Professor Jim Litster

Department of Chemical and Biological Engineering

Head of Department

Chair of Safety Committee

Professor James Litster
james.litster@sheffield.ac.uk
+44 114 222 7592

Full contact details

Professor Jim Litster
Department of Chemical and Biological Engineering
Room F59a
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

I joined the Department in January 2016. Prior to my appointment, I was Professor of Chemical Engineering and Professor of Industrial and Physical Pharmacy at Purdue University in the USA for over eight years. I also spent 20 years in academic positions at The University of Queensland in Australia including Head of Chemical Engineering and Head of School of Engineering.

My research area is Particulate Products and Processes. My expertise is on wet granulation with over 30 years of experience in the field. My key contributions include the development of key regime maps for granulation processes and the development of mathematical models for engineering design and scaling of granulation processes. I'm the co-author of the well-known monograph in this area - The Science and Engineering of Granulation Processes and my approaches are now widely used in engineering practice in industry.

I was elected a Fellow of the Australian Academy of Technological Sciences and Engineering in 2010, and was awarded the Thomas Barron Award in Fluid-Particle Systems from the American Institute of Chemical Engineers in 2012, and Pharmaceutical Section Award for contributions to Quality by Design by the American Institute of Chemical Engineers.

I'm passionate about university education and educators. One of my most significant achievements is leading the design and implementation of a new Project Centered Curriculum across the whole Chemical Engineering Program at UQ between 1998 and 2005. This transformation was recognized as a world leading effort and received many awards, including the Australian Award for University Teaching in 2005, and one of six engineering change programs highlighted in the Royal Academy Of Engineering/MIT report on Achieving excellence in engineering: the ingredients of successful change (2012).

Research interests

Predicting the structure of complex particulate products and their performance in use is a grand challenge in engineering science. The products include pharmaceuticals (e.g. GSK, Astra Zeneca), consumer products (e.g. P&G, Unilever), agricultural chemicals (e.g. Syngenta) and foods (e.g. Nestle). The value of sales and export of these high value products for the UK is estimated at £180bn per year (Chemistry Innovation KTN Strategy Report 2010) and complex products are a designated priority area in the Innovate UK High Value Manufacturing strategy. The performance of these products is controlled by their size, structure and surface properties, as well as their chemistry. Therefore, modeling the development of these attributes must address structure at many length scales from nm to mm. Jim’s programme focuses on developing new design models to substantially improve the manufacture of these particulate products.

Particle Technology Group 

Publications

Books

Journal articles

Chapters

  • El Hagrasy A, Wang LG & Litster J (2020) Continuous Wet Granulation, Continuous Pharmaceutical Processing (pp. 269-300). Springer International Publishing RIS download Bibtex download
  • Chaudhury A, Barrasso D, Pohlman DA, Litster JD & Ramachandran R (2017) Mechanistic modeling of high-shear and twin screw mixer granulation processes, Predictive Modeling of Pharmaceutical Unit Operations (pp. 99-135). Elsevier RIS download Bibtex download
  • Afolabi A, Aliseda A, am Ende M, Barrasso D, Berchielli A, Bharadwaj R, Bilgili E, Capece M, Chatterjee S, Chaudhury A , Chen X et al (2017) List of contributors, Predictive Modeling of Pharmaceutical Unit Operations (pp. ix-xi). Elsevier RIS download Bibtex download
  • Pandey P, Bharadwaj R, Chen X, O’Connor T, Yang X, Tian G, Chatterjee S, Lee S, Dubey A, Michrafy A , Zavaliangos A et al (2017) Predictive modeling of pharmaceutical unit operations, Predictive Modeling of Pharmaceutical Unit Operations (pp. xiii-xxiv). Elsevier RIS download Bibtex download
  • Chaudhury A, Barrasso D, Pohlman DA, Litster JD & Ramachandran R (2017) Mechanistic modeling of high-shear and twin screw mixer granulation processes, Predictive Modeling of Pharmaceutical Unit Operations (pp. 99-135). RIS download Bibtex download
  • He Y, Liu LX, Litster JD & Kayak-Talay D (2009) Chapter 25 Scale Up Considerations in Granulation In Parikh D (Ed.), Handbook of Pharmaceutical Granulation Technology, Third Edition CRC Press RIS download Bibtex download
  • He Y, Litster J & Liu L (2005) Scale-Up Considerations in Granulation, Drugs and the Pharmaceutical Sciences (pp. 459-490). Informa Healthcare RIS download Bibtex download
  • Hapgood KP & Litster JD () WET GRANULATION PROCESSES, Chemical Engineering in the Pharmaceutical Industry (pp. 147-171). John Wiley & Sons, Inc. RIS download Bibtex download
  • Hapgood KP & Litster JD () Wet Granulation Processes, Chemical Engineering in the Pharmaceutical Industry (pp. 757-780). John Wiley & Sons, Inc. RIS download Bibtex download

Conference proceedings papers

  • Zandi M, Patwardhan S, Kotta L & Litster J (2018) A New Curriculum to Train Chemical Engineers to Solve 21st Century Grand Challenges. 5 TH Annual Symposium of the United Kingdom & Ireland Engineering Education Research Network: View this article in WRRO RIS download Bibtex download
  • Pitt K, Smith RM, Hounslow MJ & Litster JD (2015) Kinetics of immersion nucleation driven by surface tension.. 7th International Granulation Workshop. Sheffield, UK, 1 July 2015 - 3 July 2015. RIS download Bibtex download
  • Sayin R, El Hagrasy AS & Litster JD (2014) Characterization of distributive mixing elements and effect of downstream conveying elements in twin screw granulation. Particle Technology Forum 2014 - Core Programming Area at the 2014 AIChE Annual Meeting (pp 251-260) RIS download Bibtex download
  • Oucherif AK, Lu J, Bermingham SK, Braido D, Calado F, Taylor L & Litster JD (2013) Modeling drug precipitation in the human gastrointestinal tract using gCOAS. Pharmaceutical Discovery, Development and Manufacturing Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future (pp 75-76) RIS download Bibtex download
  • Jones J, Meckl P, Harris M, Cox M, Cekic O, Okos M, Campanella O, Houze N, Litster J, Mosier N , Radcliffe D et al (2009) Purdue's Engineer of 2020: The journey. ASEE Annual Conference and Exposition, Conference Proceedings RIS download Bibtex download
  • Jones J, Meckl P, Harris M, Cox M, Cekic O, Okos M, Campanella O, Houze N, Litster J, Mosier N , Radcliffe D et al (2009) Purdue's Engineer of 2020: The journey. ASEE Annual Conference and Exposition, Conference Proceedings RIS download Bibtex download
  • Van Der Hoeven MJ, Howes T, Litster JD, Wildeboer WJ, Meesters GMH & Cameron IT (2008) Dynamic modelling of particle-droplet collisions. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Kayrak-Talay D, Baird J, Taylor LS & Litster JD (2008) Crystallization of pharmaceuticals via microfluidic crystallization. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Ramachandran R, Immanuel CD, Litster JD, Iii FJD & Stepanek F (2008) A combined mechanistic model for nucleation, aggregation and breakage in a population balance model of granulation. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Poon JMH, Ramachandran R, Sanders CFW, Glaser T, Doyle FJ, Litster JD, Stepanek F, Wang FY, Cameron IT & Immanuel CD (2007) A mechanistic model for nucleation and aggregation in population balances of granulation: Batch characterisation studies and experimental validation. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Mehta CM, White ET, Litster JD, Hardin MT & Lenhoff A (2007) Correlating molecular interactions with solubility of alpha-amylase from bacillus licheniformis. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Mehta CM, White ET, Litster JD, Hardin MT & Lenhoff A (2007) Effect of other protein on the solubility of hen egg white lysozyme. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Dombrowski RD, Litster JD & Wagner NJ (2006) Kinetics and modeling of crystallization in surfactant-free monodisperse emulsions. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Van Der Hoeven MJ, Litster JD, Cameron IT, Howes T, Meesters GMH & Wildeboer WJ (2006) Influence of surface tack of food products on agglomeration in spray drying. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Tait S, White ET, Litster JD & Liu LX (2006) The attrition and breakage propensity of some industrially crystallized materials. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Litster JD, Smith RM & Page N (2006) Dynamic mechanical properties of partially saturated granules. AIChE Annual Meeting, Conference Proceedings RIS download Bibtex download
  • Litster JD, Smith R & Page N (2005) Wet granule breakage in high shear mixer granulation. AIChE Annual Meeting, Conference Proceedings (pp 3010) RIS download Bibtex download
  • Dombrowski RD, Litster JD, Wagner NJ & He Y (2005) Crystallization in monodisperse emulsions. AIChE Annual Meeting, Conference Proceedings (pp 2410) RIS download Bibtex download
  • Cherian KA, Litster J, Rudolph V & White ET (1997) Chemical Etching of Diamond Revisited: Past Basic Research as Guide to New Processing Technologies. MRS Proceedings, Vol. 495 RIS download Bibtex download
  • Cherian KA, Litster J, Rudolph V & White ET (1995) Diamond Needles And Tips As Engineered Growth Shapes. MRS Proceedings, Vol. 416 RIS download Bibtex download
  • Liu LX & Litster JD (1990) Effect of process variables on the maximum coating rate in a spouted bed seed coater. CHEMECA '90, Australasian Chemical Engineering Conference (pp 626-633) RIS download Bibtex download
  • Litster JD, Desai M & Adetayo AA (1990) Modelling of fertilizer granulation using population balance techniques. CHEMECA '90, Australasian Chemical Engineering Conference (pp 642-649) RIS download Bibtex download
  • Newell RB, Bell PRF & Litster JD (1982) ASPECTS OF PARTICLE SIZE IN THE PROCESSING OF OIL SHALE.. National Conference Publication - Institution of Engineers, Australia(82 /9) (pp 46-50) RIS download Bibtex download
  • Litster JD, Bell PRF, Newell RB & White ET (1982) ROLE OF KINETICS IN OIL SHALE RETORTING.. National Conference Publication - Institution of Engineers, Australia(82 /9) (pp 35-39) RIS download Bibtex download

Datasets

Presentations

  • Al-aaraj DKA, Litster JD & Smith RM An investigation into growth of non-wetting system in high shear granulation. AIChE Annual Meeting 2016. RIS download Bibtex download
  • Al-aaraj DKA, Litster JD & Smith RM An Investigation into growth of non-wetting system in high shear granulation. Joint IFPRI Robert Pfeffer Symposium & UK Particle Technology Forum. RIS download Bibtex download