Dr Marcelo N. Rivolta
Reader in Sensory Stem Cell Biology
Centre for Stem Cell Biology
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
Room: C226 Alfred Denny building
Phone: +44 (0) 114 222 2385
email : m.n.rivolta@sheffield.ac.uk
Career history
- 2012-Present: Reader in Sensory Stem Cell Biology, Department of Biomedical Sciences, University of Sheffield. UK.
- 2003-2011: Senior Research Fellow, Department of Biomedical Sciences, University of Sheffield. UK.
- 2001-2003: Research Fellow, Department of Biomedical Sciences, University of Sheffield. UK.
- 1998-2001: Research Fellow, Department of Physiology, University of Bristol. UK.
- 1995-1998: Postdoctoral Research Associate, Department of Physiology, University of Bristol. UK.
- 1992-1995: Ph.D., NIH. Bethesda, Maryland, USA and University of Córdoba, Argentina.
- 1992-1995: Visiting Associate at the Laboratory of Molecular Genetics, NIDCD, NIH. Bethesda. Maryland. USA.
- 1992-1991: Visiting Fellow at the Laboratory of Molecular Biology, NIDCD, NIH. Bethesda. Maryland. USA.
- 1989-1991: Visiting Fellow at the Laboratory of Cellular Biology, NIDCD, NIH. Bethesda. Maryland. USA.
- 1989: M.D. School of Medicine, University of Córdoba. Argentina.
- 1984-1989: Research Assistant. Institute of Cell Biology and Department of Histology, Embryology and Genetics. School of Medicine, University of Córdoba. Argentina.
Research interests
Deafness is a major public health issue worldwide, with more than 3 million people in the UK alone enduring a moderate to profound hearing loss. The Rivolta laboratory is dedicated to study the biology and behaviour of auditory stem cells (primarily human) and to explore their potential to regenerate the damaged inner ear.
Read more on research in the Rivolta laboratory
Activities and distinctions
- Reviewer for leading scientific journals.
- Reviewer for research proposals submitted to Action on Hearing Loss, Deafness Research UK, The Wellcome Trust, MRC, BBSRC and other funding bodies.
- Invited speaker at several national and international meetings.
- Trustee of the charity ‘The Ear Foundation’.
Funding
Recent publications
Chen, W; Jongkamonwiwat, N; Abbas, L; Jacob Eshtan, S; Johnson, SL; Kuhn, S; Thurlow, JK; Andrews, PW; Marcotti, W; Moore, HD and Rivolta, MN.
Restoration of auditory evoked responses by human ES cell-derived cochlear progenitors.
Nature, 2012 DOI 10.1038/nature11415
Boddy, SL; Chen, W; Romero-Guevara, R; Kottam, L; Bellantuono, I and Rivolta, MN.
Inner ear progenitor cells can be generated in vitro from human bone marrow mesenchymal stem cells.
Regenerative Medicine, 2012 in press.
Abbas, L and Rivolta, M.N.
Auditory Progenitors: their biology and applications for therapy.
In Progenitor and stem cell technologies and therapies: Tissue specific progenitors (Atala A ed). Woodhead Publishing, pp 282-308, 2012.
Huisman MA, Rivolta MN.
Neural crest stem cells and their potential application in a therapy for deafness.
Front Biosci (Schol Ed). 2012 Jan 1;4:121-32.
Jongkamonwiwat N, Zine A, Rivolta MN.
Stem cell based therapy in the inner ear: appropriate donor cell types and routes for transplantation.
Curr Drug Targets. 2010 Jul;11(7):888-97.
Rivolta MN.
Stem cells and cell lines from the human auditory organ: applications, hurdles and bottlenecks in the development of regenerative therapies for deafness.
Drug Discov Today. 2010 Apr;15(7-8):283-6. Epub 2010 Feb 25.
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M and Marcotti W (2010)
Synaptotagmin IV determines the linear calcium dependence of vesicle fusion at auditory ribbon synapses.
Nature Neurosci 2010 Jan;13(1):45-52.
Objoon, T and Rivolta, M.N.
Neural differentiation of human embryonic stem cells and their potential application in a therapy for sensorineural hearing loss.
In Trends in Stem Cell Biology and Technology (Baharvand H ed) Humana Press, pp 261-282, 2009.
Chen W, Johnson SL, Marcotti W, Andrews PW, Moore HD, Rivolta MN.
Human fetal auditory stem cells can be expanded in vitro and differentiate into functional auditory neurons and hair cell-like cells.
Stem Cells. 2009 May;27(5):1196-204.
Rivolta, M.N. and Holley, M.C.
Gene arrays, cell lines, stem cells and sensory regeneration in mammalian ears.
In the Springer Handbook of Auditory Research: Hair cell regeneration, repair and protection. (Salvi RJ, Popper AN & Fay RR eds).
Springer, New York, pp 257-307, 2008.