16), 3897-3904.
- With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. Experimental Hematology, 52, 32-39.
- Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems. Bioorganic & Medicinal Chemistry Letters, 27(15), 3219-3225.
- ATM
/Wip1 activities at chromatin control Plk1 re‐activation to determine G2 checkpoint duration. The EMBO Journal, 36(14), 2161-2176.
- Structure–metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines. MedChemComm, 8(7), 1553-1560.
- Mutations in cancer cause gain of cysteine, histidine, and tryptophan at the expense of a net loss of arginine on the proteome level. Biomolecules, 7(3). View this article in WRRO
- CHD1: a new treatment biomarker for recombination deficiency in castration resistant prostate cancer?. Annals of Oncology, 28(7), 1407-1408.
- Identification of novel small molecules that inhibit STAT3-dependent transcription and function. PLoS ONE, 12(6). View this article in WRRO
- SAMHD1 protects cancer cells from various nucleoside-based antimetabolites. Cell Cycle, 16(11), 1029-1038.
- Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma. Immunologic Research, 65(3), 706-712.
- Global survey of the immunomodulatory potential of common drugs. Nature Chemical Biology, 13(6), 681-690.
- Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. Journal of Medicinal Chemistry, 60(10), 4279-4292.
- Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature, 544(7651), 508-508.
- Abstract IA12: Poisoning cancer with oxidized nucleotides by targeting MTH1. Replication Stress.
- dUTPase inhibition augments replication defects of 5-Fluorouracil. Oncotarget, 8(14), 23713-23726. View this article in WRRO
- Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. Journal of Medicinal Chemistry, 60(5), 2148-2154.
- Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Research, 77(4), 937-948.
- Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle, 16(2), 189-199.
- Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nature Medicine, 23(2), 256-263.
- A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation. Nucleic Acids Research, 45(2). View this article in WRRO
- Chemotherapy-induced toxicity—a secondary effect caused by released DNA?. Annals of Oncology, 28(9), 2054-2055.
- Validation and development of MTH1 inhibitors for treatment of cancer. Annals of Oncology, 27(12), 2275-2283.
- Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell Reports, 17(12), 3407-3416.
- The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis, 5(12). View this article in WRRO
- hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis, 5(12). View this article in WRRO
- NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Cancer Research, 76(18), 5501-5511.
- Pathways controlling dNTP pools to maintain genome stability. DNA Repair, 44, 193-204.
- PathwAX: a web server for network crosstalk based pathway annotation. Nucleic Acids Research, 44(W1), W105-W109. View this article in WRRO
- Ex vivo culture of circulating tumour cell derived explants to facilitate rapid therapy testing in small cell lung cancer. European Journal of Cancer, 61, S120-S120.
- Drugging DNA repair. Science, 352(6290), 1178-1179.
- Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks. Cell Death & Disease, 7(6). View this article in WRRO
- PARP inhibitor receives FDA breakthrough therapy designation in castration resistant prostate cancer: beyond germline BRCA mutations. Annals of Oncology, 27(5), 755-757.
- Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition. Cancer Research, 76(8), 2366-2375.
- DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair. Cancer Research, 76(5), 1078-1088.
- PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites. Oncogene, 35(6), 761-770.
- Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal of Medicinal Chemistry, 59(3), 1140-1148.
- Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell Reports, 14(2), 298-309.
- Correction: Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell, 61(1), 181-181.
- Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies. FEBS Journal, 283(2), 232-245.
- Production, Purification, and Characterization of 15N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements, 305-332.
- Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. ONCOTARGET, 6(35), 37385-37393.
- Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6(35), 37638-37646. View this article in WRRO
- Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair. Science Translational Medicine, 7(312), ---.
- Poisoning Cancer Cells with Oxidized Nucleosides. New England Journal of Medicine, 373(16), 1570-1571.
- ChemInform Abstract: Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.. ChemInform, 46(40), no-no.
- Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell, 60(1), 163-176.
- PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription. Molecular Cell, 59(6), 984-997.
- Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry. DNA Repair, 33, 101-110.
- Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nature Communications, 6(1). View this article in WRRO
- Processing of protein ADP-ribosylation by Nudix hydrolases. Biochemical Journal, 468(2), 293-301.
- Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles. Chemistry - A European Journal, 21(20), 7394-7398.
- Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox. Progress in Lipid Research, 58, 51-75.
- Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. Journal of Pharmaceutical and Biomedical Analysis, 104, 1-11.
- A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery, 1(1). View this article in WRRO
- Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Scientific Reports, 4(1). View this article in WRRO
- The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes & Development, 28(24), 2726-2738.
- P047 Castration promotes radiosensitivity by direct regulation of DNA repair in prostate cancer. European Urology Supplements, 13(5), 126-126.
- Mechanisms underlying mutational signatures in human cancers. Nature Reviews Genetics, 15(9), 585-598.
- The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions. Nucleic Acids Research, 42(14), 9108-9120. View this article in WRRO
- 835: Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool. European Journal of Cancer, 50, S203-S203.
- Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival. Annals of Oncology, 25(7), 1253-1255.
- SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability. Cell Reports, 7(6), 2006-2018.
- Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42(10), 6326-6336. View this article in WRRO
- Chemical strategies for development of ATR inhibitors. Expert Reviews in Molecular Medicine, 16.
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature, 508(7495), 215-221.
- Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature, 508(7495), 222-227.
- ChemInform Abstract: A New Concise Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives.. ChemInform, 45(13), no-no.
- ChemInform Abstract: A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis.. ChemInform, 45(7), no-no.
- Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells. Science, 343(6166), 88-91.
- miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors. Molecular Cell, 53(1), 162-163.
- SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways. Cell Cycle, 12(24), 3770-3780.
- PrimPol breaks replication barriers. Nature Structural & Molecular Biology, 20(12), 1348-1350.
- Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice. Current Opinion in Oncology, 25(6), 609-614.
- ChemInform Abstract: A Facile and Efficient Synthesis of Tetrahydro-β-carbolines.. ChemInform, 44(42), no-no.
- Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proceedings of the National Academy of Sciences, 110(42), 16856-16861.
- E2F-7 couples DNA damage-dependent transcription with the DNA repair process. Cell Cycle, 12(18), 3037-3051.
- A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis. European Journal of Organic Chemistry, 2013(26), 5879-5885.
- Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability. Nature, 500(7463), 490-490.
- Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene, 32(32), 3744-3753.
- A facile and efficient synthesis of tetrahydro-β-carbolines. Tetrahedron Letters, 54(27), 3554-3557.
- Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy. Radiotherapy and Oncology, 108(1), 155-161.
- 5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. Nucleic Acids Research, 41(11), 5827-5836. View this article in WRRO
- Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer. Clinical Cancer Research, 19(6), 1547-1556.
- Replication stress links structural and numerical cancer chromosomal instability. Nature, 494(7438), 492-496. View this article in WRRO
- Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair. Carcinogenesis, 34(2), 325-330.
- A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives. New Journal of Chemistry, 37(11), 3595-3595.
- DNA damage response in peritumoral regions of oesophageal cancer microenvironment. Carcinogenesis, 34(1), 139-145.
- Targeting Protein forXenopusKinesin-like Protein 2 (TPX2) Regulates γ-Histone 2AX (γ-H2AX) Levels upon Ionizing Radiation. Journal of Biological Chemistry, 287(50), 42206-42222.
- Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. Carcinogenesis, 33(11), 2026-2034.
- PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2.. Journal of Biological Chemistry, 287(41), 34494-34494.
- The Relationship Between Homologous Recombination Repair and the Sensitivity of Human Epidermis to the Size of Daily Doses Over a 5-Week Course of Breast Radiotherapy. Clinical Cancer Research, 18(19), 5479-5488.
- CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation. Nucleic Acids Research, 40(17), 8440-8448. View this article in WRRO
- Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation. Nucleic Acids Research, 40(14), 6585-6594. View this article in WRRO
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Research, 40(12), 5794-5794.
- Minor structural modifications to alchemix influence mechanism of action and pharmacological activity. Biochemical Pharmacology, 83(11), 1514-1522.
- Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1. Cancer Research, 72(11), 2814-2821.
- N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells. Lipids, 47(4), 355-361.
- Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells. Environmental and Molecular Mutagenesis, 53(2), 114-124.
- Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival. Clinical Cancer Research, 18(5), 1257-1267.
- Castration Therapy of Prostate Cancer Results in Downregulation of HIF-1α Levels. International Journal of Radiation Oncology*Biology*Physics, 82(3), 1243-1248.
- PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy. Clinical Cancer Research, 18(4), 1015-1027.
- Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival. Molecular Cancer Therapeutics, 11(1), 98-107.
- Biological Relevance of DNA Polymerase Beta and Translesion Synthesis Polymerases to Cancer and its Treatment. Current Molecular Pharmacology, 5(1), 54-67.
- Inhibitors of DNA Repair and Response to Ionising Radiation, 143-171.
- CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA Repair, 10(9), 961-969.
- UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Research, 39(16), 7049-7057. View this article in WRRO
- New Translational Possibilities for Microenvironmental Modulation of Radiosensitivity. Radiation Research, 176(3), 412-414.
- DNA repair as treatment target. European Journal of Cancer, 47, S333-S335.
- Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities Report of an NCI Workshop held September 1–3, 2010. Radiation Research, 176(3), e0016-e0021.
- Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Letters, 585(16), 2617-2621.
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings. Molecular Oncology, 5(4), 387-393.
- Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010.. Radiat Res.
- ATM‐mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double‐strand break repair. EMBO reports, 12(7), 713-719.
- Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2fraction. Cancer Biology & Therapy, 11(12), 1028-1035.
- Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Research, 39(8), 3166-3175. View this article in WRRO
- Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells. Experimental Cell Research, 317(3), 330-337.
- miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors. Molecular Cell, 41(2), 210-220.
- Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 706(1-2), 1-6.
- Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. Biochemical and Biophysical Research Communications, 404(1), 206-210.
- Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination. Molecular Cell, 40(4), 632-644.
- The XPD subunit of TFIIH is required for transcription-associated but not DNA double-strand break-induced recombination in mammalian cells. Mutagenesis, 25(6), 623-629.
- Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks.. Oncotarget, 1(7), 606-619. View this article in WRRO
- Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment. Cancer Research, 70(20), 8045-8054.
- Pathways of mammalian replication fork restart. Nature Reviews Molecular Cell Biology, 11(10), 683-687.
- Chk1 promotes replication fork progression by controlling replication initiation. Proceedings of the National Academy of Sciences, 107(37), 16090-16095.
- Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage. Journal of Molecular Biology, 402(1), 70-82.
- Targeting homologous recombination repair defects in cancer. Trends in Pharmacological Sciences, 31(8), 372-380.
- 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance. Cancer Research, 70(15), 6268-6276.
- Human RECQL5 overcomes thymidine-induced replication stress. DNA Repair, 9(9), 964-975.
- Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2. Cell, 142(1), 65-76.
- XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA Repair, 9(7), 835-841.
- Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients. Oncotarget, 1(3), 175-184. View this article in WRRO
- Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination–Defective Cells. Cancer Research, 70(13), 5389-5398.
- Homologous recombination in cancer development, treatment and development of drug resistance. Carcinogenesis, 31(6), 955-960.
- Correction: A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown. Cancer Research, 70(9), 3853.3-3853.
- A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown. Cancer Research, 70(7), 2984-2993.
- PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA. Journal of Biological Chemistry, 285(11), 8054-8060.
- Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. The Journal of Cell Biology, 188(5), 629-638. View this article in WRRO
- Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair. Molecular Cell, 37(4), 492-502.
- Mutagenesis: Mutating a Gene While Reading It. Current Biology, 20(2), R57-R58.
- Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget, 1(7), 606-619.
- Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination. DNA Repair, 8(12), 1424-1433.
- The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Research, 37(19), 6400-6413. View this article in WRRO
- PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. The EMBO Journal, 28(17), 2601-2615.
- BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells. Nucleic Acids Research, 37(15), 5105-5113. View this article in WRRO
- PCNA on the crossroad of cancer. Biochemical Society Transactions, 37(3), 605-613.
- Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3†. Journal of Medicinal Chemistry, 52(9), 3108-3111.
- Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination. Mutagenesis, 24(3), 203-210.
- Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proceedings of the National Academy of Sciences, 105(52), 20752-20757.
- WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks. Molecular Biology of the Cell, 19(9), 3923-3933.
- Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11. Clinical Cancer Research, 14(17), 5476-5483.
- Bacteriophage P2 integrase: another possible tool for site-specific recombination in eukaryotic cells. Journal of Applied Microbiology, 105(1), 290-299.
- Claspin Promotes Normal Replication Fork Rates in Human Cells. Molecular Biology of the Cell, 19(6), 2373-2378.
- Zinc Binding Catalytic Domain of Human Tankyrase 1. Journal of Molecular Biology, 379(1), 136-145.
- Amplifying tumour-specific replication lesions by DNA repair inhibitors – A new era in targeted cancer therapy. European Journal of Cancer, 44(7), 921-927.
- DNA repair pathways as targets for cancer therapy. Nature Reviews Cancer, 8(3), 193-204.
- Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells. Molecular and Cellular Biology, 28(1), 154-164.
- The histone methyltransferase SET8 is required for S-phase progression. Journal of Cell Biology, 179(7), 1337-1345. View this article in WRRO
- RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells. Journal of Molecular Biology, 373(1), 38-47.
- DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair, 6(7), 923-935.
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature, 447(7142), 346-346.
- RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair. Molecular and Cellular Biology, 27(7), 2562-2571.
- RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis. Cytogenetic and Genome Research, 116(1-2), 38-45.
- Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines. DNA Repair, 5(12), 1449-1458.
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 444(7119), 633-637.
- Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 599(1-2), 116-123.
- Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility. Human Molecular Genetics, 15(7), 1217-1224.
- Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Research, 34(6), 1685-1691. View this article in WRRO
- Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy. Cell Cycle, 4(9), 1176-1178.
- Spontaneous Homologous Recombination Is Induced by Collapsed Replication Forks That Are Caused by Endogenous DNA Single-Strand Breaks. Molecular and Cellular Biology, 25(16), 7158-7169.
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Research, 33(12), 3799-3811. View this article in WRRO
- Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage. Molecular and Cellular Biology, 25(9), 3553-3562.
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature, 434(7035), 913-917.
- Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434(7029), 108-113.
- The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biology, 7(2), 195-201.
- Up-regulation of the error-prone DNA polymerase κ promotes pleiotropic genetic alterations and tumorigenesis. Cancer Research, 65(1), 325-330.
- Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells. Oncogene, 23(56), 9136-9141.
- ATM is required for the cellular response to thymidine induced replication fork stress. Human Molecular Genetics, 13(23), 2937-2945.
- Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents. Biochemical Society Transactions, 32(6), 959-961.
- Methods in Molecular Biology, Vol. 262: Genetic Recombination Reviews and Protocols. Edited by Alan S. Waldman.. ChemBioChem, 5(11), 1606-1607.
- Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminants. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 563(1), 35-47.
- p53 protects from replication-associated DNA double-strand breaks in mammalian cells. Oncogene, 23(13), 2324-2329.
- Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Research, 32(12), 3683-3688.
- Pathways for mitotic homologous recombination in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 532(1-2), 103-115.
- Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Research, 31(17), 4959-4964.
- P-128 Regulation of RAD51 levels in response to etoposide (VP16) induced DNA strand breaks in small cell lung cancer cells. Lung Cancer, 41, S123-S123.
- The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer. International Journal of Cancer, 105(4), 472-479.
- RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells. Journal of Molecular Biology, 328(3), 521-535.
- DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer. Lung Cancer, 40(2), 157-164.
- Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. Carcinogenesis, 24(2), 249-253.
- Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells. Molecular and Cellular Biology, 22(16), 5869-5878.
- Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. Human Molecular Genetics, 11(18), 2189-2200.
- Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells. Biochemical and Biophysical Research Communications, 296(2), 363-367.
- ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 493(1-2), 55-66.
- The DRAG Test: An Assay for Detection of Genotoxic Damage. Alternatives to Laboratory Animals, 29(3), 233-241.
- DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells11Edited by J. Karn. Journal of Molecular Biology, 307(5), 1235-1245.
- RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors. Nucleic Acids Research, 29(3), 662-667.
- Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells. Mutation Research/DNA Repair, 461(3), 221-228.
- Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in thehprt gene of V79 Chinese hamster cells. Environmental and Molecular Mutagenesis, 35(2), 114-122.
- The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells 1 1Edited by J. Karn. Journal of Molecular Biology, 289(5), 1231-1238.
- Brominated flame retardants induce intragenic recombination in mammalian cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 439(2), 137-147.
- Session 1: Signal Transduction. Toxicology in Vitro, 12(5), 519-522.
- A partial HPRT gene duplication generated by non-homologous recombination in V79 chinese hamster cells is eliminated by homologous recombination. Journal of Molecular Biology, 279(4), 687-694.
- Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells. Carcinogenesis, 19(6), 973-978.
- P XVII B.13 Interaction of fatty acids in mutagenicity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 379(1), S175-S175.
- P VIII.8 Recombinogenic effects may diverge depending on different recombination mechanisms. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 379(1), S57-S57.
- Untersuchung von Eiern und Eikonserven. Fresenius' Zeitschrift für analytische Chemie, 115(11-12), 455-455.
- Beziehung zwischen Oberfläche und Gestalt der Hühnereier. Zeitschrift für Untersuchung der Lebensmittel, 73(4), 313-326.
- Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions. European Journal of Organic Chemistry.
- Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions. European Journal of Organic Chemistry.
- Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. Blood Journal.
- Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism.
- NUDT22 promotes cancer growth through pyrimidine salvage. Oncogene.
- Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming. Journal of Translational Medicine, 21(1).
- An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation. Cells, 11(24), 4121-4121.
- Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules, 12(12), 1777-1777.
- Precision oncology using ex vivo technology: a step towards individualised cancer care?. Expert Reviews in Molecular Medicine, 1-48.
- Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo Guanine DNA Glycosylase 1. ChemMedChem.
- Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones. Nature Communications, 13(1).
- Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids. Viruses, 13(1), 37-37.
- Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses. Viruses, 12(12), 1423-1423.
- OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions. Biomolecules, 10(11), 1483-1483.
- MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression. View this article in WRRO
- A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. MedChemComm, 9(7), 1105-1113.
- Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction. Organic & Biomolecular Chemistry, 15(37), 7758-7764.
- Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress. Proteomes, 2(3), 341-362.
- Early replication fragile sites: where replication–transcription collisions cause genetic instability. The EMBO Journal, 32(4), 493-495.
- Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy. Biomolecules, 2(4), 635-649. View this article in WRRO
- PCNA (proliferating cell nuclear antigen). Atlas of Genetics and Cytogenetics in Oncology and Haematology(3).
- FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ. PLoS ONE, 6(5), e19659-e19659. View this article in WRRO
- Transcription Inhibition by DRB Potentiates Recombinational Repair of UV Lesions in Mammalian Cells. PLoS ONE, 6(5), e19492-e19492. View this article in WRRO
- Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ. PLoS ONE, 6(6).
- Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair. Nucleic Acids Research, 37(2), 405-412. View this article in WRRO
- The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Research, 36(1), 1-9. View this article in WRRO
- A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. Human Molecular Genetics, 13(2), 203-212.
- PFKFB3 mediates ATM dependent break-1 induced dNTP supply for effective double-strand break repair. Nature Communications.
- Polθ inhibitors unchained. Nature Cancer.
- Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion. Cells, 10(11), 3040-3040.
Chapters
- Targeting DNA Repair in Anti-Cancer Treatments, Cancer Drug Discovery and Development (pp. 1-9). Springer International Publishing
- Inhibition of DNA repair as therapeutic target, Cancer Drug Design and Discovery (pp. 284-304).
- Contributors, Cancer Drug Design and Discovery (pp. xi-xiii). Elsevier
- Inhibition of DNA repair as a therapeutic target, Cancer Drug Design and Discovery (pp. 284-304). Elsevier
Conference proceedings papers
- Abstract ES12-2: Targeted DNA repair in cancer and new NUDT5 inhibitors to block hormone signalling to target breast cancer. Invited Speaker Abstracts
- Targeting DNA Repair: Beyond Cancer.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol. 60 (pp 44-45)
- Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells. Tumor Biology
- Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells. Tumor Biology
- Repurposing Old Drugs as SAMHD1 Inhibitors to Improve Efficacy of Cytarabine in Paediatric Acute Myeloid Leukaemia. PEDIATRIC BLOOD & CANCER, Vol. 65 (pp S419-S420)
- Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxia. STRAHLENTHERAPIE UND ONKOLOGIE, Vol. 194 (pp S172-S172)
- 1180 Effects of MTH1 inhibitor TH1579 on cutaneous melanoma. Journal of Investigative Dermatology, Vol. 138(5) (pp S200-S200)
- Development of a Small Molecule Inhibitor for SAMHD1 to Improve Outcome for Patients with Acute Myelogenous Leukaemia and Relapsed T-Lymphoblastic Malignancies Treated with Nucleoside Analogues. PEDIATRIC BLOOD & CANCER, Vol. 64 (pp S135-S135)
- Poisoning cancer with oxidized nucleotides by targeting MTH1. MOLECULAR CANCER RESEARCH, Vol. 15
- INVESTIGATING THE ROLE OF MTH1 INHIBITION IN THE TREATMENT OF OVARIAN CANCER. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol. 26 (pp 727-727)
- Introducing a new method for absolute quantification of DNA repair proteins in relation to drug development: LC–MS/MS with isotope dilution. Toxicology Letters, Vol. 258 (pp S57-S57)
- Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer. Tumor Biology
- Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell. Experimental and Molecular Therapeutics
- Ex vivo culture of circulating tumour cell derived explants to facilitate rapid therapy testing in small cell lung cancer. EUROPEAN JOURNAL OF CANCER, Vol. 61 (pp S120-S120)
- Inhibition of the nucleotide pool sanitizing enzyme MTH1 augments genotoxic effects of ionizing radiation and hypoxia on tumor cells. ACTA PHYSIOLOGICA, Vol. 216
- MTH1 inhibitors in cancer treatment. Annals of Oncology, Vol. 26 (pp ii8-ii8)
- 5-aza-2 ' deoxycytidine induces DNA lesions that are repaired via Transcription-Coupled Repair involving Cockayne syndrome protein B. MUTAGENESIS, Vol. 29(6) (pp 533-533)
- 240 The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells. European Journal of Cancer, Vol. 50 (pp 81-81)
- The PARP inhibitor Olaparib disrupts Base Excision Repair of 5-aza-2 '-deoxycytidine lesions. MUTAGENESIS, Vol. 29(6) (pp 541-542)
- Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by Homologous Recombination. MUTAGENESIS, Vol. 29(6) (pp 534-534)
- 365: The interplay between the redox environment, MTH1 and cancer. European Journal of Cancer, Vol. 50 (pp S87-S87)
- 6: Targeting MTH1 prevents sanitation of oxidised dNTP pools and causes cancer-selective DNA damage and cell death. European Journal of Cancer, Vol. 50 (pp S3-S3)
- Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool. EUROPEAN JOURNAL OF CANCER, Vol. 50 (pp S203-S203)
- Abstract CN05-04: Novel DNA repair targets for anticancer treatments.. DNA Repair and Modulation
- New DNA repair targets in cancer treatment. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S38-S39)
- DNA repair pathways as target for cancer therapy. Toxicology Letters, Vol. 211 (pp S9-S9)
- Interplay between DNA replication and the DNA damage response. MUTAGENESIS, Vol. 27(1) (pp 108-109)
- DNA Damage and Repair in Cancer: From Basic Science to Anti-Cancer Treatments.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol. 52 (pp S13-S13)
- Transcription-Associated Recombination at Replication Forks in Mammalian Cells.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol. 52 (pp S25-S25)
- 247 INVITED PARP Inhibitors Sensitivity and Resistance. European Journal of Cancer, Vol. 47 (pp S58-S58)
- Breast cancer stem-like cells show enhanced homologous recombination due to a larger S-G2 fraction. STRAHLENTHERAPIE UND ONKOLOGIE, Vol. 187 (pp 54-54)
- 332 POLQ (DNA polyermase theta) as a novel therapeutic target: preclinical and clinical data. European Journal of Cancer Supplements, Vol. 8(7) (pp 106-106)
- THE INCREASING COMPLEXITY OF PARP FAMILY PROTEINS IMPLICATIONS FOR CANCER THERAPY. RADIOTHERAPY AND ONCOLOGY, Vol. 96 (pp S34-S34)
- SENSITIVITY TO RADIOTHERAPY FRACTION SIZE IS MODULATED BY DNA DOUBLE STRAND BREAK (DSB) REPAIR SYSTEMS. RADIOTHERAPY AND ONCOLOGY, Vol. 96 (pp S154-S154)
- Anti-proliferative effects of taurine conjugated fatty acids. Chemistry and Physics of Lipids, Vol. 163 (pp S36-S36)
- 611 Homologous recombination in cancer development, treatment and development of drug resistance. European Journal of Cancer Supplements, Vol. 8(5) (pp 156-156)
- Loss of PTEN sensitizes cells to DNA damaging agents in a RAD51-independent manner. CANCER RESEARCH, Vol. 70
- Abstract 3932: Loss of PTEN sensitizes cells to DNA damaging agents in a RAD51-independent manner. Cellular and Molecular Biology
- Radiotherapy fraction size sensitivity is modulated by DNA repair systems. Breast Cancer Research, Vol. 12(S1)
- Abstract A115: Contextual synthetic lethality: Repair‐deficient hypoxic tumor cells are sensitized to poly(ADP‐ribose) polymerase (PARP) inhibition. DNA Repair and Modulation
- 156 Exploiting cancer defects in targeted therapy. European Journal of Cancer Supplements, Vol. 7(2) (pp 39-39)
- Exploiting Homologous Recombination Repair Defects in Cancer Cells. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol. 50(7) (pp 544-544)
- Anti-proliferative effects of glycine conjugated fatty acids. Chemistry and Physics of Lipids, Vol. 160 (pp S23-S23)
- Replication as origin for chromosome fragility - mechanistic insights.. CHROMOSOME RESEARCH, Vol. 17 (pp 16-16)
- Voreloxin is active in breast cancer biopsies and potency is enhanced in a BRCA2 mutant background. CANCER RESEARCH, Vol. 69
- Recombination repair in bypass of replication blocks in mammalian cells. MUTAGENESIS, Vol. 24(1) (pp 100-100)
- EXPLOITING DNA REPAIR AS TARGET FOR IMPROVING RADIOTHERAPY. RADIOTHERAPY AND ONCOLOGY, Vol. 88 (pp S15-S15)
- DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy. Biochemical Society Transactions, Vol. 35(5) (pp 1352-1354)
- 119 EACR award DNA replication repair: molecular insights towards new approaches to targeted anti-cancer therapy. European Journal of Cancer Supplements, Vol. 5(4) (pp 33-33)
- Identification of proteins relocated to the chromatin following DNA damage. FEBS JOURNAL, Vol. 274 (pp 79-79)
Presentations
- NUDT22 promotes cancer growth through pyrimidine salvage and the TCA cycle.
Preprints
- scCUTseq is a versatile framework for spatially resolved single-cell genomic analyses of intratumor heterogeneity, Research Square Platform LLC.
- Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM, Cold Spring Harbor Laboratory.
- Overexpressed C-Myc Sensitize Cells to TH1579, an Mitotic Arrest and Oxidative DNA Damage Inducer, MDPI AG.
- OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice, Cold Spring Harbor Laboratory.
- MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells, Cold Spring Harbor Laboratory.
- Development of a chemical probe against NUDT15. Nature Chemical Biology. View this article in WRRO
- Grants
-
- ERC Proof of Concept grant.
- Novo Nordisk Foundation.
- Swedish Cancer Society.
- The Swedish Childhood Cancer Foundation.
- Swedish Foundation for Strategic Research.
- Swedish Research Council- Grant for Distinguished Professors.
- Söderberg Professor of Translational Medicine and Chemical Biology.