Dr Alex Best
School of Mathematics and Statistics
Departmental Director of Equality, Diversity and Inclusion
+44 114 222 3749
Full contact details
School of Mathematics and Statistics
- 2016 - Current: Lecturer, SoMaS, University of Sheffield
- 2013 - 2016 : Leverhulme Early Career Research Fellow, SoMaS, University of Sheffield
- 2012 - 2012 : Associate Research Fellow, Biosciences, University of Exeter
- 2010 - 2011 : Postodctoral Research Associate, Animal and Plant Sciences, University of Sheffield
- 2006 - 2010 : PhD, Animal and Plant Sciences, University of Sheffield
- Research interests
I am a mathematical biologist who uses theoretical models to investigate the dynamics of infectious disease systems. I use tools from dynamical systems theory to explore disease dynamics at a range of scales. My research interests include:
- models of host-parasite coevolution;
- spatial structure in epidemic/evolutionary models;
- immune processes in epidemic/evolutionary models;
- within-host models of bacteria-cell dynamics.
This person does not have any publications available.
- Evolutionarily stable strategies are well studied in periodically fluctuating populations.. Proceedings of the National Academy of Sciences, 118(18).
- Herd immunity. Current Biology.
- A mathematical model shows macrophages delay staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance. Journal of Theoretical Biology, 497. View this article in WRRO
- The evolution of host resistance and parasite infectivity is highest in seasonal resource environments that oscillate at intermediate amplitudes. Proceedings of the Royal Society B: Biological Sciences, 287(1927), 20200787-20200787.
- The effect of temporal fluctuations on the evolution of host tolerance to parasitism. Theoretical Population Biology, 130, 182-190.
- The paradox of tolerance: parasite extinction due to the evolution of host defence. Journal of Theoretical Biology, 474, 78-87. View this article in WRRO
- The Impact of Selective Predation on Host–Parasite SIS Dynamics. Bulletin of Mathematical Biology, 81(7), 2510-2528.
- Understanding the role of eco-evolutionary feedbacks in host-parasite coevolution. Journal of Theoretical Biology, 464, 115-125. View this article in WRRO
- Host–pathogen coevolution in the presence of predators: fluctuating selection and ecological feedbacks. Proceedings of The Royal Society B Biological Sciences, 285(1885), 20180928-20180928. View this article in WRRO
- The evolution of constitutive and induced defences to infectious disease. Proceedings of the Royal Society B: Biological Sciences, 285(1883), 20180658-20180658. View this article in WRRO
- The evolution of host defence to parasitism in fluctuating environments. Journal of Theoretical Biology, 440, 58-65. View this article in WRRO
- Host-parasite fluctuating selection in the absence of specificity. Proceedings of the Royal Society of London: Biological Sciences, 284(1866). View this article in WRRO
- View this article in WRRO The evolution of host defence when parasites impact reproduction. Evolutionary ecology research, 18, 393-409.
- Evolution of Host Defense against Multiple Enemy Populations. American Naturalist, 187(3), 308-319. View this article in WRRO
- Spatial heterogeneity lowers rather than increases host–parasite specialization. Journal of Evolutionary Biology, 28(9), 1682-1690. View this article in WRRO
- Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense. Current Biology, 25(8), 1043-1049.
- Evolution, the loss of diversity and the role of trade-offs. Mathematical Biosciences, 264, 86-93.
- The evolution of host resistance to disease in the presence of predators. Journal of Theoretical Biology, 365, 104-111.
- Higher resources decrease fluctuating selection during host-parasite coevolution. Ecology Letters, 17(11), 1380-1388. View this article in WRRO
- How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites.. Evolution, 68(6), 1594-1606. View this article in WRRO
- The coevolutionary implications of host tolerance.. Evolution, 68(5), 1426-1435.
- A limited host immune range facilitates the creation and maintenance of diversity in parasite virulence. Interface Focus, 3(6).
- The effects of seasonal forcing on invertebrate-disease interactions with immune priming.. Bull Math Biol, 75(11), 2241-2256.
- The evolution of costly acquired immune memory.. Ecol Evol, 3(7), 2223-2232. View this article in WRRO
- The evolutionary dynamics of within-generation immune priming in invertebrate hosts.. J R Soc Interface, 10(80), 20120887.
- Seasonality selects for more acutely virulent parasites when virulence is density dependent. Proceedings of the Royal Society B: Biological Sciences, 280(1751).
- The importance of who infects whom: the evolution of diversity in host resistance to infectious disease.. Ecol Lett, 15(10), 1104-1111.
- The epidemiological consequences of immune priming.. Proc Biol Sci, 279(1746), 4505-4512.
- The implications of immunopathology for parasite evolution.. Proc Biol Sci, 279(1741), 3234-3240.
- Predation on infected host promotes evolutionary branching of virulence and pathogens' biodiversity. Journal of Theoretical Biology, 307, 29-36.
- Local transmission processes and disease-driven host extinctions. Theoretical Ecology, 5(2), 211-217.
- Evolution of host resistance towards pathogen exclusion: the role of predators. EVOLUTIONARY ECOLOGY RESEARCH, 14(2), 125-146.
- Local transmission processes and disease-driven host extinctions. Theoretical Ecology, 1-7.
- Epidemiological, evolutionary, and coevolutionary implications of context-dependent parasitism. American Naturalist, 177(4), 510-521.
- Host resistance and coevolution in spatially structured populations.. Proc Biol Sci, 278(1715), 2216-2222.
- The evolution of host-parasite range.. Am Nat, 176(1), 63-71.
- Resistance is futile but tolerance can explain why parasites do not always castrate their hosts.. Evolution, 64(2), 348-357.
- The implications of coevolutionary dynamics to host-parasite interactions.. Am Nat, 173(6), 779-791.
- The role of ecological feedbacks in the evolution of host defence: what does theory tell us?. Philos Trans R Soc Lond B Biol Sci, 364(1513), 27-36.
- Maintenance of host variation in tolerance to pathogens and parasites.. Proc Natl Acad Sci U S A, 105(52), 20786-20791.
- Deleterious mutations can surf to high densities on the wave front of an expanding population. MOL BIOL EVOL, 24(10), 2334-2343.
- Which species will succesfully track climate change? The influence of intraspecific competition and density dependent dispersal on range shifting dynamics. Oikos, 116(9), 1531-1539.
- Research group
- Teaching activities
MAS212 Scientific Computing and Simulation MAS286 Mathematics and Statistics in Action MAS316 Mathematical modelling of natural systems MAS377 Mathematical Biology