Dr Tom Farrow BSc (Hons) PhD

Senior Lecturer in Psychiatric Neuroimaging and Honorary NHS Clinical Scientist

Telephone: 0114 2261511
E-mail: t.f.farrow@sheffield.ac.uk

Present Research

• Investigating the cognitive and autonomic components of regulating one’s own and other’s emotions using concurrent fMRI and skin conductance response (SCR [EDA/GSR]) – see ‘Current Grants’ below. Sixty healthy volunteers will undergo an fMRI brain scan whilst socially interacting via video-link with an actor outside of the scanner. The subject’s task will involve regulating their own or the conspecific’s emotional state. Furthermore, the effect of an intervention (e.g. implementation intentions vs. surface acting) will be examined on neural activation and autonomic arousal. These interventions will be administered in collaboration with Professor Paschal Sheeran and Dr. Tom Webb, (Department of Health and Social Psychology, University of Sheffield). The work will be conducted by myself and the RA employed on the grant, Glyn Hallam.

Research interests

• Structural and functional magnetic resonance imaging (MRI) of clinical populations and healthy subjects.
• Conducting concurrent skin-conductance response (SCR) recording and fMRI to elucidate dynamic interaction between autonomic and cognitive systems.
• Clinical populations studied to date include first episode psychosis (FEP; schizophrenia and bipolar disorder), chronic, stable schizophrenia, posttraumatic stress disorder (PTSD), Alzheimer’s Disease, complicated early childhood convulsion (ECC) and adult temporal lobe epilepsy (TLE).
• Theory of mind, social cognition, empathy and emotion regulation.
• Relationship between regionally-specific grey-matter brain volume differences (measured using voxel-based morphometry [VBM]) and cognitive and behavioural function.
• Using transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) to modulate brain function.

Current grants

2009-2012 Economic and Social Research Council (ESRC) Large Grant "Emotion regulation of others and self (EROS): A collaborative research network.". £2million+. The grant involves seven investigators, researching an overarching theme of `emotion regulation´ at five UK universities. The other six investigators are:-

• Professor Peter Totterdell (PI), Institute of Work Psychology, University of Sheffield;
• Professor Paschal Sheeran and Dr. Tom Webb, Department of Health and Social Psychology, University of Sheffield;
• Dr. Warren Mansell, Department of Clinical Psychology, University of Manchester;
• ● Dr. Pasco Fearon, School of Psychology and Language Sciences, University of Reading;
• Professor Andrew Lane, Institute for Sport and Learning, University of Wolverhampton and;
• Professor Brian Parkinson, Department of Psychology, University of Oxford.

Plenary and Invited Lectures at National/International Conferences

• Mary Reynolds Babcock Foundation visiting lecturer, Wake Forest University, North Carolina, USA (2008).
• International Conference on Psycho-Social Rehabilitation, Bangalore, India. Plenary lecture (2008).
• International Workshop on "Neural basis and ontogeny of depressive psychopathology", San Raffaele Turro, Milan, Italy (2007).
• 2nd Biennial Conference of the International Society for Bipolar Disorders, Edinburgh, Scotland. (2006).
• Psychosis Interest Group seminar, Institute of Psychiatry, London, UK (2005).
• 3rd Sheffield Psychopathology Symposium - “Psychiatry and the Problem of Evil.” Sheffield, UK (2003).
• John Templeton Foundation Scientific Findings about Forgiveness Conference, Atlanta, Georgia, USA (2003).
• Faculty of Science research colloquium, University of Sydney, Australia (2002).
• 2^a Reunión de Investigatión en Psicopatología. (2nd Psychopathology Meeting). El Puerto de Santa María, Cádiz, Spain (2001).

Research supervision

Since 2001, I have (co-)supervised over 40 research student projects (2 Ph.D., 1 D.Clin.Psy. 2 M.Sc., 5 Research Associates, 5 B.Med.Sci., and 28 Phase 1b/3a medical students). These have included:

• Glyn Hallam (Ph.D.; ongoing).
• Subha Thiyagesh (Ph.D.; ongoing).
• Sudheer Lankappa: (Ph.D.; ongoing).
• Thomas Whitford: (Ph.D.; Awarded 2007).
• Isabelle Van Heeswijk (B.Med.Sci.; ongoing).
• Jenny Burgess (B.Med.Sci.; awarded 1st class 2010).
• Alice Mackay (B.Med.Sci.; awarded 1st class 2009).
• Molly Douglas (B.Med.Sci.; awarded 1st class 2009).
• Declan Hyland: (B.Med.Sci.; awarded 1st class 2008).
• Naomi Johnson: (B.Med.Sci..; awarded 1st class 2007).
• Michael Hogan (M.Sc.; awarded [with merit] 2008).
• Quasim Khan (M.Sc.; awarded [with merit] 2008).

Academic Honours and Awards

• Eli Lilley prize for best early career researcher at the 7th Biennial Australasian Schizophrenia Conference, Sydney, Australia (2002).
• Visiting Royal Society Overseas Fellowship. Hosted by the Brain Dynamics Centre, University of Sydney (2002-2003).

Membership of Editorial Boards/Editorships

• Editorial board member, The Open Neuroimaging Journal, Bentham Science Publishers Ltd. IL, USA.
• Co-editor (with Professor Peter Woodruff) Empathy in Mental Illness, Cambridge University Press (2007).

Teaching

• MED601 (Human neuroanatomy / practical brain dissection) to undergraduate medical students.
• MED6032 “Neuroimaging and Neuropsychiatry” module of Molecular Medicine MSc course – Module leader.
• Neuroanatomy to postgraduate psychiatry trainees (for MRCPsych exam).

Reviewing duties

• I review manuscripts for the following scientific journals: i) Acta Neuropsychologica; ii) Archives of General Psychiatry; iii) Archives of Neurology; iv) Behavioural Neurology; v) Biological Psychiatry; vi) Bipolar Disorders; vii) Brain; viii) British Journal of Psychiatry; ix) Cerebral Cortex; x) Cognitive Neuropsychiatry; xi) Dementia and Geriatric Cognitive Disorders; xii) European Archives of Psychiatry and Clinical Neuroscience; xiii) International Journal of Psychophysiology; xiv) Journal of Forensic Psychiatry and Psychology; xv) Journal of the International Neuropsychological Society; xvi) Journal of Psychiatry and Neuroscience; xvii) Journal of Psychophysiology; xviii) NeuroImage; xix) Neuropsychologia; xx) Neuropsychology; xxi) Perceptual and Motor Skills; xxii) Personality and Individual Differences; xxiii)Physiology and Behaviour; xxiv) Progress in Neuro-Psychopharmacology & Biological Psychiatry; xxv) Psychiatry Research; xxvi) Psychiatry Research-Neuroimaging; xxvii) Psychological Reports; xxviii) Psychological Medicine; xxix) The Open Neuroimaging Journal; xxx) Psychology and Psychotherapy: Theory; Research and Practice; xxxi) Quarterly Journal of Mental Health; xxxii) Schizophrenia Bulletin; and xxxiii) Schizophrenia Research.
• I have reviewed grant proposals for i) The Alzheimer's Research Trust; ii) Sheffield Hospitals Charitable Trust (SHCT) Medical Research Committee; iii) Sheffield Teaching Hospitals (STH) NHS Foundation Trust; iv) National Science Foundation, Virginia, USA; v) Ontario Mental Health Foundation, Canada and vi) Agència d’Avaluació de Technologia i Recerca Mèdiques (Catalan Agency for Health Technology Assessment and Research).

Interests

• I am a keen runner, who enjoys hill-walking, fine wine and good food.

Selected publications

• Performance on the clock drawing task correlates with fMRI response to a visuospatial task in Alzheimer's disease
  Parks RW, Thiyagesh SN, Farrow TFD, Ingram L, Wilkinson K, Hunter M, Wilkinson ID, Young C, Woodruff PWR, The International Journal of Neuroscience 120 (2010) pp. 335-343
• Delusionality and dorsomedial frontal cortex volume in first-episode schizophrenia: a voxel-based morphometry study
  Whitford TJ, Farrow TFD, Harris AWF, Gomes L, Brennan J, Williams LM, Psychiatry Research Neuroimaging 172 (2009) pp. 175-179
• The development of a clinically useful tool for predicting the development of psychological disorder following injury
  Mason S, Farrow TFD, Fawbert D, Smith R, Bath PA, Hunter M, Woodruff PW, Turpin G, British Journal of Clinical Psychology 48:1 (2009) pp. 31-45
• Speaking of secrets and lies: The contribution of ventrolateral prefrontal cortex to vocal deception
  Spence SA, Kaylor-Hughes CJ, Farrow TFD, Wilkinson ID, NeuroImage 40:3 (2008) pp. 1411-1418
• Voice familiarity engages auditory cortex
  Birkett P, Hunter M, Parks R, Farrow T, Lowe H, Wilkinson I, Woodruff P, NeuroReport 18:13 (2007) pp. 1375-1378
• Volumetric White Matter Abnormalities in First-Episode Schizophrenia: A Longitudinal, Tensor-Based Morphometry Study
  Whitford TJ, Grieve SM, Farrow TFD, Gomes L, Brennan J, Harris AWF, Gordon E, Williams LM, American Journal of Psychiatry 164 (2007) pp. 1082-1089
• Fronto-temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology
  Farrow TFD, Thiyagesh SN, Wilkinson ID, Parks RW, Ingram L, Woodruff PWR, Psychiatry Research: Neuroimaging 155:1 (2007) pp. 11-19
• Longitudinal changes in neuroanatomy and neural activity in early schizophrenia
  Whitford TJ, Farrow TFD, Rennie CJ, Grieve SM, Gomes L, Brennan J, Harris AWF, Williams LM, NeuroReport 18:5 (2007) pp. 435-439
• Empathy in Mental Illness
  Farrow TFD, Woodruff PWR, Cambridge: Cambridge University Press (2007)
• Neuroimaging of Empathy
  Farrow TFD, In Empathy in Mental Illness, Cambridge: Cambridge University Press (2007) pp. 201-216
• Increased cerebellar vermis white-matter volume in men with schizophrenia
  Lee KH, Farrow TFD, Parks RW, Newton LD, Mir NU, Egleston PN, Brown WH, Wilkinson ID, Woodruff PWR, Journal of Psychiatric Research 41 (2007) pp. 645-651
• Modafinil and unconstrained motor activity in schizophrenia
  Farrow TFD, Hunter MD, Haque R, Spence SA, British Journal of Psychiatry 189:5 (2006) pp. 461-463
• A Functional Magnetic Resonance Imaging Study of Social Cognition in Schizophrenia During an Acute Episode and After Recovery
  Lee KH, Brown WH, Egleston PN, Green RD, Farrow TF, Hunter MD, Parks RW, Wilkinson ID, Spence SA, Woodruff PWR, American Journal of Psychiatry 163:11 (2006) pp. 1926-1933
• A Six-Year Follow-Up MRI Study of Complicated Early Childhood Convulsion
  Farrow TFD, Dickson JM, Gr?newald RA, Pediatric Neurology 35:4 (2006) pp. 257-260
• Progressive grey matter atrophy over the first 2-3 years of illness in first-episode schizophrenia: A tensor-based morphometry study
  Whitford TJ, Grieve SM, Farrow TFD, Gomes L, Brennan J, Harris AWF, Williams LM, NeuroImage 32:2 (2006) pp. 511-519
• Neural activity in speech-sensitive auditory cortex during silence
  Hunter MD, Eickhoff SB, Miller TWR, Farrow TFD, Wilkinson ID, Woodruff PWR, Proceedings of the National Academy of Sciences 103:1 (2006) pp. 189-194
• A cognitive neurobiological account of deception: evidence from functional neuroimaging
  Spence SA, Hunter MD, Farrow TFD, Green RD, Leung DH, Hughes CJ, Ganesan V, In Law and the Brain, Oxford: Oxford University Press (2006) pp. 169-182
• Diagnosis-Related Regional Gray Matter Loss Over Two Years in First Episode Schizophrenia and Bipolar Disorder
  Farrow TFD, Whitford TJ, Williams LM, Gomes L, Harris AWF, Biological Psychiatry 58:9 (2005) pp. 713-723
• Structural brain correlates of unconstrained motor activity in people with schizophrenia
  Farrow TFD, Hunter MD, Wilkinson ID, Green RDJ, Spence SA, British Journal of Psychiatry 187 (2005) pp. 481-482
• Quantifiable change in functional brain response to empathic and forgivability judgments with resolution of posttraumatic stress disorder
  Farrow TFD, Hunter MD, Wilkinson ID, Gouneea C, Fawbert D, Smith R, Lee KH, Mason S, Spence SA, Woodruff PWR, Psychiatry Research: Neuroimaging 140:1 (2005) pp. 45-53
• Neuroimaging of forgivability
  Farrow TFD, Woodruff PWR, In Handbook of Forgiveness, New York: Brunner-Routledge (2005)
• Grey matter deficits and symptom profile in first-episode schizophrenia.
  Whitford TJ, Farrow TFD, Gomes L, Brennan J, Harris AWF, Williams LM, Psychiatry Research - Neuroimaging 139:3 (2005) pp. 229-238
• Recent developments in deception research.
  Hughes CJ, Farrow TFD, Hopwood MC, Pratt A, Hunter MD, Spence SA, Current Psychiatry Reviews. 1:3 (2005) pp. 273-279
• Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder
  Wignall EL, Dickson JM, Vaughan P, Farrow TFD, Hunter MD, Woodruff PWR, Biological Psychiatry 56:11 (2004) pp. 832-836
• Social cognition, brain networks and schizophrenia
  Lee KH, Farrow TFD, Spence SA, Woodruff PWR, Psychological Medicine 34 (2004) pp. 391-400
• A cognitive neurobiological account of deception: evidence from functional neuroimaging
  Spence SA, Hunter MD, Farrow TFD, Green RD, Leung DH, Hughes CJ, Ganesan V, Philosophical Transactions of the Royal Society of London: Biological Sciences 359 (2004) pp. 1755-1762
• Sex and personality traits influence the difference between time taken to tell the truth or lie
  Farrow TFD, Reilly R, Rahman TA, Herford AE, Woodruff PWR, Spence SA, Perceptual and Motor Skills 97 (2003) pp. 451-460
• Lying as an executive function
  Spence SA, Farrow TFD, Leung D, Shah S, Reilly B, Rahman A, Herford A, In Malingering and illness deception, Oxford: Oxford University Press (2003) pp. 255-266
• A neural basis for the perception of voices in external auditory space
  Hunter MD, Griffiths TD, Farrow TFD, Zheng Y, Wilkinson ID, Hegde N, Woods W, Spence SA, Woodruff PWR, Brain 126 (2003) pp. 161-169
• Approaching an ecologically valid functional anatomy of spontaneous "willed" action
  Hunter MD, Farrow TFD, Papadakis N, Wilkinson ID, Woodruff PWR, Spence SA, NeuroImage 20 (2003) pp. 1264-1269
• Behavioural and functional anatomical correlates of deception in humans
  Spence SA, Farrow TFD, Herford AE, Wilkinson ID, Zheng Y, Woodruff PWR, NeuroReport 12:13 (2001) pp. 2849-2853
• Investigating the functional anatomy of empathy and forgiveness
  Farrow TFD, Zheng Y, Wilkinson ID, Spence SA, Deakin JFW, Tarrier N, Griffiths PD, Woodruff PWR, NeuroReport 12:11 (2001) pp. 2433-2438
• A magnetic resonance study of complicated early childhood convulsion
  Grunewald RA, Farrow TFD, Vaughan P, Rittey CDC, Mundy J, Journal of Neurology, Neurosurgery and Psychiatry 71:5 (2001) pp. 638-642