Professor Walter Marcotti
Professor of Sensory Neuroscience
Centre for Membrane Interactions and Dynamics
Department of Biomedical Science
The University of Sheffield
Sheffield S10 2TN. United Kingdom
Room: B1 221 Alfred Denny
Telephone: +44 (0) 114 222 1098
One of the challenges in modern medicine is to develop gene and stem cell therapeutic strategies to treat deafness by targeting specific genes that play a crucial role in the generation of the disease. In all cases, it is important to understand how the auditory system normally develops and operates and how defects at molecular level lead to deafness. Moreover, understanding how the ear processes sound is essential to further technical and software development of hearing aids, including cochlear implants.
In my laboratory, we aim to identify the normal development of the mammalian auditory system and, most importantly, to determine the functional/physiological consequences of genes that when mutated cause deafness in humans.This is achieved by studying the physiological properties of the individual sensory hair cells of the mammalian cochlea using electrophysiological, calcium imaging and molecular biology techniques.
- 2012 - present: Professor of Sensory Neuroscience
- 2006 - present: Royal Society University Research Fellow, University of Sheffield, UK.
- 2004 - 2005: Royal Society University Research Fellow, University of Sussex, UK.
- 2001 - 2004: Postdoctoral Fellow, University of Sussex, UK.
- 1997 - 2000: Postdoctoral Fellow, University of Bristol, UK.
- 1994 - 1997: PhD, University of Pavia, Italy.
- 1989 - 1992: University Degree in Biological Science, University of Pavia, Pavia, Italy.
Grants and funding
- Olt J, Mburu P, Johnson SL, Parker A, Kuhn S, Bowl M, Marcotti W & Brown SD (2014) The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of Mammalian cochlear outer hair cells.. PLoS One, 9(1), e87331.
- Chen J, Lewis MA, Hilton JM, Huma A, Steel KP, Johnson SL & Marcotti W (2014) A reduction in Ptprq associated with specific features of the deafness phenotype of the miR-96 mutant mouse diminuendo. European Journal of Neuroscience, 39(5), 744-756.
- Marcotti W, Corns LF, Desmonds T, Kirkwood NK, Richardson GP & Kros CJ (2014) Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel.. J Neurosci, 34(16), 5505-5514.
- Olt J, Johnson SL & Marcotti W (2014) In vivo and in vitro biophysical properties of hair cells from the lateral line and inner ear of developing and adult zebrafish. Journal of Physiology, 592(10), 2041-2058.
- Johnson SL, Kuhn S, Franz C, Ingham N, Furness DN, Knipper M, Steel KP, Adelman JP, Holley MC & Marcotti W (2013) Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity.. Proc Natl Acad Sci U S A, 110(21), 8720-8725.
- Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U & Knipper M (2013) Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells.. J Neurosci, 33(22), 9508-9519.
- Furness DN, Johnson SL, Manor U, Rüttiger L, Tocchetti A, Offenhauser N, Olt J, Goodyear RJ, Vijayakumar S, Dai Y, Hackney CM, Franz C, Di Fiore PP, Masetto S, Jones SM, Knipper M, Holley MC, Richardson GP, Kachar B & Marcotti W (2013) Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.. Proc Natl Acad Sci U S A.
- Zampini V, Johnson SL, Holley MC, Marcotti W, Magistretti J, Masetto S, Franz C & Knipper M (2013) Burst activity and ultrafast activation kinetics of Ca1.3 Ca channels support presynaptic activity in adult gerbil hair cell ribbon synapses. Journal of Physiology, 591(16), 3811-3820.
- Johnson SL, Wedemeyer C, Vetter DE, Adachi R, Holley MC, Elgoyhen AB & Marcotti W (2013) Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.. Open Biol, 3(11), 130163.