Evaluating a nutritional management intervention for people with Amyotrophic Lateral Sclerosis (ALS).
Sheffield Institute for Translational Neuroscience (SITraN), Clinical Trials Research Unit (CTRU) and School of Health and Related Research (ScHARR) staff were awarded a six-year programme grant from the NIHR (National Institute for Health Research) Programme Grants for Applied Research, focused on the nutritional management of people living with ALS (also known as Motor Neurone Disease).
The HighCALS research programme is led by Christopher McDermott, Professor of Translational Neurology, University of Sheffield, in collaboration with a number of colleagues including those from ScHARR, University of Leeds, University of Oxford and King’s College, London.
Underpinning HighCALS was a programme of work designed to understand the current national service models, the beliefs of stakeholders and the development of behaviour change strategies to support and improve nutritional interventions.
We are now in the final phase of the programme, conducting an effectiveness and cost effectiveness study to investigate whether the OptiCALS intervention can prolong life in people with ALS (pwALS). We believe addressing this potentially simple issue could have a dramatic impact on survival, function and quality of life for the 6000 people with ALS (pwALS) in the UK.
The OptiCALS trial is seeking to recruit 304 participants across 20 research sites.
|Professor Christopher McDermott||Chief Investigator||Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffieldemail@example.com|
|Dan Beever||Programme Manager||University of Sheffieldfirstname.lastname@example.org|
|David White||CTRU Oversight||University of Sheffieldemail@example.com|
|Gemma Hackney||Research Assistant||University of Sheffieldfirstname.lastname@example.org|
|Pavithra Kumar||Research Assistant||University of Sheffieldemail@example.com|
|Jack Rose||Trials Support Officer||University of Sheffieldfirstname.lastname@example.org|
|Ammar Al-Chalabi||Professor of Neurology and Complex Disease Genetics||King's College London|
|Wendy Baird||Professor of Health Services Research||University of Sheffield|
|Mike Bradburn||Senior Medical Statistician||University of Sheffield|
|Janet Cade||Professor of Nutritional Epidemiology||University of Leeds|
|Lizzie Coates||Qualitative Researcher||University of Sheffield|
|Cindy Cooper||Professor of Health Services Research and Clinical Trials||
University of Sheffield
|Vanessa Halliday||Senior Lecturer in Public Health||University of Sheffield|
|Gillian Marsden||Deputy Operations Director Head & Neck Care Group||Sheffield Teaching Hospitals NHS Foundation Trust|
|Paul Norman||Professor of Health Psychology||University of Sheffield|
|Alicia O'Cathain||Process Evaluation Lead||University of Sheffield|
|Pamela Shaw||Director the Sheffield NIHR Biomedical Research Centre for Translational Neuroscience||University of Sheffield|
|Theocharis Stavroulakis||Post-doctoral Research Associate||University of Sheffield|
|Martin Turner||Professor of Clinical Neurology & Neuroscience||University of Oxford|
|David White||Research Fellow||University of Sheffield|
|Sean White||Home Enteral Feed Dietitian||Sheffield Teaching Hospitals NHS Foundation Trust|
|Tracey Young||Senior Researcher in Health Economics||University of Sheffield|
Sheffield Teaching Hospitals NHS Foundation Trust
The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.