Dr Xinyue Chen
Department of Materials Science and Engineering
Henry Royce Institute Experimental Officer (Nanocharacterisation)
+44 114 222 5476
Full contact details
Department of Materials Science and Engineering
Royce Discovery Centre
5 Portobello Street
Sheffield
S1 4ND
- Profile
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I obtained my BSc (2008) in theoretical physics from Lanzhou University, China, and MRes (2011) in chemical biology from the University of Liverpool, UK. I started my PhD at CIC BiomaGUNE, Spain in 2012, where I aimed to understand the physical principles underlying the mechanical properties of hyaluronan-rich extracellular matrices. After the completion of my PhD in 2016, I moved to the University of Sheffield for a postdoc position in the Department of Physics and Astronomy, where I was heavily committed to the studies of the mechanical architectures of both complex tissue (breast cancer metastasis in bone microenvironment) and supramolecular composite (cell wall of S. Aureus). In April 2023, I joined the Department of Materials Science and Engineering as an Experimental Officer, where I'm actively supporting academic/industrial research projects by providing expert guidance, experimental services and training using atomic force microscopy and nanoindentation.
- Publications
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Journal articles
- A review on mechanobiology of cell adhesion networks in different stages of sporadic colorectal cancer to explain its tumorigenesis. Progress in Biophysics and Molecular Biology, 175, 63-72.
- Penicillin-binding protein 1 (PBP1) of Staphylococcus aureus has multiple essential functions in cell division. mBio, 13(4). View this article in WRRO
- Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases. Nanoscale, 13(43), 18237-18246. View this article in WRRO
- Osteoblast-derived paracrine and juxtacrine signals protect disseminated breast cancer cells from stress. Cancers, 13(6). View this article in WRRO
- Mechanical heterogeneity in the bone microenvironment as characterized by atomic force microscopy. Biophysical Journal, 119(3), 502-513. View this article in WRRO
- Bone marrow osteoprogenitors are depleted whereas osteoblasts are expanded independent of the osteogenic vasculature in response to zoledronic acid. The FASEB Journal, 33(11), 12768-12779. View this article in WRRO
- Effect of calcium ions and pH on the morphology and mechanical properties of hyaluronan brushes. Interface Focus, 9(2). View this article in WRRO
- Micromechanical Analysis of the Hyaluronan-Rich Matrix Surrounding the Oocyte Reveals a Uniquely Soft and Elastic Composition. Biophysical Journal, 110(12), 2779-2789. View this article in WRRO
- Features of Thiolated Ligands Promoting Resistance to Ligand Exchange in Self-Assembled Monolayers on Gold Nanoparticles. Australian Journal of Chemistry, 65(3), 266-266.
- ZIF‐67‐Derived Antivirus Cobalt Hydroxide LDH Nanosheets Produced through High‐Concentration Cobalt Ion‐Assisted Hydration. Advanced Functional Materials.
Conference proceedings papers
- Supracellular Mechanical Architecture of the Intact Bone Microenvironment. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 48 (pp S100-S100)
- Breast Cancer Metastasis To Bone: The Perivascular Niche. JOURNAL OF VASCULAR RESEARCH, Vol. 54 (pp 55-56)
- A review on mechanobiology of cell adhesion networks in different stages of sporadic colorectal cancer to explain its tumorigenesis. Progress in Biophysics and Molecular Biology, 175, 63-72.