Professor John E Brazier BA (Exeter), MSc (York), PhD (Sheffield)
HEDS, ScHARR
The University of Sheffield
Regent Court
30 Regent Street
Sheffield
S1 4DA
UK
Office:1016
Tel: (+44) (0)114 222 0726
Fax: (+44) (0)114 272 4095
E-mail: j.e.brazier@sheffield.ac.uk
Biography
I was awarded a Personal Chair in Health Economics in 1999. I have more than 20 years experience of conducting economic evaluations for policy makers. My main interests have been in the measurement and valuation of health for economic evaluation, including the development of preference-based measures of health from the SF-36 and a number of condition specific measures. I have published widely in the area (over 150 papers and a book published by OUP).
Research interests
SF-6D preference-based index
- Developed by Brazier et al (2002). Syntax files available from http://www.shef.ac.uk/scharr/sections/heds/mvh/sf-6d
- International valuation studies in Japan, Hong Kong, Portugal, Brazil, Australia and Singapore
- Comparisons to other generic preference-based measures
Deriving preference-based measures from condition specific measures
- Published studies: Kings Health Questionnaire, Atopic Dermatitis in Children, Menopausal specific health related quality of life questionnaire, Asthma Quality of Life Questionnaire, Overactive Bladder Questionnaire, Sexual Functioning Questionnaire.
- Current studies: Dementia Quality of Life (DEMQoL), Epilepsy QoL battery.
Modelling preference data
- Applying Bayesian methods to estimating preference-based algorithms
- Estimating health state values from ordinal data (rank and DCE)
Validity of EQ-5D across medical conditions.
Mapping from condition specific and other generic measures onto EQ-5D
- Recent and ongoing trial based economic evaluations: Complementary therapy (YACBAC trial), treatments for varicose veins, computerised cognitive behavioural therapy in MS, Borderline Personality Disorder (SPeDi trial)
- Model based economic evaluations: computerised cognitive behavioural therapy (NICE), Dialectical behavioural therapy for Borderline Personality Disorder (HTA)
Examining the relationship between health and well-being (and the role of adaptation)
Professional activities
- NIHR Senior Investigator award 2009-2013
- The estimation of a preference-based single index measure for health from the SF-36. Journal of Health Economics 2002; 21(2): 271-292 was 'Article of the Year", International Society of Quality of Life, 2002 and listed as a Thompson Essential Scientific Indicators Special Topic on Fast Moving Fronts in Economics and Business.
- Associate editor for 'Quality of life Research' from 2006-2010 and 'Applied Health Economics and policy' from 2003
- Member of the Fellowship Panel of the MRC Public Health and Health Services Research Board until 2010
- ScHARR Director of Research
Current projects
- Preparatory Study for the Re-evaluation of the EQ-5D Tariff (PRET)
Co-investigator (PI: Aki Tsuchiya)
Medical Research Council £280,000 (2010-2012) - Use of generic and condition-specific measures in NICE decision-making
Co-investigator (PI: Louise Longworth)
Medical Research Council £280,000 (2010-2012) - Assessing the impact of children with ADHD on the health and wellbeing of their families
Principal Investigator
Shire Pharmaceuticals Limited £597,146 (2009-2011) - Validating generic preference-based measures of health in mental health populations and estimating mapping functions for widely used specific measures
Principal Investigator
Medical Research Council £222,313 (2009-2010) - Health and Wellbeing
Principal Investigator
NIHR Senior Investigator support - via Sheffield Teaching Hospital Trust £75,000 - NIHR Senior Investigator award
Principal Investigator
NIHR, £75,000 (2009-2014) - Health economic evaluations in epilepsy: developing a preference-based outcome measure
Principal Investigator
Epilepsy Research UK £67,305 (2009-2010) - RCT and CE Evaluation of a "booster" intervention to sustain increases in physical activities in middle-aged adults in deprived neighbourhoods
Co-investigator (PI:Liddy Goyder)
NIHR HTA £1,200,000 (2009-2012) - Development and testing of methods for deriving preference-based measures from condition specific measures
Principal Investigator
NIHR HTA methods Programme £167,286 (2008-2010) - Generation of preference-based measures form the DEMQoL and DEMQoL proxy for use in economic evaluation
Joint Principal Investigator (with Sube Banerjee)
NIHR HTA methods Programme £550,000 (2008-2010) - Deriving a QALY measure in social care
Co-investigator (PI:Ann Netten)
NIHR HTA £300,000 (2008-2010) Subject to contract - Developing a broader measure for economic evaluation
Co-investigator (PI: Joanne Coast)
MRC £411,000 (2008-2010) - Review and empirical study of health related quality of life instruments for measuring the impact of oral medication versus insulin injection
Principal Investigator
Merck £220,000 (2008-2010)
Key publications
- Brazier JE, Ratcliffe J, Tsuchiya A, Salomon J. Measuring and valuing health for economic evaluation. Oxford: Oxford University Press 2007.
- Brazier J. Measuring and valuing mental health for economic evaluation. Journal of Health Services Research and Policy 2008; 13 (S3): 70-75.
- Ratcliffe, Brazier JE, Tsuchiya A, Symonds T, Brown M. Using DCE and ranking data to estimate cardinal values for health states for deriving a preference-based single index from the sexual quality of life questionnaire. Health Economics 2009; 18(11): 1261-1276.
- Yang Y, Brazier J, Tsuchiya A, Young T. Estimating a preference-based index for a 5-dimensional health state classification for asthma (AQL-5D) derived from the Asthma Quality of Life Questionnaire (AQLQ). Medical Decision Making (in press)
- Brazier J, Roberts J, Deverill M. The estimation a preference-based single index measure for health from the SF-36. Journal of Health Economics 2002; 21(2):271-292
- Brazier JE, Tsuchiya A, Roberts J, Busschbach J. A comparison of the EQ-5D and the SF-6D across seven patient groups. Health Economics 2004, 13(90):873-884