Dr Frederik Claeyssens

Licentiate, PhD

Department of Materials Science and Engineering

Reader in Biomaterials

Bioengineering Course Director, Dr Frederik Claeyssens, photo image
f.claeyssens@sheffield.ac.uk
+44 114 222 5513

Full contact details

Dr Frederik Claeyssens
Department of Materials Science and Engineering
North Campus
Broad Lane
Sheffield
S3 7HQ
Profile

Frederik Claeyssens joined the department in 2008 from the University of Bristol, where he was a Research Fellow at the Life Sciences Interface of the Chemistry Department.

He obtained his first degree in Chemistry at Ghent University (Belgium) and his PhD in Chemistry at the University of Bristol, and he was a PDRA at the University of Birmingham and the University of Bristol.

Research interests

Frederik´s research expertise focusses mainly on laser processing of biomaterials and its applications. This research portfolio can be divided into three projects:

Coatings for biology: Biocompatible coatings of semiconductors to be integrated into cell-silicon interfaces for biosensors. These coatings are currently investigated for in vivo/in vitro recording devices of electroactive cells (heart/brain cells).

Bioprinting: Laser-based techniques for printing biomolecules/cells for producing biomolecule arrays and biosensors. I have further developed this technique as a parallel direct-write technique, able to print 1000 pixels in one single laser shot. This technique is able to print viscous fluids containing DNA, proteins and even living cell.

Biomaterials manufacture via micro stereolithography: Using top-down approaches to controllable (via CAD/CAM) produce 3D biocompatible/degradable polymer structures with micrometre resolution. Combination of this technique with bottom-up approaches to achieve hybrid biomaterials as 3D scaffolds for implants, tissue engineering and pharmaceutical testing.

Additionally, Frederik has a keen research interest in computational solid-state and biological chemistry. His previous work in this area includes predicting the stabilisation mechanism for the growth of polar wurtzite surfaces, based on the existence of a low energy graphite-like structure (or h-BN) for ultra-thin wurtzite films. This model has recently been confirmed experimentally and forms the basis for understanding growth of polar surfaces in a large number of key technological materials (e.g. ZnO, GaN, CdSe and SiC).

Frederik has also studied enzyme reactions on an unprecedented high level of theory, providing powerful new tools for modelling enzyme reactions, and enabling for the first time the study of enzyme reactions computationally with chemical accuracy.


Key projects

  • Laser based bioprinting (EPSRC funded)
  • 3D microstructure fabrication of biomaterials for tissue engineering
Publications

Journal articles

Chapters

  • Gill A & Claeyssens F (2013) Two-Photon Polymerization for Tissue-Engineered Scaffold Fabrication, Optical Techniques in Regenerative Medicine (pp. 93-114). Taylor & Francis RIS download Bibtex download
  • Sun Y, Warren JL, Ashfold MNR & Claeyssens F (2008) Growth of ZnO Nanorods from the Gas Phase In Prescott WV & Schwartz AI (Ed.), Nanorods, nanotubes, and nanomaterials research progress (pp. 239-278). Nova Science Publishers RIS download Bibtex download

Conference proceedings papers

  • Thanarak J, Mohammed H, Pashneh-Tala S, Claeyssens F & Green N (2019) Enhanced Collagen Production from Human Dermal Fibroblasts on Poly(glycerol sebacate)-methacrylate Scaffolds. 2018 11th Biomedical Engineering International Conference (BMEiCON), 21 November 2018 - 24 November 2018. View this article in WRRO RIS download Bibtex download
  • Dikici BA, Reilly G & Claeyssens F (2018) Assessment of the osteogenic and angiogenetic potential of in vitro generated extracellular matrix decorated multiscale porous polyHIPE scaffolds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256 RIS download Bibtex download
  • Dikici S, Dikici BA, Reilly G & Claeyssens F (2018) Investigating the barrier membrane properties of biphasic PCL scaffolds for guided tissue regeneration. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256 RIS download Bibtex download
  • Claeyssens F (2018) Hierarchically structured biocompatible materials for tissue engineering. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256 RIS download Bibtex download
  • Pashneh-Tala S, Sherborne C, MacNeil S & Claeyssens F (2017) Tissue-Engineered Blood Vessels with User-Defined Geometries. TISSUE ENGINEERING PART A, Vol. 23 (pp S140-S140) RIS download Bibtex download
  • Romero-Gonzalez M, Skipworth P, Morley N, Turton T, Holdsworth E, Chimonides G, Hassani F & Claeyssens F (2016) Measuring continuous concentration of mass pollutants in the aquatic environment. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 251 RIS download Bibtex download
  • Butterworth J, Briston K, Claeyssens F & Inkson BJ (2015) Nanodiamond stability with friction and heat. Journal of Physics: Conference Series, Vol. 644 (pp 012022-012022) RIS download Bibtex download
  • Dugan JM & Claeyssens F (2015) Patterning of Neurons on Diamond-like Carbon by Pulsed Laser Ablation. TISSUE ENGINEERING PART A, Vol. 21 (pp S259-S260) RIS download Bibtex download
  • Brif A, Holland C & Claeyssens F (2015) Light-based Bioprinting of Native Silk. TISSUE ENGINEERING PART A, Vol. 21 (pp S339-S339) RIS download Bibtex download
  • Paterson TE, Dugan JM, Sherborne C, Green NH, Reilly GC & Claeyssens F (2015) Highly Porous Particles for Cell Recruitment and Delivery in Bone Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 21 (pp S287-S288) RIS download Bibtex download
  • Valderrama LRL, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325) RIS download Bibtex download
  • Pashneh-Tala S, MacNeil S & Claeyssens F (2015) Developing a Degradable Polymer Scaffold for Vascular Graft Tissue Engineering using a Novel Photocurable Poly(glycerol Sebacate). TISSUE ENGINEERING PART A, Vol. 21 (pp S182-S182) RIS download Bibtex download
  • Clarke J, Harding AJ, Boissonade FM, Haycock JW & Claeyssens F (2015) 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360) RIS download Bibtex download
  • Dew L, Ortega I, Kelly A, Claeyssens F & MacNeil S (2015) Development of a Three-Dimensional In Vitro Model to Study Neovascularization. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S326) RIS download Bibtex download
  • Lizarraga-Valderrama LR, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185) RIS download Bibtex download
  • Wan Q, Plenderleith RA, Dapor M, Rimmer S, Claeyssens F & Rodenburg C (2015) Separating topographical and chemical analysis of nanostructure of polymer composite in low voltage SEM. Journal of Physics: Conference Series, Vol. 644 (pp 012018-012018) View this article in WRRO RIS download Bibtex download
  • Ortega AI, MacNeil S, Crawford A, Hatton P & Claeyssens F (2014) Microfabrication of artificial stem cell microenvironments for tissue regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 175-176) RIS download Bibtex download
  • Pateman CJ, Harding A, Plenderleith R, Boissonade F, Rimmer S, Haycock JW & Claeyssens F (2014) Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172) RIS download Bibtex download
  • Malayeri A, Hatton PV, Ortega I & Claeyssens F (2014) In vitro biocompatibility of a poly(high internal phase emulsion) biomaterial. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 452-453) RIS download Bibtex download
  • Ramachandran C, Ortega I, Sefat F, Deshpande P, Claeyssens F, Ryan AJ, Balasubramanian D, Sangwan VS & Macneil S (2014) Microfabricated niches for the culture of limbal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 55(13) RIS download Bibtex download
  • (2012) Tissue Engineering and Regenerative Medicine. Journal of Tissue Engineering and Regenerative Medicine, Vol. 6 (pp 1-429) RIS download Bibtex download
  • Malayeri A, Gabbott C, Reilly G, Ghassemieh E, Hatton PV & Claeyssens F (2012) Feasibility of 3D printing and stereolithography for fabrication of custom-shaped poly (lactic acid): hydroxyapatite composite biomaterial scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 367-367) RIS download Bibtex download
  • Sherborne CR, Pateman CJ & Claeyssens F (2012) Direct Laser Writing of Neural Tissue Engineering Scaffolds for Biohybrid Devices.. Living Machines, Vol. 7375 (pp 392-393) RIS download Bibtex download
  • Melissinaki V, Gill AA, Ortega I, Vamvakaki M, Ranella A, Fotakis C, Farsari M & Claeyssens F (2011) Direct laser writing of polylactide 3D scaffolds for neural tissue engineering applications. 2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference (CLEO EUROPE/EQEC), 22 May 2011 - 26 May 2011. RIS download Bibtex download
  • Claeyssens F, Klini A, Mourka A & Fotakis C (2007) Laser patterning of Zn for ZnO nanostructure growth: Comparison between laser induced forward transfer in air and in vacuum. THIN SOLID FILMS, Vol. 515(24) (pp 8529-8533) RIS download Bibtex download
  • Szefczyk B, Claeyssens F, Mulholland AJ & Sokalski WA (2007) Quantum chemical analysis of reaction paths in chorismate mutase: Conformational effects and electrostatic stabilization. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Vol. 107(12) (pp 2274-2285) RIS download Bibtex download
  • Claeyssens F, Freeman CL, Harding JH & Allan NL (2007) A Theoretical Study of Ultra-Thin Films with the Wurtzite and Zinc Blende Structures. Materials Research Society Symposium Proceedings, Vol. 1035-L09-08(1035E) RIS download Bibtex download
  • Freeman CL, Claeyssens F, Allan NL & Harding JH (2006) Thin films of wurtzite materials - AlN vs. AlP. JOURNAL OF CRYSTAL GROWTH, Vol. 294(1) (pp 111-117) RIS download Bibtex download
  • Pearce SRJ, Henley SJ, Claeyssens F, May PW, Hallam KR, Smith JA & Rosser KN (2004) Production of nanocrystalline diamond by laser ablation at the solid/liquid interface. DIAMOND AND RELATED MATERIALS, Vol. 13(4-8) (pp 661-665) RIS download Bibtex download
  • Claeyssens F, Oliva JM, May PW & Allan NL (2003) Binary phosphorus-carbon compounds: The series P4C3+8n. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Vol. 95(4-5) (pp 546-553) RIS download Bibtex download
  • Lade RJ, Claeyssens F, Rosser KN & Ashfold MNR (1999) 193-nm laser ablation of CVD diamond and graphite in vacuum: plume analysis and film properties. APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, Vol. 69 (pp S935-S939) RIS download Bibtex download
  • Patterson T, Sherborne C, Reilly G & Claeyssens F () Manufacturing of PolyHIPE-based Porous Microparticles for Bone Tissue Engineering. USES Conference Proceedings RIS download Bibtex download
  • Lee Y-C, Claeyssens F, Fisher M, Lefley D, Kanthou C, Tozer G & English WR () Differences in VEGFA isoform expression regulate modes of migration and their sensitivity to anti-VEGFA therapy. International Journal of Experimental Pathology, Vol. 100(4) RIS download Bibtex download

Datasets

Research group

Postdoctoral researchers
Dr Adam Glen (Neurimp-FP7)
Dr Jim Dugan (EPSRC)
Dr Richard Plenderleith (TSB)

Former group members
Dr Ilida Ortega (Lecturer in School of Clinical Dentistry, Sheffield)
Dr Ivana Barbaric (Lecturer in Biomedical Sciences, Sheffield)
Dr Andrew Gill (KTP Associate, Sheffield)

Professional activities

I’ve had a few opportunities to highlight my work to a broader audience, and my work has been publicised on various different media websites, amongst them:

I have also been interviewed on live radio by BBC Sheffield during the evening drive-time program, and I have been interviewed together with my colleague Prof. J.W. Haycock by the BBC World News for their 'Horizon' programme.


  • Member of the Materials Research Society
  • Member of the Royal Society of Chemistry
  • Member of the scientific editorial board for ‘The Open Materials Science Journal’ (Bentham Science)