Professor John W Haycock

BSc (Hons) PhD
Professor of Bioengineering
Director – Centre for Biomaterials & Tissue Engineering
Associate Director – Kroto Research Institute

Address:
The Kroto Research Institute
North Campus
University of Sheffield
Broad Lane
Sheffield
S3 7HQ

Telephone: +44 (0) 114 222 5972
Fax: +44 (0) 114 222 5943

Email: j.w.haycock@sheffield.ac.uk

John Haycock is a Professor in the Department Materials Science & Engineering, Associate Director of the Kroto Research Institute and Director of the Centre for Biomaterials & Tissue Engineering. He joined the department in 2001 from the Medical School at Sheffield University where he was a Research Fellow. He obtained his first degree and PhD in Biochemistry at Newcastle University and was a PDRA at Albany Medical College in New York. His research group is based in the Kroto Research Institute.

John is also Course Director for the B.Eng/M.Eng (Hons) Biomaterial Science Tissue Engineering degree programme and Admissions Tutor for the new B.Eng/M.Eng (Hons)  Bioengineering degree programme at Sheffield, being launched in 2011.

Research interests

John´s research spans three interdisciplinary themes:

1. Bioactive surfaces. Controlling the behaviour of skin and nerve cells with adhesive, migratory and anti-inflammatory peptides.
2. Nerve tissue engineering. The integration of bioreactors and nerve guidance channels for repairing nerve injury, and the use of stem cells for glial cell differentiation.
3. Skin tissue engineering. The use of synthetic fibre scaffolds and human skin cells for 3D in vitro models to detect toxic and inflammatory compounds as an alternative to animal models.

John also has an interest in single and 2-photon laser scanning microscopy for supporting a number of interdisciplinary research programmes, including tissue engineering. He was responsible for establishing the confocal and multiphoton imaging facility in the Kroto Research Institute funded by the BBSRC with support from Carl Zeiss.

Key projects

• Development of a nerve guide product for promoting neural integration and migration (with Prof. Giorgio Terenghi, Manchester University; Jim Rowland, Xiros; Mr Andrew Hart, Glasgow NHS; Dr John Lang, Medwise International, York). RegeNer8.
• Micro-structured conduits for peripheral nerve repair (with Dr Fred Claeyssens & Dr Andrew Scutt) NIHR i4i.
• Engineering peripheral nerve using aligned polymeric nerve fibres. EPSRC.
• The use of adult-derived stem cells for peripheral nerve repair (Royal Thai Government).
• Development of engineered skin for inflammatory detection (Royal Thai Government).
• Imaging of 3D Engineered Tissues. BBSRC Research Equipment Initiative award to establish a confocal microscope facility in the Kroto Research Institute.
• Two-Photon Imaging: From Polymeric Materials to Engineered Tissues. BBSRC Research Equipment Initiative award to establish a multiphoton microscope facility in the Kroto Research Institute.
• Construction of an immunocompetent three dimensional human skin model to investigate the allergenic potential of novel chemicals (with Prof. Sheila MacNeil & Dr. Amir Ghaem Maghami, Nottingham University). COLIPA.

Professional activities and recognition

• Director – Centre for Biomaterials & Tissue Engineering (Sheffield University)
• Associate Director – Kroto Research Institute
• Editor – 3D Cell Culture: Methods & Protocols
• Panel Member – NC3Rs (studentships, co-opted 2010)
• Board Member of UK Tissue & Cell Engineering Society (TCES)
• External Examiner for Manchester University (MRes in TERM: 2007-2010)
• Member of EPSRC Peer Review College
• Chair and lead organiser of TCES 2006
• Member of the Tissue Engineering and Regenerative Medicine International Society (TERMIS)
• Referee for BBSRC, EPSRC, MRC, NSF (USA), The Wellcome Trust, ARC, NC3Rs & several medical charities
• Referee for several journals spanning medicine/biology & the physical/life science interface

Key publications

John has recently edited a book on Biomaterials and Tissue Engineering

• 3D Cell Culture: Methods and Protocols. Methods in Molecular Biology, Vol. 695
• Haycock, John W. (Ed.)
• 1st Edition., 2011, XI, 343 p. 104 illus., 6 in colour., Hardcover
• ISBN: 978-1-60761-983-3
• A Humana Press product

• Kaewkhaw R, Scutt AM, Haycock JW (2011) Anatomical site influences the differentiation of adipose-derived stem cells for Schwann cell phenotype and function. GLIA (In press).
• Murray-Dunning C & Haycock JW (2011) Three-dimensional alignment of Schwann cells using hydrolysable microbibre scaffolds: Strategies for peripheral nerve repair. Methods in Molecular Biology, 695, 155-166.
• Haycock JW.  (2011) 3D Cell culture – a review of current techniques.  Methods in Molecular Biology, 695, 1-16.
• Cantón I, Kemp EH, Ryan AJ, MacNeil S, Haycock JW (2010). A 3D in vitro skin model for detecting paracrine-dependant inflammatory responses in real-time.  Biotechnology & Bioengineering, 106, 794–803.
• Morris HL, Reed CI, Reilly GC, Haycock JW (2010). Mechanisms of fluid flow induced matrix production in bone tissue engineering.  Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine, 224 (12), 1509-1521.
• Haycock JW, Botchway S, Weinstein JA, Williams JAG (2009).  Development of novel probes for time resolved imaging.  SPIE (DOI: 10.1117/2.1200906.1684).
• Charnley M, McArthur SL, Williams NH, Haycock JW. (2009). Generation of bioactive materials with rapid self-assembling resorcinarene-peptides. Advanced Materials. 21 (28): 2909-2915.
• Hopkins S, Carter SR, Haycock JW, Fullwood NJ, MacNeil S, Rimmer S (2009). Sub-micron poly(N-isopropyl acrylamide) particles as temperature responsive vehicles for the detachment and delivery of human cells. Soft Matter, 5 (24): 4928-4937.
• Botchway S, Charnley M, Haycock JW*, Parker A, Rochester D, Weinstein J*, Williams JAG*. (2008) Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes. Proceedings of the National Academy of Sciences (USA), 105 (42): 16071-16076.  Alphabetical authors (*PIs).

Publication list (pdf, 90kb) in right-hand Downloads box.

Research group

Postdoctoral Researchers
Dr. Celia Murray-Dunning
Dr. Igor Sasanovich
Dr. Kiran Pawar

Experimental Officer
Dr. Nicola Green

PhD Students
Candy Ho
Christopher Pateman
Mohammed Daud
Hayley Morris
Jirapat Chunthapong
Rossukon Kaewkhaw
Juliet Bell
Elizabeth Baggaley (PI Julia Weinstein)

Technicians
Claire Johnson

Recently graduating PhD students
Dr. Queta Real San Miguel (Scientist, Mexico City, Mexico)
Dr. Stephen Roberts (R&D facilitator - North Middlesex Hospital, NHS)
Dr. Mirren Charnley (PDRA, ETH, Switzerland)
Dr. Rebecca Hill (PDRA, Durham University)
Dr. Sarah Grubb (Programme Manager, Cambridge)
Dr. Richard Elliott (Lecturer at Northampton University)

Research themes/centres

Centre for Biomaterials & Tissue Engineering

The Kroto Research Institute

The Polymer Centre

Teaching

MAT 1410 – 10 credits – Biomaterials (10% - practical classes)
MAT 2530 – 10 credits – Biology & Chemistry of Living Systems (10% - practical classes)
MAT 209 – 10 credits – Cell & Molecular Biology
MAT 300 – 20 credits – Tissue Engineering (10% with Prof. Sheila MacNeil & Dr Andy Scutt)
MAT 372 – 20 credits – Group Projects in Bioengineering (with Dr Russell Goodall)
MAT 405 – 10 credits – Scientific Writing

Supervision of 3-4 honours project students per year for 30 credit B.Eng (MAT356) and 60 credit (MAT404) research projects.

Administration

Course Director for B.Eng/M.Eng (Hons) degree in Biomaterial Science & Tissue Engineering
Admissions tutor for B.Eng/M.Eng (Hons) degree in Bioengineering

Useful information - Confocal tutorial

You can find information here on how to use the Zeiss LSM 510 confocal microscope in John´s lab. Zeiss LSM 510 Power Point tutorial is in the right-hand Downloads box (file size=27Mb).