22 December 2005
International project cracks key genome
An international consortium of researchers, including experts from the University of Sheffield has deciphered the gene code of a key family of fungi, which includes the leading cause of death in leukaemia and bone marrow transplant patients. The research, which has been published in Nature, is a major development in the understanding of why this group of fungi is so lethal and allergenic.
The project has taken over six years and has involved more than 150 scientists from around the world including universities in the USA and Japan as well as the UK. Professor Geoffrey Turner, from the Department of Molecular Biology and Biotechnology at the University of Sheffield, led on a crucial aspect of the research, helping to compile data and identifying the genes involved in making toxins and antibiotics.
The fungi, Aspergillus fumigatus, Aspergillus nidulans and Aspergillus oryzae, while having some useful functions, also produce toxins known as mycotoxins, which can cause liver cancer. Aspergillus causes a life-threatening infection for transplant and leukaemia patients, as well as being a major allergen for asthmatics.
The results from this major research project will help with the development of new drugs and diagnostic tests, and will improve the understanding and prevention of allergies and diseases such as pneumonia and sinusitis.
Professor Turner said: ""I´m proud to have been involved with this enormous project that has produced such successful results. These species of fungi are tremendously significant for medicine, biology and biotechnology and this collaboration will provide a lasting advantage for these areas."
For further information please contact:
Matt Barker at the University of Sheffield press office on 0114 222 1046, or matt.barker@sheffield.ac.uk
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