Dr Kai Erdmann
Department of Biomedical Science
& Centre for Membrane Interactions and Dynamics (CMIAD)
The University of Sheffield
Sheffield S10 2TN
- 2012-present: Senior Lecturer, University of Sheffield
- 2006-2012: Privatdozent, Group leader, Ruhr-University Bochum, Germany
- 2005-2006: Research Associate, Yale University School of Medicine, USA
- 2003-2005: Feodor Lynen Fellow (Alexander von Humboldt foundation), Yale University School of Medicine, USA
- 1998-2003: Junior group leader, Ruhr-University Bochum, Germany
- 1996-1998: Postdoctoral work, Ruhr-University Bochum, Germany
- 1993-1996: PhD, Ruhr-University Bochum, Germany
- 1987-1992: Diploma, Ruhr-University Bochum, Germany
Membrane trafficking and signalling in polarised cells. Role of multi-PDZ domain proteins in cancer formation, metastasis and tumor invasion.
Our group is interested in the regulation of membrane trafficking and its relation to human diseases. In particular we are interested in the molecular mechanism leading to Lowe syndrome, a X-linked disease characterized by congenital cataracts, mental retardation and kidney failure. Moreover, we analyze the molecular function of multi-PDZ domain proteins (PTPN13 and FRMPD2) in vesicular trafficking and signal transduction as well as their role in cancer development and progression.
Activities and distinctions
- Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2013) The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene, 32(39), 4602-4613.
- Hagemann N, Hou X, Goody RS, Itzen A & Erdmann KS (2012) Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome.. Small GTPases, 3(2), 107-110.
- Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2012) The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene.
- Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Has ler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S & Rosenstiel P (2012) RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition. Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21426-21431.
EU Marie Curie-CIG-project Endosignal
Inflammatory bowel disease is a devastating disease affecting several million people in Europe. This project addresses the molecular mechanism of inflammatory bowel disease. The multi-PDZ domain protein FRMPD2 (FERM and PDZ domain containing protein 2) has been shown to be an integral part of the immune host defense of epithelial cells by recruiting NOD2 (Nucleotide-binding and oligomerization protein 2), a key player of the innate immune system, to the basolateral membrane in epithelial cells.
In addition, FRMPD2 is involved in epithelial cell/cell adhesion regulating tight junction formation. Interaction of NOD2 with FRMPD2 places the NOD2 protein into a novel context being part of a larger protein complex. Using an interdisciplinary approach combining state of the art techniques from cell biology, protein chemistry, membrane physics and developmental genetics, this project aims at the identification and functional characterization of novel components of the FRMPD2 protein complex.
In particular, this protein complex will be characterized with respect to mechanisms relevant to epithelial cell polarization and inflammatory bowel disease. Finally, the project aims to complement in vitro mechanistic and cell culture data with in vivo results by analyzing the role of the FRMPD2 complex in zebrafish development. The results of this project will lead to a better molecular understanding of the disease opening potentially new avenues of treatments.