Professor Walter Marcotti
Professor of Sensory Neuroscience
Wellcome Trust Senior Investigator
Department of Biomedical Science
Centre for Sensory Neuroscience
Alfred Denny Building (B1 221)
University of Sheffield
Sheffield, S10 2TN, UK
- Telephone: +44 (0) 114 222 1098
- Email: firstname.lastname@example.org
My research group is part of the Centre for Sensory Neuroscience and the Centre for Membrane Interactions and Dynamics (CMIAD).
Awards and prizes
Current grants funding
Selected Publications (since 2014)
Corns, L. F., Johnson, S. L., Kros, C. J., & Marcotti, W. (2014).
Corns, L. F., Johnson, S. L., Kros, C. J., & Marcotti, W. (2016).
Auditory neuroscience and Deafness Sensory transduction Synaptic transmission
Sensory organs and the neural networks responsible for processing sensory information are supremely well adapted for detecting input from the external environment. Their challenge is to maximize sensitivity and fidelity over a wide dynamic range. The sensory receptors of the mammalian auditory system, the inner hair cells (IHCs), do this with unparalleled temporal precision (kHz range). We know little about the molecular and physiological mechanisms controlling the functional maturation of the auditory system or signal processing at the primary auditory synapses, the IHC ribbon synapses. Crucial to this work, is the need of near-physiological in vitro and the development of in vivo experimental models.
My laboratory is uniquely suited for this task because it is the only one in the world that routinely uses near-physiological conditions for in vitro mammalian cochlear physiology and performs in-vivo electrophysiology from the zebrafish. How biological systems orchestrate their development and how complex signals are processed by mature neuronal networks are major challenges in the quest to understand human biology and disease.
The auditory system provides an ideal model with which to address these questions, primarily because it involves a highly ordered array of a very small number of sensory cells with well-defined neuronal circuitry. It is also a key priority for human health because hearing loss affects more than 360 million people worldwide (WHO 2013), a number that will increase with the aging population.