Professor Steve Winder
Professor of Molecular Cell Biology
Director: MSc in Stem Cell & Regenerative Medicine
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
email : s.winder@sheffield.ac.uk
Tel: +44 (0) 114 222 2332
Room: B2 06 Florey building
Career history
- Present: Professor of Molecular Cell Biology, Department of Biomedical Sciences, Department, University of Sheffield, Sheffield UK
- 2003-2005: Reader, Department of Biomedical Sciences, University of Sheffield, Sheffield UK
- 1999-2003 : Lecturer (99-01) Reader (02-03), University of Glasgow
- 1995-1999 : Wellcome Trust Fellow, University of Edinburgh,
- 1992-1995 : Staff Scientist, Laboratory of Molecular Biology, Cambridge - Advisor, Jake Kendrick-Jones
- 1988-1992: Postdoctoral Fellow, Biochemistry, University of Calgary, Advisor - Mike Walsh.
- 1994-1998 : PhD, University of Reading, Supervisor - Isabel Forsyth
Research interests
The main research focus of my group is centered around understanding the normal functions of the cell adhesion and signalling adaptor protein dystroglycan and in diseases such as muscular dystrophy and cancer. In particular we are investigating the regulation of the actin cytoskeleton, adhesion mediated signalling and cell motility and invasion using molecular cell biology and transgenic approaches.
Read more on research in the Winder laboratory
Activities and distinctions
- Member of Editorial Boards of: International Journal of Cell Biology, Journal of Biomedicine and Biotechnology, Advanced Studies in Biology, Landes Bioscience, also member of Biochemical Journal Editorial Advisory Panel, and Board of Protein Modules Consortium.
- Catalan Agency for Health Technology Assessment and Research grant review committee member. Regular grant reviewer for BBSRC, Welcome Trust, Telethon Italia and Asociation Française Contre les Myopathies.
- Invited talks at FASEB Summer Research Conference Snowmass USA; EMBO Workshop on 'Coiled coils collagen and co-proteins' Alpbach, Austria; ESF Conference on ‘Functional Protein Modules’ Seefeld, Austria; British Society for Cell Biology Annual Meeting, York, England.
- Invited peer reviewed reviews in Trends in Cell Bioloy, Current Opinion in Cell Biology and Trends in Biochemical Science. Editor and author of Molecular Mechanisms of Muscular Dystrophies, Landes Bioscience.
Funding
Recent publications
Winder SJ, Lipscomb L, Angela Parkin C, Juusola M.
The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.
PLoS Curr. 2011 Nov 17;3
Parberry-Clark C, Bury JP, Cross SS, Winder SJ.
Loss of dystroglycan function in oesophageal cancer.
Histopathology. 2011 Aug;59(2):180-7.
Le Rumeur E, Winder SJ, Hubert JF.
Dystrophin: more than just the sum of its parts.
Biochim Biophys Acta. 2010 Sep;1804(9):1713-22. Epub 2010 May 21. Review.
Moore CJ, Winder SJ.
Dystroglycan versatility in cell adhesion: a tale of multiple motifs.
Cell Commun Signal. 2010 Feb 17;8:3.
Thompson O, Moore CJ, Hussain SA, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJ.
Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.
J Cell Sci. 2010 Jan 1;123(Pt 1):118-27.
PDF version [Journal of Cell Science provides access to first 50 downloads free. Subscription to the journal thereafter.]
Robertson AS, Allwood EG, Smith AP, Gardiner FC, Costa R, Winder , Ayscough KR.
The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.
Mol Biol Cell. 2009; 20(6):1618-28.