Dr Alexander Fletcher

School of Mathematics and Statistics

Senior Lecturer

A.G.Fletcher@shef.ac.uk
+44 114 222 3846

Full contact details

Dr Alexander Fletcher
School of Mathematics and Statistics
G15
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
Profile
  • 2022 - present: Senior Lecturer, School of Mathematics and Statistics, University of Sheffield
  • 2019 - 2022: Lecturer, School of Mathematics and Statistics, University of Sheffield
  • 2015 - 2019 : Vice-Chancellor's Fellow, School of Mathematics and Statistics, University of Sheffield
  • 2011 - 2015 : Research Fellow in Computational Science, Mathematical Institute, University of Oxford
  • 2008 - 2015 : Stipendiary Lecturer in Mathematics, St Hugh's College, University of Oxford
  • 2008 - 2011 : Postdoctoral Research Assistant, Mathematical Institute, University of Oxford
  • 2005 - 2010 : DPhil, Mathematical Institute, University of Oxford
Research interests

I develop and apply mathematical models to study complex biological systems. Techniques range from discrete and continuous models of temporal dynamics to more computationally intensive individual-based and multiscale simulations. Major applications include mechanisms underlying tissue homeostasis and their disruption in cancer formation and progression, and the orchestration of cell-level processes such as proliferation, death, adhesion and migration to give correct tissue-level proportions in embryos.

Publications

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All publications

Journal articles

Chapters

Conference proceedings papers

  • Parker A, Maclaren O, Watson A, Byrne H, Fletcher A, Carding S, Maini P & Pin C (2014) A multidisciplinary approach to studying crypt-villus homeostasis and regeneration in the intestinal epithelium. FEBS JOURNAL, Vol. 281 (pp 217-218) RIS download Bibtex download
Research group

Mathematical Biology

Grants
Current grants, as Principal Investigator:  
Understanding self-organised tissue patterning across scales    EPSRC  
Chaste: developing sustainable software for computational biology    BBSRC  
Current grants, as Coinvestigator:  
Hypothalamic development from self-organising progenitors    Wellcome Trust
Past grants, as Coinvestigator:
How do the atypical cadherins Fat and Dachsous integrate growth and patterning during development?    BBSRC  
Teaching activities
MAS116

Mathematical Investigation Skills

MAS286 Mathematics and Statistics in Action