The University of Sheffield
Chemical and Biological Engineering

Dr Paul Dobson

Lecturer in Biomanufacturing
Biological and Environmental Systems Group

Tel: +44 (0)114 222 7649
Email: P.D.Dobson@sheffield.ac.uk

Biography

I hold a degree in biochemistry and a PhD (2005) in structural biology with machine learning from UMIST.

Following short postdoctoral positions in text mining and Raman spectroscopy, in 2006 I joined the group of Professor Douglas Kell at The University of Manchester, where I led cheminformatics research on mechanisms of drug uptake into cells, and yeast systems biology.

I moved to Sheffield in 2010 as a ChELSI postdoctoral researcher with Dr Stephen Wilkinson, and in 2012 was appointed to a lectureship in biomanufacturing. My current research applies computer modelling to improve cell factories for the production of high value chemicals and biotherapeutics.

Research Interests

Links

Yeast Metabolic Network

Key Publications

  • Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, Pnar Pir, Douglas B Kell and Stephen G Oliver. Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biology, (2011).
  • Paul D Dobson, Kieran Smallbone, Daniel Jameson, Evangelos Simeonidis, Karin Lanthaler, Pnar Pir, Chuan Lu, Neil Swainston, Warwick B Dunn, Paul Fisher, Duncan Hull, Marie Brown, Olusegun Oshota, Natalie J Stanford, Douglas B Kell, Ross D King, Stephen G Oliver, Robert D Stevens and Pedro Mendes. Further developments towards a genome-scale metabolic model of yeast. BMC Systems Biology, (2010)
  • Dobson, P.D., Patel, Y. & Kell, D.B. ‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries. Drug Discov Today 14, 31-40 (2009).
  • Dobson, P.D. & Kell, D.B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7, 205-220 (2008).

All Publications